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  • How Healthy Are Baruka Nuts?

    How Healthy Are Baruka Nuts?

    How do barukas, also known as baru almonds, compare with other nuts?

    There is a new nut on the market called baru almonds, branded as “barukas” or baru nuts. Technically, it isn’t a nut but a seed native to the Brazilian Savannah, known as the Cerrado, which is now among the most threatened ecosystems on the planet. Over the last 30 years, much of the Cerrado’s ecosystem has been destroyed by extensive cattle ranching and feed crop production to fatten said cattle. If it were profitable not to cut down the native trees and instead sell baru nuts, for example, that could be good for the ecosystem’s health. But what about our health?

    “Although baru nuts are popular and widely consumed, few studies report on their biological properties.” They do have a lot of polyphenol phytonutrients, presumably accounting for their high antioxidant activity. (About 90% of their phytonutrients are present in the peel.) Are they nutritious? Yes, but do they have any special health benefits—beyond treating chubby mice?

    Researchers found that individuals fed baru nuts showed lower cholesterol, supposedly indicating the nuts “have great potential for dietary use” in preventing and controlling cholesterol problems. But the individuals were rats, not humans, and the baru nuts were compared to lard. Pretty much everything lowers cholesterol compared to lard. Nevertheless, there haven’t been any reports about the effect of baru nut consumption on human health, until this: A randomized, controlled study of humans found that eating less than an ounce a day for six weeks led to a 9% drop in LDL cholesterol. Twenty grams would be about 15 nuts or a palmful.

    Like many other nut studies, even though the research subjects were told to add nuts to their regular diets, there was no weight gain, presumably because nuts are so filling that we inadvertently cut down on other foods throughout the day. How good is a 9.4% drop in LDL? It’s the kind of drop we can get from regular almonds, though macadamias and pistachios may work even better, but those were at much higher doses. It appears that 20 grams of baru nuts work as well as 73 grams of almonds. So, on a per-serving basis or a per-calorie basis, baru nuts really did seem to be special.

    There are lower-dose nut studies that show similar or even better results. In this one, for instance, people were given 25 grams of almonds for just four weeks and got about a 6% drop in their LDL cholesterol. In another study, after consuming just 10 grams of almonds a day, or just seven individual almonds a day, study participants got more like a 30% drop in LDL during the same time frame as the baru nuts. Three times better LDL at half the dose with regular almonds, as you can see below and at 2:47 in my video Are Baruka Nuts the Healthiest Nut?.

    The biggest reason we are more confident in regular almonds than baru almonds is that studies have been done over and over in more than a dozen randomized controlled trials, whereas in the only other cholesterol trial of baru nuts, researchers found no significant benefit for LDL cholesterol, even at the same 20-gram dose given for even longer—a period of eight weeks.

    That’s disappointing, but it isn’t the primary reason I would suggest choosing other nuts instead of baru nuts. I would do so because we can’t get raw baru nuts. They contain certain compounds that must be inactivated by heat before we can eat them. The reason raw nuts are preferable is because of advanced glycation end-products (AGEs), so-called glycotoxins, which are known to contribute to increased oxidative stress and inflammation.

    Glycotoxins are naturally present in uncooked animal-derived foods, and dry-heat cooking like grilling can make things worse. The three highest recorded levels have been in bacon, broiled hot dogs, and roasted barbecued chicken skin—nothing even comes close to that, not even Chicken McNuggets, as you can see below and at 3:50 in my video.

    However, any foods high in fat and protein can create AGEs at high enough temperatures. So, although plant foods tend to “contain relatively few AGEs, even after cooking,” there are some high-fat, high-protein plant foods. But, again, AGEs aren’t a problem at all with most plant foods. See the AGE content in boiled tofu (in a soup, for instance), broiled tofu, a raw apple, a baked apple, a veggie burger—I was surprised that veggie burgers are so low in AGEs, even when baked or fried—and nuts and seeds, which are up in tofu territory, especially when roasted, which is why I would recommend raw nuts and seeds and nut and seed butters whenever you have a choice. See below and at 4:33 in my video.

    Doctor’s Note

    In my Daily Dozen checklist, I recommend eating a quarter cup of nuts or seeds or two tablespoons of nut or seed butter each day. Why? See related posts below. 

    For those unfamiliar with advanced glycation end-products (AGEs), check out the first two videos I did on them way back when: Glycotoxins and Avoiding Glycotoxins in Food.



