Tag: Reverse

  • Scientists Develop Nasal Spray That May Help Reverse Brain Aging

    Scientists Develop Nasal Spray That May Help Reverse Brain Aging

    Source: Science Daily

    Sometimes, the simplest approach may be the most effective. Scientists at Texas A&M University have developed an experimental nasal spray that could one day help reverse brain aging and restore memory. The promising research is raising hopes for future treatments targeting dementia and age-related cognitive decline.

    The study found that the nasal therapy produced significant and long-lasting effects after just two doses. According to the researchers, the treatment showed highly promising results in brain activity, including reduced inflammation in the brain, improved memory performance, and restored cellular energy systems associated with aging.

    The nasal therapy works by delivering microscopic particles known as extracellular vesicles through the nostrils and into the sinuses. This approach allows the particles to bypass the brain’s protective barrier and travel directly into brain tissue. The spray contains microRNAs—tiny molecules designed by scientists to help regulate genes and cellular activity. These particles specifically target chronic brain inflammation, a condition long associated with aging, dementia, and neurodegenerative disease.

    To provide background on persistent low-grade brain inflammation associated with aging, often referred to as neuroinflammaging, it is an inflammatory process within the brain and spinal cord, primarily driven by immune cells such as microglia and astrocytes. Over time, this process may gradually impair memory, learning, and cognitive flexibility.

    The nasal spray appears to work by reducing and suppressing inflammatory pathways linked to this process while also reviving mitochondrial activity—the energy-producing systems inside cells that tend to weaken with age.

    Beyond reducing neuroinflammaging, researchers said the treatment helped brain cells regain their “spark.” This effect was achieved by lowering oxidative stress and restoring energy production. Behavioral testing also showed significant improvements in memory and object recognition tasks compared with untreated subjects.

    The findings, published in the Journal of Extracellular Vesicles, add to growing scientific interest in whether certain aspects of aging can be slowed—or even partially reversed—at the cellular level. Other recent studies have explored ways to target aging-related inflammation, senescent cells, and metabolic dysfunction to improve long-term brain health.

    Researchers believe the approach could eventually have applications beyond normal aging, including conditions such as Alzheimer’s disease, stroke recovery, and other disorders linked to cognitive decline. They also noted that the therapy produced similar effects across both sexes, something that remains relatively uncommon in biomedical research.

    Humankind has long sought ways to reverse aging, both of the mind and the brain. With the development of this nasal spray therapy—and, hopefully, with more in-depth research, further findings, and additional testing—researchers may have taken a step toward addressing this long-standing challenge. While aging has long been considered unavoidable, this medical breakthrough presents an intriguing possibility: brain aging may not be as irreversible as once believed.

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  • Is Surgery Necessary to Reverse Diabetes?

    Is Surgery Necessary to Reverse Diabetes?

    Losing weight without rearranging your gastrointestinal anatomy carries advantages beyond just the lack of surgical risk.

    The surgical community objects to the characterization of bariatric surgery as internal jaw wiring and cutting into healthy organs just to discipline people’s behavior. They’ve even renamed it “metabolic surgery,” suggesting the anatomical rearrangements cause changes in digestive hormones that offer unique physiological benefits. As evidence, they point to the remarkable remission rates for type 2 diabetes.

    After bariatric surgery, about 50% of obese people with diabetes and 75% of “super-obese” diabetics go into remission, meaning they have normal blood sugar levels on a regular diet without any diabetes medication. The normalization of blood sugar can happen within days after the surgery. And 15 years after the surgery, 30% remained free from their diabetes, compared to a 7% remission rate in a nonsurgical control group. Are we sure it was the surgery, though?

