Tag: research

  • Is Mindfulness a Treatment for Depression?

    Is Mindfulness a Treatment for Depression?

    Depression is a classic example of what’s referred to today as an invisible illness. When you’re depressed, you may find yourself expending precious energy just so you can appear to the world as if nothing at all is troubling you. 

    This “it’s-work-to-seem-fine” coping mechanism illustrates just one way in which depression complicates your life. Not only are you exhausting yourself pretending to be OK, you may find it hard to rally support from friends, family, and coworkers who only see how well you seem to be functioning. 

    While there is rapidly growing recognition of the very real difficulty and damage caused by depression, the stigma of past decades and centuries lingers. We often still hear the familiar notion that you can just “pull yourself together and get on with it,” as though keeping a “stiff upper lip” should be enough to defeat depression. But strong neurochemical, social, and environmental factors contribute to this very real, physical illness, and successful treatment requires more than maintaining an “upbeat attitude.”

    Depression Is a Chameleon 

    Our ability to recognize and effectively treat depression—which 1 in 14 people will experience in their lifetime—is complicated by the fact that it manifests differently in everyone affected, according to the National Institutes of Health. Anything—your age, your gender, or the stage of your depression—can change what the illness looks like for you, meaning it’s not necessarily simple to get a diagnosis, or even recognize symptoms of depression, whether in yourself or in other people.

    For women, depression is more likely to appear as sadness, worthlessness, and guilt. Hormonal and life cycle-related changes, as in postpartum depression, can make women more susceptible to developing the illness. In fact, women are statistically more likely than men to experience depression. 

    For men, depression often looks like exhaustion, irritability, and sleeping problems. They also lose interest in things they once enjoyed. Men are also more likely to turn to drugs and alcohol, experiment with reckless activity, or become intensely devoted to work in order to distract themselves from their illness.  

    For teens and tweens, depression can look like extended and severe periods of sulking, getting into trouble at school, prolonged irritability, and an intense feeling of being misunderstood. 

    These are by no means the only ways depression can appear. Some people experience short, intense periods of depression, while others feel it as an unmoving cloud over their awareness; for some, it’s linked to difficult life events, while for others it doesn’t go away even when their outward circumstances seem fine. 

    Should You Try Mindfulness for Depression?

    Various treatment options for depression exist, including drug regimens and talk therapies. However, the jury continues to be out on how effective antidepressants are for treating depression. A comprehensive 2018 study conducted by an international research team examined 522 studies, including 116,477 patients, to learn about the effectiveness of 21 antidepressant medications. The researchers discovered that, although nearly all of the drugs were more effective than placebos, their effects were still “modest” in most cases.

    Complicating treatment is the fact that depression is often a chronic condition that tends to relapse, even with medication and talk therapy. According to research, relapse rates range from 50% to as high as 80%.

    Interestingly, when mindfulness is added to the standard depression treatment protocols, relapse rates decline. But it’s unlikely that simply practicing basic mindfulness meditation will ease your depression symptoms. In fact, such an attempt could be supremely unhelpful, notes Julienne Bower, PhD, professor of health psychology at UCLA.

    She tells us that the research showing that mindfulness meditation improves symptoms of depression is, at best, vague. She also notes that it’s really hard to meditate on your own when you’re depressed.

    Zindel Segal, PhD, concurs. The Distinguished Professor of Psychology in Mood Disorders at the University of Toronto, Dr. Segal has pioneered the use of mindfulness meditation for promoting wellness in the area of mood disorders. He was also one of the team who developed Mindfulness-Based Cognitive Therapy (MBCT), a research-backed mindfulness protocol for depressive disorders.

    Chronic Unhappiness?

    “When we talk about depression, and where mindfulness is strong and less strong as a treatment, we have to know what type of depression you have,” says Segal.

    “Don’t consider mindfulness a treatment when you’re dealing with acute depression,” he advises. Depression “shuts down your concentration and disrupts your executive network ability,” which makes practicing mindfulness difficult, says Dr. Segal. Instead, for acute depression, consider seeing a mental health professional for treatment with antidepressants, cognitive behavior therapy, or both. Mindfulness can bolster those treatments, but not replace them.