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  • Is It Normal Aging or Early Dementia? Key Memory Loss Causes and Alzheimer’s Early Signs to Watch For

    Is It Normal Aging or Early Dementia? Key Memory Loss Causes and Alzheimer’s Early Signs to Watch For

    Memory changes happen to everyone as they age. Occasionally misplacing keys or forgetting someone’s name is part of normal aging, and these moments usually don’t interfere with daily life. Dementia symptoms, however, involve ongoing cognitive decline that affects independence, decision-making, and routine tasks. The difference lies in consistency and impact. When memory problems begin to disrupt familiar activities or relationships, they shift from typical aging into something that needs medical attention.

    Memory loss causes vary widely. Some stem from simple stress, medication effects, or lack of sleep. Others point to Alzheimer’s early signs, where changes slowly build and progress over time. Understanding the difference helps people seek care sooner, protect cognitive function, and avoid mistaking serious symptoms for minor forgetfulness. Recognizing what’s normal and what’s not allows for timely evaluation and early intervention.

    Everyday Memory Lapses vs Progressive Dementia Symptoms

    There is a clear line between everyday forgetfulness and the more serious dementia symptoms that interfere with functioning. Normal age-related lapses tend to be occasional and improve with reminders, while dementia symptoms escalate slowly and become more consistent over months or years.

    1. Forgetting recent events but recalling them later is typical aging. People might miss an appointment or overlook a detail, but the memory returns when prompted. Dementia symptoms involve forgetting the same information repeatedly and needing constant reminders.
    2. Word-finding struggles improve with cues in normal aging. A person may momentarily forget a word but quickly find it again with context. Dementia symptoms make communication difficult because language retrieval becomes unpredictable and conversations break down.
    3. Misplacing items is common, but tracing them logically is preserved. If someone loses their glasses, they can usually retrace steps. Dementia symptoms lead to placing objects in illogical locations, like keys in the refrigerator, and forgetting the reasoning behind it.
    4. According to the National Institute on Aging, normal aging does not significantly affect the ability to perform daily activities, while dementia disrupts problem-solving, routine tasks, and self-care.
    5. Judgment and reasoning differ sharply. Aging adults may take longer to make decisions but typically reach logical conclusions. Dementia symptoms cause confusion and difficulty weighing options, especially under stress.
    6. Memory decline in dementia affects safety. Wandering, leaving appliances on, or forgetting to lock doors are red flags that go beyond typical forgetfulness.

    Everyday lapses are frustrating. Dementia symptoms, however, reshape how someone navigates their entire day.

    Beyond Memory: Alzheimer’s Early Signs in Daily Functioning

    Dementia involves more than memory loss. Alzheimer’s early signs include subtle behavioral and functional shifts that others may notice first.

    1. Poor judgment and financial mistakes appear early. Adults who once managed money well may overpay bills, miss payments, or fall for scams. According to the Alzheimer’s Association, impaired judgment is one of the earliest markers of cognitive decline.
    2. Disorientation in familiar places increases. Getting lost during routine trips or feeling confused in known environments signals changes in spatial awareness linked to Alzheimer’s early signs.
    3. Personality changes emerge. Withdrawal from social activities, irritability, or decreased motivation can reflect early neurological changes rather than mood shifts.
    4. Task abandonment becomes common. People may start cooking and forget to finish, or begin a project and lose track of steps. While normal aging slows task speed, Alzheimer’s early signs interrupt the task entirely.
    5. Progression differentiates the condition. Alzheimer’s early signs worsen gradually and consistently. Normal aging plateaus, but neurodegeneration does not.
    6. Awareness declines. Individuals may deny or fail to notice changes, while family members observe increasing confusion or anxiety.

    Recognizing these early functional shifts helps prompt assessment before significant decline occurs.

    Lifestyle Factors and Memory Loss Causes You Should Know

    Memory loss causes extend beyond dementia and can be reversible. Understanding these factors helps prevent misdiagnosis and supports better cognitive health.

    1. Stress and sleep deprivation impair memory. Chronic stress elevates cortisol, which affects recall and concentration.
    2. Medications play a major role. Antihistamines, sleep aids, and certain blood pressure drugs may cause forgetfulness.
    3. Vitamin deficiencies contribute to memory problems. According to Harvard Medical School, low B12 levels can mimic early dementia symptoms but are fully treatable once identified.
    4. Depression often looks like cognitive decline. People withdraw, lose interest, and appear forgetful, but treating the mood disorder often restores clarity.
    5. Head injuries affect long-term cognition. Even mild concussions can impact memory decades later, especially in older adults.
    6. Chronic conditions matter. Thyroid disorders, infections, and uncontrolled diabetes all impact concentration, recall, and decision-making.
    7. Alcohol use affects brain function. Excessive drinking damages memory centers and accelerates cognitive aging.
    8. Lifestyle patterns influence risk. Sedentary habits, poor diet, and lack of mental stimulation increase the likelihood of cognitive decline.

    Identifying these factors helps separate benign memory loss causes from more serious dementia symptoms.

