Tag: Longevity

  • Does Less Protein Increase FGF21 for Longevity?

    Does Less Protein Increase FGF21 for Longevity?

    Fasting and exercise can boost the longevity hormone FGF21, but what can we eat—or avoid eating—to get similar effects?

    Over a century ago, fasting was hailed not only as a means of combating “cerebral lassitude,” but also for the “prolongation of healthy longevity.” If that turns out to be true, FGF21 might be a missing link. FGF21 is characterized as a “systemic enhancer of longevity.” It can be boosted through prolonged fasting, but thankfully, there are other, less drastic measures, such as more carbs or less protein.

    Give people lots of starchy foods, and their FGF21 levels shoot up. The healthiest sources would likely be whole grains and beans, since butyrate appears to boost FGF21, too, and we get that from fiber. That’s one of the things our good gut bugs make from fiber-rich foods.

    Circulating FGF21 levels also increase dramatically after eating a lower-protein diet—more than a 150% increase within four weeks. By the way, “lower protein” simply means reducing intake from the typical excess consumed by most Americans down to the recommended amount.

    The recommended daily allowance of protein for most men is 56 grams of protein a day, though most American men are getting more than 100 grams. When researchers studied men who had been getting the typical excess of about 112 grams a day and reduced them down to 64, which is still more than the recommended 56 grams, so the protein “restricted” group was still getting more than enough protein—they found that FGF21 levels in the blood essentially doubled. That may help explain why they lost more body fat, despite getting significantly more calories. How can you eat 300 more calories a day and still lose two more pounds of straight body fat? By just bringing your protein levels down to normal levels. Who hasn’t fantasized about a diet that allows eating excess calories that are effortlessly burned off by ramping up fat-burning? So, maybe we should “play down protein to play up metabolism,” thanks to FGF21.

    Even just a modest protein restriction regimen down to recommended levels might have significant clinical benefits. Now, this was after a month and a half. A similar study found that even less protein restriction, taking men down to just 73 grams a day, resulted in a sixfold increase in FGF21 within a single week, accompanied by a significant increase in insulin sensitivity, as you can see below and at 2:46 in my video How to Boost FGF21 with Diet for Longevity.Researchers concluded that dietary protein dilution promotes our metabolic health.

    Evidence suggesting that lower protein intake has positive associations with better health, survival, and insulin sensitivity has continued to grow, but we weren’t sure exactly how. Maybe FGF21 provides an explanation. Interestingly, the studies were feeding people 9 percent of calories from protein, which is about what the Okinawans were getting when they were one of the healthiest, longest-living populations in the world.

    I’ve talked previously about methionine restriction to fight cancer and as a life-extension strategy. Methionine is an amino acid found predominantly in animal proteins, so one could achieve methionine restriction by cutting back on animal foods. That may actually be an FGF21 effect. Methionine restriction boosts levels, so much so that it’s been called “the most important mediator of metabolic reprogramming in methionine restriction.” Some proteins may be more important to restrict than others. The highest methionine levels are in meat. Legumes (beans, split peas, chickpeas, and lentils) have about three times less methionine than meat, as you can see below and at 3:55 in my video.FGF21 has been proposed as a potential mediator of the protection from cancer, autoimmune diseases, diabetes, and obesity, afforded by strictly plant-based diets. Maybe that’s one of the reasons whole food, plant-based diets have been shown to have such extraordinary results. Take Dr. Esselstyn’s work, for example, showing that coronary disease—the number one killer of men and women—can be largely halted or reversed, and the risk of heart attack almost eliminated, with the help of a whole food, low-fat vegan diet. This benefit can’t be attributed solely to cholesterol reduction, as we have powerful cholesterol-lowering drugs now that can force cholesterol levels as low as those of healthy eaters but appear to have less effect. So, the marked benefits Esselstyn reported seem to reflect a variety of protective mechanisms associated with whole food, plant-based diets, and FGF21 may be one of those mechanisms. So, it’s not just the fat and cholesterol—the quantity and quality of protein may also be playing a role. But there’s never been a study to see whether vegans do indeed have higher levels of FGF21…until now.

    In addition to studying New Zealand obese mice, researchers investigated the circulating FGF21 levels among those eating plant-based diets, and then put it to the test by removing meat from other people’s diets to see if FGF21 levels would go up. They found that FGF21 levels were markedly higher in vegan people compared to omnivores, and the levels went up when the omnivores were switched to vegetarian diets after just four days. And not just by a small amount—FGF21 levels increased by 232% after just four meat-free days.

    The bottom line is that “the various fasting approaches are likely to have limited efficacy, particularly on aging and conditions other than obesity, unless combined with high-nourishment diets such as the moderate calorie intake and mostly plant-based Mediterranean or Okinawa low-protein diets,” by which they mean the recommended amount of protein.

    Doctor’s Note

    I introduced FGF21 in the first video. If you missed it, check out Life Extension with FGF21.

    The methionine videos I mentioned are Methionine Restriction as a Life-Extension Strategy and Starving Cancer with Methionine Restriction.



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  • How to Boost Your Longevity Hormone

    How to Boost Your Longevity Hormone

    What can we do to boost the longevity hormone FGF21?

    In the year 2000, a new human hormone was discovered. It was the 21st documented fibroblast growth factor, so they called it FGF21. Since its discovery, FGF21 has become recognized as a key agent for the promotion of metabolic and arterial health, leanness, and longevity. Inject it into fat monkeys, and they lose body weight without reducing their food intake. And they don’t just lose a little weight—they have a 27% drop in body fat while eating the same amount. In mice, it increases their lifespan by 30 to 40%, which is comparable to lifelong caloric restriction, and, again, they achieve this without decreasing their food intake. The researchers conclude that FGF21 could possibly be used as a hormone therapy to extend mammals’ lifespans, which has gotten Big Pharma salivating, raising the question: “Can aging be ‘drugged’?”

    That’s not all FGF21 can do, either. “The idea that one drug can treat obesity, diabetes, dyslipidemia [like high cholesterol], and hypertension all at once might have seemed impossible a few years ago but is now a tantalizing and exciting prospect.” The reason you can’t just give people straight FGF21 is that it gets rapidly broken down in the body, so you’d need injections every hour or two, around the clock. So, drug companies are trying to patent a variety of longer-acting FGF21 look-alikes. And, indeed, give people a little PF-05231023, and they can lose about 10 pounds in 25 days, as well as get dramatic drops in triglycerides and cholesterol, as you can see below and at 1:48 in my video Life Extension with FGF21.Then, the side effects of these new-fangled drugs started cropping up. Okay, so what are the options? How about packaging the FGF21 gene into a virus and then injecting it so it can stitch extra FGF21 genes into our DNA? Or you can just lace up your running shoes. Exercise boosts FGF21 levels, which may in fact be one of the reasons exercise is so good for us.

    Which works better, though, aerobic exercise (eight weeks of running training) or resistance exercise (eight weeks of weights)? The answer is both, but the resistance exercise edged out the running, a 42% increase in FGF21 versus a 25% increase in the aerobic exercise group. Okay, but what can we do with food? Yes, you could try engineering and injecting it, but wouldn’t it be easier to just stimulate our own natural, endogenous production through diet? One way is through no diet at all. It’s been dubbed the starvation hormone because fasting induces FGF21, but not after just a day or two.

    Physiologically, FGF21 expression rises markedly in response to fasting or starvation. But, unlike mice, which show an increase after just six hours of fasting, humans don’t get a notable surge in FGF21 until after a week. Fasting can quadruple FGF21, but it takes 10 days of fasting, which is the very poster child of an unsustainable eating pattern. You can see the increase below and at 3:19 in my video.So, how do you get the benefits without the starvation? Might a ketogenic diet be able to mimic the fast? Nope. Keto diets don’t work. In fact, keep it up for a few months, and you can actually get a significant decline in levels. High-fat diets may even interfere with the boost you get from exercise, which was seen in a study of high-intensity interval training.

    What kind of diet does work, then? We’ll find out next.

    Doctor’s Note

    Stay tuned for part two: How to Boost FGF21 with Diet for Longevity.

    Flashback Friday: How Much Should You Exercise? Check out the video to find out.

    For more on longevity, see Friday Favorites:  How to Increase Your Life Expectancy 12 to 14 Years.



