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Tag: Study

  • Less Sugar In First 1000 Days Of Life Slashes Diabetes, Hypertension Risk: Study

    Less Sugar In First 1000 Days Of Life Slashes Diabetes, Hypertension Risk: Study

    Healthy eating with minimal sugar is essential for long-term health and lowering the risk of chronic conditions. A recent study suggests these efforts should begin as early as conception. Researchers found that limiting sugar intake during the first 1000 days of life, from pregnancy through a child’s second birthday, could dramatically reduce their risk of diabetes and hypertension.

    The study revealed that less sugar intake during the critical period of early life could cut the diabetes risk by 35% and the risk of hypertension by 20%.

    The researchers came up with these interesting findings by evaluating the long-term health impact of sugar rationing that occurred during World War II. They used recent data from the U.K. Biobank, which includes medical histories and genetic and lifestyle factors, to examine how early-life sugar restrictions impacted adult health in those conceived just before and after wartime sugar rationing ended.

    “Using an event study design with UK Biobank data comparing adults conceived just before or after rationing ended, we found that early-life rationing reduced diabetes and hypertension risk by about 35% and 20%, respectively, and delayed disease onset by 4 and 2 years,” the researchers wrote in the study published in the journal Science.

    The researchers noted that the chronic health risks were significantly reduced when expectant mothers limited their sugar intake during pregnancy. However, the benefits increased even more when children continued to be on a sugar restriction after birth, averaging no more than 8 teaspoons (40 grams) per day.

    The end of wartime rationing offered a unique window for a natural experiment when sugar intake surged sharply, while other foods remained unchanged. Individuals’ early-life sugar exposure varied depending on whether they were conceived or born before or after September 1953. While those conceived just before experienced sugar-scarce conditions, those born just after entered a more sugar-rich environment.

    “Studying the long-term effects of added sugar on health is challenging. It is hard to find situations where people are randomly exposed to different nutritional environments early in life and follow them for 50 to 60 years. The end of rationing provided us with a novel natural experiment to overcome these problems,” study corresponding author Tadeja Gracner said in a news release.

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  • Behavioral Therapy For Insomnia May Lower Risk Of Postpartum Depression: Study

    Behavioral Therapy For Insomnia May Lower Risk Of Postpartum Depression: Study

    Good sleep is essential for mental well-being of every human being. While it is difficult to ensure good sleep during pregnancy, getting behavioral therapy for insomnia could not only solve sleep issues, but could even reduce the risk of postpartum depression, a recent study has revealed.

    Postpartum depression is a mental health condition that affects around 10% of women after giving birth. The symptoms include severe mood disorder, constant fatigue, difficulty sleeping at night with daytime drowsiness, difficulty caring for oneself or the baby, withdrawal from social contact, trouble concentrating and making decisions, and distressing thoughts, such as fears of harming the baby.

    The patients are recommended to get sleep, rest, and exercise, and seek therapy or medications for relief, depending on the severity of the symptoms.

    According to the latest study published in the Journal Of Affective Disorders, getting cognitive behavioral therapy for insomnia (CBTi) may serve as a protective factor against postpartum depression.

    “Early intervention is crucial for infant and parental mental health. Our research explores how addressing sleep problems like insomnia can lead to better mental health outcomes for families, helping parents and their children thrive,” said Dr. Elizabeth Keys, the study’s co-author, in a news release.

    The therapy starts by identifying a patient’s thoughts, behaviors, and sleep patterns that contribute to insomnia. Misconceptions or habits disrupting sleep are then challenged and reframed to enhance sleep quality.

    “CBTi is the gold standard for the treatment of insomnia and has consistently been shown to improve symptoms of depression. Its treatment effects are similar to antidepressant medications among adults, but with fewer side effects, and is therefore often preferred by pregnant individuals,” said Dr. Keys.

    During the trial, researchers evaluated 62 women with insomnia, who underwent a five-week CBT-I intervention specifically adapted for pregnancy. The participants’ insomnia and depression symptoms were tested before the intervention, immediately after, and again six months postpartum.