    Conclusion

    Understanding when memory lapses become concerning helps people take action sooner. While normal aging brings occasional forgetfulness, dementia symptoms disrupt independence, daily routines, and decision-making. Recognizing Alzheimer’s early signs allows families to pursue testing, treatment approaches, and safety planning when it matters most.

    Not all memory loss causes dementia. Many are reversible with lifestyle adjustments, medical care, or improved mental habits. Paying attention to patterns, changes in behavior, and early red flags supports healthier aging and ensures that anyone experiencing symptoms gets the right evaluation at the right time.

    Frequently Asked Questions

    1. What memory loss causes mimic early dementia symptoms?

    Vitamin deficiencies, thyroid problems, depression, and medication effects can all resemble dementia.

    2. How do Alzheimer’s early signs differ from normal aging?

    They affect daily functioning, increase over time, and include behavioral or judgment changes, not just forgetfulness.

    3. When does occasional forgetfulness become dementia symptoms?

    When memory problems disrupt routine tasks, repeat frequently, or interfere with independence.

    4. Can lifestyle changes reverse memory loss causes?

    Yes. Treatable conditions, improved sleep, exercise, better diet, and stress management can restore memory clarity.



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  • Unlocking the Secrets of Fat Loss: A Scientific Approach to Weight Reduction (Target keywords: fat loss, weight reduction, scientific approach)

    Unlocking the Secrets of Fat Loss: A Scientific Approach to Weight Reduction (Target keywords: fat loss, weight reduction, scientific approach)

    The quest for fat loss and weight reduction has become a ubiquitous goal for many individuals, with numerous approaches and methods being touted as the most effective way to achieve this objective. However, with so much misinformation and pseudoscience surrounding the topic, it can be challenging to discern what truly works and what doesn’t. Fortunately, a scientific approach to fat loss and weight reduction can provide a clear and evidence-based understanding of the underlying mechanisms and most effective strategies.

    Understanding the Fundamentals of Fat Loss

    To unlock the secrets of fat loss, it’s essential to comprehend the fundamental physiological processes that occur within the body. Fat loss, also known as lipolysis, is the process by which the body breaks down stored fat (triglycerides) into fatty acids and glycerol, which can then be utilized as energy. This process is mediated by various hormones, including epinephrine, norepinephrine, and insulin, which play a crucial role in regulating fat metabolism.

    When it comes to fat loss, the concept of energy balance is paramount. The body’s energy balance is determined by the difference between the amount of energy consumed (in the form of calories) and the amount of energy expended (through physical activity, thermogenesis, and other physiological processes). To achieve fat loss, an individual must create a calorie deficit, where the energy expended exceeds the energy consumed. This can be accomplished through a combination of reducing daily caloric intake and increasing physical activity.

    The Science of Weight Reduction

    Weight reduction is a complex process that involves the coordinated effort of multiple physiological systems, including the nervous, endocrine, and digestive systems. From a scientific perspective, weight reduction can be achieved through various mechanisms, including:

    • Reducing energy intake: Decreasing daily caloric consumption can lead to a calorie deficit, resulting in weight reduction.
    • Increasing energy expenditure: Engaging in regular physical activity, such as aerobic exercise, resistance training, and high-intensity interval training (HIIT), can increase energy expenditure and enhance fat loss.
    • Improving insulin sensitivity: Enhancing insulin sensitivity can improve glucose uptake in the muscles, reducing glucose levels in the bloodstream and promoting fat loss.
    • Modulating hormone levels: Hormones such as leptin, ghrelin, and cortisol play a crucial role in regulating energy balance and fat metabolism. Modulating these hormone levels through dietary and lifestyle interventions can facilitate fat loss.

    Dietary Strategies for Fat Loss

    A well-structured diet is essential for achieving and maintaining fat loss. From a scientific perspective, the following dietary strategies can be effective:

    • Macronutrient balance: Ensuring an optimal balance of protein, carbohydrates, and fat can help regulate hunger, satiety, and energy balance.
    • Meal frequency and timing: Eating frequent, balanced meals can help regulate energy balance and support fat loss.
    • Caloric restriction: Reducing daily caloric intake can lead to a calorie deficit, resulting in fat loss.
    • Nutrient-dense foods: Focusing on whole, unprocessed foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats, can provide essential nutrients while supporting fat loss.

    The Role of Exercise in Fat Loss

    Regular exercise is a crucial component of a comprehensive fat loss program. Exercise can increase energy expenditure, improve insulin sensitivity, and enhance fat oxidation. The following types of exercise can be effective for fat loss:

    • Aerobic exercise: Activities such as brisk walking, jogging, cycling, and swimming can increase energy expenditure and enhance fat loss.
    • Resistance training: Building muscle mass through resistance training can increase resting metabolic rate, enhancing fat loss.
    • High-intensity interval training (HIIT): HIIT involves short bursts of high-intensity exercise followed by brief periods of rest. This type of training can be effective for improving insulin sensitivity and enhancing fat loss.

