Tag: risk

  • Diabetes Onset Before 40 Raises Risk Of Death To Four Times: Study

    Diabetes Onset Before 40 Raises Risk Of Death To Four Times: Study

    Diabetes is not just about having high blood sugar levels; it is a chronic condition that could potentially lead to several health issues, such as heart attack and stroke. But does the timing of diabetes onset affect the risk of complications and mortality? A recent study revealed that developing diabetes before age 40 is linked to a significantly higher risk of early death.

    While diagnosing diabetes before 40 quadrupled the risk of early death, later onset was linked to a one-and-a-half times higher risk of death compared with the general population without the condition, according to the study published in the Lancet Diabetes & Endocrinology. The findings underscore the importance of delaying the onset of diabetes to reduce complications and risk of premature death.

    To understand the impact of diabetes on overall health, researchers followed up 4,550 individuals newly diagnosed with diabetes for over 30 years. The participants were between the ages of 25 and 65.

    The analysis revealed that diabetic diagnosis at an earlier stage was linked to a higher rate of related complications, particularly microvascular diseases such as eye damage and kidney failure, and a higher risk of death. Diabetes onset at a younger age also was linked to poorer blood sugar control.

    “Over the past 30 years, the number of young adults diagnosed with type 2 diabetes has increased markedly worldwide. Evidence to date suggests that younger-onset type 2 diabetes, characterized by earlier and longer exposure to high levels of blood glucose, maybe more aggressive than later onset disease. This might include a faster deterioration in β-cell function—the cells in the pancreas that produce and release insulin- and a greater risk of complications such as cardiovascular and kidney disease,” said Amanda Adler, co-author of the study in a news release.

    According to the lead author of the study, Dr. Beryl Lin, more clinical trials should focus on tailored treatments for delaying diabetic complications in young people.

    “We particularly need to understand why young adults with type 2 diabetes suffer greater risks of complications, and how we can identify and help this vulnerable group of people who have to live with diabetes for the rest of their lives,” Dr. Lin said.

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  • History Of Eating Disorders, Pre-Pregnancy Obesity Raises Offspring’s Risk Of Mental Health Diagnosis

    History Of Eating Disorders, Pre-Pregnancy Obesity Raises Offspring’s Risk Of Mental Health Diagnosis

    Children whose mothers have a history of eating disorders and obesity before pregnancy are at a greater risk of mental health diagnosis, a recent study revealed.

    The results of the latest study involving a Finnish population of nearly 400,000 mothers and around 650,000 offspring revealed significant links between maternal health and the mental well-being of their children.

    The research suggests associations between a mother’s history of eating disorders and pre-pregnancy body mass index (BMI) higher than the normal weight range to most of the nine psychiatric diagnoses examined in the offspring.

    The psychiatric diagnoses involved in the study include mood and anxiety disorders, sleep disorders, intellectual disabilities, specific developmental disorders, autism spectrum disorder (ASD), ADHD, conduct disorders, social functioning and tic disorders (like selective mutism and Tourette syndrome), as well as feeding disorders in infancy and childhood.

    The results showed that around 53% had pre-pregnancy overweight or obesity, nearly 6% had underweight, and 1.6% had a history of an eating disorder.

    When comparing differences in the impact of maternal eating disorders and higher BMI on children’s mental health diagnoses, the study found generally stronger associations with maternal eating disorders than those linked to maternal BMI.

    “The largest effect sizes were observed for maternal eating disorders not otherwise specified in association with offspring sleep disorders and social functioning and tic disorders, while for maternal severe pre-pregnancy obesity, offspring intellectual disabilities had the largest effect size,” the researchers wrote in the study published in Jama Network.

    Eating disorders not otherwise specified (EDNOS) refer to a category of eating disorders that do not fit the specific criteria for more commonly recognized disorders such as anorexia nervosa, bulimia nervosa, and binge eating disorder. Some examples of EDNOS include behaviors such as pica, which involves cravings for and consumption of non-food items, or night eating syndrome, characterized by binge eating during the evening hours.

    “The study confirms previously published associations between maternal eating disorders and BMI and offspring psychiatric disorder, but also reports new associations,” Ida Nilsson, a study author told MedPage Today.

