Tag: research

  • Plant-Based Diet for Heart Reversal, Cholesterol Reduction, and Easy Recipe Ideas Backed by Research

    Plant-Based Diet for Heart Reversal, Cholesterol Reduction, and Easy Recipe Ideas Backed by Research

    Plant-powered eating has drawn interest as more people explore how a plant-based diet can support heart health alongside standard medical care. Research suggests that focusing on whole plant foods may help with heart reversal, cholesterol reduction, and long-term protection when followed consistently.

    In this context, a plant-based diet is seen as a therapeutic pattern that emphasizes minimally processed plants over animal products and ultra-processed foods.

    What Is a Plant-Based Diet for Heart Reversal?

    A plant-based diet centers vegetables, fruits, whole grains, legumes, nuts, and seeds, while minimizing or excluding animal products and heavily processed foods. For heart reversal, many protocols use a whole-food, low-fat variation that limits added oils, refined sugars, and refined grains.

    The aim is to supply abundant fiber, antioxidants, and phytonutrients while reducing components that contribute to plaque buildup in the arteries.

    “Plant-based” does not always mean strictly vegan, but heart-focused programs often encourage eating as close to fully plant-based as possible. In these cases, the diet functions less as a trend and more as part of an intensive lifestyle approach to supporting cardiovascular repair and reducing symptoms.

    Can a Plant-Based Diet Really Reverse Heart Disease?

    Heart reversal usually refers to regression of atherosclerotic plaque, improved blood flow, fewer angina episodes, and reduced cardiac events, rather than complete erasure of disease.

    Clinical programs and long-term observations have reported such changes in some participants who follow a carefully designed plant-based diet alongside exercise, stress management, and appropriate medical treatment. Diet is one component of a broader strategy, not a replacement for professional care.

    Responses vary between individuals, and significant changes rarely happen overnight. The most promising results tend to appear in people who make substantial, sustained dietary changes. In this setting, a plant-based diet is part of an overall lifestyle pattern that can lessen symptom burden and improve quality of life.

    How Long Does It Take to See Results?

    Some people report early improvements, such as better energy and reduced chest discomfort, within weeks to a few months of adopting a plant-based diet.

    Laboratory measures like cholesterol reduction and improved blood pressure can also shift within this period when the pattern is followed consistently. These short-term gains often motivate people to continue.

    Structural changes, including partial regression of plaque or improved imaging results, usually require longer.

    Long-term study findings and intensive programs often track participants over several years, observing how sustained adherence to a plant-based diet and lifestyle influences heart function and event rates. In practice, heart reversal is viewed as a gradual, cumulative process.

    Does a Plant-Based Diet Lower Cholesterol?

    Cholesterol reduction is one of the clearest benefits linked with a plant-based diet. LDL (“bad”) cholesterol plays a central role in plaque formation, and lowering it is a priority in heart disease care. By replacing foods high in saturated fat and cholesterol with fiber-rich plant foods, many individuals see improvements in their lipid profiles.

    Soluble fiber from oats, barley, beans, lentils, apples, and citrus fruits can help remove cholesterol through the digestive tract. When these foods form the base of meals, total and LDL cholesterol often fall over time, according to the World Health Organization.

    Swapping butter, fatty meats, and full-fat dairy for nuts, seeds, avocado, and modest amounts of minimally processed plant oils supports this shift while preserving satisfaction at meals.

    What Does Long-Term Research Say?

    Long-term study data link plant-centered eating patterns with lower rates of cardiovascular disease, heart attacks, and overall mortality.

    People whose diets rely heavily on whole plant foods, with limited animal products and low intake of ultra-processed items, tend to have better outcomes over many years than those on more conventional diets. These associations suggest that dietary patterns meaningfully affect heart health trajectories.

    Interventional programs that emphasize a plant-based diet plus lifestyle change add more detail. Over multi-year follow-up, participants often show improved symptoms, better cholesterol reduction, and fewer cardiac events.

    While study designs differ, the recurring pattern is that sustained plant-based eating aligns with more favorable cardiovascular markers and experiences.

    What Can You Eat on a Heart-Reversal Plant-Based Diet?

    A heart-reversal style plant-based diet highlights foods rich in fiber, antioxidants, and healthy fats. Whole grains such as oats, brown rice, barley, quinoa, and whole wheat offer steady energy and support blood sugar control.

    Legumes, including beans, lentils, chickpeas, and peas, provide plant protein and contribute significantly to cholesterol reduction.

    Vegetables and fruits form the foundation of each plate, with emphasis on leafy greens, cruciferous vegetables, berries, and citrus. Nuts and seeds like walnuts, almonds, flax, and chia supply beneficial fats and additional fiber.

