Tag: risk

  • Healthy-Looking Teens Also At Risk Of Heart Damage From This Hidden Condition

    Healthy-Looking Teens Also At Risk Of Heart Damage From This Hidden Condition

    It is time to pay attention to your teen’s health. Even adolescents who look healthy and fall within a normal weight range could be on the path to heart damage if they have one hidden health condition, warns a recent study.

    Teens with prediabetes, a condition marked by elevated blood sugar levels and insulin resistance, may face a much higher risk of heart trouble than previously thought. According to the latest study published in the journal Diabetes Care, adolescents with prediabetes are nearly three times more likely to have worsening of both structural and functional heart damage during growth to young adulthood.

    Even more striking was the discovery that heart damage progresses five times faster in females than in males, highlighting the urgent need for parents and health professionals to pay closer attention to adolescent girls when it comes to early detection and prevention of prediabetes.

    In the study, researchers followed 1,595 adolescents from age 17 to 24, using data from the University of Bristol’s Children of the 90s cohort. The prevalence of high blood sugar, insulin resistance, and heart enlargement of the participants was evaluated during the period.

    Teens with fasting blood sugar levels of ≥5.6 mmol/L during the follow-up period faced a 46% higher risk of developing left ventricular hypertrophy, a thickening of the heart muscle that can lead to serious heart issues. For those with even higher blood sugar (≥6.1 mmol/L), the risk tripled. Researchers also noted that insulin resistance also played a role, raising the risk of premature heart damage by 10%.

    “Earlier results from the same cohort indicate that late adolescence is a critical period in the evolution of cardiometabolic diseases. The current findings further confirm that even healthy-looking adolescents and young adults who are mostly normal weight may be on a path towards cardiovascular diseases, if they have high blood glucose and insulin resistance,” said researcher Andrew Agbaje, in a news release.

    “Worsening insulin resistance and increased fat mass have a bidirectional reinforcing vicious cycle. In the new study, we observed that two-thirds of the effect of insulin resistance on excessive heart enlargement was explained by increased total body fat. The five-fold increase in the prevalence of prediabetes within seven years of growth from adolescence to young adulthood underscores the critical importance of lifestyle behavior and dietary habits, especially after adolescents have become independent from their families,” Agbaje added.

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  • Popular Dinner Staple May Increase Risk Of Death From Cancer

    Popular Dinner Staple May Increase Risk Of Death From Cancer

    A dinner without chicken feels incomplete for many. Known for its protein-packed benefits, especially for muscle building and energy, chicken has long been a staple for many, particularly those hitting the gym. However, new research cautions that regularly eating chicken may put you at an increased risk of dying from gastrointestinal cancers.

    The findings of the latest study, published in the journal Nutrients, offer a surprising twist since poultry, long considered a “noble food” due to its high protein and low-fat content compared to red meat, may not be as harmless as once thought.

    The Dietary Guidelines for Americans recommend 100 grams as a standard serving of poultry, suggesting it be consumed one to three times a week. However, the latest study raises concerns that exceeding 300 grams weekly could increase the risk of death from gastrointestinal cancers.

    The study, which analyzed the health data and meat consumption habits of 4,869 adults in Italy, revealed that individuals who ate more than 300 grams of poultry per week had a significantly higher incidence of gastrointestinal cancers and a greater risk of early death from these cancers. Those consuming over 300 grams of poultry weekly had a 27% higher likelihood of dying from gastrointestinal cancer compared to those who kept their intake to 100 grams or less each week.

    Another interesting reveal was that men were more at risk of death from gastrointestinal cancers compared to women, even with the same amount of poultry consumption.

    The impact of poultry consumption on the risk of dying from gastrointestinal cancer increased with age. For those around 60, there was no significant difference between eating less than 100 grams or more than 300 grams of poultry a week. However, by 83, the risk of death was twice as high for those eating more poultry. This effect was more noticeable in men, who showed a higher risk even before age 60.

    “We believe it is beneficial to moderate poultry consumption, alternating it with other equally valuable protein sources, such as fish. We also believe it is essential to focus more on cooking methods, avoiding high temperatures and prolonged cooking times,” the researchers conclude.

    However, an important limitation of the study is that it did not consider whether the chicken consumed was processed or how it was cooked. The researchers also did not account for the participants’ levels of physical activity, which could have influenced the results.