    One of the most challenging parts of bariatric surgery is lifting the liver. Since obese individuals tend to have such large, fatty livers, there is a risk of liver injury and bleeding. An enlarged liver is one of the most common reasons a less invasive laparoscopic surgery can turn into a fully invasive open surgery, leaving the patient with a large belly scar, along with an increased risk of wound infections, complications, and recovery time. But lose even just 5% of your body weight, and your fatty liver may shrink by 10%. That’s why those awaiting bariatric surgery are put on a diet. After surgery, patients are typically placed on an extremely low-calorie liquid diet for weeks. Could their improvement in blood sugar levels just be from the caloric restriction, rather than some sort of surgical metabolic magic? Researchers decided to put it to the test.

    At a bariatric surgery clinic at the University of Texas, patients with type 2 diabetes scheduled for a gastric bypass volunteered to stay in the hospital for 10 days to follow the same extremely low-calorie diet—less than 500 calories a day—that they would be placed on before and after surgery, but without undergoing the procedure itself. After a few months, once they had regained the weight, the same patients then had the actual surgery and repeated their diet, matched day to day. This allowed researchers to compare the effects of caloric restriction with and without the surgical procedure—the same patients, the same diet, just with or without the surgery. If there were some sort of metabolic benefit to the anatomical rearrangement, the patients would have done better after the surgery, but, in some ways, they actually did worse.

    The caloric restriction alone resulted in similar improvements in blood sugar levels, pancreatic function, and insulin sensitivity, but several measures of diabetic control improved significantly more without the surgery. The surgery seemed to put them at a metabolic disadvantage.

    Caloric restriction works by first mobilizing fat out of the liver. Type 2 diabetes is thought to be caused by fat building up in the liver and spilling over into the pancreas. Everyone may have a “personal fat threshold” for the safe storage of excess fat. When that limit is exceeded, fat gets deposited in the liver, where it can cause insulin resistance. The liver may then offload some of the fat (in the form of a fat transport molecule called VLDL), which can then accumulate in the pancreas and kill off the cells that produce insulin. By the time diabetes is diagnosed, half of our insulin-producing cells may have been destroyed, as seen below and at 3:36 in my video Bariatric Surgery vs. Diet to Reverse Diabetes. Put people on a low-calorie diet, though, and this entire process can be reversed.

    A large enough calorie deficit can cause a profound drop in liver fat sufficient to resurrect liver insulin sensitivity within seven days. Keep it up, and the calorie deficit can decrease liver fat enough to help normalize pancreatic fat levels and function within just eight weeks. Once you drop below your personal fat threshold, you should then be able to resume normal caloric intake and still keep your diabetes at bay, as seen below and at 4:05 in my video

    The bottom line: Type 2 diabetes is reversible with weight loss, if you catch it early enough.

    Lose more than 30 pounds (13.6 kilograms), and nearly 90% of those who have had type 2 diabetes for less than four years can achieve non-diabetic blood sugar levels (suggesting diabetes remission), whereas it may only be reversible in 50% of those who’ve lived with the disease for eight or more years. That’s by losing weight with diet alone, though. For people with diabetes, losing more than twice as much weight with bariatric surgery, diabetes remission may only be around 75% of those who’ve had the disease for up to six years and only about 40% for those who’ve had diabetes longer, as seen below and at 4:41 in my video.

    Losing weight without surgery may offer other benefits as well. Individuals with diabetes who lose weight with diet alone can significantly improve markers of systemic inflammation, such as tumor necrosis factor, whereas levels significantly worsened when about the same amount of weight was lost from a gastric bypass.

    What about diabetic complications? One reason to avoid diabetes is to avoid its associated conditions, like blindness or kidney failure requiring dialysis. Reversing diabetes with bariatric surgery can improve kidney function, but, surprisingly, it may not prevent the occurrence or progression of diabetic vision loss—perhaps because bariatric surgery affects quantity but not necessarily quality when it comes to diet. This reminds me of a famous study published in The New England Journal of Medicine that randomized thousands of people with diabetes to an intensive lifestyle program focused on weight loss. Ten years in, the study was stopped prematurely because the participants weren’t living any longer or having any fewer heart attacks. This may be because they remained on the same heart-clogging diet but just in smaller portions.