    “The findings underline the importance of considering maternal eating disorders and BMI in maternity care, aiming to reduce the number of offspring with neurodevelopmental and psychiatric disorders. The findings also strengthen the importance of the nutrition of pregnant women,” Nilsson said.

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  • Vitamin D Deficiency In Kids Raises Risk Of Auto-Immune Disorders: Study Explains How

    Vitamin D Deficiency In Kids Raises Risk Of Auto-Immune Disorders: Study Explains How

    Ensure your child is getting adequate sunshine vitamins. Beyond the role of calcium absorption and bone strengthening, researchers have discovered more about its connection to the immune system. A recent study revealed how a deficiency of vitamin D in young children can raise the risk of developing autoimmune disorders.

    According to the latest study published in the journal Science Advances, the deficiency of vitamin D in kids is linked to premature aging of the thymus gland. The thymus is a small lymph gland that makes and trains T-cells that are crucial for the immune system, defending the body against infections and diseases. While most of these vital cells are produced before birth, the remainder are generated during childhood, and by puberty, individuals would have developed the complete T cells for their lifetime.

    “An aging thymus leads to a ‘leaky’ immune system. This means the thymus becomes less effective at filtering out immune cells that could mistakenly attack healthy tissues, increasing the risk of autoimmune diseases like type 1 diabetes,” said the lead author of the study John White in a news release.

    Studies have shown that vitamin D is essential for immunity but according to White, the recent study findings “bring new clarity to this connection and could lead to new strategies for preventing autoimmune diseases.”

    During the trial, researchers examined mice that could not produce vitamin D to assess how this deficiency affected their thymus glands. They then conducted cell analyses and gene sequencing to understand the impact of vitamin D deficiency on the immune system. The researchers expect similar findings in humans as the thymus functions similarly in both species.

    Based on the study findings, researchers suggest that young children should get adequate vitamin D, either through natural sources such as fortified food and sunlight or through supplementation.

    “If you have a young child, it’s important to consult with your healthcare provider to ensure they’re getting enough,” said White.

    Earlier research conducted by the same team in 2021, which followed up more than 10,000 children showed that early vitamin D supplementation can reduce the risk of developing type 1 diabetes by up to five-fold.

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  • COVID-19 Vaccine Linked To Elevated Risk Of Facial Palsy: Study

    COVID-19 Vaccine Linked To Elevated Risk Of Facial Palsy: Study

    Researchers have found that COVID-19 vaccination is linked to an elevated risk of facial palsy, with the risk particularly high within 28 days of taking the shot.

    Facial palsy, also known as Bell’s palsy, leads to temporary weakness or paralysis of the facial muscles, resulting in drooping on one side of the face and difficulty making facial expressions. Although the exact cause of the condition is not known, experts believe that certain viral infections, autoimmune mechanisms, or vaccination can be potential triggers.

    Although the pivotal clinical trials during the development of COVID-19 vaccines revealed no severe safety concerns, there has been an imbalance in the incidence of facial palsy among vaccinated individuals compared to the general population. This prompted the researchers to conduct a large-scale study involving over 44 million patients in South Korea to investigate the risk of facial palsy among individuals vaccinated against COVID-19.

    The researchers examined a national health information database of individuals who received more than one dose of the COVID-19 vaccine and were then diagnosed with facial palsy within 240 days post-vaccination.

    When the incidence of facial palsy within 1–28 post-vaccination was compared to a control window (the remainder of the 240-day observation period), the researchers noted that there were 5,211 cases within the risk window and 10,531 cases within the control window.

    The study revealed a 12% increase in the risk of facial palsy within 1 to 28 days after any COVID-19 vaccine dose. The researchers also noted that the risk increased regardless of whether individuals received homologous or heterologous vaccines.

    While the second dose showed a 7% higher risk, the combination of the first and second doses indicated an 8% increase. However, no increased risk was associated with the third dose.

    “Facial Palsy (FP) risk increased within 28 days postvaccination, primarily after first and second doses, and was observed for both mRNA and viral vaccines. Clinicians should carefully assess the FP risk-benefit profile associated with the COVID-19 vaccines and monitor neurologic signs after vaccination,” the researchers wrote in a news release.