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  • Vaccine To Protect Against Dementia? This One Reduces Risk By 20%

    Vaccine To Protect Against Dementia? This One Reduces Risk By 20%

    As dementia and Alzheimer’s cases continue to rise, researchers are exploring new ways to curb their impact. But a surprising breakthrough suggests that protection might already be within reach. A recent study suggests that shingles vaccine, which protects against the painful viral rash, may also reduce the risk of dementia in older adults.

    Earlier studies have shown that there is reduced dementia risk among those vaccinated with shingles. However, many were biased, as vaccinated individuals tend to be more health-conscious, making it difficult to determine whether the vaccine itself offered protection or if lifestyle factors like diet and exercise played a role.

    To address this, researchers at Stanford Medicine took advantage of an unusual public health policy in Wales. In 2013, a shingles vaccination program set strict age-based eligibility rules: those who were 79 on September 1 could receive the vaccine that year, while those who turned 80 before the cutoff were never eligible.

    The two groups had similar education levels, vaccination habits, and rates of conditions like diabetes and heart disease. This created a unique opportunity to compare two nearly identical groups, differing only in vaccine access, allowing researchers to isolate the vaccine’s true impact from lifestyle factors.

    “What makes the study so powerful is that it’s essentially like a randomized trial with a control group — those a little bit too old to be eligible for the vaccine — and an intervention group — those just young enough to be eligible,” said Dr. Pascal Geldsetzer, senior author of the study in a news release.

    The study showed that those who received the shingles vaccine were 20% less likely to develop dementia over the next seven years than those who did not receive the vaccine. The researchers also noted that the protection against dementia was notably stronger in women than in men. This is possibly due to sex differences in immune response or the difference in the way dementia develops.

    “For the first time we are able to say much more confidently that the shingles vaccine causes a reduction in dementia risk. If this truly is a causal effect, we have a finding that’s of tremendous importance,” Dr. Geldsetzer added.

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  • Could A Simple At-Home Smell Test Predict Risk?

    Could A Simple At-Home Smell Test Predict Risk?

    Catching Alzheimer’s early is key to slowing its progression; however, often, by the time memory loss becomes noticeable, the disease may already have progressed a long way.

    Now, researchers at Mass General Brigham have taken a major step toward earlier detection — using the sense of smell.

    Alzheimer’s currently affects nearly 7 million Americans, and that number is expected to double to 13.9 million by 2060. An even more shocking statistic is that around 90% of individuals with mild cognitive decline have never received a formal diagnosis.

    Diagnosing Alzheimer’s disease in its early stages is challenging when symptoms can be subtle and easily overlooked. There is no single definitive test to distinguish normal age-related forgetfulness from the onset of cognitive decline. Early warning signs often include memory lapses, difficulty finding words, trouble with problem-solving, and changes in mood or behavior.

    Studies have shown a connection between a declining sense of smell and dementia. The brain regions responsible for processing smells are often among the first to be impacted by Alzheimer’s, with changes beginning 15-20 years before memory issues surface.

    Scientists at Mass General Brigham have now built on this knowledge to develop a simple, digital, at-home smell test called the AROMHA Brain Health Test (ABHT) that could detect Alzheimer’s years before traditional symptoms appear.

    The ABHT can evaluate a person’s ability to identify, distinguish, remember, and gauge the strength of different odors to provide clues about brain health and potential early signs of cognitive decline.

    “Early detection of cognitive impairment could help us identify people who are at risk of Alzheimer’s disease and intervene years before memory symptoms begin,” said lead study author Mark Albers, a neurologist at Massachusetts General Hospital, in a news release.

    The researchers used ABHT on different groups, including cognitively normal individuals, those with subjective cognitive complaints, and those with mild cognitive impairment. Results showed that olfactory performance declined with age, and people with mild cognitive impairment had lower scores in odor identification and discrimination compared to cognitively normal individuals, regardless of age, sex, or education.

    “Our results suggest that olfactory testing could be used in clinical research settings in different languages and among older adults to predict neurodegenerative disease and development of clinical symptoms,” Albers added.

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  • This Body Measurement Could Predict Cancer Risk In Men

    This Body Measurement Could Predict Cancer Risk In Men

    Obesity has long been associated with an increased risk of health problems, including cancer. However, researchers have recently discovered that a specific body measurement in men could serve as a strong predictor of their cancer risk.