    Many heart-focused approaches also recommend minimizing added oils and choosing steaming, baking, stewing, or dry sautéing instead of deep-frying.

    Foods typically limited include red and processed meats, high-fat dairy, butter, and sources of trans fats.

    Refined grains, sugary drinks, and heavily processed snacks can interfere with lipid and weight goals. Shifting the everyday balance toward whole plant foods and away from these items creates a pattern more consistent with heart reversal and long-term protection.

    Practical Plant-Based Recipe Ideas for Heart Health

    Simple recipe ideas make this style of eating more sustainable. For breakfast, overnight oats with plant-based milk, ground flax or chia, and berries deliver fiber, antioxidants, and healthy fats. Green smoothies built from leafy greens, fruit, and unsweetened plant milk offer a quick way to increase daily vegetable and fruit intake.

    Lunch and dinner can revolve around bean or lentil soups, vegetable stews, and chili served over brown rice or quinoa. Tacos filled with black beans or chickpeas, topped with salsa, cabbage, and avocado, combine satisfaction with heart-friendly ingredients.

    Stir-fries using tofu or tempeh, mixed vegetables, and whole grains keep meals varied while maintaining a plant-based focus, as per Harvard Health.

    Snacks such as fresh fruit, raw vegetables with hummus, roasted chickpeas, and small portions of nuts or seeds help maintain energy and reduce reliance on processed options. Batch-cooking beans and grains, prepping vegetables, and planning several plant-based recipe ideas each week can make adherence more realistic.

    Plant-Based Diet Strategies for Lasting Heart Support

    For those interested in heart reversal and long-term protection, gradual change is often the most sustainable approach. Starting with one or two plant-based meals a day, experimenting with new recipe ideas, and steadily increasing the share of whole plant foods can build a pattern that supports cholesterol reduction and better vascular health.

    Over time, a consistent plant-based diet can become the everyday backdrop for improved heart function, fewer symptoms, and a stronger foundation for long-term cardiovascular well-being.

    Frequently Asked Questions

    1. Can someone follow a plant-based diet for heart health if they are not fully vegetarian?

    Yes. Even if someone still eats small amounts of animal products, shifting most meals toward whole plant foods can support cholesterol reduction and overall heart health.

    2. Does a plant-based diet always mean very low fat for heart reversal?

    Not always. Some heart-reversal programs are very low fat, but others allow moderate amounts of whole-food fats like nuts, seeds, and avocado while still emphasizing plants.

    3. Can a plant-based diet interfere with heart medications?

    It can change blood pressure, cholesterol, and blood sugar, which may affect medication needs, so adjustments should always be made with a healthcare professional.

    4. Is it necessary to count calories on a plant-based diet for heart health?

    Many people focus more on food quality than calories, but portion awareness still matters, especially with higher-fat foods like nuts and oils.



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  • Emerging gut health research | Dietitian Connection

    Emerging gut health research | Dietitian Connection


    Gut health is a hot topic in nutrition, and new research is reshaping how we think about the role of everyday foods in supporting the microbiome. In this episode, Associate Professor Jessica Biesiekierski unpacks the latest preliminary science on eggs and gut health. You’ll hear about surprising research findings on everyday foods, like eggs, and walk away with practical ways to apply this knowledge in patient care.

    Hosted by Brooke Delfino

    Biography

    Associate Professor Jessica Biesiekierski is Head of Human Nutrition at the University of Melbourne and an NHMRC Emerging Leadership Fellow. Her research explores how diet shapes gastrointestinal function and gut-brain interactions, spanning nutrient-specific investigations through whole-diet interventions and, most recently, egg-consumption trials. A recipient of the 2024 Rome Foundation Research Award and the Nutrition Society of Australia Mid-Career Research Award, Jess leads a multidisciplinary team advancing clinical and mechanistic nutrition studies.

    In this episode, we discuss:

    • How food influences gut health and the microbiome
    • Key nutrients for digestive health
    • The emerging science behind eggs and gut health
    • Short-chain fatty acids and the gut barrier
    • Evidence-based tips for communicating effectively with patients


    Additional resources

    • Sign up here for research updates and resources from Australian Eggs, shared straight to your inbox every two months.

    • Click here to connect with Jess on LinkedIn

     

    Supported by

     


    The content, products and/or services referred to in this podcast are intended for Health Care Professionals only and are not, and are not intended to be, medical advice, which should be tailored to your individual circumstances. The content is for your information only, and we advise that you exercise your own judgement before deciding to use the information provided. Professional medical advice should be obtained before taking action. The reference to particular products and/or services in this episode does not constitute any form of endorsement. Please see  here  for terms and conditions.