    Doctor’s Note

    This is the third blog in a four-part series on bariatric surgery. If you missed the first two, check out The Mortality Rate of Bariatric Weight-Loss Surgery and The Complications of Bariatric Weight-Loss Surgery.

    My book How Not to Diet is focused exclusively on sustainable weight loss. Check it out from your local library, or pick it up from wherever you get your books. (All proceeds from my books are donated to charity.)



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  • Got Prediabetes? Nutritionist Recommends Simple Hacks To Reverse It

    Got Prediabetes? Nutritionist Recommends Simple Hacks To Reverse It

    Prediabetes could be the beginning of all your chronic woes, paving the way for diabetes and its potentially irreversible health consequences. But what if you could reverse the condition without medications or complicated treatments? According to a nutritionist, all it takes is timely action—combining the right exercise with a nutritious diet.

    Adrian Chavez, a nutritionist specializing in weight loss and blood sugar management, recently shared his simple strategies to reverse prediabetes on social media. “If I had prediabetes and wanted to reverse it in 2025, here’s exactly what I would do,” Chavez wrote in an Instagram post, offering practical advice to help people take control of their health.

    “As someone who spent my entire PhD studying this topic, I can confidently say this is the most evidence-based approach to this issue, Chavez wrote.

    Exercise:

    Getting adequate physical activity is the first step Chavez recommends. “A single exercise session (if done correctly) can reduce blood sugar levels up to 2-3 days,” Chavez explained. For those who can make exercise a habit, for example, training every other day, blood sugar levels will show continuous improvement.

    Although both cardio and strength training are beneficial, Chavez believes that combining both would be the best option.

    Nutrition:

    What you eat and the timing of your meals play a vital role in managing blood sugar levels. Chavez also stresses the importance of monitoring total calorie intake, being mindful of the types of carbs you include, and ensuring you get enough protein and micronutrients to support overall health.

    “You have to eat the right amount of calories for your needs. In most cases, this means eating in an energy deficit (less calories than your body is burning for fuel) to lose excess body fat,” Chavez said. However, for people with prediabetes who do not have excess body fat and lack muscle mass, this means eating at “maintenance or even slight surplus.”

    While consuming the right amount of protein helps maintain and build muscle, slows digestion, and improves satiety, Chavez notes that the total proportion of energy coming from carbs should be kept under 55%. “Also choose high fiber carbohydrates such as legumes, vegetables, fruits and whole grains,” he added.

    When planning your diet, Chavez suggests ensuring adequate intake of micronutrients like magnesium, vitamin D, and chromium for better blood sugar control. He also recommends including antioxidant-rich foods such as berries, leafy greens, herbs, spices, coffee, and tea. Additionally, Chavez advises planning meal timings so that more of your daily calories are consumed earlier in the day rather than at night.



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  • Reverse Fatty Liver Home Page 2023 CB | How I Reversed And Healed My Fatty Liver

    Reverse Fatty Liver Home Page 2023 CB | How I Reversed And Healed My Fatty Liver

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  • Eating to Reverse Heart Failure 

    Eating to Reverse Heart Failure 

    An entire issue of a cardiology journal dedicated to plant-based nutrition explores the role an evidence-based diet can play in the reversal of congestive heart failure.

    It is a hopeful sign of the times when an entire issue of a cardiology journal is not just dedicated to nutrition, but to a plant-based diet in particular. Dr. Kim Williams, past president of the American College of Cardiology, starts his editorial with a quote attributed to the philosopher Arthur Schopenhauer: “All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident.” He goes on to write that “the truth (i.e., evidence) for the benefits of plant-based nutrition continues to mount.” We’ve got the evidence. The problem is the “inertia, culture, habit, and widespread marketing of unhealthy foods. Our goal must be to get the data out to the medical community and the public where it can actually change lives—creating healthier and longer ones.” That’s essentially my life’s mission in four words: Get the data out. Based on what we already know in the existing medical literature, “plant-based nutrition…clearly represents the single most important yet underutilized opportunity to reverse the pending obesity and diabetes-induced epidemic of morbidity and mortality,” meaning disease and death.