    Although Body Mass Index (BMI) serves as a strong indicator of health adversities, a recent study published in The Journal of the National Cancer Institute suggests that waist circumference is an even stronger predictor of cancer risk in men.

    The study found that with an additional 4-inch increase in waist size, the risk of cancer rises by 25 percent in men. In comparison, an increase in BMI by 3.7 kg/m² (like going from 24 to 27.7) only raised the risk by 19%. So, even when taking BMI into account, a large waist circumference was still linked to a higher risk of developing obesity-related cancers in men.

    This is because unlike BMI, which only measures body size, waist circumference reflects abdominal fat, a key factor linked to increased health risks like insulin resistance, inflammation, and abnormal blood fat levels. This explains why even with the same BMI, differences in fat distribution can lead to varying cancer risks.

    However, the study showed that for women, both waist circumference and BMI had similar effects on the risk of obesity-related cancers, but the link was weaker than for men. For example, a 12 cm increase in waist size (like going from 80 cm to 91.8 cm) or a 4.3 increase in BMI (like going from 24 to 28.3) both raised the risk by 13%.

    Researchers attribute the difference in cancer risk between men and women to the way fat is distributed in the body. Men tend to accumulate more visceral fat around the abdomen, which is more metabolically active and linked to higher health risks, including cancer. On the other hand, women typically store fat more evenly in peripheral areas like the hips and thighs, where it poses a lower risk.

    “Our study provides evidence that waist circumference is a stronger risk factor than BMI for obesity-related cancers in men, but not in women. Additionally, waist circumference appears to provide additional risk information beyond that conveyed by BMI in men,” the researchers wrote in the news release.

    “Future research incorporating more precise measures of adiposity, along with comprehensive data on potential confounding factors, could further elucidate the relationship between body fat distribution and cancer risk,” they added.

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  • Weight Gain Risky For Obese, But Losing Over 10kg Raises Death Risk By 50%

    Weight Gain Risky For Obese, But Losing Over 10kg Raises Death Risk By 50%

    Can weight loss be always the answer to obesity? While it’s well-known that gaining weight increases the risk of heart disease and death, scientists have now found that losing a significant amount of weight can also carry its own set of dangers.

    In a recent study, researchers from the Anglia Ruskin University (ARU) in the U.K. found that for individuals with obesity, “maintaining a stable weight, even within the obese range,” can help reduce the risk of death, particularly for those with heart disease risk factors.

    “It was perhaps unsurprising that significant weight gain was associated with higher mortality, but interesting that a similar association was found among those who lost a lot of weight,” said researcher Dr. Jufen Zhang in a news release.

    The study analyzed data from over 8,000 obese participants from the UK Biobank study, all of whom had been diagnosed with cardiovascular diseases. These individuals were tracked over nearly 14 years, with researchers closely monitoring changes in their weight throughout the period.

    The findings revealed that participants who gained more than 10 kg during the study had a threefold increase in the risk of cardiovascular death and nearly double the risk of dying from any cause, compared to those who maintained a stable weight.

    However, the study uncovered an even more striking finding: those who lost more than 10 kg faced a 54% higher risk of all-cause mortality. This suggests that, while weight loss is often encouraged for obese individuals, significant weight loss may have adverse effects, particularly in those already at risk for cardiovascular issues.

    “This study is the first of its kind to examine the link between weight change and all-cause mortality in obese individuals with cardiovascular disease,” Dr. Zhang.

    While more research is needed to fully understand the underlying mechanisms behind the link between both weight loss and weight gain and increased death risk, Dr. Zhang advises that “clinicians should be cautious, especially with new drugs on the market that are promoted for rapid weight loss.”

    “While weight loss is generally recommended for obese adults, those in at-risk groups, like these individuals, should only pursue weight loss under the close guidance of their doctor,” Dr. Zhang added.

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  • Can Time Of Week Affect Your Risk Of Death From Surgery? Here’s Worst Day For Operation

    Can Time Of Week Affect Your Risk Of Death From Surgery? Here’s Worst Day For Operation

    If you’re scheduled for surgery, here’s an interesting study you should know about: Researchers have found that the risk of death from surgery can depend on the time of week it’s scheduled, identifying the worst day for an operation.