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  • UPF: Research & reality | Dietitian Connection

    UPF: Research & reality | Dietitian Connection


    With growing concerns about the impact of ultra-processed foods on health, it is essential for dietitians to stay informed on the complexities of this heavily publicized topic. In this episode of Dietitian to Dietitian, Joy Bauer of NBC’s Today Show along with Julie Hess, PhDand Janet Helm, MS, RDN discuss the research on ultra-processed foods, the intersection of food processing and nutrient density, and how to combat misinformation in the media.

    Biographies

    Julie Hess, PhD, is a Research Nutritionist at the Grand Forks Human Nutrition Research Center in Grand Forks, ND. Her research is centered on identifying and evaluating strategies to help Americans meet recommendations from the Dietary Guidelines for Americans. Her work involves investigating how American diets currently align with dietary guidance and recognizing and addressing barriers to following recommendations. She is also an adjunct assistant professor at the University of North Dakota. Dr. Hess received a BA in French and English from the University of Texas at Austin and earned a PhD in Human Nutrition from the University of Minnesota.

     

     

    is a registered dietitian and culinary professional with 20+ years’ agency experience working with food and beverage brands and agricultural commodity boards. As the former Chief Food and Nutrition Strategist for Weber Shandwick, a global PR agency, she’s helped clients intersect with food culture, tell their story and engage stakeholders. Janet recently started her own consultancy Food at the Helm. She is a sought-after speaker on food trends and has discussed the latest nutrition topics in the media, including segments on Good Morning America, Today and CNN. Her work has appeared in many national publications, including U.S. News & World Report, where she is a regular contributor.

     

    Joy Bauer, MS, RDN, CDN, one of America’s leading health authorities, is the nutrition and healthy lifestyle expert for NBC’s TODAY show. She also hosts her own Amazon Live weekly show, Health, Happiness, Joy, where she cooks up mouthwatering recipes, answers viewers’ questions in real-time, and shares her favorite products and kitchen hacks. In addition, Joy is the official nutritionist for the New York City Ballet, the creator of JoyBauer.com, and a #1 New York Times bestselling author with 14 bestsellers to her credit.

     

     

     

    In this episode, we discuss:

    • The Nova classification system for food processing and its’ complexities
    • What the research on ultra-processed foods tell us
    • The public discourse on ultra-processed foods and its impact on consumers
    • How the science can inform dietary guidelines around the world

     


    Additional resources

    You can find a handout with information about the Nova classification system and the speakers’ references here.

    Click here and here for Julie Hess’ research on ultra-processed foods.


    The content, products and/or services referred to in this podcast are intended for Health Care Professionals only and are not, and are not intended to be, medical advice, which should be tailored to your individual circumstances. The content is for your information only, and we advise that you exercise your own judgement before deciding to use the information provided. Professional medical advice should be obtained before taking action. The reference to particular products and/or services in this episode does not constitute any form of endorsement. Please see  here  for terms and conditions.

     

     

     


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  • Trump Applauds 13-Year-Old Cancer Survivor After Slashing Funding for Pediatric Cancer Research

    Trump Applauds 13-Year-Old Cancer Survivor After Slashing Funding for Pediatric Cancer Research

    President Donald Trump honored and applauded a young cancer survivor during his recent joint address to Congress despite his numerous attempts to cut funding for healthcare, including pediatric cancer research.

    DJ Daniel, 13, was introduced to the audience by the 47th president on Tuesday night, receiving a standing ovation from the crowd.

    “Joining us in the gallery tonight is a young man who truly loves our police,” Trump announced. “His name is DJ Daniel is 13 years old, and he has always dreamed of becoming a police officer. But in 2018, DJ was diagnosed with brain cancer. The doctors gave him five months at most to live. That was more than six years ago.”

    Daniel and his father have been trying to actualize Daniel’s dream of becoming a real police officer, Trump explained. Since they began, the child has become an honorary member of local police departments, reported ABC News.

    “Tonight, DJ, we’re going to do you the biggest honor of them all,” Trump said. “I am asking our new Secret Service Director, Sean Curran, to officially make you an agent of the United States.”

    Last month, the Trump administration attempted to enact cuts worth $4 billion for funding towards cancer research at universities, cancer centers and hospitals. He attempted to impose a policy under which indirect costs for research grants distributed by the National Institutes of Health (NIH) would be capped at 15 percent.

    Universities and research centers responded to this initiative with a lawsuit claiming that cutting this funding represented “flagrantly unlawful action” and “will devastate medical research at America’s universities.” US District Court Judge Angel Kelley ordered the administration to hold off on the cuts.