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  • Proven Longevity Habits That Extend Healthspan

    Proven Longevity Habits That Extend Healthspan

    Aging is inevitable, but how we age is far more flexible than once believed. Longevity science shows that daily habits influence healthspan—the years lived in good health—more than inherited genes alone. While genetics play a role, consistent lifestyle choices shape inflammation levels, cellular repair, and resilience over decades.

    Healthy aging depends on movement, nutrient-dense foods, restorative sleep, and strong social bonds. Vitality research suggests these multidimensional factors reduce mortality risk and delay chronic disease. Rather than focusing solely on lifespan, modern longevity science emphasizes extending vitality, mobility, and cognitive clarity well into later years.

    Longevity Science Behind Healthy Aging and Cellular Repair

    Longevity science highlights how nutrient-sensing pathways such as IGF-1, insulin signaling, and mTOR regulate cellular repair and oxidative stress. These pathways influence inflammation, DNA stability, and metabolic efficiency. While certain gene variants like FOXO3A are associated with increased odds of reaching advanced age, lifestyle remains the dominant factor in determining overall health outcomes.

    According to the National Institute on Aging, genetics account for roughly 20–30% of lifespan variation, with environmental and behavioral factors contributing the majority. Avoiding smoking, managing blood pressure, maintaining a healthy weight, and staying physically active significantly increase the likelihood of living longer in good health.

    Vitality research also connects lower inflammation markers, such as IL-6, with extended healthspan. Caloric moderation and nutrient-rich diets appear to reduce oxidative stress, supporting cellular maintenance mechanisms. Together, these factors delay morbidity and preserve function into advanced age.

    Healthy Aging Through Exercise and Nutrition

    Healthy aging accelerates when exercise and nutrition work together. Muscle mass declines about 1–2% per year after midlife, increasing frailty risk. Strength training and aerobic activity help preserve lean tissue, maintain metabolic rate, and improve cardiovascular endurance.

    According to the Centers for Disease Control and Prevention, adults who engage in at least 150 minutes of moderate-intensity physical activity per week reduce their risk of heart disease, type 2 diabetes, certain cancers, and premature death. Regular movement also improves balance and cognitive function, lowering fall and dementia risks.

    Nutrition complements activity by supplying antioxidants, fiber, and essential fats that reduce chronic inflammation. Mediterranean-style, plant-rich diets support microbiome diversity and heart health. Intermittent fasting and moderate calorie reduction may activate autophagy, a cellular cleanup process linked to improved metabolic resilience.

    Vitality Research on Sleep and Social Connection

    Vitality research underscores the importance of restorative sleep and meaningful relationships in supporting longevity. Sleep between seven and nine hours nightly supports DNA repair, immune function, and hormone balance. Poor sleep is linked with accelerated aging markers and increased chronic disease risk.

    According to the National Heart, Lung, and Blood Institute, adequate sleep improves cardiovascular health, cognitive performance, and metabolic regulation. Chronic sleep deprivation is associated with higher risks of obesity, hypertension, and heart disease.

    Social bonds are equally powerful. Strong relationships correlate with significantly lower mortality rates compared to social isolation. Mental stimulation, lifelong learning, and stress management techniques such as mindfulness reduce cortisol levels and support brain health, delaying cognitive decline.

    Genetics Versus Lifestyle in Longevity Science

    Although genetic inheritance influences aging, lifestyle shapes how those genes are expressed. Twin studies indicate that only a fraction of lifespan variation is directly genetic. Environmental exposures, nutrition, physical activity, and stress management accumulate effects over decades.

    After age 60, genetic predispositions may become more visible, but modifiable behaviors still determine disease onset and functional independence. Lifestyle choices build resilience early, compounding protective benefits across the lifespan.

    Longevity science consistently demonstrates that proactive habits outweigh passive inheritance. Healthy aging becomes achievable when daily actions support metabolic and inflammatory balance.

    Emerging Biomarkers in Healthy Aging

    Biomarkers offer measurable insight into biological aging. Inflammation markers, oxidative stress indicators, insulin-like growth factor-1 levels, and glycation end products help assess physiological age beyond chronological years.

    Tracking these indicators allows researchers to evaluate how exercise, nutrition, and sleep influence cellular aging. Lower inflammation and improved metabolic markers often correlate with extended healthspan.

    As vitality research evolves, biomarker monitoring may guide personalized interventions that maintain function longer. Preventive strategies grounded in measurable physiology strengthen the science behind feeling younger.

    Longevity Science Practical Applications in Daily Life

    Practical longevity strategies mirror patterns seen in long-lived communities worldwide. Plant-forward diets, regular movement, strong social networks, and purposeful living consistently appear in populations with extended life expectancy.

    Daily routines matter more than occasional extremes. Walking regularly, preparing whole foods, prioritizing sleep, and cultivating supportive relationships create cumulative benefits over decades.

    When applied consistently, these habits reduce chronic disease risk, preserve cognitive clarity, and enhance emotional resilience. Longevity science translates into simple daily practices that build lasting vitality.

    Habits That Extend Healthspan and Preserve Vitality

    Feeling younger is less about chasing trends and more about sustaining foundational habits. Exercise, nutrient-dense meals, restorative sleep, and social engagement work together to reduce inflammation and strengthen cellular repair. These elements form the backbone of healthy aging.

    While genetics influence aging, lifestyle choices determine how those genes express over time. By prioritizing movement, balanced nutrition, sleep quality, and connection, individuals can extend not only lifespan but healthspan. Longevity science supports a practical message: consistent daily habits are the most powerful tools for maintaining vitality.

    Frequently Asked Questions

    1. How much does genetics influence longevity?

    Genetics typically account for about 20–30% of lifespan variation. Lifestyle and environmental factors contribute the majority. Healthy behaviors can offset some inherited risks. Daily habits play a major role in determining healthspan.

    2. What type of exercise best supports healthy aging?

    A combination of strength training and aerobic activity is most effective. Strength training preserves muscle mass and bone density. Aerobic exercise supports heart and brain health. Balance exercises also reduce fall risk in later years.

    3. Does sleep really affect aging?

    Yes, sleep supports cellular repair and hormone regulation. Chronic sleep deprivation increases inflammation and metabolic risk. Consistent restorative sleep protects cardiovascular and cognitive health. Quality sleep contributes to longer healthspan.

    4. Can diet alone extend lifespan?

    Diet is a critical factor but works best alongside exercise and stress management. Nutrient-dense foods reduce inflammation and oxidative stress. Balanced eating supports immune and metabolic function. Combined lifestyle strategies offer the greatest benefit.



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  • How Longevity Science is Revolutionizing Cellular Repair for a Longer Life

    How Longevity Science is Revolutionizing Cellular Repair for a Longer Life

    Longevity scientists focus on autophagy due to its role in cellular repair, a process that degrades damaged proteins and organelles to maintain healthy cells. Autophagy benefits extend to reducing age-related diseases and promoting lifespan extension in various organisms. In longevity science, enhancing this mechanism counters aging hallmarks like inflammation and mitochondrial dysfunction.​

    What Is Autophagy?

    Autophagy serves as the body’s cellular housekeeping system, where cells engulf and break down dysfunctional components for recycling. This process activates under stress conditions such as nutrient scarcity, enabling cellular repair by clearing debris that accumulates with age. Longevity science views autophagy’s decline as a key driver of pathologies including neurodegeneration and metabolic disorders.​

    Discovered by Yoshinori Ohsumi, whose 2016 Nobel Prize work highlighted its mechanisms, autophagy involves forming autophagosomes that fuse with lysosomes for degradation. In humans, basal autophagy sustains daily cellular maintenance, while induced forms respond to fasting or exercise, according to Harvard Health.

    Autophagy benefits include preserved energy production and reduced oxidative stress, positioning it central to longevity science efforts. Recent 2025 research from the World Longevity Summit in Kyotango reinforces autophagy’s molecular basis, with ATG genes enabling selective forms like xenophagy for pathogen clearance and lysophagy for organelle renewal.​

    How Does Autophagy Promote Longevity?

    Autophagy promotes longevity by mitigating oxidative damage and supporting mitochondrial health, essential for energy and cellular repair. Studies in yeast, worms, and mice demonstrate that boosting autophagy genes extends lifespan, often via pathways like mTOR inhibition. Longevity science links this to evolutionary advantages in long-lived species like whales and naked mole rats, where high autophagic activity correlates with disease resistance.​

    Enhanced autophagy preserves proteostasis, preventing protein aggregates seen in Alzheimer’s and Parkinson’s. It also fosters metabolic flexibility, allowing cells to adapt to nutrient shifts and reduce inflammation. Pharmacological agents like rapamycin, which induce autophagy, extend mouse lifespan, underscoring its therapeutic potential in longevity science.