    The study published in JAMA Network highlights an important trend known as the “weekend effect,” in relation to surgeries. Researchers found that patients undergoing planned surgeries on Friday, just before the weekend, face a significantly higher risk of death, complications, and readmission compared to those scheduled after the weekend.

    “Hospitals and health care systems have variations in operational structure and organization during the transition from weekdays to weekends. The weekend effect refers to the potential for worse patient outcomes during the weekends, compared with weekdays. In surgery, this concept may also apply to those undergoing surgery immediately before the weekend, who receive postoperative care during the weekend,” the researchers wrote.

    The findings were based on an analysis of large-scale data from 429,691 adult patients in Ontario, Canada, who underwent one of 25 common surgical procedures between 2007 and 2019, with a one-year follow-up.

    Of the 429,691 patients studied, nearly 46.5% had surgery before the weekend and researchers noted that they were more likely to experience negative outcomes, including complications, readmissions, and death compared to the pre-weekend group.

    The risk of mortality increased by 9% at 30 days, 10% at 90 days, and a striking 12% at one year for patients who underwent surgery just before the weekend.

    The study suggests that negative outcomes may be linked to differences in hospital staffing and fewer specialists available on weekends, which could impact post-surgery care. To improve outcomes, researchers recommend future studies focusing on ensuring high-quality care for all patients, regardless of when their surgery is scheduled.

    However, interestingly, the researchers noted a contrasting trend regarding unplanned, urgent surgeries. While scheduled or elective procedures performed before the weekend were linked to worse postoperative outcomes, urgent, unplanned surgeries tended to show slightly better outcomes when performed before the weekend.

    “Our findings underscore the need for a critical examination of current surgical scheduling practices and resource allocation. One approach for consideration is the optimization of perioperative care pathways to mitigate adverse outcomes,” the researchers noted.

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  • Plant-Based Meats and Puberty, Obesity, and Fracture Risk

    Plant-Based Meats and Puberty, Obesity, and Fracture Risk

    What are the effects of plant-based meats on premature puberty, childhood obesity, and hip fracture risk?

    As noted in an editorial in the Journal of the American Medical Association on plant-based meats, if you look only at the nutrition facts information for a conventional burger versus a Beyond Meat or Impossible Burger, as seen here and at 0:20 in my video Plant-Based Meat Substitutes Put to the Test, you wouldn’t necessarily be able to predict the health consequences without further studies.

    We’ve had plant-based meats in the marketplace for more than a century, though, as you can see in this ad for “good eating” Protose, below and at 0:35 in my video. Dr. John Harvey Kellogg filed a patent for Protose, what he called “the modern vegetable meat,” in 1899.

    Of course, products like tempeh and tofu have been eaten throughout Asia for centuries, but I think of those as separate foods in their own right, as opposed to products intentionally designed to mimic the taste and texture of meat. With such a rich history, harkening back to the days of pass-the-Proteena—another great ad here and at 1:06 in my video—you’d think there’d be some studies of consumers—and indeed, there are. 

    Researchers have found, for example, that girls who eat meat may start their periods six months earlier than girls who don’t. Is the earlier menstruation because the meat-eating girls were eating a lot of protein and fat? No, because vegetarian girls who instead ate meat analogs, like veggie burgers and veggie dogs, were able to delay menstruation by nine months. Of course, it’s hard to tease out how much of that is just from avoiding meat, but compared with girls who ate meat a few times a week, those who ate meat a few times a day had a significantly earlier age of first menstruation. This may help explain why childhood meat consumption is linked to breast cancer later in life, since the earlier you start your period, the higher your lifetime risk. 

    Now, obesity itself may contribute to the early onset of puberty in girls, so that could be another factor. Studies have suggested that “vegetarian children tend to be lighter and leaner than nonvegetarian children,” but veg kids aren’t smaller in general, though. Vegetarian boys and girls may measure to be about an inch taller than their classmates; they just aren’t as wide. So, the fact that girls who eat plant-based meats may be less likely to experience premature puberty may, in part, be because they were leaner.

    Indeed, as shown here and at 2:48 in my video, childhood obesity research found that meat consumption seems to double the odds of schoolchildren becoming overweight, compared to plant-based meat. Now, whole plant food sources of protein, such as beans, do even better and are associated with halving the odds of kids becoming overweight.