    “Once again, President Trump and Elon Musk are acting in direct violation of the law. In this case, they are causing irreparable damage to ongoing research to develop cures and treatments for cancer, Alzheimer’s disease and related dementias, ALS, Diabetes, Mental Health disorders, opioid abuse, genetic diseases, rare diseases, and other diseases and conditions affecting American families,” said Education Subcommittee Ranking Member Rosa DeLauro. “The Trump Administration is attempting to steal critical funds promised to scientific research institutions funded by the NIH, despite an explicit legal prohibition against this action.”

    “The reduction in research and care funding is a devastating setback for the pediatric cancer community, one that threatens all the progress we’ve made. This unfortunate turn of events only reinforces the urgent need for us to continue advancing care, supporting cutting-edge research, and improving conditions for pediatric cancer patients and their families,” Danielle Fragalla, the Chief Executive Officer of Pediatric Cancer Research Foundation, said.

    “At the Pediatric Cancer Research Foundation, our work has never been more critical. Through our institutional priorities—Powering Research, Equitable Care, and Survivorship & Mental Health—we are committed to driving innovating solutions that not only improve outcomes but also ensure that every child and family has access to the support they need.”

    Originally published by Latin Times.

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  • The Secret to a Happy and Healthy Life: Research Reveals the Surprising Truth

    The Secret to a Happy and Healthy Life: Research Reveals the Surprising Truth

    The Secret to a Happy and Healthy Life: Research Reveals the Surprising Truth

    For centuries, people have been searching for the secret to a happy and healthy life. From ancient wisdom to modern self-help books, the quest for a better life has been a constant theme in human history. But what if the answer wasn’t as elusive as we thought? Recent research has uncovered some surprising truths about what it takes to live a truly happy and healthy life.

    The Surprising Truth About Happiness

    Research has shown that happiness is not just about achieving success, wealth, or material possessions. In fact, studies have found that once basic needs are met, additional wealth does not necessarily lead to increased happiness. This phenomenon is known as the "Easterlin paradox". So, what does it take to achieve happiness?

    A study conducted by the University of Michigan found that the key to happiness is not what we do, but rather who we are. The study discovered that people who scored high on a scale of emotional intelligence, such as being able to recognize and understand emotions, had higher levels of happiness.

    The Surprising Truth About Health

    When it comes to health, the picture is not much clearer. Conventional wisdom would suggest that a healthy diet and regular exercise are the keys to good health. But is that really true?

    A study published in the Journal of the American Medical Association found that people who engaged in regular physical activity were not necessarily healthier than those who did not. In fact, the study suggested that physical activity may not be the most effective way to improve health.

    So, what does work? Research has shown that a healthy social network, good relationships, and a sense of purpose are all important factors in maintaining good health. A study conducted by the University of California, Berkeley found that people who had a strong sense of purpose and meaning in life were less likely to experience depression and anxiety.

    The Surprising Truth About Success

    Success is often seen as the ultimate goal, but what does it really mean? Research has found that success is not as closely linked to external factors such as wealth, fame, or status as we might think. A study conducted by the University of Washington found that people who were successful in their personal and professional lives were not necessarily the happiest or healthiest.

    So, what does success really look like? Research has shown that success is often linked to internal factors such as self-awareness, self-acceptance, and self-compassion. A study conducted by the University of Pennsylvania found that people who had high levels of self-acceptance were more likely to experience success and happiness.

    Conclusion

    The secret to a happy and healthy life is not as elusive as we thought. Research has revealed that it is not about achieving success, wealth, or material possessions, but rather about cultivating emotional intelligence, a sense of purpose, and self-awareness. By focusing on internal measures of success, rather than external ones, we can find the happiness and health we are searching for.

    Frequently Asked Questions

    Q: How can I cultivate emotional intelligence?
    A: A number of strategies can help, including practicing mindfulness, developing empathy, and taking the time to understand and recognize emotions.

    Q: How can I find a sense of purpose?
    A: Start by asking yourself what gives you a sense of fulfillment and meaning. This could be anything from helping others to pursuing a hobby or passion.

    Q: How can I cultivate self-acceptance?
    A: Start by practicing self-compassion and self-kindness. Acceptance of yourself as you are, flaws and all, is key to finding true happiness and success.

    Q: How can I prioritize my well-being?
    A: Prioritize self-care, take time for yourself, and focus on your mental and emotional health.

    Q: What are some ways to cultivate a strong sense of community and social connection?
    A: Join a community group, volunteer, or take a class. Building strong, meaningful relationships with others is key to happiness and health.