    Supplements and Fat Loss

    While a well-structured diet and regular exercise should be the primary focus of a fat loss program, certain supplements may be beneficial in supporting this process. Some of the most effective supplements for fat loss include:

    • Protein powder: Increasing protein intake can help regulate hunger, satiety, and energy balance.
    • Conjugated linoleic acid (CLA): CLA, a fatty acid found in meat and dairy products, may help enhance fat loss by increasing fat oxidation and reducing fat storage.
    • Green tea extract: Green tea extract, rich in catechins, may help enhance fat loss by increasing fat oxidation and improving insulin sensitivity.

    Conclusion

    Unlocking the secrets of fat loss requires a comprehensive understanding of the underlying physiological processes and most effective strategies. By adopting a scientific approach to fat loss, individuals can create a personalized program that incorporates dietary, exercise, and lifestyle interventions to achieve and maintain weight reduction. Remember, fat loss is not just about aesthetics; it’s about improving overall health and well-being. By focusing on sustainable, evidence-based strategies, individuals can achieve a healthier, happier life.

    Frequently Asked Questions (FAQs)

    • Q: What is the most effective way to achieve fat loss?
      A: The most effective way to achieve fat loss is through a combination of reducing daily caloric intake, increasing physical activity, and improving insulin sensitivity.
    • Q: How can I ensure I’m getting enough protein to support fat loss?
      A: Aim to consume 1.6-2.2 grams of protein per kilogram of body weight from sources such as lean meats, fish, eggs, dairy, and plant-based options.
    • Q: What is the role of exercise in fat loss?
      A: Exercise can increase energy expenditure, improve insulin sensitivity, and enhance fat oxidation, making it a crucial component of a comprehensive fat loss program.
    • Q: Can supplements really help with fat loss?
      A: While supplements should not replace a well-structured diet and regular exercise, certain supplements such as protein powder, CLA, and green tea extract may be beneficial in supporting fat loss.
    • Q: How long does it take to achieve significant fat loss?
      A: The time it takes to achieve significant fat loss varies depending on individual factors such as starting body composition, diet, and exercise. However, with a consistent and well-structured program, individuals can expect to see noticeable results within 12-24 weeks.

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  • Scoliosis in Children and Teens: Diagnosis, Treatment, and Steps to Take

    Scoliosis in Children and Teens: Diagnosis, Treatment, and Steps to Take

    Source: National Institute of Arthritis and Musculoskeletal and Skin Diseases – From the National Institutes of Health
    Related MedlinePlus Pages: Scoliosis

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  • How Treatment Is Safely Started and Supported

    How Treatment Is Safely Started and Supported

    Seeking mental health support no longer has to involve long wait times or uncomfortable appointments. As telehealth continues to expand across the United States, online care platforms like Nurx are helping people access mental health support in a way that feels more personal, private, and flexible, without compromising safety or clinical oversight.

    Designed to meet people where they are, Nurx offers a fully online approach that allows individuals to request care, connect with licensed medical providers, and receive ongoing support from home. For many, this model makes it easier to take the first step toward feeling better and maintaining emotional well-being.

    Starting Care Online Begins With a Thoughtful Intake Process

    Mental health care through Nurx begins with a comprehensive online consultation. Patients complete a detailed intake that covers symptoms, medical history, current medications, and lifestyle factors. This process helps ensure care is tailored to each individual’s needs rather than applying a one-size-fits-all approach.

    All information is reviewed by a licensed medical provider authorized to prescribe in the patient’s state. If responses indicate that online care may not be appropriate, patients are guided toward other care options. This screening step reflects established medical safety practices and helps ensure people receive the right level of support.

    Personalized Treatment Led by Licensed Medical Providers

    Once a consultation is reviewed, a licensed medical provider determines whether treatment can be safely initiated through telehealth. Care plans are developed based on evidence-based practices and adjusted over time as needed.

    Nurx focuses on personalized care, recognizing that mental health experiences vary widely. Treatment decisions are guided by the individual’s health history, goals, and how they’re feeling with ongoing check-ins built into the process to support long-term well-being.

    Medication Support With Safety at the Forefront

    When medication is part of a care plan, prescribing follows the same regulatory standards required for in-person care. Providers comply with state and federal guidelines, and not all medications are eligible for online prescribing, reflecting safety-first protocols.

    Patients receive clear guidance on how to use their treatment, what to expect, and when to reach out with questions. Orders are fulfilled through licensed pharmacies and shipped in discreet packaging, helping protect privacy while removing the need for in-person pharmacy visits.