    The results revealed that there was a significant improvement in sleep among the participants and reduced depressive symptoms six months after postpartum.

    “These are enormously encouraging results for anyone who has struggled in those early weeks and months with their newborns. Our study adds to the growing evidence that treating insomnia during pregnancy is beneficial for various outcomes. It’s time to explore how we can make this treatment more accessible to pregnant individuals across the country to improve sleep health equity,” Dr. Keys added.

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  • Diabetes Onset Before 40 Raises Risk Of Death To Four Times: Study

    Diabetes Onset Before 40 Raises Risk Of Death To Four Times: Study

    Diabetes is not just about having high blood sugar levels; it is a chronic condition that could potentially lead to several health issues, such as heart attack and stroke. But does the timing of diabetes onset affect the risk of complications and mortality? A recent study revealed that developing diabetes before age 40 is linked to a significantly higher risk of early death.

    While diagnosing diabetes before 40 quadrupled the risk of early death, later onset was linked to a one-and-a-half times higher risk of death compared with the general population without the condition, according to the study published in the Lancet Diabetes & Endocrinology. The findings underscore the importance of delaying the onset of diabetes to reduce complications and risk of premature death.

    To understand the impact of diabetes on overall health, researchers followed up 4,550 individuals newly diagnosed with diabetes for over 30 years. The participants were between the ages of 25 and 65.

    The analysis revealed that diabetic diagnosis at an earlier stage was linked to a higher rate of related complications, particularly microvascular diseases such as eye damage and kidney failure, and a higher risk of death. Diabetes onset at a younger age also was linked to poorer blood sugar control.

    “Over the past 30 years, the number of young adults diagnosed with type 2 diabetes has increased markedly worldwide. Evidence to date suggests that younger-onset type 2 diabetes, characterized by earlier and longer exposure to high levels of blood glucose, maybe more aggressive than later onset disease. This might include a faster deterioration in β-cell function—the cells in the pancreas that produce and release insulin- and a greater risk of complications such as cardiovascular and kidney disease,” said Amanda Adler, co-author of the study in a news release.

    According to the lead author of the study, Dr. Beryl Lin, more clinical trials should focus on tailored treatments for delaying diabetic complications in young people.

    “We particularly need to understand why young adults with type 2 diabetes suffer greater risks of complications, and how we can identify and help this vulnerable group of people who have to live with diabetes for the rest of their lives,” Dr. Lin said.

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  • Poor Sleep In 40s May Add Years To Your Brain Age: Study Finds

    Poor Sleep In 40s May Add Years To Your Brain Age: Study Finds

    Missing out on sleep not only makes you feel groggy the next day, but the effects can be long-lasting. Adding to the growing body of evidence, researchers have now found that poor sleep in the middle ages is linked to accelerated brain aging in the next ten years.

    The latest study that evaluated participants’ brain health using brain scans revealed that having poor sleep quality in the 40s might add more years to the brain age.

    “Sleep problems have been linked in previous research to poor thinking and memory skills later in life, putting people at higher risk for dementia. Our study which used brain scans to determine participants’ brain age, suggests that poor sleep is linked to nearly three years of additional brain aging as early as middle age,” said study author, Clémence Cavaillès from the University of California San Francisco in a news release.

    The researchers evaluated the sleep patterns of 589 participants with an average age of 40 using questionnaires at the start of the study and five years later. After 15 years, the researchers evaluated the brain shrinkage of the participants using brain scans.

    The questionnaires evaluated participants based on six sleep issues: difficulty falling asleep, waking up in between sleep, waking up too early, short sleep duration, bad sleep quality, and daytime sleepiness.

    Based on the results, participants were divided into three groups according to their sleep quality. Those in the low group had just one poor sleep characteristic and 70% belonged to this group. However, the middle group, comprising 22% of participants, had two to three poor sleep features, while the high group, with more than three poor sleep characteristics, made up 8% of the population.