    Mindfulness-Based Cognitive Therapy, however, was specifically designed to help people who are depressed or chronically unhappy. MBCT is a therapeutic protocol that combines cognitive therapy, which helps people interrupt the disturbing behavior or thought patterns that interfere with their lives, with mindfulness practices that help you learn to develop a healthier relationship to unhelpful thought patterns.

    “Our research looked at specific ways that MBCT helps people work with rumination and worry in ways that are more generous and compassionate,” says Dr. Segal. “This therapy helps you learn to ‘de-center’ and allows you to see your thoughts unfold moment to moment. It helps you to not listen to the messages that depression is sending you.”

    How MBCT Helps

    The goal of MBCT is to help you become familiar with the ways your mind and your thinking patterns contribute to depression, which helps you to develop a new relationship to your depression.

    According to Dr. Segal, many people describe leaving the MBCT training with these two major insights:

    1) Thoughts are not facts.

    2) Depression is not me.

    At first, these points may seem overly simplistic—but when we pay attention to how we are thinking and feeling, over time we become better at spotting the buildup of difficult emotions and thoughts. In that way, we can deal with them more skillfully, instead of just reacting in ways that might not be good for us.

    “Mindfulness practices—focusing on the breath and body, as well as mindful movement and developing greater mindful attention to everyday activities—help us learn to recognize the feelings and patterns of thinking that cause unhappiness,” says Willem Kuyken, PhD, the Ritblat Professor of Mindfulness and Psychological Science at the University of Oxford.  “We learn that thoughts are just thoughts. They are not facts, and we can choose whether to give them power over our minds and hearts. In time they can even help us savor and enjoy all the things that give us pleasure and a sense of accomplishment,” adds Kuyken.

    When it comes to depression that relapses after treatment, he suggests that MBCT has proven to be particularly helpful, if you adhere to the program. The program consists of eight weeks of classes, as well as at-home practices you do on your own for about an hour a day. “Many people [with depression] are trying to turn around very long-standing and ingrained habits of thinking and behaving, and that will take time and effort,” says Dr. Kuyken. He notes that a recent study by Dr. Segal showed that the more a person practices MBCT over time, the greater the benefits for easing depression.

    To find a therapist who has been trained and certified in practicing MBCT, visit accessmbct.com

    If You Need Help

    If you or someone you care for is having suicidal thoughts, these helplines in the US, Canada, and UK offer free, confidential prevention, crisis resources, and support 24/7/365.

    US: Dial 988 to reach the Suicide & Crisis Lifeline.
    988lifeline.org

    Canada: Dial 988 to reach the Suicide Crisis Helpline.
    988.ca

    UK: Dial 116-123 to reach Samaritans.
    samaritans.org

    This article was first published in the April 2020 issue of Mindful magazine.

    The Ultimate Guide to Mindfulness for Sleep 

    Sufficient sleep heals our bodies and minds, but for many reasons sleep doesn’t always come easily. Mindfulness practices and habits can help us fall asleep and stay asleep. Consult our guide to find tips for meditation, movement, and mindfulness practices to ease into sleep. Read More 

    • Mindful Staff
    • July 13, 2023



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  • Peptides And Dermatological Research

    Peptides And Dermatological Research

    Peptides have emerged as promising agents in dermatology research, offering potential support to the function of the skin barrier. Studies suggest that these bioactive compounds, consisting of short chains of amino acids, may interact with skin cells to influence various physiological processes. As the understanding of peptides’ mechanisms expands, their implication in developmental research becomes increasingly sophisticated.

    Peptides: Structural and Functional Overview

    Peptides are composed of two or more amino acids linked by peptide bonds. Research indicates that they may play diverse roles within an organism, ranging from signaling molecules to structural components. In dermatology research, peptides are speculated to interact with skin cells to promote various physiological responses.

    One type of peptide, signal peptides, may influence cellular communication. These peptides are believed to bind to receptors on the cell surface, initiating a cascade of events that can lead to cellular proliferation, migration, or differentiation. Another category, carrier peptides, might facilitate the delivery of essential trace elements required for enzymatic activities. For instance, copper peptides are hypothesized to support skin elasticity by promoting collagen synthesis.

    Peptides: Mechanisms of Action

    The mechanisms through which peptides may exert their impacts are not fully understood, but several theories have been proposed. One hypothesis suggests that signal peptides may stimulate collagen production by activating specific cellular pathways. Collagen, a critical protein in the skin’s extracellular matrix, provides structural support and elasticity. By promoting collagen synthesis, peptides might help reduce the depth and length of wrinkles along the surface of the skin barrier.