    Ongoing Monitoring Without Extra Appointments

    Unlike traditional models that rely on infrequent office visits, online mental health care emphasises continuous support. Through the Nurx app, patients can message their medical team with questions, share updates, and discuss how they’re feeling without scheduling new appointments or making phone calls.

    Licensed medical providers proactively check in to monitor progress and make adjustments when appropriate. This ongoing connection allows concerns to be addressed early and helps patients feel supported throughout their care journey.

    Making Mental Health Care More Accessible and Affordable

    Access and affordability remain major barriers to mental health support. Nurx aims to reduce these obstacles by offering transparent pricing and insurance-friendly options. For some patients with insurance, care may cost as little as $0. Even without insurance, affordable treatment options are available.

    Importantly, more than two-thirds of Nurx mental health patients report a significant reduction in symptoms, highlighting how timely access and consistent support can make a meaningful difference in quality of life.

    Privacy, Convenience, and Care on Your Terms

    For many people, privacy and convenience are essential when seeking mental health support. Nurx operates under strict healthcare privacy standards, with secure digital systems and encrypted communications. Medications are delivered discreetly, and all care happens on the patient’s schedule.

    By eliminating waiting rooms, commutes, and unnecessary barriers, Nurx creates a supportive environment where seeking help feels manageable and stigma-free.

    Understanding What Online Mental Health Care Can — and Can’t — Do

    Online mental health care is not intended for every situation. Severe emergencies or cases requiring intensive supervision may still require in-person treatment. Responsible telehealth providers clearly define these limits and prioritise patient safety above convenience.

    For many people, however, online care offers a practical and empowering way to begin managing anxiety, depression, sleep concerns, seasonal mood changes, and other mental health challenges with professional oversight.

    Supporting Well-Being Through Modern Care Models

    As awareness of mental health continues to grow, platforms like Nurx demonstrate how technology can expand access without sacrificing safety or quality. By combining faster intake, licensed medical provider review, and ongoing monitoring, online mental health care helps more people get the support they deserve, when and where they need it.

    When delivered responsibly, telehealth offers a meaningful path toward improved mood, greater resilience, and a better quality of life.

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  • 1 Tasteless Drop Into Coffee Burns Fat 24/7

    1 Tasteless Drop Into Coffee Burns Fat 24/7

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  • Tap Into Ease with This Guided Meditation for Holiday Stress

    Tap Into Ease with This Guided Meditation for Holiday Stress

    Get the latest on everything mindfulness


    Our free newsletter delivers updates on the science of mindfulness, guided mindfulness meditation practices from leading teachers, special offers, and rich content to support your mindful growth.


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  • Cultivating Resilience: How to Stay Positive in the Face of Adversity

    Cultivating Resilience: How to Stay Positive in the Face of Adversity

    Introduction to Cultivating Resilience

    Cultivating resilience is an essential skill for navigating the challenges of modern life. Resilience is the ability to bounce back from adversity, trauma, or significant stress, and it is a quality that can be developed and strengthened over time. When we are resilient, we are better equipped to handle the ups and downs of life, and we are more likely to emerge from difficult situations with a positive outlook and a renewed sense of purpose. In this article, we will explore the concept of resilience, discuss the benefits of cultivating resilience, and provide practical tips and strategies for staying positive in the face of adversity.

    Understanding Resilience

    Resilience is not just about being able to withstand challenges; it is also about being able to learn and grow from them. When we are resilient, we are able to approach problems with a sense of curiosity and openness, rather than fear or resistance. We are able to see challenges as opportunities for growth and development, rather than threats to our well-being. Resilience is also closely linked to emotional intelligence, which involves being able to recognize and manage our emotions, as well as empathize with others.

    The Benefits of Cultivating Resilience

    Cultivating resilience has numerous benefits, both for individuals and for society as a whole. Some of the key benefits of resilience include:

    • Improved mental health: Resilience is closely linked to mental health, and people who are resilient are less likely to experience anxiety, depression, and other mental health problems.
    • Better relationships: Resilient people are more likely to have strong, supportive relationships, which are essential for both physical and mental health.
    • Increased productivity: When we are resilient, we are more able to manage stress and stay focused, which can lead to greater productivity and achievement.
    • Greater sense of purpose: Resilience is closely linked to a sense of purpose and meaning, and people who are resilient are more likely to feel connected to their values and goals.