    As I discuss in my video How to Reverse Heart Failure with Diet, the issue featured your typical heart disease reversal cases, including a 77-year-old woman with such bad heart disease that she couldn’t walk more than half a block or go up a single flight of stairs. She had severe blockages in all three of her main arteries and was referred to open-heart surgery for a bypass. However, instead of surgery, “she chose to adopt a whole-food plant-based diet, which included all vegetables, fruits, whole grains, potatoes, beans, legumes and nuts.” Even though “she described her previous diet as a ‘healthy’ Western one,” within a single month of going plant-based, “her symptoms had nearly resolved”—and forgot about walking a block. “She was able to walk on a treadmill for up to 50 min without chest discomfort or dyspnea,” becoming out of breath. Her cholesterol dropped about a hundred points from around 220 mg/dL (5.7 mmol/L) down to 120 mg/dL (3.2 mmol/L), with an LDL under 60 mg/dL (1.5 mmol/L). Then, four to five months later, she must have started missing her “chicken, fish, low-fat dairy and other animal products” and “returned to her prior eating habits.” Within a few weeks, with no change in her medications or anything else, her chest pain returned and she went on to have her chest sawed in half after all. After the surgery, she continued to eat the same diet that had contributed to causing her disease in the first place, then went on to have further disease progression.

    Another case featured in the journal has a happier ending. It started out similarly: A 60-year-old man with severe chest pain after walking just half a block decided to take control of his health destiny and switched to a whole food, plant-based diet. “He described his prior diet as a ‘healthy’ diet of skinless chicken, fish, and low-fat dairy with some vegetables, fruits, and nuts”—a diet that had been choking off his heart. Within a few weeks, he experienced the same amazing transformation—from not being able to exercise at all to walking a mile, then being able to jog more than four miles (6.4 km), completely asymptomatic, off all drugs, without any surgery, and off to live happily ever after.

    Now, of course, case reports are just glorified anecdotes. What we need is a randomized controlled trial to prove that heart disease can be reversed with lifestyle changes alone. Guess what? There was one published three decades ago, proving angiographic reversal of heart disease in 82 percent of the patients. Their arteries opened up without drugs and without surgery. So, these case reports are just to remind us that hundreds of thousands of individuals continue to needlessly die every year from what was proven to be a reversible condition decades ago.

    The conventional use of case reports, though, is to present novel results in the hopes of inspiring trials to put them to the test. For example, consider this case report on a plant-based diet for congestive heart failure—not simply coronary artery disease. In this case, the heart muscle itself was so weakened that it couldn’t efficiently pump blood. It was only able to eject about 35 percent of the blood in the main heart chamber with every beat, whereas, normally, the heart can pump out at least 50 percent. And that’s exactly what the patient’s heart was able to do just six weeks after switching to a whole food, plant-based diet, which he chose to do instead of getting his chest cracked open. The researchers wrote: “To our knowledge, this is the first report of an improvement in heart failure symptoms and left ventricular ejection fraction following adoption of a plant-based diet.” It may be the first, but it isn’t the last.

    Another case: A 54-year-old woman, obese and diagnosed with type 2 diabetes, presented with swelling ankles due to her heart failure. She switched from her regular diet of chicken and fish to whole plant foods. She started eating more healthfully, lost 50 pounds, and reversed her diabetes—meaning she had normal blood sugars on a normal diet without the use of diabetes medications. Her heart function normalized, too, going from an abysmal ejection fraction of just 25 percent up to normal, as you can see below and at 5:00 in my video. Since it wasn’t a randomized controlled trial, all we can say is that her improvements coincided with her adoption of a whole food, plant-based diet. But, “given the burden of heart failure [as a leading cause of death], its adverse prognosis,” meaning it usually worsens progressively, “and the overall evidence to date, a plant-based diet should be considered as part of a multifaceted approach to heart failure care.” We already know it can reverse coronary artery disease, so any heart failure benefits would just be a bonus.