    Breakthroughs in 2025, such as AutoPhagyGO’s human autophagy measurement tools and Rubicon protein suppression, show lifespan extension in models by countering age-related autophagy inhibitors, enhancing motor function and reducing senescence signals.​

    What Are Autophagy Benefits for Healthy Aging?

    Autophagy benefits for healthy aging include neuroprotection by clearing toxic proteins linked to cognitive decline. Cellular repair through this process supports stem cell renewal and telomere maintenance, delaying senescence. Longevity science research shows autophagy reduces frailty, cancer risk, and chronic inflammation, improving overall healthspan.​

    Additional autophagy benefits encompass better insulin sensitivity for diabetes prevention and enhanced immune function against infections. In brain health, it combats oxidative stress, preserving memory and slowing Parkinson’s progression.

    These effects make autophagy a cornerstone of longevity science strategies for disease mitigation, with 2025 studies highlighting its dual role in aging and cancer suppression by recycling molecules during tumor stress.​

    • Clears damaged mitochondria, boosting energy and reducing reactive oxygen species.​
    • Promotes DNA repair and epigenetic stability for youthful gene expression.​
    • Aids fat metabolism, supporting weight control and cardiovascular health.​
    • Suppresses senescence via Rubicon modulation, extending functional lifespan.​

    How to Induce Autophagy for Longevity?

    Fasting induces autophagy by mimicking starvation, activating AMPK and inhibiting mTOR to trigger cellular repair. Intermittent fasting protocols, like 16:8 or 24-hour fasts, elevate autophagic flux within 12-24 hours, aligning with longevity science findings from experts like Valter Longo. Caloric restriction similarly extends lifespan in models by sustaining autophagy.​

    Exercise stimulates autophagy through muscle stress, enhancing mitochondrial biogenesis and insulin sensitivity, as per the Cleveland Clinic. Compounds like resveratrol, spermidine, and metformin pharmacologically boost it, with trials showing lifespan benefits in animals.

    Emerging 2025 options include IU1 for dual proteasome-autophagy activation and food molecules like fermented teas that trick cells into youth-like cleanup. Longevity science recommends combining these, fasting with activity, for optimal autophagy benefits without extremes.​

    Heat exposure via saunas and polyphenol-rich diets further promote autophagy. Consistency yields cumulative cellular repair, but consulting professionals ensures safety, especially for those with conditions. AutoPhagyGO’s lifestyle programs integrate diet, exercise, and AI-tracked supplements like Awabancha extract, achieving 14% lifespan gains in worms superior to rapamycin.​

    Longevity scientists prioritize autophagy for its proven role across species in extending healthy years. Ongoing 2025 trials, including XPRIZE challenges, explore drugs and measurable interventions targeting its pathways, promising interventions for age-related decline. Autophagy benefits and cellular repair mechanisms offer a blueprint for healthier aging.

    Frequently Asked Questions

    1. Is autophagy safe to induce through fasting for everyone?

    Autophagy induction via fasting carries risks for certain groups, such as pregnant individuals, those with eating disorders, or people on medications affecting blood sugar. Clinical studies emphasize monitoring by healthcare providers to avoid nutrient deficiencies or metabolic stress, particularly in older adults where baseline autophagy may already be low.

    Longevity science trials, like those on intermittent time-restricted eating, confirm benefits in healthy obese adults but stress personalized approaches.​

    2. What role does autophagy play in cancer prevention versus progression?

    Autophagy acts dualistically in cancer: early stages promote cellular repair to suppress tumors by eliminating damaged cells, while advanced cancers exploit it for survival under stress. 2025 research positions it as a convergence point, where inhibitors or activators could target specific phases, but human trials remain exploratory. Longevity science views balanced autophagy as protective against oncogenic mutations.​

    3. Are there genetic factors influencing autophagy efficiency for longevity?

    Genetic variations in ATG genes affect autophagy flux, with some alleles linked to faster aging in model organisms due to condition-dependent impairments. Human studies suggest polymorphisms influence responses to inducers like daf-2 mutations analogs, impacting lifespan extension potential. Longevity science explores these for personalized interventions, as seen in long-lived species genetics.​

    4. How do emerging drugs like AA-20 differ from rapamycin in autophagy activation?

    AA-20 enhances autophagy without mTORC1 inhibition, reducing lipid and protein aggregates to extend lifespan in nematodes via TFEB pathways. Unlike rapamycin’s broad immunosuppression risks, AA-20 shows promise for proteinopathies without pathway overlap, per 2025 preclinical data. This positions it as a safer candidate in longevity science pipelines.



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  • NMN Supplements for Peak Performance, Prevention & Longevity

    NMN Supplements for Peak Performance, Prevention & Longevity

    Performance isn’t just about pushing harder, it’s about recovering smarter. Founded by Dr Pedram Kordrostami, Omre is a US-based supplement brand focused on science-backed nutrition for longevity and peak human performance.

    Omre bridges clinical science with real-world application, developing products that enhance recovery, resilience, and focus at the cellular level. Every supplement is doctor-formulated, third-party tested, and made in FDA-registered facilities, combining transparency and scientific integrity with measurable results.

    At the core of its longevity line is NMN + Resveratrol, a precision blend designed to help high achievers sustain performance while supporting long-term health.

    What Is NMN — and Why It Matters

    Nicotinamide Mononucleotide (NMN) is a key compound that supports the body’s natural production of NAD+ (nicotinamide adenine dinucleotide), a coenzyme vital for cellular energy and DNA repair. NAD+ powers mitochondrial function, essentially the body’s energy engines, and helps cells recover from daily stress.

    As NAD+ levels naturally decline with age, so does the body’s capacity for energy and recovery. NMN supplementation helps support NAD+ metabolism, allowing cells to perform efficiently and repair themselves more effectively.

    When paired with Resveratrol, a plant-based antioxidant found in grapes and berries, the combination amplifies benefits, supporting mitochondrial health, cellular protection, and longevity.

    Omre’s Doctor-Led Edge

    Omre’s NMN + Resveratrol stands out for its clinical precision and transparency.

    Key features include:

    • Doctor-Formulated: Created by Dr Pedram Kordrostami with clinically researched ingredients.
    • Pharmaceutical-Grade Purity: Manufactured in FDA-registered facilities and third-party tested for quality assurance.
    • Bioavailable Forms: Designed for optimal absorption and cellular utilisation.
    • Transparent Labelling: No fillers, additives, or misleading claims, just verified science.

    This makes Omre’s formulation ideal for athletes, biohackers, and professionals who demand peak cognitive and physical performance while prioritising long-term health.

    The Real Performance Hack: Recovery

    Recovery is increasingly recognised as the foundation of sustainable performance. Supporting NAD+ levels helps cells regenerate and maintain energy balance, allowing you to train harder, focus longer, and recover faster.

    Unlike stimulants or quick fixes, NMN works from within, aligning with how the body naturally manages energy production and repair. This cellular-level support ensures endurance today and resilience tomorrow.

    Top reasons to include NMN + Resveratrol in your daily routine:

    • Supports healthy NAD+ levels for energy metabolism.
    • Promotes DNA repair and cellular defence.
    • Aids recovery and reduces cellular stress.
    • Encourages longevity through improved mitochondrial function.

    In short, Omre’s NMN + Resveratrol is not just a supplement, it’s a longevity strategy.

    A Longevity Lifestyle Rooted in Science

    For those seeking a smarter, more sustainable edge, Omre offers a science-backed solution. Whether you’re training, working long hours, or simply striving to age well, consistent NMN supplementation can be part of a holistic longevity approach that combines exercise, rest, and precision nutrition.

    It’s about supporting your body at the most fundamental level, the cells, so you can perform, recover, and thrive across all stages of life.

    Ready to Optimise Your Energy?

    Discover how Omre’s NMN + Resveratrol can help you unlock your next level of performance and longevity.

    Shop now at Omre.co and experience recovery that starts from within.

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  • 5 Daily Habits That Boost Vitality and Longevity

    5 Daily Habits That Boost Vitality and Longevity

    Maintaining vitality and a strong sense of well-being is essential for a fulfilling, healthy life. In today’s fast-paced world, feeling energized can seem like a challenge. Still, it often comes down to building consistent daily habits that naturally boost energy and strengthen the body’s ability to function at its best.