    After analyzing brain scans alongside sleep patterns, researchers found that participants in the middle group had an average brain age of 1.6 years older than those in the low group. Meanwhile, those in the high group showed an average brain age of 2.6 years older than the low group.

    Out of the six poor sleep characteristics studied, bad sleep quality, difficulty falling asleep, difficulty staying asleep and early morning awakening were linked to greater brain age. This was particularly strong when the participants consistently had it for over five years.

    “Our findings highlight the importance of addressing sleep problems earlier in life to preserve brain health, including maintaining a consistent sleep schedule, exercising, avoiding caffeine and alcohol before going to bed and using relaxation techniques,” said author Dr. Kristine Yaffe, from the University of California San Francisco.

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  • Vitamin D Deficiency In Kids Raises Risk Of Auto-Immune Disorders: Study Explains How

    Vitamin D Deficiency In Kids Raises Risk Of Auto-Immune Disorders: Study Explains How

    Ensure your child is getting adequate sunshine vitamins. Beyond the role of calcium absorption and bone strengthening, researchers have discovered more about its connection to the immune system. A recent study revealed how a deficiency of vitamin D in young children can raise the risk of developing autoimmune disorders.

    According to the latest study published in the journal Science Advances, the deficiency of vitamin D in kids is linked to premature aging of the thymus gland. The thymus is a small lymph gland that makes and trains T-cells that are crucial for the immune system, defending the body against infections and diseases. While most of these vital cells are produced before birth, the remainder are generated during childhood, and by puberty, individuals would have developed the complete T cells for their lifetime.

    “An aging thymus leads to a ‘leaky’ immune system. This means the thymus becomes less effective at filtering out immune cells that could mistakenly attack healthy tissues, increasing the risk of autoimmune diseases like type 1 diabetes,” said the lead author of the study John White in a news release.

    Studies have shown that vitamin D is essential for immunity but according to White, the recent study findings “bring new clarity to this connection and could lead to new strategies for preventing autoimmune diseases.”

    During the trial, researchers examined mice that could not produce vitamin D to assess how this deficiency affected their thymus glands. They then conducted cell analyses and gene sequencing to understand the impact of vitamin D deficiency on the immune system. The researchers expect similar findings in humans as the thymus functions similarly in both species.

    Based on the study findings, researchers suggest that young children should get adequate vitamin D, either through natural sources such as fortified food and sunlight or through supplementation.

    “If you have a young child, it’s important to consult with your healthcare provider to ensure they’re getting enough,” said White.

    Earlier research conducted by the same team in 2021, which followed up more than 10,000 children showed that early vitamin D supplementation can reduce the risk of developing type 1 diabetes by up to five-fold.

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  • The Largest Study on Fasting in the World 

    The Largest Study on Fasting in the World 

    The Buchinger-modified fasting program is put to the test.

    A century ago, fasting—“starvation, as a therapeutic measure”—was described as “the ideal measure for the human hog…” (Fat shaming is not a new invention in the medical literature.) I’ve covered fasting for weight loss extensively in a nine-video series, but what about all the other purported benefits? I also have a video series on fasting for hypertension, but what about psoriasis, eczema, type 2 diabetes, lupus, metabolic disorder, rheumatoid arthritis, other autoimmune disorders, depression, and anxiety? Why hasn’t it been tested more?

    One difficulty with fasting research is: What do you mean by fasting? When I think of fasting, I think of water-only fasting, but, in Europe, they tend to practice “modified therapeutic fasting,” also known as Buchinger fasting, which is more like a very low-calorie juice fasting with some vegetable broth. Some forms of fasting may not even cut calories at all. As you can see below and at 1:09 in my video The World’s Largest Fasting Study, Ramadan fasting, for example, is when devout Muslims abstain from food and drink from sunrise to sunset, yet, interestingly, they end up eating the same amount—or even more food—overall.