    Strategies for Cultivating Resilience

    So, how can we cultivate resilience? Here are some practical strategies for staying positive in the face of adversity:

    • Practice self-care: Taking care of our physical, emotional, and spiritual needs is essential for building resilience. This can include activities such as exercise, meditation, and spending time in nature.
    • Develop a growth mindset: People with a growth mindset believe that their abilities and intelligence can be developed through hard work and dedication. This mindset is essential for resilience, as it allows us to approach challenges with a sense of curiosity and openness.
    • Build a support network: Having a strong support network of friends, family, and colleagues is essential for resilience. When we have people to turn to in times of need, we are more likely to feel supported and less alone.
    • Practice mindfulness: Mindfulness involves being present in the moment, without judgment. This can help us to stay focused and calm, even in the face of challenges.

    Overcoming Obstacles to Resilience

    While cultivating resilience is an important goal, there are often obstacles that can get in the way. Some common obstacles to resilience include:

    • Negative thinking patterns: Negative thinking patterns, such as self-criticism and catastrophizing, can make it difficult to cultivate resilience.
    • Lack of self-care: Failing to take care of our physical, emotional, and spiritual needs can make us more vulnerable to stress and adversity.
    • Trauma and adversity: Experiencing trauma or significant adversity can make it difficult to cultivate resilience, as it can affect our ability to trust ourselves and others.

    Building Resilience in the Face of Adversity

    So, how can we build resilience in the face of adversity? Here are some strategies for staying positive and focused, even in difficult circumstances:

    • Stay present: When we are faced with challenges, it can be tempting to get caught up in worries about the future or regrets about the past. However, staying present and focused on the moment can help us to stay grounded and calm.
    • Practice gratitude: Focusing on the things we are grateful for, rather than the things that are going wrong, can help us to stay positive and resilient.
    • Seek support: Reaching out to friends, family, or a therapist can provide us with the support and guidance we need to navigate challenging situations.

    Conclusion

    Cultivating resilience is an essential skill for navigating the challenges of modern life. By understanding the concept of resilience, recognizing its benefits, and practicing strategies for building resilience, we can develop the skills and resources we need to stay positive and focused, even in the face of adversity. Whether we are facing personal or professional challenges, resilience can help us to emerge stronger, wiser, and more compassionate. By prioritizing self-care, developing a growth mindset, and building a support network, we can cultivate the resilience we need to thrive in all areas of our lives.

    FAQs

    Q: What is resilience, and why is it important?
    A: Resilience is the ability to bounce back from adversity, trauma, or significant stress. It is important because it allows us to navigate challenges with greater ease and emerge stronger, wiser, and more compassionate.

    Q: How can I cultivate resilience?
    A: You can cultivate resilience by practicing self-care, developing a growth mindset, building a support network, and practicing mindfulness.

    Q: What are some common obstacles to resilience?
    A: Common obstacles to resilience include negative thinking patterns, lack of self-care, and trauma or adversity.

    Q: How can I build resilience in the face of adversity?
    A: You can build resilience in the face of adversity by staying present, practicing gratitude, and seeking support from friends, family, or a therapist.

    Q: Is resilience something that can be developed, or is it an innate trait?
    A: Resilience is something that can be developed and strengthened over time, with practice and dedication.

    Q: How can I prioritize self-care and make it a part of my daily routine?
    A: You can prioritize self-care by scheduling time for activities that nourish your mind, body, and spirit, such as exercise, meditation, and spending time in nature.

  • Can Vegan Fecal Transplants Lower TMAO Levels?

    Can Vegan Fecal Transplants Lower TMAO Levels?

    If the microbiome of those eating plant-based diets protects against the toxic effects of TMAO, what about swapping gut flora?

    “Almost 2,500 years ago, Hippocrates stated that ‘All disease begins in the gut.’” When we feed our gut bacteria right with whole plant foods, they feed us right back with beneficial compounds like butyrate, which our gut bugs make from fiber. On the other hand, if we feed them wrong, they can produce detrimental compounds like TMAO, which they make from cheese, eggs, seafood, and other meat.

    We used to think that TMAO only contributed to cardiovascular diseases, like heart disease and stroke, but, more recently, it has been linked to psoriatic arthritis, associated with polycystic ovary syndrome, and everything in between. I’m most concerned about our leading killers, though. Of the top ten causes of death in the United States, we’ve known about its association with increased risk of heart disease and stroke, killers number one and five, but recently, an association has also been found between blood levels of TMAO and the risks of various cancers, which are our killer number two. The link between TMAO and cancer could be attributed to the inflammation caused by TMAO, but it could also be oxidative stress (free radicals), DNA damage, or a disruption in protein folding.

    What about our fourth leading killer, chronic obstructive pulmonary disease (COPD), like emphysema? TMAO is associated with premature death in patients with exacerbated COPD, though it’s suspected that it’s due to them dying from more cardiovascular disease.