    Simple, science-backed routines can improve mood, focus, and resilience while also supporting longevity. From physical activity to better sleep and mindful work routines, these habits are the foundation for anyone who wants to feel more energetic every day.

    Why Daily Habits Are Key to Boosting Energy and Vitality

    Energy isn’t something that appears overnight—it’s cultivated through consistency. Regular, healthy daily habits have been shown to improve metabolic health, stabilize mood, and enhance mental clarity. Over time, these small actions add up, helping you feel more energetic and vital.

    • Consistent choices such as regular exercise, nutritious meals, and good sleep patterns can lead to improved stamina and focus.
    • Mind-body balance plays a crucial role: habits that support both mental and physical health contribute to overall energy.
    • Scientific research has linked consistent healthy behaviors—such as movement, hydration, and stress management—to increased life expectancy and a better quality of life.

    Building sustainable habits ensures that energy is about more than short-term boosts; it’s about long-term vitality and longevity.

    1. Regular Physical Activity to Enhance Energy

    Exercise remains one of the most effective ways to boost energy naturally. Physical activity stimulates the production of endorphins and norepinephrine—chemicals that improve mood, alertness, and overall vitality.

    • Even a 10-minute walk or a brief stretching session can reenergize the body.
    • Incorporate movement breaks throughout your day, especially if you have a sedentary job.
    • Activities like yoga, cycling, or dancing can increase oxygen flow, helping muscles and the brain function more efficiently.

    The key is consistency over intensity. It’s not about hitting the gym daily; it’s about moving your body regularly in ways you enjoy.

    2. Balanced and Regular Nutrition for Sustained Energy

    Nutrition is at the heart of lasting energy. Eating balanced meals at consistent times helps maintain steady blood sugar levels and prevents the fatigue that comes from sudden energy crashes.

    • Prioritize whole foods such as fruits, vegetables, whole grains, lean proteins, and healthy fats.
    • Incorporate energy-supporting nutrients like iron, B vitamins, and magnesium to improve stamina.
    • Stay hydrated throughout the day; even mild dehydration can cause tiredness and difficulty concentrating.

    Avoid skipping meals or relying on high-sugar snacks. Stable nutrition means stable energy—and over time, it directly contributes to longevity and better overall wellness.

    3. Prioritizing Quality Sleep and Rest

    Rest is the foundation of true vitality. Without adequate sleep, the body struggles to repair itself, and energy levels plummet. Consistent sleep patterns help regulate hormones, boost immunity, and improve cognitive performance.

    • Maintain a regular sleep schedule, even on weekends.
    • Limit screen time an hour before bed and create a calming nighttime routine.
    • Keep your sleep environment cool, dark, and quiet for maximum rest.

    Getting 7–9 hours of quality sleep each night allows the body to recharge, ensuring you wake up feeling refreshed and ready to take on the day.

    4. Managing Stress to Preserve Energy Reserves

    Chronic stress drains both mental and physical energy. When cortisol levels remain high for extended periods, fatigue sets in and vitality suffers. Learning to manage stress effectively is essential for maintaining long-term energy.

    • Practice mindfulness or deep breathing for just 5 minutes a day to calm the nervous system.
    • Engage in social connections—talking to friends or loved ones can reduce emotional strain.
    • Schedule downtime into your day to prevent burnout.

    Stress management not only helps you feel more energetic but also supports longevity by protecting heart health and reducing inflammation.

    5. Mindful Work and Break Scheduling to Maximize Daily Energy

    Energy management isn’t only about what you do—it’s also about when and how you do it. Structuring your day around natural energy peaks can help maintain focus and prevent burnout.

    • Schedule demanding tasks when you feel most alert, usually mid-morning or early afternoon.
    • Take short breaks every 60–90 minutes to stretch or walk.
    • Use power naps (10–20 minutes) to recharge without feeling groggy.
    • Set daily intentions each morning to keep motivation high and energy directed toward meaningful goals.

    These mindful habits enhance productivity and prevent the energy dips that often come from overexertion or lack of rest.

    Supporting Longevity Through Daily Energy-Boosting Habits

    Energy and longevity are deeply connected. When you sustain daily habits that boost energy, you’re not just enhancing short-term focus—you’re supporting long-term physical and mental health. Consistent activity strengthens the heart, good nutrition supports cellular repair, and stress management preserves emotional balance.

    Even small lifestyle changes—like walking after meals, drinking more water, or sleeping on a schedule—can make a measurable difference in vitality. Over time, these improvements help reduce disease risks and improve quality of life. The best approach is to make adjustments gradually so they become natural and lasting parts of your routine.

    Conclusion

    The path to lasting vitality doesn’t require drastic change—it’s about building steady daily habits that nurture body and mind. From staying active and eating well to managing stress and resting deeply, these choices collectively boost energy and promote longevity.

    When you make these practices part of your everyday life, you’ll not only feel more energetic but also strengthen the foundation for long-term health and happiness. Energy is the fuel of life—and the right habits keep it flowing strong for years to come.

    Frequently Asked Questions

    1. What are the best daily habits to boost energy?

    Regular exercise, balanced meals, quality sleep, and stress management are the most effective habits to maintain high energy levels throughout the day.

    2. How can I feel more energetic throughout the day?

    Start with hydration, move regularly, eat balanced meals, and take short breaks to prevent fatigue. Avoid excessive caffeine and screen time before bed.

    3. What lifestyle changes promote longevity and vitality?

    Consistent physical activity, nutritious eating, emotional well-being, and strong social relationships contribute to long-term vitality and longevity.

    4. How does stress affect my energy?

    Chronic stress depletes your energy reserves by keeping the body in “fight or flight” mode. Managing it through relaxation and mindfulness helps maintain stamina.



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  • Extreme longevity and health optimization: What it really takes

    Extreme longevity and health optimization: What it really takes

    If so, you don’t have to look very far to find claims about how to improve—no, “optimize”—your health.

    Want to reverse chronic disease? Extend that youthful glow? Live to 115… or forever? Lots of fitness influencers, authors, and podcasters will tell you how to do it.

    In this infographic, we’ll explore.

    By the end of it, you’ll have clarity about how to get the health and longevity you want, while living a life you enjoy.


    You can help people build sustainable nutrition and lifestyle habits that will significantly improve their physical and mental health—while you make a great living doing what you love. We’ll show you how.

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  • Do They Really Power Up Your Energy and Longevity?

    Do They Really Power Up Your Energy and Longevity?

    With the growing buzz around NAD supplements and their potential to boost energy, slow ageing, and enhance overall cellular health, many wonder whether these capsules work. One product that has been turning heads in the wellness community is Wonderfeel Youngr™ NMN, a high-potency supplement formulated by Harvard MD and longevity expert Dr. Andrew Salzman. Backed by decades of research in cellular health and ageing, Wonderfeel promises more than just a wellness boost—it aims to deliver a measurable upgrade to energy, cognition, and vitality.

    Built on scientific rigour and real-world results, Wonderfeel’s approach to NAD supplementation is refreshingly comprehensive. Here’s a closer look for those looking to understand how it works, what sets it apart, and whether it lives up to the hype.

    A Clinically Effective Formula with Extra Firepower

    At the heart of Wonderfeel Youngr™ NMN is a clinically effective 900mg dose of NMN (nicotinamide mononucleotide), the same amount used in the largest human NMN clinical trial. NMN is a direct precursor to NAD+, essential for energy production, DNA repair, and overall cellular function. As NAD+ naturally declines with age, supplementing with NMN can help restore vitality at the cellular level.

    But Wonderfeel’s formula goes far beyond NMN alone. It includes a patented blend of antioxidants designed to combat oxidative stress and support cellular resilience. Key ingredients include:

    • Ergothioneine from mushrooms is known for its powerful cell-protective properties
    • Resveratrol from grapes, supporting cardiovascular and cognitive health
    • Hydroxytyrosol from olives, which helps manage inflammation
    • Vitamin D3 is essential for immune function and gut stem cell generation

    Together, these compounds enhance NAD production and help prevent NAD depletion by lowering CD38 activity, a major NAD-consuming enzyme. This targeted formulation makes Wonderfeel Youngr™ NMN more than just a supplement—it’s a holistic longevity tool.