    The largest study on fasting to date was published in 2019. More than a thousand individuals were put through a modified fast, cutting daily intake down to about ten cups of water, a cup of fruit juice, and a cup of vegetable soup. They reported very few side effects. In contrast, the latest water-only fasting data from a study that involved half as many people reported nearly 6,000 adverse effects. Now, the modified fasting study did seem to try to undercount adverse effects by only counting reported symptoms if they were repeated three times. However, adverse effects like nausea, feeling faint, upset stomach, vomiting, or palpitations were “observed only in single cases,” whereas the water-only fasting study reported about 100 to 200 of each, as you can see below and at 2:05 in my video. What about the benefits though?

    In the modified fasting study, participants self-reported improvements in physical and emotional well-being, along with a surprising lack of hunger. What’s more, the vast majority of those who came in with a pre-existing health complaint reported feeling better, with less than 10 percent stating that their condition worsened, as you can see in the graph below and at 2:24 in my video. 

    However, the study participants didn’t just fast; they also engaged in a lifestyle program, which included being on a plant-based diet before and after the modified fast. If only the researchers had had some study participants follow the healthier, plant-based diet without the fast to tease out fasting’s effects. Oh, but they did! About a thousand individuals fasted for a week on the same juice and vegetable soup regimen and others followed a normocaloric (normal calorie) vegetarian diet.

    As you can see below and at 2:54 in my video, both groups experienced significant increases in both physical and mental quality of life, and, interestingly, there was no significant difference between the groups.

    In terms of their major health complaints—including rheumatoid arthritis; chronic pain syndromes, like osteoarthritis, fibromyalgia, and back pain; inflammatory and irritable bowel disease; chronic pulmonary diseases; and migraine and chronic tension-type headaches—the fasting group appeared to have an edge, but both groups did well, with about 80 percent reporting improvements in their condition and only about 4 percent reporting feeling worse, as you can see below and at 3:25 in my video. 

    Now, this was not a randomized study; people chose which treatment they wanted to follow. So, maybe, for example, those choosing fasting were sicker or something. Also, the improvements in quality of life and disease status were all subjective self-reporting, which is ripe for placebo effects. There was no do-nothing control group, and the response rates to the follow-up quality of life surveys were only about 60 to 70 percent, which also could have biased the results. But extended benefits are certainly possible, given they all tended to improve their diets, as you can see below and at 4:00 in my video.

    They ate more fruits and vegetables, and less meats and sweets, and therein may lie the secret. “Principally, the experience of fasting may support motivation for lifestyle change. Most fasters experience clarity of mind and feel a ‘letting go’ of past actions and experiences and thus may develop a more positive attitude toward the future.”

    As a consensus panel of fasting experts concluded, “Nutritional therapy (theory and practice) is a vital and integral component of fasting. After the fasting therapy and refeeding period, nutrition should follow the recommendations/concepts of a…plant-based whole-food diet…”

    If you missed the previous video, check out The Benefits of Fasting for Healing.



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  • RSV Vaccine Effective In Cutting Hospitalization In Older Adults, Immunocompromised Individuals: Study

    RSV Vaccine Effective In Cutting Hospitalization In Older Adults, Immunocompromised Individuals: Study

    Researchers have now found that the vaccine against Respiratory Syncytial Virus (RSV) can prevent hospitalization in a significant majority of older adults and immunocompromised individuals.

    The latest study published in the Lancet journal analyzed the effectiveness of the RSV vaccine in U.S. adults aged 60 and older using large-scale data from 36,706 patients. The researchers looked at hospital and emergency room visits for RSV-like illnesses between October 2023 and March 2024 across eight U.S. states. They then compared vaccination rates between patients who tested positive for RSV and those who tested negative while adjusting for factors like age, sex, race, underlying health conditions, and location. There were 3,275 vaccinated patients in the study.

    The analysis showed that the RSV vaccine is highly effective, reducing the risk of hospitalization due to infection complications by 80%. Even among typically more vulnerable immunocompromised individuals, the vaccine was 73% effective at preventing hospitalization.