    Q: How can I measure success?
    A: Focus on internal measures of success, such as personal growth, self-awareness, and self-acceptance, rather than external factors.

  • STRIPED 2024 Newsletter: Advancing eating disorder prevention through advocacy, research, and youth voices

    STRIPED 2024 Newsletter: Advancing eating disorder prevention through advocacy, research, and youth voices

    Decorative image showing the word Newsletter alongside STRIPED's logo

    Discover the latest updates from the Strategic Training Initiative for the Prevention of Eating Disorders (STRIPED) in our 2024 Annual Newsletter. This edition spotlights the inspiring work of youth advocates featured in the new documentary Generation Flex, the restoration of critical disordered eating questions into the CDC’s Youth Risk Behavior Surveillance System, and efforts to protect youth from harmful diet pills and muscle-building supplements. Through policy change, research, and youth-driven advocacy, STRIPED continues to push for meaningful progress in eating disorder prevention.

    Explore More:

    Join the Conversation:

    • Follow Us: Stay connected through our social media channels for real-time updates and community engagement.
    • Contact Us: For inquiries or to get involved, email us at STRIPED@hsph.harvard.edu.

    Last Updated

    Get the latest public health news

    Stay connected with Harvard Chan School

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  • InnaPeace™ – Official – Brainwave Research UK

    InnaPeace™ – Official – Brainwave Research UK

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  • Is Mindfulness a Treatment for Depression?

    Is Mindfulness a Treatment for Depression?

    Depression is a classic example of what’s referred to today as an invisible illness. When you’re depressed, you may find yourself expending precious energy just so you can appear to the world as if nothing at all is troubling you. 

    This “it’s-work-to-seem-fine” coping mechanism illustrates just one way in which depression complicates your life. Not only are you exhausting yourself pretending to be OK, you may find it hard to rally support from friends, family, and coworkers who only see how well you seem to be functioning. 

    While there is rapidly growing recognition of the very real difficulty and damage caused by depression, the stigma of past decades and centuries lingers. We often still hear the familiar notion that you can just “pull yourself together and get on with it,” as though keeping a “stiff upper lip” should be enough to defeat depression. But strong neurochemical, social, and environmental factors contribute to this very real, physical illness, and successful treatment requires more than maintaining an “upbeat attitude.”

    Depression Is a Chameleon 

    Our ability to recognize and effectively treat depression—which 1 in 14 people will experience in their lifetime—is complicated by the fact that it manifests differently in everyone affected, according to the National Institutes of Health. Anything—your age, your gender, or the stage of your depression—can change what the illness looks like for you, meaning it’s not necessarily simple to get a diagnosis, or even recognize symptoms of depression, whether in yourself or in other people.

    For women, depression is more likely to appear as sadness, worthlessness, and guilt. Hormonal and life cycle-related changes, as in postpartum depression, can make women more susceptible to developing the illness. In fact, women are statistically more likely than men to experience depression. 

    For men, depression often looks like exhaustion, irritability, and sleeping problems. They also lose interest in things they once enjoyed. Men are also more likely to turn to drugs and alcohol, experiment with reckless activity, or become intensely devoted to work in order to distract themselves from their illness.  

    For teens and tweens, depression can look like extended and severe periods of sulking, getting into trouble at school, prolonged irritability, and an intense feeling of being misunderstood. 

    These are by no means the only ways depression can appear. Some people experience short, intense periods of depression, while others feel it as an unmoving cloud over their awareness; for some, it’s linked to difficult life events, while for others it doesn’t go away even when their outward circumstances seem fine. 

    Should You Try Mindfulness for Depression?

    Various treatment options for depression exist, including drug regimens and talk therapies. However, the jury continues to be out on how effective antidepressants are for treating depression. A comprehensive 2018 study conducted by an international research team examined 522 studies, including 116,477 patients, to learn about the effectiveness of 21 antidepressant medications. The researchers discovered that, although nearly all of the drugs were more effective than placebos, their effects were still “modest” in most cases.

    Complicating treatment is the fact that depression is often a chronic condition that tends to relapse, even with medication and talk therapy. According to research, relapse rates range from 50% to as high as 80%.

    Interestingly, when mindfulness is added to the standard depression treatment protocols, relapse rates decline. But it’s unlikely that simply practicing basic mindfulness meditation will ease your depression symptoms. In fact, such an attempt could be supremely unhelpful, notes Julienne Bower, PhD, professor of health psychology at UCLA.

    She tells us that the research showing that mindfulness meditation improves symptoms of depression is, at best, vague. She also notes that it’s really hard to meditate on your own when you’re depressed.