    While the exact reason for facial palsy after vaccination is unclear, researchers suggest possible explanations.

    One explanation is that mRNA vaccines use lipid nanoparticles to deliver SARS-CoV-2 spike antigen which triggers an immune response that can lead to the release of proinflammatory cytokines. This response may damage the myelin sheath and potentially result in facial palsy.

    In the case of viral vector vaccines, they are designed to make antibodies against the virus’s proteins. Since these antibodies are similar to proteins in the nerves, they may mistakenly attack the myelin resulting in nerve damage.

    Researchers also noted that COVID-19 infection is associated with a higher risk of facial palsy. Recent studies suggest that this increased risk may be due to nerve compression resulting from inflammation triggered by the virus.

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  • Three cups of coffee daily boosts heart health, reduces cardiometabolic multimorbidity risk: study

    Three cups of coffee daily boosts heart health, reduces cardiometabolic multimorbidity risk: study

    Can’t start your day without coffee? A recent study reveals that your morning ritual might do more than just wake you up, it could also benefit your heart health. The research found that moderate caffeine intake, or three cups of coffee daily, significantly reduces the risk of cardiometabolic multimorbidity.

    Cardiometabolic multimorbidity refers to having at least two coexisting cardiometabolic diseases. Studies indicate that having a single cardiometabolic condition doubles the risk of death from all causes. In contrast, individuals with cardiometabolic multimorbidity may face a risk of all-cause mortality that is four to seven times higher.

    According to the latest study published in the Journal of Clinical Endocrinology & Metabolism, any level of coffee and caffeine consumption could play an important protective role in all phases of cardiometabolic multimorbidity development.

    After analyzing the caffeine consumption of over 500,000 participants from the UK Biobank who are part of a detailed longitudinal dietary study, researchers noted that compared with non-consumers or those who take less than 100mg of caffeine per day, moderate consumption of coffee, meaning three drinks per day or 200–300 mg of caffeine had the lowest risk for new-onset cardiometabolic multimorbidity.

    The study focused on participants aged 37 to 73, excluding those with unclear caffeine intake data. This resulted in a pool of 172,315 individuals free of cardiometabolic diseases at the start, for analyzing caffeine effects. Additionally, a separate group of 188,091 participants was included to examine the impact of coffee and tea consumption.

    The results suggest that those who drank three cups a day experienced a 48.1% reduction in risk, while those consuming 200–300 mg of caffeine daily saw a 40.7% decrease, compared to individuals who either did not consume caffeine or had less than 100 mg per day.

    “Consuming three cups of coffee, or 200–300 mg caffeine, per day might help to reduce the risk of developing cardiometabolic multimorbidity in individuals without any cardiometabolic disease,” said the study’s lead author, Chaofu Ke in a news release.

    “The findings highlight that promoting moderate amounts of coffee or caffeine intake as a dietary habit for healthy people might have far-reaching benefits for the prevention of cardiometabolic multimorbidity,” Ke said.

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  • What About Vegan Junk Food and Vegetarians’ Stroke Risk? 

    What About Vegan Junk Food and Vegetarians’ Stroke Risk? 

    Just because you’re eating a vegetarian or vegan diet doesn’t mean you’re eating healthfully.

    “Plant-Based Diets Are Associated with a Lower Risk of Incident Cardiovascular Disease, Cardiovascular Disease Mortality, and All-Cause Mortality in a General Population of Middle-Aged Adults”: This study of a diverse sample of 12,000 Americans found that “progressively increasing the intake of plant foods by reducing the intake of animal foods is associated with benefits on cardiovascular health and mortality.” Still, regarding plant-based diets for cardiovascular disease prevention, “all plant foods are not created equal.” As you can see in the graph below and at 0:40 in my video Vegetarians and Stroke Risk Factors: Vegan Junk Food?, a British study found higher stroke risk in vegetarians. Were they just eating a lot of vegan junk food? 

    “Any diet devoid of animal food sources can be claimed to be a vegetarian [or vegan] diet; thus, it is important to determine” what is being eaten. One of the first things I look at when I’m trying to see how serious a population is about healthy eating is something that is undeniably, uncontroversially bad: soda, aka liquid candy. Anyone drinking straight sugar water doesn’t have health on top of mind.

