Health Journal Online

Tag: Tumor

  • Teen Dies From Rare Brain Tumor After Unusual Symptoms; Heartbroken Mom Urges Others To Recognize Signs

    Teen Dies From Rare Brain Tumor After Unusual Symptoms; Heartbroken Mom Urges Others To Recognize Signs

    When 12-year-old Jody tripped and fell multiple times, had trouble walking straight, and struggled to fasten her shirt buttons, her mother never suspected it could be a sign of something serious—until doctors delivered the devastating news of a rare brain tumor.

    After years of battling the disease, Jody passed away in 2022, at the age of 16, and her heartbroken mother, Sarah Levett, from Surrey in South East England, now raises awareness about the condition, hoping that parents could spot the signs as soon as possible.

    Levett, who is organizing a fundraiser next month for the Brain Tumor Charity in her daughter’s memory, says she does it so no other parent or child has to endure the unimaginable heartbreak they experienced.

    When Jody first experienced symptoms like migraines, difficulty with balance, and frustration that led to screaming fits, Levett thought it might be related to her autism. But during a check-up, doctors discovered that Jody was in the advanced stages of a rare brain tumor.

    “It was absolutely terrifying. As the doctor spoke about how big the tumor was, I couldn’t take it all in,” Levett recollected the moments following the diagnosis.

    “I just wanted it gone. But I tried as hard as I could to hide how scared I was, as Jody was so young. I didn’t want her to worry – in fact, she was more bothered about the fact she was unable to go to school. She started bumping into things, like a wheelie bin on the pavement, only a few months before the diagnosis,” she said.

    Jody underwent treatment for around 10 months, including a surgery that removed 80% of the tumor, followed by chemotherapy and radiotherapy until she was stable. However, a year later, a follow-up scan revealed that the tumor had returned.

    As Jody’s condition rapidly declined, she underwent four more surgeries and doctors discovered a brain bleed before she tragically died.

    “The main aim [of the fundraiser] is to continue the awareness of brain tumors and changes needed, and the lack of mental health support for bereaved parents. I know there’s a lot of strain on healthcare at the moment, but I really don’t want any other parents or children to have to go through the unimaginable heartbreak like we have done,” Levett said.

    Brain tumors may present with symptoms such as seizures, balance issues, behavioral changes, slurred speech, fatigue, weakness, headaches, nausea, and vomiting.

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  • Dad Dies Year After Brain Tumor Diagnosis, Doctor Initially Dismissed Symptoms As Stress, Accused Him Of Faking

    Dad Dies Year After Brain Tumor Diagnosis, Doctor Initially Dismissed Symptoms As Stress, Accused Him Of Faking

    A 53-year-old U.K. man with troubling signs, including headaches and jumbled speech, was initially dismissed as stressed. His doctor even accused him of faking symptoms before being diagnosed with an aggressive brain tumor. A year later, he died. Now, his daughter is running a marathon to raise awareness and money for cancer research.

    Stephen Blakeston, from Hull, England, started experiencing massive headaches and was jumbling up sentences when his wife noticed the symptoms and took him to a doctor in October 2010.

    “I couldn’t believe it when we visited the GP, who dismissed his symptoms as stress-related and even said he was faking, something I know my dad wouldn’t do,” Blakeston’s daughter Hollie Rhodes recollected.

    Blakeston later got a CT scan done and realized that a tumor was growing on the left side of his brain, which was affecting his speech. He underwent surgery soon, and a biopsy confirmed that the tumor was a glioblastoma, a fast-growing, incurable cancer, leaving him with just 12-18 months to live.

    After the surgery, Blakeston underwent intensive radiotherapy and two rounds of chemotherapy to halt the growth of the tumor and scans showed no signs of further regrowth.

    However, around 9 months later, Blakeston suddenly collapsed and died after a blood clot, believed to be related to his treatment, or the tumor traveled to his heart.