    The link to stroke is a no-brainer—no pun intended. It is due to the higher blood pressure associated with higher TMAO levels, as well as the greater likelihood of clots forming in those with atrial fibrillation. Those with higher TMAO levels also appear to have worse strokes and four times the odds of death.

    Killer number six is Alzheimer’s disease. Can TMAO even get up into our brains? Yes, TMAO is present in human cerebrospinal fluid, which bathes the brain, and TMAO levels are higher in those with mild cognitive dysfunction and those with Alzheimer’s disease dementia. “In the brain, TMAO has been shown to induce neuronal senescence [meaning, deterioration with age], increase oxidative stress, impair mitochondrial function, and inhibit mTOR signaling, all of which contribute to brain aging and cognitive impairment.”

    Killer number seven is diabetes, and people with higher TMAO levels are about 50% more likely to have diabetes. Killer number eight is pneumonia, and TMAO predicts fatal outcomes in pneumonia patients even without evident heart disease. Kidney disease is killer number nine, and TMAO is strongly related to kidney function and predicts fatal outcomes there as well. Over a period of five years, more than half of chronic kidney disease patients who started out with average or higher TMAO levels were dead, whereas among those in the lowest third of levels, nearly 90% remained alive.

    How can we lower the TMAO levels in our blood? Because TMAO originates from dietary sources, we could limit our intake of choline- and carnitine-rich foods. They’re so widespread in foods,” though we’re talking about meat, eggs, and dairy. “Therefore, restriction of foods rich in TMA-containing nutrients may not be practical.” Can we just get a vegan fecal transplant? “Vegan donors provided the investigators with a fresh morning fecal sample…”

    If you remember, if you give a vegan a steak, despite all that carnitine, they make almost no TMAO compared to a meat-eater, presumably because the vegan hasn’t been fostering steak-eating bugs in their gut. See below and at 3:40 in my video Can Vegan Fecal Transplants Lower TMAO Levels?.

    Remarkably, even if you give plant-based eaters the equivalent of a 20-ounce steak every day for two months, only about half start ramping up production of TMAO, showing just how far their gut flora has to change. The capacity of veggie feces to churn out TMAO is almost nonexistent. Instead of eating healthier, what about getting some vegan poop?

    In a double-blind, randomized, controlled trial, research subjects either got vegan poop or their own poop back through a hose snaked down their nose, and it didn’t work.

    First of all, the vegans recruited for the study started out making TMAO themselves, in contrast to the other study, where they didn’t make any at all. This may be because the earlier study required the vegans to have been vegan for at least a year, and this study didn’t. So, there wasn’t much of a change in TMAO running through their bodies two weeks after getting the vegan poop, but the vegan poop they got seemed to start out with some capacity to produce TMAO in the first place.

    So, the failure to improve after the vegan fecal transplant “could be related to limited baseline microbiome differences and continuation of an omnivorous diet” after the vegan-donor transplant. What’s the point of trying to reset your microbiome if you’re just going to eat meat? Well, the researchers didn’t want to switch people to a plant-based diet since they knew that alone can change our microbiome, and they didn’t want to introduce any extra factors. The bottom line is that it seems there may not be any shortcuts. We may just have to eat a healthier diet.

    Doctor’s Note

    Want to become a donor? Find out How to Become a Fecal Transplant Super Donor.

    For more on TMAO, check out related posts below. 

    See the microbiome topic page for even more.



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  • The Women Engineering the Future of Cardiovascular Tech

    The Women Engineering the Future of Cardiovascular Tech

    Few health threats loom larger in the U.S. than heart disease. It remains the nation’s leading cause of death, killing over 900,000 people in 2023, according to the CDC. Yet despite the universal stakes, the cardiovascular technology sector responsible for developing treatments and devices continues to be led overwhelmingly by men. This imbalance matters: when leadership and R&D teams do not reflect the diversity of the patient population, blind spots in design and decision-making can emerge.

    One exception is FastWave Medical, where women hold pivotal roles in both operations and technology, shaping the company’s next-generation intravascular lithotripsy (IVL) platforms for calcified arteries. It’s a model that remains relatively uncommon in cardiovascular device development — and one that’s influencing how the technology itself is being designed.

    Why Representation Matters in Cardiovascular Innovation

    How did that composition come about? It wasn’t the result of deliberate targets, as FastWave Co-Founder and CEO Scott Nelson explains. “At FastWave, we have a majority female leadership team — not because of quotas, but because they were simply the best people for the job,” he says. That framing — merit first, diversity as outcome — reflects a hiring philosophy that prioritizes environment over intention. “Our philosophy is straightforward: create a great place to work, and you’ll attract top talent. That’s exactly how we’ve ended up with such a strong team.”