    A large study was conducted of plant-based eaters in the United States, where people tend to cut down on meat for health reasons far more than for ethics, as you can see in the graph below and at 1:20 in my video.

    Researchers found that flexitarians drink fewer sugary beverages than regular meat eaters, as do pescatarians, vegetarians, and vegans, as you can see below and at 1:30.

    However, in the study from the United Kingdom where the increased stroke risk in vegetarians was found and where people are more likely to go veg or vegan for ethical reasons, researchers found that pescatarians drink less soda, but the vegetarians and vegans drink more, as shown in the graph below and at 1:44. 

    I’m not saying that’s why they had more strokes; it might just give us an idea of how healthfully they were eating. In the UK study, the vegetarian and vegan men and women ate about the same amounts of desserts, cookies, and chocolate, as you can see in the graph below and at 1:53. 

    They also consumed about the same total sugar, as shown below and at 2:02. 

    In the U.S. study, the average non-vegetarian is nearly obese, the vegetarians are a little overweight, and the vegans were the only ideal weight group. In this analysis of the UK study, however, everyone was about the same weight. The meat eaters were lighter than the vegans, as you can see below, and at 2:19 in my video. The EPIC-Oxford study seems to have attracted a particularly “health-conscious” group of meat eaters weighing substantially less than the general population. 

    Let’s look at some specific stroke-related nutrients. Dietary fiber appears to be beneficial for the prevention of cardiovascular disease, including stroke, and it seems the more, the better, as you can see in the graph below and at 2:43 in my video

    Based on studies of nearly half a million men and women, there doesn’t seem to be any upper threshold of benefit—so, again, “the more, the better.” At more than 25 grams of soluble fiber and 47 grams of insoluble dietary fiber, you can start seeing a significant drop in associated stroke risk. So, one could consider these values “as the minimal recommendable daily intake of soluble and insoluble fiber…to prevent stroke at a population level.” That’s what you see in people eating diets centered around minimally processed plant foods. Dean Ornish, M.D., got up around there with his whole food, plant-based diet. It might not be as much as we were designed to eat, based on the analyses of fossilized feces, but that’s about where we might expect significantly lower stroke risk, as shown below and at 3:25 in my video

    How much were the UK vegetarians getting? 22.1 grams. Now, in the UK, they measure fiber a little differently, so it may be closer to 30 grams, but that’s still not the optimal level for stroke prevention. It’s so little fiber that the vegetarians and vegans only beat out the meat eaters by about one or two bowel movements a week, as you can see below and at 3:48 in my video, suggesting the non-meat eaters were eating lots of processed foods. 

    The vegetarians were only eating about half a serving more of fruits and vegetables. Intake is thought to reduce stroke risk in part because of their potassium content, but the UK vegetarians at higher stroke risk were eating so few greens and beans that they couldn’t even match the meat eaters. The vegetarians (and the meat eaters) weren’t even reaching the recommended minimum daily potassium intake of 4,700 mg a day.

    What about sodium? “The vast majority of the available evidence indicates that elevated salt intake is associated with higher stroke risk…” There is practically a straight-line increase in the risk of dying from a stroke, the more salt you eat, as you can see in the graph below and at 4:29 in my video

    Even just lowering sodium intake by a tiny fraction every year could prevent tens of thousands of fatal strokes. “Reducing Sodium Intake to Prevent Stroke: Time for Action, Not Hesitation” was the title of the paper, but the UK vegetarians and vegans appeared to be hesitating, as did the other dietary groups. “All groups exceeded the advised less than 2400 mg daily sodium intake”—and that didn’t even account for salt added to the table! The American Heart Association recommends less than 1,500 mg a day. So, they were all eating a lot of processed foods. It’s no wonder the vegetarians’ blood pressures were only one or two points lower. High blood pressure is perhaps “the single most important potentially modifiable risk factor for stroke.” 

    What evidence do I have that the vegetarians’ and vegans’ stroke risk would go down if they ate more healthfully? Well, in rural Africa, where they were able to nail the fiber intake that our bodies were designed to get by eating so many whole, healthy plant foods—including fruits, vegetables, grains, greens, beans, and protein almost entirely from plant sources—not only was heart disease, our number one killer, “almost non-existent,” but so was stroke. It only surged up from nowhere “with the introduction of salt and refined foods” to their diet. 