    Zindel Segal, PhD, concurs. The Distinguished Professor of Psychology in Mood Disorders at the University of Toronto, Dr. Segal has pioneered the use of mindfulness meditation for promoting wellness in the area of mood disorders. He was also one of the team who developed Mindfulness-Based Cognitive Therapy (MBCT), a research-backed mindfulness protocol for depressive disorders.

    Chronic Unhappiness?

    “When we talk about depression, and where mindfulness is strong and less strong as a treatment, we have to know what type of depression you have,” says Segal.

    “Don’t consider mindfulness a treatment when you’re dealing with acute depression,” he advises. Depression “shuts down your concentration and disrupts your executive network ability,” which makes practicing mindfulness difficult, says Dr. Segal. Instead, for acute depression, consider seeing a mental health professional for treatment with antidepressants, cognitive behavior therapy, or both. Mindfulness can bolster those treatments, but not replace them.

    Mindfulness-Based Cognitive Therapy, however, was specifically designed to help people who are depressed or chronically unhappy. MBCT is a therapeutic protocol that combines cognitive therapy, which helps people interrupt the disturbing behavior or thought patterns that interfere with their lives, with mindfulness practices that help you learn to develop a healthier relationship to unhelpful thought patterns.

    “Our research looked at specific ways that MBCT helps people work with rumination and worry in ways that are more generous and compassionate,” says Dr. Segal. “This therapy helps you learn to ‘de-center’ and allows you to see your thoughts unfold moment to moment. It helps you to not listen to the messages that depression is sending you.”

    How MBCT Helps

    The goal of MBCT is to help you become familiar with the ways your mind and your thinking patterns contribute to depression, which helps you to develop a new relationship to your depression.

    According to Dr. Segal, many people describe leaving the MBCT training with these two major insights:

    1) Thoughts are not facts.

    2) Depression is not me.

    At first, these points may seem overly simplistic—but when we pay attention to how we are thinking and feeling, over time we become better at spotting the buildup of difficult emotions and thoughts. In that way, we can deal with them more skillfully, instead of just reacting in ways that might not be good for us.

    “Mindfulness practices—focusing on the breath and body, as well as mindful movement and developing greater mindful attention to everyday activities—help us learn to recognize the feelings and patterns of thinking that cause unhappiness,” says Willem Kuyken, PhD, the Ritblat Professor of Mindfulness and Psychological Science at the University of Oxford.  “We learn that thoughts are just thoughts. They are not facts, and we can choose whether to give them power over our minds and hearts. In time they can even help us savor and enjoy all the things that give us pleasure and a sense of accomplishment,” adds Kuyken.

    When it comes to depression that relapses after treatment, he suggests that MBCT has proven to be particularly helpful, if you adhere to the program. The program consists of eight weeks of classes, as well as at-home practices you do on your own for about an hour a day. “Many people [with depression] are trying to turn around very long-standing and ingrained habits of thinking and behaving, and that will take time and effort,” says Dr. Kuyken. He notes that a recent study by Dr. Segal showed that the more a person practices MBCT over time, the greater the benefits for easing depression.

    To find a therapist who has been trained and certified in practicing MBCT, visit accessmbct.com

    If You Need Help

    If you or someone you care for is having suicidal thoughts, these helplines in the US, Canada, and UK offer free, confidential prevention, crisis resources, and support 24/7/365.

    US: Dial 988 to reach the Suicide & Crisis Lifeline.
    988lifeline.org

    Canada: Dial 988 to reach the Suicide Crisis Helpline.
    988.ca

    UK: Dial 116-123 to reach Samaritans.
    samaritans.org

    This article was first published in the April 2020 issue of Mindful magazine.

    The Ultimate Guide to Mindfulness for Sleep 

    Sufficient sleep heals our bodies and minds, but for many reasons sleep doesn’t always come easily. Mindfulness practices and habits can help us fall asleep and stay asleep. Consult our guide to find tips for meditation, movement, and mindfulness practices to ease into sleep. Read More 

    • Mindful Staff
    • July 13, 2023



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  • Peptides And Dermatological Research

    Peptides And Dermatological Research

    Peptides have emerged as promising agents in dermatology research, offering potential support to the function of the skin barrier. Studies suggest that these bioactive compounds, consisting of short chains of amino acids, may interact with skin cells to influence various physiological processes. As the understanding of peptides’ mechanisms expands, their implication in developmental research becomes increasingly sophisticated.

    Peptides: Structural and Functional Overview

    Peptides are composed of two or more amino acids linked by peptide bonds. Research indicates that they may play diverse roles within an organism, ranging from signaling molecules to structural components. In dermatology research, peptides are speculated to interact with skin cells to promote various physiological responses.