    This is why I consider plant-based meats like the Impossible Burger and Beyond Meat more of a useful stepping stone towards a healthier diet, rather than the endgame ideal. The same amount of protein in a bean burrito would be better in nearly every way, as you can see here and at 3:05 in my video

    Similarly, in terms of hip fracture risk, in the Adventist Health Study–2, which followed tens of thousands of men and women for years, researchers found that daily intake of plant-based meats appeared to reduce the risk of hip fracture by nearly half, but daily intake of legumes—beans, split peas, chickpeas, and lentils—may drop the risk of hip fracture by even more—by nearly two-thirds.

    This is the fourth in a nine-part series on plant-based meats. If you missed the first three, see the related posts below.

    Stay tuned for: 



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  • Mental Health Interpreters Are at Risk of Burnout—But Mindfulness Could Help

    Mental Health Interpreters Are at Risk of Burnout—But Mindfulness Could Help

    The first time Adele Routliff tried communicating with her Deaf mother in public using sign language, her mother, she says, “put her hands on mine and placed [them] back in my lap. In other words, no, we don’t sign in public.” Her mother had grown up in a residential school for the Deaf where sign language was forbidden—enforced by physical punishment—and had internalized the idea that signing was only safe in private settings. Adele didn’t understand her mother’s resistance and so continued signing, even as her mother’s eyes grew wide with fear. “I didn’t understand it then,” she says. “But I know now it was shame.” 

    Now a certified American Sign Language-English interpreter, Adele actively works to raise awareness of deafness by bridging the communication gap and highlighting the importance of mental health in Deaf communities. Her lived experiences have motivated her in becoming a trained mental health interpreter, in providing mental health interpreting workshops for those looking to develop their skills, and in designing and implementing a curriculum for training new interpreters through Canadian Hearing Services.

    Historically, Deaf mental health has been overlooked, and it received minimal attention until the past decade. Dr. Cathy Chovaz—director of the Centre for Deaf Education and Accessibility Forum (CDEAF) and an associate professor of psychology at King’s University College (Western University)—provides mental health care to Deaf individuals. She has led research that suggests that Deaf people face heightened risks of depression and anxiety, compounded by significant barriers and poorer outcomes within the justice system, mainstream education, and healthcare settings. Dr. Chovaz’ research shows that many healthcare professionals aren’t trained to recognize mental health conditions in Deaf patients. As a result, Deaf individuals are often misdiagnosed or go undiagnosed, even though they face unique challenges that put them at higher risk, such as limited early access to sign language, communication barriers within their families, neurological conditions linked to certain causes of deafness, and experiences of trauma or abuse.

    The Challenges of Mental-Health Interpreting

    Considering the challenges faced by Deaf individuals, it’s not surprising that sign language interpreters working in medical and mental health settings also face heightened risks.

    Sign language interpreting requires the interpreter to use their face and their body to communicate, both with the Deaf person and to the hearing person, an experience that can be emotionally and physically taxing. Sign language interpreters also have to remember that their job is to relay every word exactly as it’s signed—no matter how uncomfortable it makes them. One mental health interpreter, who wishes to remain anonymous—we’ll call her Jane—shared how challenging this can be: “There have been times I felt like I needed to wash my mouth out with soap,” referring to the language she had to interpret. “You almost want to say, ‘It’s not me, it’s them.’”

    You walk into the most intimate moments in people’s lives as an interpreter. I’ve been at births, I’ve been at deaths, I’ve been at funerals. I’ve been there when families have blown up.

    Jane explained that while interpreters are trained to remain impartial, it’s hard not to have a natural human reaction to some of the distressing things they hear in medical and mental health settings. “You’re told you’re just there to convey the language—to maintain professionalism, set boundaries, and be mindful of how you come across,” she said. This is especially crucial in high-stress or emotionally charged situations, which interpreters often find themselves navigating. As Adele said, “You walk into the most intimate moments in people’s lives as an interpreter. I’ve been at births, I’ve been at deaths, I’ve been at funerals. I’ve been there when families have blown up.”

    The Health Risks of Helping People Be Heard

    Medical interpreters who work with hearing people play a critical role in helping patients with limited English access and navigate the healthcare system, but the job can bring with it significant emotional strain. They often find themselves in high-stress situations: delivering difficult news, bridging cultural gaps, and facilitating conversations between doctors, patients, and families. Research shows that interpreters, especially those working with cancer patients and children, experience high levels of stress and struggle to manage their own mental health while supporting others. 