    “It is notable that stroke and senile dementia appear to be virtually absent in Kitava, an Oceanic culture [near Australia] whose quasi-vegan traditional diet is very low in salt and very rich in potassium.” They ate fish a few times a week, but the other 95 percent or so of their diet was made up of vegetables, fruits, corn, and beans. They had an apparent absence of stroke, even despite their ridiculously high rates of smoking, 76 percent of men and 80 percent of women. We evolved by eating as little as less than an eighth of a teaspoon of salt a day, and our daily potassium consumption is thought to have been as high as 10,000 mg or so. We went from an unsalted, whole-food diet to eating salty, processed foods depleted of potassium whether we eat meat or not. 

    Caldwell Esselstyn at the Cleveland Clinic tried putting about 200 patients with established cardiovascular disease on a whole food, plant-based diet. Of the 177 who stuck with the diet, only a single patient went on to have a stroke in the subsequent few years, compared to a hundred-fold greater rate of adverse events, including multiple strokes and deaths in those who strayed from the diet. “This is not vegetarianism,” Esselstyn explains. Vegetarians can eat a lot of less-than-ideal foods, “such as milk, cream, butter, cheese, ice cream, and eggs. This new paradigm is exclusively plant-based nutrition.” 

    This entire train of thought—that the reason typical vegetarians don’t have better stroke statistics is because they’re not eating particularly stellar diets—may explain why they don’t have significantly lower stroke rates. However, it still doesn’t explain why they may have higher stroke rates. Even if they’re eating similarly crappy, salty, processed diets, at least they aren’t eating meat, which we know increases stroke risk. There must be something about vegetarian diets that so increases stroke risk that it offsets their inherent advantages. We’ll continue our hunt for the answer next. 

    From a medical standpoint, labels like vegan and vegetarian just tell me what you don’t eat. It’s like identifying yourself as a “No-Twinkie-tarian.” You don’t eat Twinkies? Great, but what’s the rest of your diet like? 

    What are the healthiest foods? Check out my Daily Dozen.

    To catch up on the rest of this series, see related posts below. 



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  • What About Homocysteine, Vitamin B12, and Vegetarians’ Stroke Risk? 

    What About Homocysteine, Vitamin B12, and Vegetarians’ Stroke Risk? 

    Not taking vitamin B12 supplements or regularly eating B12-fortified foods may explain the higher stroke risk found among vegetarians.

    Leonardo da Vinci had a stroke. Might his vegetarian diet have been to blame? “His stroke…may have been related to an increase in homocysteine level because of the long duration of his vegetarian diet.” A suboptimal intake of vitamin B12 is common in those eating plant-based diets (unless they take B12 supplements or regularly eat B12-fortified foods) and can lead to an increased level of homocysteine in the blood, which “is accepted as an important risk factor for stroke.”

    “Accepted” may be overstating it as there is still “a great controversy” surrounding the connection between homocysteine and stroke risk. But, as you can see in the graph below and at 0:57 in my video Vegetarians and Stroke Risk Factors: Vitamin B12 and Homocysteine?, those with higher homocysteine levels do seem to have more atherosclerosis in the carotid arteries that lead up to the brain, compared to those with single-digit homocysteine levels, and they also seem to be at higher risk for clotting ischemic strokes in observational studies and, more recently, bleeding hemorrhagic strokes, as well as increased risk of dying from cardiovascular disease and all causes put together. 

    Even more convincing are the genetic data. About 10 percent of the population has a gene that increases homocysteine levels by about 2 points, and they appear to have significantly higher odds of having a stroke. Most convincing would be randomized, double-blind, placebo-controlled trials to prove that lowering homocysteine with B vitamins can lower strokes, and, indeed, that appears to be the case for clotting strokes: Strokes with homocysteine-lowering interventions were more than five times as likely to reduce stroke compared with placebo.

    Ironically, one of the arguments against the role of homocysteine in strokes is that, “assuming that vegetarians have lower vitamin B12 concentrations than meat-eaters and that low vitamin B12 concentrations cause ischaemic stroke, then the incidence of stroke should be increased among vegetarians…but this is not the case.” However, it has never been studied until now.