    One type of peptide, signal peptides, may influence cellular communication. These peptides are believed to bind to receptors on the cell surface, initiating a cascade of events that can lead to cellular proliferation, migration, or differentiation. Another category, carrier peptides, might facilitate the delivery of essential trace elements required for enzymatic activities. For instance, copper peptides are hypothesized to support skin elasticity by promoting collagen synthesis.

    Peptides: Mechanisms of Action

    The mechanisms through which peptides may exert their impacts are not fully understood, but several theories have been proposed. One hypothesis suggests that signal peptides may stimulate collagen production by activating specific cellular pathways. Collagen, a critical protein in the skin’s extracellular matrix, provides structural support and elasticity. By promoting collagen synthesis, peptides might help reduce the depth and length of wrinkles along the surface of the skin barrier.

    Additionally, some peptides are theorized to have antimicrobial properties. These antimicrobial peptides (AMPs) might disrupt the membranes of bacteria, thereby protecting the skin from infections. AMPs might be crucial in maintaining the skin’s microbiome, a complex community of microorganisms contributing to skin function.

    Peptides & Oxidative Stress

    Investigations purport that another potential of peptides may be their antioxidant activity. Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidants, may lead to cellular damage and cell aging. Certain peptides might scavenge ROS, reducing oxidative stress and its detrimental impacts on the skin. Findings imply that these peptides might help maintain the skin’s integrity by mitigating oxidative damage.

    Peptides & Wounds

    Peptides are also thought to play a role in wound healing. The wound healing process involves a series of coordinated events, including inflammation, tissue formation, and remodeling. Research indicates that certain peptides may accelerate wound healing by promoting cell migration and proliferation, angiogenesis (creating new blood vessels), and extracellular matrix synthesis. For example, the peptide Thymosin beta-4 is theorized to support wound healing by stimulating keratinocyte and fibroblast migration, two cell types essential for skin repair.

    Peptides & Cell Aging

    The anti-aging potential of peptides is a significant area of interest. As the skin ages, it is believed to undergo structural and functional changes, such as reduced collagen production and increased formation of matrix metalloproteinases (MMPs), which degrade collagen. Studies postulate that some peptides may inhibit MMP activity, preserving collagen and maintaining skin firmness. Additionally, scientists speculate that peptides that stimulate collagen synthesis might counteract the age-related decline in collagen levels, potentially reducing the depth of wrinkles and improving skin texture.

    Skin Barrier Function

    The skin barrier, composed of the stratum corneum and lipid matrix, is essential for maintaining skin hydration and protecting against external aggressors. It has been hypothesized that peptides might support skin barrier function by promoting the synthesis of barrier lipids and proteins. For example, ceramide-containing peptides are thought to boost the production of ceramides, lipids that play a critical role in skin barrier integrity. Improved barrier function can lead to better hydration and protection against irritants.

    Some peptides are theorized to interfere with the melanin synthesis pathway, thereby reducing hyperpigmentation. For instance, peptide complexes that inhibit tyrosinase, the enzyme responsible for melanin production, have been speculated to effectively lighten dark spots and support a homeostatic appearance.

    Growth Factors

    Growth factors are proteins that regulate cell growth, proliferation, and differentiation. Peptides appear to interact with growth factors to modulate their activity. For example, peptides that mimic growth factor binding sites are believed to support the activity of endogenous growth factors.

    Peptides: Future Research Directions

    The field of peptides is continually evolving, with ongoing research aimed at elucidating their mechanisms and optimizing their formulations. Biotechnology and molecular biology advances will likely contribute to developing novel peptides with supported properties and targeted actions.

    In conclusion, peptides hold significant promise in dermatology studies due to their diverse potential properties, including promoting collagen synthesis, enhancing wound healing, providing antioxidant protection, improving skin barrier function, and addressing hyperpigmentation.

    Scientists interested in purchasing high-quality, affordable peptides for sale are encouraged to visit the Core Peptides website.

    References

    [i] Pai VV, Bhandari P, Shukla P. Peptides as cosmeceuticals. Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):9-18. doi: 10.4103/0378-6323.186500. PMID: 27451932.

    [ii] Gorouhi F, Maibach HI. Role of peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009 Oct;31(5):327-45. doi: 10.1111/j.1468-2494.2009.00490.x. Epub 2009 Jun 30. PMID: 19570099.

    [iii] Skibska A, Perlikowska R. Signal Peptides – Promising Ingredients in Cosmetics. Curr Protein Pept Sci. 2021;22(10):716-728. doi: 10.2174/1389203722666210812121129. PMID: 34382523.