    “No vaccine is 100 percent effective. An 80 percent vaccine effectiveness rate is quite impressive and higher than we see, for example, with the influenza vaccine,” study co-author, Brian Dixon said in a statement.

    “The bottom line is that using real-world data from electronic medical records routinely captured in care for people from diverse walks of life we found that having the vaccine was highly protective against hospitalization, severe illness and death,” Dixon said.

    As per the Centers for Disease Control and Prevention (CDC) guidelines, everyone aged 75 and older is recommended to take at least one dose of the RSV vaccine, while adults aged 60 to 74 should consider it if they are at higher risk of severe RSV. This includes individuals with chronic heart or lung diseases, severe obesity, weakened immune systems, certain diabetes conditions, or those living in nursing homes.

    To protect infants from severe RSV, two options are available: Pfizer’s Abrysvo vaccine given to pregnant women or an RSV antibody treatment given to infants after birth.

    As of October 5, 2024, the CDC estimates that 36.9% of adults aged 75 and older have received an RSV vaccine. Among adults aged 60 to 74 with high-risk conditions for RSV, about 29% have been vaccinated.

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  • COVID-19 Vaccine Linked To Elevated Risk Of Facial Palsy: Study

    COVID-19 Vaccine Linked To Elevated Risk Of Facial Palsy: Study

    Researchers have found that COVID-19 vaccination is linked to an elevated risk of facial palsy, with the risk particularly high within 28 days of taking the shot.

    Facial palsy, also known as Bell’s palsy, leads to temporary weakness or paralysis of the facial muscles, resulting in drooping on one side of the face and difficulty making facial expressions. Although the exact cause of the condition is not known, experts believe that certain viral infections, autoimmune mechanisms, or vaccination can be potential triggers.

    Although the pivotal clinical trials during the development of COVID-19 vaccines revealed no severe safety concerns, there has been an imbalance in the incidence of facial palsy among vaccinated individuals compared to the general population. This prompted the researchers to conduct a large-scale study involving over 44 million patients in South Korea to investigate the risk of facial palsy among individuals vaccinated against COVID-19.

    The researchers examined a national health information database of individuals who received more than one dose of the COVID-19 vaccine and were then diagnosed with facial palsy within 240 days post-vaccination.

    When the incidence of facial palsy within 1–28 post-vaccination was compared to a control window (the remainder of the 240-day observation period), the researchers noted that there were 5,211 cases within the risk window and 10,531 cases within the control window.

    The study revealed a 12% increase in the risk of facial palsy within 1 to 28 days after any COVID-19 vaccine dose. The researchers also noted that the risk increased regardless of whether individuals received homologous or heterologous vaccines.

    While the second dose showed a 7% higher risk, the combination of the first and second doses indicated an 8% increase. However, no increased risk was associated with the third dose.

    “Facial Palsy (FP) risk increased within 28 days postvaccination, primarily after first and second doses, and was observed for both mRNA and viral vaccines. Clinicians should carefully assess the FP risk-benefit profile associated with the COVID-19 vaccines and monitor neurologic signs after vaccination,” the researchers wrote in a news release.

    While the exact reason for facial palsy after vaccination is unclear, researchers suggest possible explanations.

    One explanation is that mRNA vaccines use lipid nanoparticles to deliver SARS-CoV-2 spike antigen which triggers an immune response that can lead to the release of proinflammatory cytokines. This response may damage the myelin sheath and potentially result in facial palsy.

    In the case of viral vector vaccines, they are designed to make antibodies against the virus’s proteins. Since these antibodies are similar to proteins in the nerves, they may mistakenly attack the myelin resulting in nerve damage.

    Researchers also noted that COVID-19 infection is associated with a higher risk of facial palsy. Recent studies suggest that this increased risk may be due to nerve compression resulting from inflammation triggered by the virus.