    Easy to Take, Hard to Miss the Benefits

    Wonderfeel Youngr™ NMN is designed for simplicity and consistency: just two capsules daily, taken with or without food. Over time, many users report noticeable improvements in sustained energy, sharper focus, and better recovery from mental and physical fatigue. Enhanced sleep quality and mood regulation are common themes, indicating broader hormonal and neurological health support.

    Importantly, the product is third-party tested for purity and potency, manufactured in cGMP-certified facilities. Plus, the product’s Certificate of Analysis (COA) includes a QR code that links directly to the independent third-party lab’s website, ensuring full transparency for the product’s quality. It’s also packaged sustainably—an increasingly important feature for eco-conscious consumers.

    A Flexible Option for Supplement Stackers: Wonderfeel NMN Capsuls™

    Wonderfeel NMN Capsuls™

    For those who prefer to tailor their supplement regimen, Wonderfeel NMN Capsuls™ offers a more modular approach. Each capsule delivers 500mg of pure NMN—clean, filler-free, and encapsulated in vegetable cellulose. With 1000mg per serving, it aligns with longevity-focused dosage recommendations from experts like Dr. David Sinclair.

    Priced at $52 per bottle or $45 with multi-pack savings, NMN Capsuls™ represent one of the most accessible, high-quality NMN options available. Like the Youngr™ formula, they are third-party tested, made in the USA, and come in biodegradable packaging for minimal environmental impact.

    The benefits of NMN Capsuls™ mirror those of Youngr™, supporting energy metabolism, brain function, muscle recovery, metabolic regulation, and even mold detoxification and oxidative damage reduction. With a Subscribe & Save $6 option or $78 off when purchasing a six-pack, it’s an appealing choice for long-term NAD support.

    Does Wonderfeel Deliver on Its Promises?

    Wonderfeel Youngr™ NMN

    According to the science—and growing user feedback—Wonderfeel’s NMN supplements do more than boost NAD+ levels. The Youngr™ NMN formula, in particular, supports a wide range of functions, from enhancing cognition and memory to improving muscle function, skin health, fertility, and hormonal balance. These benefits make it an attractive option not just for biohackers but also for everyday wellness seekers.

    Dr. Salzman’s trusted formulation, combined with transparent testing, quality manufacturing, and eco-friendly practices, positions Wonderfeel as a leader in the NAD supplement space. It’s a premium solution that doesn’t feel inaccessible, thanks to reasonable pricing and HSA/FSA eligibility.

    ***

    For anyone serious about optimising their health, ageing gracefully, or simply feeling more energised and focused each day, Wonderfeel Youngr™ NMN and Wonderfeel NMN Capsuls™ are well worth considering. Their formulas are rooted in rigorous science, supported by real-world results, and offered with consumer transparency that’s refreshing in the supplement industry.

    To explore the benefits yourself, check out Wonderfeel’s offerings: the Wonderfeel Youngr™ NMN – Subscribe & Save $15; and Wonderfeel NMN Capsuls™ – Save $6 or Buy six and Save $78. After all, NAD+ support doesn’t get much smarter—or simpler—than this.

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  • Extreme longevity and health optimization: What it really takes

    Extreme longevity and health optimization: What it really takes

    “I want to know I’m doing absolutely everything I can to preserve my health for as long as possible.”

    We hear this kind of thing a lot.

    People tell us they not only want to stay in good shape as they age, they also want to outlive their peers and age expectancies.

    Imagine you could maximize your healthspan and lifespan, fend off disease, and generally remain fit, lean, and youthful into your 90’s, 100’s, and then some.

    Sounds pretty compelling, doesn’t it?

    There’s just one problem: Common longevity advice seems to involve an extraordinary amount of effort. And time. And money. And complexity.

    Is all the effort necessary? Is it worth it?

    And, will it even work?

    In this article, we’ll explore:

    And, we’ll help you weigh the pros and cons so you can make informed decisions about your health, your body, and your life.

    The myths—and realities—of “optimizing” your health

    Health and longevity advice is everywhere these days: podcasts, books, social media, that guy at the gym…

    Plus, influential “figureheads” have given the movement outsized attention. Think: popular podcasters and health experts Dr. Peter Attia, Dr. Andrew Huberman, and Dr. Rhonda Patrick, and biohacker Bryan Johnson.

    We understand the appeal of this kind of content. Who doesn’t want a longer, healthier life? (Not to mention the comforting sense of control that can come from designing and executing a “perfect” health plan.)

    But for us at PN, where we’ve collectively coached hundreds of thousands of people with real human lives, we know that “optimal” is rarely realistic.

    Not only that, optimal isn’t necessary.

    Making modest, relatively consistent efforts towards health and well-being will likely give you better results than following an intense, highly “optimized” protocol.

    If that sounds hard to believe, we get it. So let’s explore that bold statement, starting with the biggest myths surrounding longevity and health optimization.

    Myth: The “basics” aren’t enough.

    There’s an idea that getting and staying healthy must require a set of complex, “cutting edge” strategies—especially if your goal is to outlive the average American.

    In reality, the “basics” work really, really well. (These are things like exercising regularly; eating a nutrient-rich diet; getting adequate sleep; managing stress; and staying socially connected. We’ll discuss these more later.)

    Only, very few people do the basics consistently.

    The real reason more people aren’t living as long, or as well, as they could be isn’t because they’re not taking ice baths or getting vitamin C infusions…

    It’s because they’re not doing the (relatively) simple stuff, consistently.

    If you’re really, truly doing a well-rounded set of health-promoting behaviors with 80-90 percent consistency, you’re probably already close to peak optimization.

    Myth: More is better

    If a handful of basic behaviors get results, then doing them perfectly and as much as possible will help you get, and stay, even healthier—right?

    Not so fast. There’s a law of diminishing returns when it comes to health and fitness efforts.

    Graph shows that with small amounts of health effort, longevity can improve a lot, but as those efforts increase, longevity benefits plateau

    Plus, in our experience, doing too many things or adding in too much complexity to your health and fitness regime can:

    • Add risk factors that could actually make your health and fitness worse (such as chronic injuries or burnout due to overtraining, and/or nutrient deficiencies or disordered eating due to an over-preoccupation with “clean” or restrictive eating).
    • Make it harder for you to sustain good habits. People who take on too much are more likely to burn out. Research shows people who try to accomplish multiple goals are less committed and less likely to succeed than those focused on a single goal.1
    • Make your life less enjoyable, which in turn compromises health. Striving to maximize physical health can interfere with mental, emotional, and social well-being, which plays an essential role in healthspan and lifespan. (One study showed people with high levels of happiness and life satisfaction lived up to 10 years longer than people with low levels.2)

    And what’s the point of living longer if you’re not living a full, well-rounded, enjoyable life? While some effort is definitely important, past a certain point, more isn’t necessarily better.

    Myth: Cutting-edge strategies offer significant benefits.

    Let’s say you could put all those advanced, complex strategies into action without sacrificing consistency or life enjoyment, or compromising your overall well-being.

    They’d have to pay off, wouldn’t they?

    Not necessarily.

    Much of the research on longevity optimization (so far) is either in mice, is observational, is theoretical, or has been tested on very small numbers of people for very short periods of time.

    In fact, many of the fringe methods and supplements touted by influencers or biohackers are not only unproven but even potentially unsafe.3 4 5 6

    Point being: Put your efforts towards foundational health behaviors with proven track records (the kind we’ll cover in this article) before you invest in fringe efforts.

    Myth: It’s all or nothing.

    You might think, “Well, I’m not getting out of bed at 5 a.m. five times a week to go running for 60 to 90 minutes to optimize my VO₂ max, so I may as well just accept I’m not going to be a healthy person.”

    Some folks feel overwhelmed by the idea of optimizing their health, so they figure they might as well do nothing.

    However, our internal data shows that you can be far from “perfect” to get results.

    In our year long PN Coaching program, even clients who practiced their (basic) habits less than half of the time got measurable results.

    10-49% consistency gets results; ALT TEXT: Graph shows men and women with 10 to 49 percent consistency still lost 11 pounds, 8 to 11 inches in girths, and 2 to 3 inches from waist

    (Read more: Nearly 1 million data points show what it REALLY takes to lose fat, get healthy, and change your body)

    Don’t let optimization culture convince you great health is beyond your capabilities.