    Now, we just need good strategies for healthcare “practitioners to support patients in plant-based eating.” Shown below and at 5:42 in my video are some excellent suggestions to pause and reflect on. 

    Doctors, for example, can “use the Plant Rx pads produced by the Plantrician Project” and prescribe a good website or two, like NutritionFacts.org, as seen below and at 5:50 in my video

    “While it is certainly true that many people would be resistant to fundamental dietary changes, it is equally true that millions of intelligent people motivated to preserve their health are now taking half-way measures that may provide only modest benefit—choosing leaner cuts of meat, using reduced-fat dairy products….Most of these people have neither the time nor the training to evaluate the biomedical literature themselves. Don’t they deserve honest, forthright advice when their lives are at stake? Those who wish to ignore this advice, or implement it only partially, are at liberty to do so.”

    Do you want to go smoke cigarettes? Bungee jump? It’s your body, your choice. It’s up to each of us to make our own decisions as to what to eat and how to live, but we should make these choices consciously, educating ourselves about the predictable consequences of our actions.

    Did I say reverse coronary heart disease? As in reverse the number one killer of men and women? I’ve got a lot of videos on the topic, and How Not to Die from Heart Disease is a good place to start.

    Check out the Plantrician Project at plantricianproject.org. I am a proud supporter. 



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  • Cutting Out This Item From Your Diet Could Reverse Aging, New Study Finds

    Cutting Out This Item From Your Diet Could Reverse Aging, New Study Finds

    Your health isn’t solely influenced by what you eat but also by what you cut off from your diet. Researchers have now identified a specific item in your daily diet that, when reduced, could potentially reverse the signs of aging.

    Fruits, veggies, and a diet rich in vitamins and minerals are all essential for healthy aging. However, a recent study identified that even when people ate healthy diets, each gram of added sugar could increase their biological age.

    The study published in Jama Network Open examined the link between added sugar and epigenetic aging, which assesses an individual’s aging through DNA methylation patterns. The findings revealed that cutting back on sugar had a profound effect, potentially reversing biological aging at the cellular level.

    “We knew that high levels of added sugars are linked to worsened metabolic health and early disease, possibly more than any other dietary factor. Now we know that accelerated epigenetic aging is underlying this relationship, and this is likely one of many ways that excessive sugar intake limits healthy longevity,” said study co-senior author Elissa Epel in a news release.

    Co-senior author Barbara Laraia said, “Given that epigenetic patterns appear to be reversible, it may be that eliminating 10 grams of added sugar per day is akin to turning back the biological clock by 2.4 months, if sustained over time. Focusing on foods that are high in key nutrients and low in added sugars may be a new way to help motivate people to eat well for longevity.”

    The study examined dietary records of 342 Black and white women with a mean age of 39 years in Northern California. To understand their epigenetic scores, they assessed the saliva samples of the participants, which were then compared against the dietary records.

    The researchers also compared the diet scores of the participants against a Mediterranean-style diet rich in anti-inflammatory and antioxidant foods and a diet linked to reduced risk for chronic disease.

    Finally, they evaluated the diets using the “Epigenetic Nutrient Index (ENI),” which measured nutrients linked to anti-oxidative or anti-inflammatory processes and DNA maintenance and repair. The results suggest that adherence to all diets rich in Vitamins A, C, B12, and E, folate, selenium, magnesium, dietary fiber, and isoflavones was associated with a lower epigenetic age. However, the strongest association was seen with the Mediterranean diet.

    The researchers came across a key finding: consuming foods with added sugar was linked to accelerated biological aging, even if the rest of the diet was healthy.

    “The diets we examined align with existing recommendations for preventing disease and promoting health, and they highlight the potency of antioxidant and anti-inflammatory nutrients in particular. From a lifestyle medicine standpoint, it is empowering to see how heeding these recommendations may promote a younger cellular age relative to chronological age,” said Dorothy Chiu, the first author of the study.

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