    The benefit extends beyond hiring philosophy. When team members bring different perspectives to the table, they surface questions that more homogeneous teams may not think to ask. In cardiovascular innovation — where patient needs vary widely across gender, age, and anatomy — that breadth of insight shapes everything from device design to workflow integration.

    Building Technology Through Diverse Perspectives

    The company is advancing a dual-platform approach to IVL, with two devices engineered to address limitations of first-generation systems: Sola, its coronary laser IVL platform, and Artero, its electric IVL platform for peripheral artery disease. But the technology isn’t being shaped just by leadership on paper — it’s being built day-to-day by women with decades of device development experience.

    Tristan Tieso, FastWave’s Chief Operating Officer, brings more than 20 years of experience in cardiovascular and neurovascular devices to her role — including leadership positions at Vention Medical, where she managed over 50 professionals, and at Worrell, a global healthcare design and strategy firm.

    At FastWave, she oversees engineering, quality, regulatory, and preclinical operations, and her leadership has been instrumental in building the company’s intellectual property portfolio. “When you consider that FastWave is only four years old, securing nine U.S. patents is really quite remarkable — it speaks to our team’s innovative capabilities and how seriously we’ve approached building our intellectual property portfolio from day one,” Tieso says. “This isn’t just about collecting patents for the sake of it. We’re strategically protecting the core technologies that differentiate our platforms.”

    What drives those technologies is “problem-first design.” Tieso explains, “Our entire development approach has been built around spending extensive time with interventional cardiologists, vascular surgeons, and interventional radiologists to understand their daily frustrations with existing IVL technology, then engineering backward from those pain points,” she explains. One clear example: doctors were consistently reporting hassles with reusable dongles and time lost to generator charging. “That direct input led us to make some compelling improvements to the user experience,” Tieso says — resulting in a plug-and-play, AC-powered system with one-click activation that does away with reusable dongles, generator charging, and the need to hold down buttons during procedures.

    Sukanya Iyer, Head of Technology, leads product development and engineering. With prior roles at Boston Scientific, Abbott, and St. Jude Medical, she holds multiple patents in ablation systems and has contributed to the development of major cardiovascular devices, including multiple generations of the WATCHMAN system, force-sensing ablation catheters, and renal denervation systems.

    At FastWave, she is reimagining how sonic pressure waves are generated and delivered. “From a technology perspective, we’ve fundamentally reimagined how sonic pressure waves are generated and delivered,” Iyer explains, “Artero utilizes independently powered emitters that deliver uniform, circumferential sonic pressure, eliminating the uneven energy delivery and localized degradation issues that plague legacy IVL systems. Sola, our other platform, takes an entirely different approach with a single, translating laser emitter that delivers true 360° sonic pressure with every pulse.”

    For Iyer, physician input is essential to the engineering itself. “We’ve spent considerable time listening to physicians describe moments when existing IVL technology simply didn’t meet their clinical needs,” she says. “What became clear was that legacy systems had fundamental engineering limitations that created clinical constraints — physicians were dealing with limited energy pulses and unpredictability when treating eccentric or nodular calcific lesions.” Those technical insights drove the team to question the underlying physics of how sonic pressure waves should be generated and delivered.

    “We’ve spent considerable time listening to physicians describe moments when existing IVL technology simply didn’t meet their clinical needs,” she says. “What became clear was that legacy systems had fundamental engineering limitations creating clinical constraints — physicians were dealing with limited energy pulses and unpredictability when treating eccentric or nodular calcific lesions.” Those technical insights drove the team to question the underlying physics of how sonic pressure waves should be generated and delivered.

    A Model for Medtech

    Despite progress in some areas of medtech, cardiovascular technology leadership remains predominantly male, particularly at the senior technical level. But there are other paths forward. When companies build leadership teams on merit and foster cultures that value diverse perspectives, technical excellence, and representation, the two don’t just coexist — they reinforce each other.

    At FastWave, women aren’t just present in leadership meetings. Tieso and Iyer are shaping intellectual property, redesigning workflow, and rethinking how procedures can be performed more efficiently and safely. As the team has grown, other FastWave leaders like Anindita Sengupta, Head of QA/RA, have joined to build out the regulatory and quality infrastructure needed to bring the technology to market.

    Crucially, they are also leading with openness — actively engaging with cardiologists and vascular specialists from a variety of backgrounds to refine and advance the company’s platforms. That willingness to integrate broad, real-world feedback ensures the technology reflects not just engineering expertise but the lived experience of those using it in practice.

    The outcome is instructive: when diverse, merit-based leadership combines technical depth with responsiveness to user needs, the technology becomes more aligned with both physician workflow and patient realities. In cardiovascular care, where the stakes are life and death, that alignment matters. Tieso and Iyer offer evidence that representation, technical rigor, and an openness to diverse voices can intersect to advance medical technology in meaningful ways.

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