    Instead, we encourage you to…

    • Consider your options. Review the facts, and get a clear understanding of which behaviors are most likely to give you the best bang for your buck.
    • Get clear on the tradeoffs. Decide which things you are, and aren’t willing to commit to.
    • Make decisions that align with your goals. Including what kind of lifestyle you want, and how you want to spend your time and dollars.

    Keep reading and we’ll guide you through it.

    The benefits—and tradeoffs—of a healthy lifestyle

    Putting effort towards your health is great. But efforts come with tradeoffs.

    Here’s a look at both the efforts, and the tradeoffs, to achieve the health you want for yourself.

    Large image shows six categories of health levels: coasting, light effort, medium, high, very high, and extreme. The medium and high categories offer the best “return on investment” in terms of effort and sacrifice versus overall health benefits.

    A deeper look: The most effective health behaviors (and their optimal dose)

    If you want to reduce your risk of chronic disease, and generally stay healthier for longer, what should you do?

    As we said earlier, the issue isn’t that we need some highly detailed, cutting-edge protocol. The basics work. The issue is that most people don’t do them.

    For example, as shown in the image below, most people don’t get enough fruits and veggies, sleep, or exercise. And the number of people who do all these things on a regular basis (while also avoiding tobacco and minimizing alcohol) is extremely low: likely a fraction of a percent.

    Graph shows only 10 percent of people eat 5 servings of fruits and veggies daily; 15 percent sleep 7 to 9 hours a night’ 24 percent get recommended weekly aerobic and resistance exercise; 71 percent drink moderately or less; and 89 percent don’t smoke

    Finally, let’s take a closer look at what these basics are, and the “sweet spot” of effort versus reward.

    Foundational Health Behavior #1: Exercise regularly

    All health experts agree: Moving your body is important.

    Yes, exercise will help you stay lean, and improve mood, energy, and function, but it will also help you stay alive (and healthier) for longer.

    In fact, a study of Harvard alumni found that any amount of physical activity reduces the risk of death from any cause. Exercise extended lifespan regardless of body weight, blood pressure, smoking habits, or genetic predisposition.7

    Another study of 272,550 older adults found engaging in even low amounts of physical activity significantly decreased risk of death from cancer, cardiovascular disease, and all causes.8

    Specifically, steep risk declines happened when accumulating at least 7.5 MET-hours* of activity per week. The greatest increase in benefits came from achieving 7.5 to 15 MET hours. Increasing activity beyond that further decreases risk, but at a continually lower rate, as the graph below shows.

    Graph show that cancer mortality, cardiovascular mortality, and all-cause mortality all decrease as exercise increases, with the greatest increase in benefits from achieving 7.5 to 15 MET hours of exercise per week

    *MET-hours (Metabolic Equivalent Hours) measures the energy cost of activity, based on duration and intensity. Some examples: 2 hours of resting = ~2 MET-hours; 2 hours of moderate-intensity aerobic activity = ~8 MET-hours; 2 hours of moderate resistance training = ~7 MET-hours.

    Increasing the intensity of exercise is an efficient way to rack up MET-hours, but plain old walking counts too: In a study of 28,000 adults, every 1,000 daily step increase was associated with a 12 percent lower risk of death. (This association began at 2,500 steps and continued up to 17,000 steps.)9

    (Cool factoid: For folks concerned with dementia in particular, one study showed that getting just 3,826 steps per day was associated with a 25 percent reduced risk of dementia—and getting 9,826 steps per day was associated with a 50 percent lower risk!10)

    Ideally, cardiovascular activity is paired with resistance or weight-bearing exercise.

    Resistance training supports health and longevity in various ways: it can help preserve valuable muscle mass, maintain mental sharpness, improve odds of surviving cancer, support metabolic health, and generally help you stay alive.11

    Among older adults especially, falls are a leading cause of death.12 Resistance training can both prevent the risk of falls–because of improved balance and muscle stability13—as well as reduce the risk of serious injury–because of better bone density.14Image shows how resistance training and aerobic training benefit numerous areas of health, such as cognitive function, blood sugar regulation, mobility, and more.

    A sedentary lifestyle does the opposite, increasing risk of cardiovascular disease, diabetes, hypertension, cancer (breast, colon, colorectal, endometrial, and epithelial ovarian cancer), and all-cause mortality.15

    In fact, two decades of sedentary lifestyle is associated with twice the risk of premature death compared to being physically active.16

    ▶ How much exercise should you do?

    Standard exercise recommendations suggest:17

    • 150 minutes per week of moderate-intensity aerobic activity, or 75 minutes per week of vigorous aerobic activity (or some combination of both), plus
    • 2 sessions per week of resistance training, targeting most major muscle groups

    Getting up to 300 minutes per week of moderate-intensity or 150 minutes of vigorous-intensity aerobic activity (or some mix of both) as well as three resistance training sessions per week provides further benefits.

    ▶ Are people getting enough exercise?

    Most people are not.

    Only 24 percent meet the recommendations for both aerobic and resistance exercise. And fewer than 47 percent of American adults meet recommendations for aerobic physical activity.17

    ▶ Is getting more than the recommended amount better?

    For the most part yes, but past a certain point, more effort delivers less benefit—and potentially more risk.

    Overtraining (and/or under-recovering) can disrupt hormone levels, mess with sleep and mood, cause excess fatigue, chronically elevate your heart rate, cause injuries, and more.18 19 Extreme volumes of endurance exercise training may be detrimental for the heart, and increase risk of myocardial fibrosis, coronary artery calcification, and atrial fibrillation.20 21 22 23

    So, the benefits of exercise exist on a U-shaped curve. (This is known as the “Extreme Exercise Hypothesis,24 as seen in the image below.)

    Graph shows a u-shaped curve where health risks are highest when exercise is either very low or extremely high, with the least risks at moderate or high exercise.

    A “high” amount of exercise is good for you, but the “highest” amount possible probably isn’t. (Health benefits likely max out around 7-10 hours of cardio, and 3-4 resistance training sessions per week.)

    We like what one study concluded: “If the mantra ‘exercise is medicine’ is embraced, underdosing and overdosing are possible.”25

    Foundational Health Behavior #2: Eat a nourishing, nutrient-rich diet

    Eating well doesn’t have to be complicated. There are a few key elements to nail down, and the rest is up to your own personal preferences and needs.

    We suggest focusing on three nutrition fundamentals.

    Nutritional key #1: Eat more whole and minimally-processed foods

    Whole and minimally-processed foods are naturally nutrient rich—complete with fiber, healthy fats, vitamins, minerals, and phytochemicals—and far less calorie-dense than highly- or ultra-processed foods (UPFs). They also have less sugar, sodium, and trans fats—the latter which is directly linked to an increased risk of cardiovascular disease, breast cancer, complications during pregnancy, colon cancer, diabetes, obesity, and allergy.26 27 28

    These qualities contribute to their many health benefits; Diets rich in whole or minimally-processed foods are associated with lower rates of depression,29 30 31 heart disease,32 type 2 diabetes,33 cancer,34 and improved longevity.35

    The largest study on processed foods—which included almost 10 million participants—found UPFs are linked to 32 harmful effects, including type 2 diabetes, mental health disorders, obesity, cardiovascular disease, and all-cause mortality.36

    Another study found that a higher consumption of ultra-processed foods (four or more servings daily) was associated with a 62 percent increased risk of all-cause mortality. (For each additional serving of ultra-processed food, all-cause mortality increased by 18 percent.)37

    Not that you need to be plucking tomatoes straight off the vine.

    Eating a minimally processed food diet is more about overall dietary patterns—and moving along the continuum of improvement—rather than rigidly avoiding all forms of processing.

    Illustrated table shows various foods types and their whole, minimally processed, or ultra-processed options. All foods exist on this continuum between whole and ultra-processed.

    ▶ How many minimally-processed foods should you eat?

    There currently aren’t any formal guidelines for the amount of minimally-processed foods to eat. In our experience coaching over 100,000 clients, we find people are most satisfied, and get significant health improvements, when 70 to 80 percent of their diet comes from whole or minimally-processed foods.

    Any improvement counts though. If you’re currently eating very few whole and minimally processed foods, getting at least 50 percent of your diet from these foods would make a big difference to your health, energy, and longevity.

    ▶ Are people eating enough minimally-processed foods?

    No.

    Recent US data shows that Americans get about 28.5 percent of their calories from whole or minimally-processed foods, and 56 percent of their calories from highly- or ultra-processed foods.38

    ▶ Is getting more than the recommended amount better?