    Additionally, some peptides are theorized to have antimicrobial properties. These antimicrobial peptides (AMPs) might disrupt the membranes of bacteria, thereby protecting the skin from infections. AMPs might be crucial in maintaining the skin’s microbiome, a complex community of microorganisms contributing to skin function.

    Peptides & Oxidative Stress

    Investigations purport that another potential of peptides may be their antioxidant activity. Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, may lead to cellular damage and cell aging. Certain peptides might scavenge ROS, reducing oxidative stress and its detrimental impacts on the skin. Findings imply that these peptides might help maintain the skin’s integrity by mitigating oxidative damage.

    Peptides & Wounds

    Peptides are also thought to play a role in wound healing. The wound healing process involves a series of coordinated events, including inflammation, tissue formation, and remodeling. Research indicates that certain peptides may accelerate wound healing by promoting cell migration and proliferation, angiogenesis (creating new blood vessels), and extracellular matrix synthesis. For example, the peptide Thymosin beta-4 is theorized to support wound healing by stimulating keratinocyte and fibroblast migration, two cell types essential for skin repair.

    Peptides & Cell Aging

    The anti-aging potential of peptides is a significant area of interest. As the skin ages, it is believed to undergo structural and functional changes, such as reduced collagen production and increased formation of matrix metalloproteinases (MMPs), which degrade collagen. Studies postulate that some peptides may inhibit MMP activity, preserving collagen and maintaining skin firmness. Additionally, scientists speculate that peptides that stimulate collagen synthesis might counteract the age-related decline in collagen levels, potentially reducing the depth of wrinkles and improving skin texture.

    Skin Barrier Function

    The skin barrier, composed of the stratum corneum and lipid matrix, is essential for maintaining skin hydration and protecting against external aggressors. It has been hypothesized that peptides might support skin barrier function by promoting the synthesis of barrier lipids and proteins. For example, ceramide-containing peptides are thought to boost the production of ceramides, lipids that play a critical role in skin barrier integrity. Improved barrier function can lead to better hydration and protection against irritants.

    Some peptides are theorized to interfere with the melanin synthesis pathway, thereby reducing hyperpigmentation. For instance, peptide complexes that inhibit tyrosinase, the enzyme responsible for melanin production, have been speculated to effectively lighten dark spots and support a homeostatic appearance.

    Growth Factors

    Growth factors are proteins that regulate cell growth, proliferation, and differentiation. Peptides appear to interact with growth factors to modulate their activity. For example, peptides that mimic growth factor binding sites are believed to support the activity of endogenous growth factors.

    Peptides: Future Research Directions

    The field of peptides is continually evolving, with ongoing research aimed at elucidating their mechanisms and optimizing their formulations. Biotechnology and molecular biology advances will likely contribute to developing novel peptides with supported properties and targeted actions.

    In conclusion, peptides hold significant promise in dermatology studies due to their diverse potential properties, including promoting collagen synthesis, enhancing wound healing, providing antioxidant protection, improving skin barrier function, and addressing hyperpigmentation.

    Scientists interested in purchasing high-quality, affordable peptides for sale are encouraged to visit the Core Peptides website.

    References

    [i] Pai VV, Bhandari P, Shukla P. Peptides as cosmeceuticals. Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):9-18. doi: 10.4103/0378-6323.186500. PMID: 27451932.

    [ii] Gorouhi F, Maibach HI. Role of peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009 Oct;31(5):327-45. doi: 10.1111/j.1468-2494.2009.00490.x. Epub 2009 Jun 30. PMID: 19570099.

    [iii] Skibska A, Perlikowska R. Signal Peptides – Promising Ingredients in Cosmetics. Curr Protein Pept Sci. 2021;22(10):716-728. doi: 10.2174/1389203722666210812121129. PMID: 34382523.

    [iv] Thapa RK, Winther-Larsen HC, Diep DB, Tønnesen HH. Preformulation studies on novel garvicin KS peptides for topical implications. Eur J Pharm Sci. 2020 Aug 1;151:105333. doi: 10.1016/j.ejps.2020.105333. Epub 2020 Apr 5. PMID: 32268197.