    “It was horrible for us to lose him so suddenly, but there is some comfort in knowing it was quick and likely the way he would have wanted to go. I’ll always miss hearing his laugh,” Rhodes said.

    Glioblastoma is a fairly common form of brain tumor, with more than 13,000 Americans are diagnosed with it every year. The symptoms vary but often include persistent headaches, nausea, confusion, memory loss, and personality changes. Other signs to watch out for include vision problems, speech difficulties, muscle weakness, and seizures, especially in those without a history of them.

    “It’s the biggest cancer killer of children and adults under 40, so it should absolutely be a priority to stop these deaths. It almost feels like people view brain tumors as a final prognosis. That whole narrative needs to change because more funding in research would bring hope to those impacted,” said Rhodes, who is running the London Marathon to raise money for Brain Tumor Research.

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  • Pregnant Woman And Baby Saved After Doctors Identify Her Bad Cough, Breathlessness Was Rare Tumor In Chest

    Pregnant Woman And Baby Saved After Doctors Identify Her Bad Cough, Breathlessness Was Rare Tumor In Chest

    MaKenna Lauterbach from Illinois was 36 weeks pregnant when she received the shocking diagnosis of a large tumor in her chest, revealing the real cause of the persistent cough and breathlessness during her pregnancy. The 26-year-old, who was diagnosed with stage 3 melanoma, is now stable and recovering, along with her healthy baby, thanks to the timely intervention and coordinated efforts of a dedicated team of doctors.

    When Lauterbach experienced a bad cough while she was expecting, she knew something was wrong. Simple tasks, like walking to the barn to feed her horses, left her unusually winded, as if she had just run two miles. However, doctors were initially hesitant to perform chest scans due to concerns about radiation exposure.

    When Lauterbach was almost due, the cough worsened to the extent that she started throwing up and had to be hospitalized for shortness of breath. The scans then revealed a grapefruit-sized tumor in her chest, blocking the artery to her right lung.

    By the time Lauterbach received the diagnosis, she was in respiratory distress, the tumor obstructing her airway, putting both her life and her baby’s at risk.

    After being airlifted to the intensive care unit at Northwestern Memorial Hospital in Chicago, her condition worsened, she went into labor, her blood pressure spiked, and the baby began showing signs of distress during contractions.

    “Lauterbach was in real trouble, and we had to act quickly – this wasn’t something that could wait for Monday morning. When you’re pregnant with a baby that’s nearly full-term, your lungs already aren’t functioning at full capacity, and when you add a huge tumor on top of it, you run the risk of having respiratory collapse and cardiac arrest,” said Dr. Lynn Yee, maternal-fetal medicine specialist at Northwestern Medicine in a news release.

    Doctors quickly prepared Lauterbach for extracorporeal life support (ECMO) and performed an emergency C-section, successfully delivering a healthy baby boy.

    “Because of the tumor, the delivery happened so quickly. I was grieving the birth plan I had spent months preparing for, while also dealing with the news of my unexpected diagnosis,” Lauterbach said.

    While her newborn remained in the hospital’s neonatal intensive care unit, doctors performed an advanced bronchoscopy on Lauterbach. The procedure revealed that her tumor was stage 3 melanoma, prompting the medical team to immediately begin developing a treatment plan.

    “Lauterbach’s diagnosis was difficult to make because we weren’t sure if the melanoma started in the chest or somewhere else, and there isn’t much literature or published cases on how to best treat tumors like these, so we had to rely on the expertise that we’ve developed here at Northwestern Medicine,” said Dr. Kalvin Lung, a thoracic surgeon with the Northwestern Medicine Canning Thoracic Institute.

    The medical team decided on surgery to remove the tumor. Before the procedure, Lauterbach was given three cycles of immunotherapy which helped shrink the tumor from 13 centimeters to nine centimeters.