    Not beyond a certain point.

    If you want to, consuming up to 90 percent of calories from minimally-processed foods will truly maximize your benefits, but beyond that there are likely no further benefits.

    Besides, some processed foods enhance health rather than detract from it. Think about the protein powder that helps you meet your protein requirements, the commercial salad dressing that helps you eat your vegetables, or the weekly brownie à la mode you share with your grandkid that brings joy to both of your lives.

    (Read more: What you should know about minimally-processed foods vs. highly-processed foods)

    Nutritional key #2: Eat five fruits and vegetables

    You’ve heard it a million times. We’ll be the nag and say it again: Eat your fruits and veggies.

    A massive study involving over 1.8 million people showed that eating more fruits and vegetables was significantly associated with a decreased risk of death—with the benefits plateauing at five servings a day. People who ate five servings a day had a 13 percent lower risk of death from any cause compared to people who ate two servings per day.39

    Additionally, the consumption of fruits and vegetables very likely reduces the risk of hypertension, coronary heart disease, and stroke; probably reduces the risk of cancer; and possibly prevents weight gain.40

    ▶ How many fruits and vegetables should you eat?

    A healthy target is five fist-sized servings of fruits and vegetables daily. (Generally, we recommend dividing that into three servings of veggies and two servings of fruit.)

    For bonus points, try to eat a variety of colors.

    The pigments in fruits and veggies come from various healthful nutrients (called phytochemicals or phytonutrients). Different colors mean different phytochemicals, giving you a diverse array of these beneficial compounds, which are likely responsible for a majority of the health benefits of fruits and vegetables.

    (Read more: What the colors of fruits and vegetables mean)

    ▶ Are people eating enough fruits and vegetables?

    No.

    Americans only eat an average of 2.5 servings of produce (fruit and vegetables combined) per day.41

    Only 12.2 percent of people meet fruit intake recommendations, and less—9.3 percent—meet vegetable intake recommendations.

    A mere ten percent of Americans get a full five servings of fruits and vegetables combined per day.42

    ▶ Is getting more than the recommended amount better?

    There are likely diminishing returns to eating more than the above suggestions.

    In that massive study mentioned earlier that observed 1.8 million people, the life-extending benefits of fruits and veggies plateaued at five servings per day.39

    In other words, higher intake (beyond two servings of fruit and three servings of vegetables) was not associated with additional disease risk reduction.

    That said, there may be other benefits to eating more fruits and vegetables. For example, due to their fiber and water content, fruits and vegetables are filling yet low in calories, so they can support weight management—and they certainly aren’t going to harm your health.

    Nutritional key #3: Eat enough protein

    Protein is the most important macronutrient to get right, especially as we age.

    Plant protein in particular is linked to a reduced risk of cardiovascular disease and death from all causes.43 44 45

    In terms of animal proteins, the results are more mixed. (That said, research on protein intake and mortality is generally based on observational studies that don’t give us clear ideas about cause and effect.) Generally, minimally processed forms of fish, poultry, and low-fat dairy are the best animal protein sources.

    To minimize health risks such as diabetes, cardiovascular disease, and cancer, limit processed forms of red meat (like bacon, hot dogs, deli slices, and pepperoni sticks). Even unprocessed forms of red meat should likely be limited to about 18 oz (~4 to 5 palm-sized portions) or less per week.46 47 48

    Nonetheless, regardless of the source, getting sufficient protein—at least 1.2 g of protein per kg of body weight—significantly reduces the risk for sarcopenia (muscle loss), frailty, and neuromuscular decline.49 50

    Protein is also vital for maintaining and building muscle, keeping bones and soft tissues healthy, supporting immunity, and more. It’s also the most satiating macronutrient, and thus helpful for fat loss and/or body recompositioning.

    ▶ How much protein should you eat?

    The current USDA recommendation for protein intake is at least 0.8 grams of protein per kg of body weight (0.35 g/lb). However, newer research suggests this is likely the absolute minimum amount, and only for relatively young sedentary individuals.

    A better minimum intake for most is likely 1.2 g/kg (0.55 g/lb, or about 3 to 5 palm-sized portions of protein-rich foods), especially for older adults, as they’re at greater risk of muscle loss.

    Protein intake for muscle growth and retention, and/or if performing resistance training or other vigorous exercise would be 1.6 to 2.2 g/kg (0.75-1 g/lb), or about 4 to 8 palm-sized portions of protein-rich foods.

    ▶ Are people eating enough protein?

    That depends on how “enough” is defined.

    Most adults eat at least 0.8 g/kg. However, up to 10 percent of young women and up to 46 percent of older adults don’t hit this mark.51 And, as noted, that recommendation is probably conservative compared to the ideal intake.

    Protein is also especially critical for those on GLP-1 medications (Ozempic, Wegovy, Zepbound) to help prevent the muscle loss they can lead to. Aiming for at least 1.2 g/kg is vital for this population, especially if they are also older. (Getting closer to 1.6 g/kg is even better, if possible.)

    ▶ Is getting more than the recommended amount better?

    Once you get up to 1.2 g/kg, not necessarily. That amount is likely adequate for most, especially sedentary folks.

    If you’re trying to build muscle and strength or recover from vigorous exercise, or are taking GLP-1 medication for fat loss, striving towards 1.6 g/kg would help you achieve that goal more easily.

    If you’re trying to maximize strength and muscle gains, and/or are doing lots of strenuous exercise, consuming 1.6-2.2 g/kg is optimal (with the highest end of that range maxing out all benefits).

    What about supplements?

    Supplements make up a large part of the discussion around aging, but in reality only play a small role when it comes to increasing health and longevity.

    Using supplements (like a multivitamin, or doctor recommended vitamin D or iron) to prevent or correct deficiencies can be helpful for overall health well-being.

    Then, there are other supplements that have reasonably strong track records and can help us meet nutritional needs (protein powder), improve performance (creatine), or potentially even slow aging (fish oil might slow biological aging by a small amount).52

    However, the buzziest, trendiest supplements are often less proven.

    For example, curcumin, spirulina, and ginger are often listed as supplements that might help with inflammation, a hallmark of aging. However, the research here is still early, and far from definitive.

    There are also even less substantiated supplements that might modify other aspects of aging (resveratrol, NAD+, NAC), but the evidence is either very minimal or only in animal models.

    Some supplements (especially herbal supplements) can even cause harm, like liver damage.53

    If you want to give supplements a try, check for high-quality third-party seals of approval from organizations such as NSF.

    Examine.com—an online database that provides independent research summaries and analyses on most popular supplements—is also an excellent resource to help you determine which supplements might actually be effective.

    Regardless, talk to your healthcare provider before taking supplements, particularly if you take other medication.

    Foundational Health Behavior #3: Get adequate sleep

    Research shows that men who get enough quality sleep live almost five years longer than men who don’t, and women who get enough live two and a half years longer.54

    Studies also show sleep is just as important for your heart health as exercise, whole foods, weight management, cholesterol, blood pressure, and blood sugar control.55

    Compared to 7 hours of sleep per day, a 1 hour decrease in sleep duration has been associated with an 11 percent increased risk of cardiovascular disease and a 9 percent increased risk of type 2 diabetes.56

    Older adults who sleep less than 6 hours per night are at higher risk for dementia and cognitive decline than those who sleep 7 to 8 hours.57 (Deep sleep helps clear beta-amyloid plaques and wash out toxins from our brain, thought to be partially responsible for dementia.)

    ▶ How much sleep should you get?

    Sleep experts agree that 7 to 9 hours a night on average—with at least 7 hours of sleep most nights of the week—is ideal for most.

    However, the exact ideal hours may vary person to person.

    Generally, the right amount of sleep for you is the amount that allows you to feel relatively refreshed shortly after waking up, and allows you to fall asleep relatively easily at bedtime, with relatively sustained energy throughout the day.

    ▶ Are people getting enough sleep?

    About a third of US adults don’t meet the recommended amount of 7 to 9 hours of sleep per night.58

    ▶ Is getting more than the recommended amount better?

    Not necessarily.

    It seems that 7 to 9 hours of sleep a night is ideal in terms of health outcomes.56

    Interestingly, longer sleep duration (over 9 hours per night on average) is associated with an increased risk of cardiovascular disease, type 2 diabetes, and overall mortality.59 60 61

    However, it’s not clear that these risks are caused by sleeping more. Just as likely, it may be other health problems (such as depression, sleep apnea, or heavy alcohol consumption) that lead to both longer sleep times and higher health risks.