    [v] Thapa RK, Winther-Larsen HC, Diep DB, Tønnesen HH. Photostability studies of GarKS peptides for topical formulation development. Eur J Pharm Sci. 2021 Mar 1;158:105652. doi: 10.1016/j.ejps.2020.105652. Epub 2020 Nov 26. PMID: 33248238.

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  • Warehousing industry increases health-harming pollutants, research shows

    Warehousing industry increases health-harming pollutants, research shows

    America’s demand for products delivered to the doorstep has led to a dramatic increase in e-commerce and the warehousing industry.

    A first-of-a-kind study now shows that people living in communities located next to these large warehouses are exposed to 20% more of a traffic-related air pollutant that can lead to asthma and other life-threatening health conditions.

    “Increased truck traffic to and from these recently built large warehouses means people living downwind are inhaling an increased amount of harmful nitrogen dioxide pollution,” said Gaige Kerr, lead author of the study and an assistant research professor of environmental and occupational health at the George Washington University Milken Institute School of Public Health. “Communities of color are disproportionately affected because they often live in close proximity to warehouses, especially dense clusters of warehouses.”

    Kerr and his colleagues measured a traffic-related pollutant called nitrogen dioxide by using a satellite instrument from the European Space Agency to zero in from space on the nearly 150,000 large warehouses located across the United States. Trucks and other vehicles traveling to and from these large warehouses spew out nitrogen dioxide, particulates, and other harmful pollutants.

    The researchers also looked at traffic information from the Federal Highway Administration and demographic data from the US Census Bureau.

    Additional key findings of the study:

    • Although the average spike of nitrogen dioxide associated with warehouses was 20%, nitrogen dioxide levels near warehouses were even larger when there was greater heavy duty vehicle activity near these facilities.
    • Warehouses with more loading docks and parking spaces attract the most traffic and are associated with the highest nitrogen dioxide levels.
    • Communities with large racial and ethnic minority populations are often located near warehouses and thus are inhaling more nitrogen dioxide and other pollutants. For example, this study found that the proportion of Hispanic and Asian people living close to the largest clusters of warehouses is about 250% higher than the average nationwide.
    • Although warehouses are located all over the US, 20% are concentrated in just 10 counties: Los Angeles, California; Harris, Texas; Cook, Illinois; Miami-Dade, Florida; Maricopa, Arizona; San Bernardino, California; Orange, California; Dallas, Texas; Alameda, California; and Cuyahoga, Ohio.

    The pandemic fueled the explosion of the e-commerce industry and warehouses that receive and sort consumer goods. The transportation infrastructure needed to ship goods to warehouses and then onto consumers is enormous, according to the researchers. For example, Amazon, an industry leader in e-commerce operated 175,000 delivery vans and more than 37,000 semi trailers in 2021 alone.

    Earlier studies have looked at warehouses and pollution in specific neighborhoods around the country, but this is the first nationwide study to show that people living near these warehouses are exposed to higher than average levels of damaging pollutants. And while other research has shown that communities of color are exposed to more nitrogen dioxide pollution than predominantly non-Hispanic white communities, this is the first study linking the warehousing industry to the exposure inequities faced by these overburdened populations, Kerr says.

    Previous research by the GW team found that communities of color in the US face a growing burden from polluted air. That study showed that such communities endure nearly 8 times higher rates of pediatric asthma from exposure to nitrogen dioxide and 30% higher rates of dying prematurely from exposure to fine particulate matter, both of which are emitted by cars, trucks and other vehicles.

    The authors say the new study underscores the need for regulations that drive zero-emission vehicle use in logistics, particularly to protect vulnerable communities located near industrial hubs. They also say that industry leaders and utilities have crucial roles in planning and implementing this transition.

    “Such measures would mean people living near warehouses could breathe cleaner air,” said Kerr. “In addition to a reduced risk of pollutant-related diseases, such measures would also reduce greenhouse gas emissions associated with climate change.”

    The study, “Air pollution impacts from warehousing in the United States uncovered with satellite data,” was published July 24, 2024 in Nature Communications. In addition to Kerr, Susan Anenberg, professor and chair of the Department of Environmental and Occupational Health at GW, and Daniel Goldberg, assistant research professor in the same department, contributed to this paper alongside researchers from the International Council on Clean Transportation.

    The research was funded by NASA.

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