    As you can see in the graph below and at 2:16 in my video, the EPIC-Oxford study researchers found that vegetarians do appear to be at higher risk.

    And no wonder, as about a quarter of the vegetarians and nearly three-quarters of the vegans studied were vitamin B12-depleted or B12-deficient, as you can see below and at 2:23, and that resulted in extraordinarily high homocysteine levels.

    Why was there so much B12 deficiency? Because only a small minority were taking a dedicated B12 supplement. And, unlike in the United States, B12 fortification of organic foods isn’t allowed in the United Kingdom. So, while U.S. soymilk and other products may be fortified with B12, UK products may not. We don’t see the same problem among U.S. vegans in the Adventist study, presumably because of the B12 fortification of commonly eaten foods in the United States. It may be no coincidence that the only study I was able to find that showed a significantly lower stroke mortality risk among vegetarians was an Adventist study.

    Start eating strictly plant-based without B12-fortified foods or supplements, and B12 deficiency can develop. However, that was only for those not eating sufficient foods fortified with B12. Those eating plant-based who weren’t careful about getting a regular reliable source of B12 had lower B12 levels and, consequently, higher homocysteine levels, as you can see below and at 3:27 in my video.

    The only way to prove vitamin B12 deficiency is a risk factor for cardiovascular disease in vegetarians is to put it to the test. When researchers measured the amount of atherosclerosis in the carotid arteries, the main arteries supplying the brain, “no significant difference” was found between vegetarians and nonvegetarians. They both looked just as bad even though vegetarians tend to have better risk factors, such as lower cholesterol and blood pressure. The researchers suggest that B12 deficiency plays a role, but how do they know? Some measures of artery function weren’t any better either. Again, they surmised that vitamin B12 deficiency was overwhelming the natural plant-based benefits. “The beneficial effects of vegetarian diets on lipids and blood glucose [cholesterol and blood sugars] need to be advocated, and efforts to correct vitamin B12 deficiency in vegetarian diets can never be overestimated.”

    Sometimes vegetarians did even worse. Worse artery wall thickness and worse artery wall function, “raising concern, for the first time, about the vascular health of vegetarians”—more than a decade before the new stroke study. Yes, their B12 was low, and, yes, their homocysteine was high, “suggest[ing] that vitamin B12 deficiency in vegetarians might have adverse effects on their vascular health.” What we need, though, is an interventional study, where participants are given B12 to see if that fixes it, and here we go. The title of this double-blind, placebo-controlled, randomized crossover study gives it away: “Vitamin B-12 Supplementation Improves Arterial Function in Vegetarians with Subnormal Vitamin B-12 Status.” So, compromised vitamin B12 status among those eating more plant-based diets due to not taking B12 supplements or regularly eating vitamin B12-fortified foods may explain the higher stroke risk found among vegetarians.

    Unfortunately, many vegetarians resist taking vitamin B12 supplements due to “misconceptions,” like “hold[ing] on to the old myth that deficiency of this vitamin is rare and occurs only in a small proportion of vegans.” “A common mistake is to think that the presence of dairy products and eggs in the diet, as in LOV [a lacto-ovo vegetarian diet], can still ensure a proper intake [of B12]…despite excluding animal flesh.”

    Now that we may have nailed the cause, maybe “future studies with vegetarians should focus on identifying ways to convince vegetarians to take vitamin B12 supplements to prevent a deficiency routinely.” 

    I have updated my recommendation for B12 supplementation. I now suggest at least 2,000 mcg (µg) of cyanocobalamin once weekly, ideally as a chewable, sublingual, or liquid supplement taken on an empty stomach, or at least 50 mcg daily of supplemental cyanocobalamin. (You needn’t worry about taking too much.) You can also have servings of B12-fortified foods three times a day (at each meal), each containing at least 190% of the Daily Value listed on the nutrition facts label. (Based on the new labeling mandate that started on January 1, 2020, the target is 4.5 mcg three times a day.) Please note, though, that those older than the age of 65 have only one option: to take 1,000 micrograms a day. 