    “We think at some point, Lauterbach had a melanoma on her skin and her own immune system took care of it, but not before a cell or two may have escaped and eventually started growing inside her body,” explained Dr. Sunandana Chandra, medical oncologist with the Robert H. Lurie Comprehensive Cancer Center of Northwestern University at Northwestern Memorial Hospital.

    During the surgery, doctors had to remove her right lung parts of the main pulmonary artery, and lymph nodes. “The tumor was sitting on top of Lauterbach’s heart and extended into the right lung, impacting all three lobes and the entire main trunk of the pulmonary artery, which is why we had to remove the right lung,” said Dr. Lung who conducted the surgery along with Dr. Chris Mehta, a cardiac surgeon with the Northwestern Medicine Bluhm Cardiovascular Institute.

    “It’s extremely rare to see this type of tumor invading into the major blood vessels of the heart. We may see something like this once every few years,” Dr. Mehta added.

    Lauterbach’s latest scans show no evidence of metastatic melanoma, and while her cancer remains stable with no new tumors, she will continue immunotherapy treatments for the next year.

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  • Tumor suppressor protein Par-4 triggers unique cell death pathway in cancerous cells

    Tumor suppressor protein Par-4 triggers unique cell death pathway in cancerous cells

    A team of researchers at NYU Abu Dhabi, led by Professor Sehamuddin Galadari, has discovered that the tumor suppressor protein Prostate apoptosis response-4 (Par-4) can cause a unique type of cell death called ferroptosis in human glioblastoma — the most common and aggressive type of brain tumor — while sparing healthy cells. This new understanding has the potential to inform the development of novel treatments for various hard-to-treat cancers and neurodegenerative diseases.

    Ferroptosis is triggered by the iron-mediated production of reactive oxygen species (ROS) and subsequent lipid peroxidation, which plays a crucial role in shrinking cancerous tumors. This is the first time that Par-4, already known for killing cancer cells through apoptosis — a form of programmed cell death — has been shown to promote ferroptosis in glioblastoma cells.

    The tumor suppressor protein Par-4 is widely expressed across species, but is often reduced, mutated, or inactivated in the presence of various cancers. In the study “Tumor suppressor Par-4 activates autophagy-dependent ferroptosis,” recently published in the journal Communications Biology, the researchers identified that Par-4 plays an unanticipated role in promoting ferroptosis-mediated cancer regression. They demonstrated that Par-4 triggers the activation of ferritinophagy (autophagic degradation of ferritin) through the nuclear receptor co-activator 4 (NCOA4). This activation is necessary for the accumulation of the labile iron pool, the production of ROS, and the subsequent lipid peroxidation, all of which lead to ferroptosis.

    Ferroptosis plays a key role in various health issues, such as cancer, heart disease, brain damage, kidney failure, lung injury, and diseases like Parkinson’s, Huntington’s, and Alzheimer’s. The identification of Par-4 as a key player in ferroptosis is essential, as it is involved in the main processes and signals that make this alternative cell death pathway, ferroptosis, occur. Many types of cancer cells don’t respond to today’s treatments or have developed resistance to existing drugs therapies.

    This research was a collaborative effort between Associate Professor Mazin Magzoub’s lab at NYU Abu Dhabi and Professor Vivek M. Rangnekar from the University of Kentucky, who discovered Par-4 in 1993.

    “Our team’s discovery that Par-4 triggers ferroptosis is a breakthrough in the field of cancer treatment development,” said Galadari, who is the Senior Vice Provost for Research and Managing Director of the Research Institute at NYU Abu Dhabi. “Developing methods to activate alternative cell death pathways presents new opportunities for the creation of more potent and effective therapies for glioblastoma and other deadly and debilitating diseases.”

    “Investing in research at institutions such as NYUAD is instrumental in transforming the UAE into a knowledge-based economy that attracts local, regional, and global talent — a symbiotic relationship that creates opportunities, knowledge, and wealth,” Galadari added.

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