    Research shows that interpreters, especially those working with cancer patients and children, experience high levels of stress and struggle to manage their own mental health while supporting others.

    And this emotional burden isn’t unique to spoken language interpreters—it also extends to sign language interpreters, who face their own distinct challenges in medical settings. Although research findings are mixed, recent studies indicate that regular exposure to emotionally charged or traumatic content significantly increases sign language interpreters’ vulnerability to vicarious trauma and secondary traumatic stress, with poor mental health outcomes reported in as many as 83% of interpreters. Jane shared with me a particularly stressful assignment: “I recognized I was no longer able to manage my emotions and it was affecting my ability to interpret in a neutral manner. So I had to take a step back.

    Mindful Skills May Help Sign Language Interpreters

    Those working in emotionally charged settings, particularly medical and mental health contexts, could benefit from preventive measures. One promising approach is the use of mindfulness practices. While it is an understudied area, some research suggests that mindfulness can help interpreters manage work-related stress. A recent study adapted Mindful Practice® in Medicine (MPIM)—an evidence-based mindfulness program created by two physicians to improve coping skills and combat burnout—for medical interpreters.

    The findings showed that the program effectively reduced distress in both spoken and sign language medical interpreters. The study also found that most participants valued the opportunity to share their stressors in an open and understanding environment with fellow medical interpreters. This sense of community not only helped them become more empathetic listeners but also provided a supportive space to debrief and develop mindful strategies for managing the challenges of their work.

    Incorporating mindfulness-based practices into interpreter training programs and providing ongoing professional development can help interpreters better handle emotionally charged situations, enhance self-awareness and emotional regulation, build resilience to burnout, and, like Jane, recognize when an assignment exceeds their capacity. Jane, though not formally trained in mindfulness practices, shared that using mindfulness has helped her. Even something as simple as parking her car further away from her workplace, requiring a longer walk, was helpful to her in processing her day. Similarly, Adele has gained the ability to check in with herself and know what her limits are. While both have been lucky enough to find mindfulness in their own lives, the industry could benefit from offering interpreters formal mindfulness training, which could significantly reduce the stress of challenging interpretation work.



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  • Just 5 Minutes Of Daily Exercise Reduces Dementia Risk By 41%

    Just 5 Minutes Of Daily Exercise Reduces Dementia Risk By 41%

    Staying active is one of the most effective ways to support long-term health and lower the risk of dementia. However, not everyone has the time, ability, or motivation for structured workouts every day. Here’s some good news- new research suggests even small amounts of movement can still give significant protection against dementia.

    A recent study published in the Journal of Post-Acute and Long-Term Care Medicine found that just 35 minutes of moderate to vigorous physical activity per week, which is about 5 minutes a day, lowered the risk of developing dementia by 41% compared to those who never exercised.

    “Our findings suggest that increasing physical activity, even as little as five minutes per day, can reduce dementia risk in older adults. This adds to a growing body of evidence that some exercise is better than nothing, especially with regard to an aging-related disorder that affects the brain that currently has no cure,” said lead author Amal Wanigatunga in a news release.

    The findings were made after following up nearly 90,000 adults with an average age of 63, for about 4.4 years. During the study period, the researchers tracked the physical activity levels and health of the participants and noted that 735 of them developed dementia. On average, participants engaged in 126 minutes of moderate to vigorous physical activity per week.

    The study found that for every additional 30 minutes of moderate to vigorous physical activity per week, the risk of developing dementia decreased by 4%. While even small amounts of movement help, the researchers noticed a clear pattern, a dose-response relationship between exercise and reduced dementia risk. This means that more people exercised, the greater the benefits.

    Those who engaged in 36 to 70 minutes of moderate to vigorous activity per week saw their dementia risk drop by 60%, while those who exercised for 71 to 140 minutes experienced a 63% reduction. The biggest impact, however, was among individuals who exceeded 140 minutes per week, slashing their risk by an impressive 69%.

    “Our results suggest engaging in any additional amount of MVPA [moderate to vigorous physical activity] reduces dementia risk, with the highest benefit appearing among individuals with no MVPA. These associations are not substantially modified by frailty status,” the researchers concluded.

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