    We started this series on what to eat and not eat for stroke prevention, and whether vegetarians really have a higher stroke risk. Check related posts for the last few videos that looked at specific factors.

    Stay tuned for: 



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  • Low-Carb, High-Fat Diet May Help Weight Loss, But Study Says It Raises Diabetes Risk

    Low-Carb, High-Fat Diet May Help Weight Loss, But Study Says It Raises Diabetes Risk

    Cutting down on carbohydrates and increasing fat intake is a popular weight loss strategy for many. However, researchers now say that in the long run, it may raise the risk of type 2 diabetes.

    A recent study published in the journal Diabetes & Metabolic Syndrome: Clinical Research & Reviews, which followed around 40,000 participants in Melbourne, Australia, found that a low-carb, high-fat diet is linked to a 20% increased risk of developing type 2 diabetes.

    Increased carbohydrate intake is known to raise diabetes risk. Earlier studies have focused on examining how a low carbohydrate diet could be used in managing or remission of type 2 diabetes. Studies have also shown that low-carbohydrate eating patterns could be effective for quick weight loss.

    However, the long-term effects of a low-carb diet on the risk of developing diabetes were not known. The latest findings suggest that while low-carb diets may aid in diabetes management, they might be ineffective in preventing the disease.

    “Studies to date have only focused on examining low carbohydrate for managing and/or remission of type 2 diabetes. Instead, this study reveals that low carbohydrate diet intake might increase the long-term risk of type 2 diabetes through obesity, potentially through increased eating of fats and foods low in fiber. Our study also highlights the need to look at the quality of carbohydrates, proteins and fats,” said Professor de Courten, a researcher of the study in a news release.

    The study was conducted on participants aged 40–69, who were part of the Melbourne Collaborative Cohort Study (MCCS) between 1990 and 1994. Researchers analyzed the percentage of carbohydrates in their diets using a Low Carbohydrate Score (LCD) and estimated the risk of developing type 2 diabetes later in life. A higher score indicated a lower percentage of carbohydrates contributing to energy intake. The health of participants was reviewed during two periods: 1995–1998 and 2003–2007.

    Participants whose diets consisted of 38% carbohydrates had a 20% higher risk of developing type 2 diabetes compared to those with 55% carbohydrates in their diet. The increased risk is attributed to a higher incidence of obesity, resulting from high-fat and low-fiber content in the diet.

    Based on their findings, researchers suggest that there should be an adequate review of dietary approaches for those wanting to lose weight and avoid diabetes.

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  • Eating Fish During Pregnancy May Cut Offspring’s Autism Risk, Not Omega-3: Study Says

    Eating Fish During Pregnancy May Cut Offspring’s Autism Risk, Not Omega-3: Study Says

    Prenatal consumption of fish may reduce autism risk in children, but omega-3 supplements may not have the same effect, a recent study revealed.

    Including fish in the diet during pregnancy is linked to a 20% reduction in the risk of autism spectrum disorder and a decreased risk of autism-related traits in children, with particularly notable benefits for female offspring, according to the study published in the American Journal Of Clinical Nutrition.

    “Our study contributes to a growing body of evidence that demonstrates the role that prenatal diet can play in autism-related outcomes in offspring,” said the researcher Dr. Emily Oken in a news release.

    To understand how intake of fish and omega-3 supplements during pregnancy affects neurodevelopmental outcomes, researchers evaluated the dietary information of around 4,000 participants. Based on the frequency of fish consumption, the participants were grouped into four: less than once a month, more than once a month but less than weekly, weekly, and two or more servings per week.

    Around 25% of them never ate fish or consumed it less than once a month, and most of the participants never took omega-3 fish oil supplements during their pregnancy.

    The researchers then examined the incidence of autism diagnoses in children and parent-reported autism-related traits, which were measured using the Social Responsiveness Scale (SRS), a widely used survey completed by parents or caregivers.

    “Consuming fish during pregnancy was associated with a lower likelihood of offspring being diagnosed with autism and a slight decrease in total SRS scores compared to not eating fish. These results were consistent across all levels of fish consumption, from “any” amount or “less than once per week” to “more than twice per week,” the news release stated.

    However, the researchers could not find any significant association between omega-3 conception and autism diagnosis, or traits.