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  • No Cardiovascular Benefits, Raises Circulatory Risks; Study Finds

    No Cardiovascular Benefits, Raises Circulatory Risks; Study Finds

    Sitting for extended periods has long been linked to various health risks including cardiovascular issues, driving the popularity of standing desks among office workers. However, a recent study suggests that standing for extended periods offers no long-term cardiovascular benefits and may not be the better option.

    According to the latest study published in the International Journal of Epidemiology, standing for long periods may not benefit heart health and could increase the risk of circulatory problems, such as deep vein thrombosis and varicose veins.

    Researchers from the University of Sydney analyzed heart conditions and circulatory disease data from 83,013 UK adults, collected over seven to eight years. These participants, who did not have any heart disease at the start, were monitored using wrist-worn wearables similar to smartwatches to track their activity and health.

    The analysis revealed that for every additional 30 minutes spent standing beyond two hours, the risk of circulatory disease increased by 11 percent.

    “The key takeaway is that standing for too long will not offset an otherwise sedentary lifestyle and could be risky for some people in terms of circulatory health. We found that standing more does not improve cardiovascular health over the long-term and increases the risk of circulatory issues,” Dr Matthew Ahmadi, the lead author of the study said in a news release.

    The researchers also found that sitting for more than 10 hours a day raises the risk of both cardiovascular disease and orthostatic issues.

    Based on these findings, the researchers recommend that people who are regularly sedentary or stand for extended periods incorporate regular movement throughout the day to mitigate these risks.

    “For people who sit for long periods on a regular basis, including plenty of incidental movement throughout the day and structured exercise may be a better way to reduce the risk of cardiovascular disease,” said Professor Emmanuel Stamatakis, Director of the Mackenzie Wearables Research Hub.

    “Take regular breaks, walk around, go for a walking meeting, use the stairs, take regular breaks when driving long distances, or use that lunch hour to get away from the desk and do some movement,” Stamatakis said.

    Earlier research by the team found that just 6 minutes of vigorous exercise or 30 minutes of moderate-to-vigorous exercise per day can reduce the risk of heart disease, even in individuals who are highly sedentary for over 11 hours a day.

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  • Being Overweight Raises Pregnancy Complications Regardless Of Women’s Country Of Birth: Study

    Being Overweight Raises Pregnancy Complications Regardless Of Women’s Country Of Birth: Study

    Obesity increases health complications during pregnancy, including miscarriage, preterm birth, and preeclampsia. Researchers have now found that being overweight during pregnancy raises these risks regardless of a woman’s country of birth.

    The latest study conducted by researchers at Linköping University and Karolinska Institutet in Sweden examined the risk of complications faced by overweight pregnant women, including both those born in Sweden and those who have moved there.

    “We know that overweight and obesity are linked to many complications during pregnancy and childbirth for women born in Sweden. Therefore, we wanted to investigate whether the inequalities in pregnancy complications between women born in different countries can to some extent be explained by differences in body weight. If you know that there are health inequalities, you want to find out why, in order to be able to do something about the inequalities in the next step,” said Pontus Henriksson who led the study in a news release.

    The researchers evaluated nearly two million pregnancies and focused on eight significant complications that can impact the mother or baby during pregnancy and childbirth. The complications examined include those related to pregnancy, including preeclampsia, gestational diabetes, and infant mortality within the first year of life. It also looked at preterm birth, extremely preterm birth, and low Apgar scores, which assess a newborn’s vitality. The researchers also considered the risks associated with having a large baby or a small baby concerning the length of the pregnancy.

    The findings published in The Lancet Public Health suggest that promoting a healthy weight has the potential to prevent pregnancy complications for all women.

    The researchers explored how many pregnancy complications, such as gestational diabetes, could be prevented if all women started their pregnancies at a normal weight.

    “For example, we concluded that about half of all cases of gestational diabetes could potentially be prevented. This applies to both women born in Sweden and foreign-born women, said Maryam Shirvanifar, the first author of the study.

    The study also revealed that the impact of weight on these complications varies significantly; for instance, high body weight is particularly linked to an increased risk of gestational diabetes compared to other pregnancy-related issues.

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