    [iv] Thapa RK, Winther-Larsen HC, Diep DB, Tønnesen HH. Preformulation studies on novel garvicin KS peptides for topical implications. Eur J Pharm Sci. 2020 Aug 1;151:105333. doi: 10.1016/j.ejps.2020.105333. Epub 2020 Apr 5. PMID: 32268197.

    [v] Thapa RK, Winther-Larsen HC, Diep DB, Tønnesen HH. Photostability studies of GarKS peptides for topical formulation development. Eur J Pharm Sci. 2021 Mar 1;158:105652. doi: 10.1016/j.ejps.2020.105652. Epub 2020 Nov 26. PMID: 33248238.

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  • Warehousing industry increases health-harming pollutants, research shows

    Warehousing industry increases health-harming pollutants, research shows

    America’s demand for products delivered to the doorstep has led to a dramatic increase in e-commerce and the warehousing industry.

    A first-of-a-kind study now shows that people living in communities located next to these large warehouses are exposed to 20% more of a traffic-related air pollutant that can lead to asthma and other life-threatening health conditions.

    “Increased truck traffic to and from these recently built large warehouses means people living downwind are inhaling an increased amount of harmful nitrogen dioxide pollution,” said Gaige Kerr, lead author of the study and an assistant research professor of environmental and occupational health at the George Washington University Milken Institute School of Public Health. “Communities of color are disproportionately affected because they often live in close proximity to warehouses, especially dense clusters of warehouses.”

    Kerr and his colleagues measured a traffic-related pollutant called nitrogen dioxide by using a satellite instrument from the European Space Agency to zero in from space on the nearly 150,000 large warehouses located across the United States. Trucks and other vehicles traveling to and from these large warehouses spew out nitrogen dioxide, particulates, and other harmful pollutants.

    The researchers also looked at traffic information from the Federal Highway Administration and demographic data from the US Census Bureau.

    Additional key findings of the study:

    • Although the average spike of nitrogen dioxide associated with warehouses was 20%, nitrogen dioxide levels near warehouses were even larger when there was greater heavy duty vehicle activity near these facilities.
    • Warehouses with more loading docks and parking spaces attract the most traffic and are associated with the highest nitrogen dioxide levels.
    • Communities with large racial and ethnic minority populations are often located near warehouses and thus are inhaling more nitrogen dioxide and other pollutants. For example, this study found that the proportion of Hispanic and Asian people living close to the largest clusters of warehouses is about 250% higher than the average nationwide.
    • Although warehouses are located all over the US, 20% are concentrated in just 10 counties: Los Angeles, California; Harris, Texas; Cook, Illinois; Miami-Dade, Florida; Maricopa, Arizona; San Bernardino, California; Orange, California; Dallas, Texas; Alameda, California; and Cuyahoga, Ohio.

    The pandemic fueled the explosion of the e-commerce industry and warehouses that receive and sort consumer goods. The transportation infrastructure needed to ship goods to warehouses and then onto consumers is enormous, according to the researchers. For example, Amazon, an industry leader in e-commerce operated 175,000 delivery vans and more than 37,000 semi trailers in 2021 alone.

    Earlier studies have looked at warehouses and pollution in specific neighborhoods around the country, but this is the first nationwide study to show that people living near these warehouses are exposed to higher than average levels of damaging pollutants. And while other research has shown that communities of color are exposed to more nitrogen dioxide pollution than predominantly non-Hispanic white communities, this is the first study linking the warehousing industry to the exposure inequities faced by these overburdened populations, Kerr says.

    Previous research by the GW team found that communities of color in the US face a growing burden from polluted air. That study showed that such communities endure nearly 8 times higher rates of pediatric asthma from exposure to nitrogen dioxide and 30% higher rates of dying prematurely from exposure to fine particulate matter, both of which are emitted by cars, trucks and other vehicles.

    The authors say the new study underscores the need for regulations that drive zero-emission vehicle use in logistics, particularly to protect vulnerable communities located near industrial hubs. They also say that industry leaders and utilities have crucial roles in planning and implementing this transition.

    “Such measures would mean people living near warehouses could breathe cleaner air,” said Kerr. “In addition to a reduced risk of pollutant-related diseases, such measures would also reduce greenhouse gas emissions associated with climate change.”

    The study, “Air pollution impacts from warehousing in the United States uncovered with satellite data,” was published July 24, 2024 in Nature Communications. In addition to Kerr, Susan Anenberg, professor and chair of the Department of Environmental and Occupational Health at GW, and Daniel Goldberg, assistant research professor in the same department, contributed to this paper alongside researchers from the International Council on Clean Transportation.

    The research was funded by NASA.

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