    “This study provides yet more evidence for the safety and benefit of regular fish consumption during pregnancy. Other proven benefits include lower risk for preterm birth and improved cognitive development,” said Dr. Oken.

    “Given the low fish intake in the United States general population and the rising autism prevalence, these findings suggest the need for better public health messaging regarding guidelines on fish intake for pregnant individuals,” the researchers concluded.

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  • What About Animal Protein and Vegetarians’ Stroke Risk? 

    What About Animal Protein and Vegetarians’ Stroke Risk? 

    Might animal protein-induced increases in the cancer-promoting growth hormone IGF-1 help promote brain artery integrity? 

    In 2014, a study on stroke risk and dietary protein found that greater intake was associated with lower stroke risk and, further, that the animal protein appeared particularly protective. Might that help explain why, as shown in the graph below and at 0:31 in my video Vegetarians and Stroke Risk Factors: Animal Protein?, vegetarians were recently found to have a higher stroke rate than meat eaters?

    Animal protein consumption increases the levels of a cancer-promoting growth hormone in the body known as IGF-1, insulin-like growth factor 1, which “accelerates the progression of precancerous changes to invasive lesions.” High blood concentrations are associated with increased risks of breast, colorectal, lung, and prostate cancers, potentially explaining the association between dairy milk intake and prostate cancer risk, for example. However, there are also IGF-1 receptors on blood vessels, so perhaps IGF-1 promotes cancer and brain artery integrity.

    People who have strokes appear to have lower blood levels of IGF-1, but it could just be a consequence of the stroke rather than the cause. There weren’t any prospective studies over time until 2017 when researchers found that, indeed, higher IGF-1 levels were linked to a lower risk of stroke—but is it cause and effect? In mice, the answer seems to be yes, and in a petri dish, IGF-1 appears to boost the production of elastin, a stretchy protein that helps keep our arteries elastic. As you can see in the graph below and at 1:41 in my video, higher IGF-1 levels are associated with less artery stiffness, but people with acromegaly, like Andre the Giant, those with excessive levels of growth hormones like IGF-1, do not appear to have lower stroke rates, and a more recent study of dietary protein intake and risk of stroke that looked at a dozen studies of more than half a million people (compared to only seven studies with a quarter million in the previous analysis), found no association between dietary protein intake and the risk of stroke. If anything, dietary plant protein intake may decrease the risk of stroke. 

    However, those with high blood pressure who have low IGF-1 levels do appear to be at increased risk of developing atherosclerosis, which is the thickening of the artery walls leading up to the brain, but no such association was found in people with normal blood pressure. So, there may be “a cautionary lesson for vegans” here. Yes, a whole food, plant-based diet “can down-regulate IGF-1 activity” and may slow the human aging process, not to mention reduce the risk of some of the common cancers that plague the Western world. But, “perhaps the ‘take-home’ lesson should be that people who undertake to down-regulate IGF-1 activity [by cutting down on animal protein intake] as a pro-longevity measure should take particular care to control their blood pressure and preserve their cerebrovascular health [the health of the arteries in their brain] – in particular, they should keep salt intake relatively low while insuring an ample intake of potassium” to keep their blood pressures down. So, that means avoiding processed foods and avoiding added salt, and, in terms of potassium-rich foods, eating beans, sweet potatoes, and dark-green leafy vegetables. 

    Might this explain the higher stroke risk found among vegetarians? No—because dairy and egg whites are animal proteins, too. Only vegans have lower IGF-1 levels in both men and women, so low levels of IGF-1 can’t explain why higher rates of stroke were found in vegetarians. Then what is it? I think the best explanation for the mystery is something called homocysteine, which I cover next. 

    If you aren’t familiar with IGF-1, my videos Flashback Friday: Animal Protein Compared to Cigarette Smoking and How Not to Die from Cancer are good primers. 

    Beyond eating a plant-based diet, how else can we lower our blood pressure? Check out the chapter of hypertension in my book How Not to Die at your local public library. 

    This is the eighth video in a 12-part series on vegetarians’ stroke risk. If you missed any of the previous ones, check out the related posts below.

    Coming up, we turn to what I think is actually going on:



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