    (Read more: Transform your sleep—The scientific way to energize your body, sharpen your mind, and stop hitting snooze)

    Foundational Health Behavior #4: Manage stress

    When left unchecked for long periods of time (say, months or years without periods of recovery), stress can have negative effects on nearly every aspect of our health, as the below image shows.

    Image shows the variety of effects chronic, unmanaged stress can have on the body, from brain fog, frequent infection, poor recovery, weight gain, and more.

    Chronic stress—which tends to increase heart rate, blood pressure, and inflammation—increases the risk of cardiovascular disease.62 63 64 Additionally, long-term stress tends to worsen mental and emotional health, increasing the risk of anxiety and depression.65 It can also make people more likely to turn to substances like alcohol as an attempt to cope.66

    That said… Not all stress is bad.

    In fact, stress is a normal, natural, and even beneficial part of life; the right amount helps us feel motivated, purposeful, and engaged with life.

    So, rather than avoiding or demonizing stress, it’s helpful to work with it, using it as an opportunity to develop healthy coping mechanisms, appropriate recovery strategies, and overall resilience.

    And this doesn’t necessarily mean sitting on a cushion and meditating.

    Stress management can include simple mindset shifts: Practicing self-compassion,67 having a growth mindset,68 and framing stress as a normal and even beneficial part of life69 have all been associated with better coping under stress.

    Basic self-regulation skills also help. This involves noticing and naming what you’re feeling, having good control over your actions, and using a broad range of coping skills to help yourself process emotions and recover from stress. With these skills, you build self-awareness and the ability to handle challenges better, because you know how to calm yourself down after an activating event—regardless of how it went.

    The below image offers a spectrum of more—small and big—ways to regulate stress.

    Image shows a continuum of options for stress management, ranging from 1 to 10 on an effort scale.

    ▶ How much stress management should you engage in?

    Think of stress management and recovery as a thing you do in proportion to the stress and demands of your life.

    We often use the analogy of a jug: When stress drains your tank, stress management and recovery practices help fill it back up again.

    Image shows a faucet pouring water into a jug next to a list of recovery practices. These are things that fill your recovery jug. There is also a faucet draining water out of the jug next to a list of stressors. These are things that drain your jug. The goal is to fill your jug as much as you are draining it.
    And, as with all of the foundational health habits we’ve discussed, every little bit counts.

    Whether you’re experiencing a little or a lot of stress in your life, even three to five minutes of purposeful recovery—doing deep breathing exercises, some journaling or gentle stretching, or just stepping outside to get some fresh air and listen to the birds—can help fill your tank.

    ▶ Are people doing enough to manage stress?

    Probably not.

    In the US, over a quarter of people report that most days, they’re so stressed they can’t function.70 In Canada, it’s similar: Just under a quarter of people say that most days in their life are either “quite a bit” or “extremely” stressful.71

    Additionally, over a third of people say they don’t know where to start when it comes to managing their stress.72

    ▶ Is getting more than the recommended amount better?

    Not necessarily.

    The goal is to find your stress “sweet spot.” Because we all enjoy and tolerate different types and amounts of stress, how you feel is actually a pretty good indicator of whether stress is too low, too high, or “just right.”

    As the image below shows, if you generally feel bored and purposeless, stress is likely too low; if you feel energized and engaged, stress is probably close to your “sweet spot”; and if you feel panicky or so overwhelmed you’ve started to feel hopeless, stress is likely too high.

    Image shows a continuum of stress. When stress is too low, we feel bored or purposeless. When stress is just right, we feel energized and engaged. When stress is too high, we feel anxious or numb.

    While having a routine for stress management is a smart idea, there’s likely a point of diminishing returns here too. If you’re in that stress “sweet spot” (energized/engaged, not bored and not overwhelmed), then adding more stress reduction techniques might not help further—and may actually add stress by giving you yet another task to do.

    Foundational Health Behavior #5: Stay socially connected

    You might not think of social connection as a health imperative, but it is.

    Not only is the social and emotional support associated with improved well-being, it’s also associated with reduced risk of premature death.73 74 When relationships are strong, people have a 50 percent increased likelihood of survival during any given time.75

    In fact, one of the longest running studies—the Study of Adult Development out of Harvard Medical School, which has been tracking participants for over 87 years (and counting)—found that strong relationships were the biggest predictor of not only life satisfaction but longevity. (Relationships were more predictive of these outcomes than social class, wealth, IQ, or genetics.)76

    No surprise, not having a social circle comes with its own distinct risks.

    Social isolation and loneliness can increase a person’s risk for heart disease and stroke, type 2 diabetes, depression and anxiety, suicidality and self-harm, dementia, and earlier death.77 78

    A frequently cited statistic highlights its profound impact:

    The effect of social isolation on mortality is comparable to smoking up to 15 cigarettes per day79—surpassing even the risks associated with obesity and physical inactivity.80

    ▶ Are people getting enough social connection?

    It seems many of us could use more friends.

    About 1 in 3 adults report feeling lonely, and 1 in 4 report not having social and emotional support.77

    Eight percent of adults say they have no close friends, 53 percent say they have between one and four close friends, and 38 percent report having five or more friends.81

    ▶ How much social connection should you aim for?

    Generally speaking, research finds that people who have three to five close friends they regularly interact with (one to three times per week, in-person or via phone call) get the most social benefit.82 83 84 85

    On average, interaction with a smaller group of people tends to provide more benefit than a large network of acquaintances.86

    That said, individual needs vary. If you feel authentically connected to others, have a strong sense of belonging, and generally feel socially fulfilled, that’s what matters most.

    ▶ Is getting more than the recommended amount better?

    Likely not. Some evidence suggests that excessive social engagement (daily or multiple times daily) actually might increase mortality risk.87 That’s probably because over-socializing can increase mental, emotional, and physical fatigue,88 and often this level of socialization includes alcohol or other potentially risky behaviors.

    Additionally, it can take away time and energy that could be put towards other life-building and health-promoting behaviors (like work, exercise, or sleep).

    The takeaway? Strive for socializing that brings value to your life. No need to add so much that you wind up exhausted, or unable to keep up with other priorities.

    Foundational Health Behavior #6: Minimize known harms

    Minimizing activities we know to be harmful is a key part of looking after your long-term health, yet it can be easy to overlook these things. (Maybe because we’d rather keep doing them.)

    Two of the biggest culprits are smoking and drinking alcohol.

    Harm Avoidance Key #1: Don’t Smoke

    We all know smoking is bad for us. But smoking is still relatively common:

    • In the US, 10.9 percent of adults smoke cigarettes, and 6.6 percent smoke e-cigarettes.89
    • Globally, the trend is even higher: 22.3 percent of the world’s population use tobacco (36.7 percent of men and 7.8 percent of women).90

    The WHO estimates more than 8 million people die prematurely yearly from tobacco use (with an additional 56,000 people dying annually from chewing tobacco).91 This makes tobacco a leading (i.e. top 3) risk factor for premature death and all-cause mortality.92

    Smoking is also a risk factor for several chronic conditions, including coronary heart disease, stroke, emphysema, and cancer.93 (Globally, about a quarter of cancer deaths are attributed to smoking.90)

    Harm avoidance key #2: Limit alcohol

    At this point, the research is pretty clear: Alcohol has negative implications for your health, especially past a certain point of regular use.

    Two graphs show that risk of cardiovascular disease and cancer increase a lot with heavy drinking, and a little with moderate drinking

    Alcohol plays a causal role in 200+ diseases, particularly liver diseases, heart diseases, at least seven types of cancers, depression, anxiety, alcohol use disorders, and dementia.94 95

    In 2019, 2.6 million deaths worldwide were attributable to alcohol consumption.96 For people in the 15-49 age range, alcohol is the leading risk factor for death, with 3.8 percent of female deaths and 12.2 percent of male deaths attributable to alcohol use.97

    ▶ How much alcohol is “safe” to drink?

    US guidance on alcohol suggests keeping intake at moderate levels, or less.98

    A moderate intake means:

    • Two drinks or less per day for men (14 or less per week), with no more than 4 at a single sitting
    • One drink or less per day for women (7 or less per week), with no more than 3 at a single sitting

    Importantly, a drink is defined as containing 14 grams (about 0.6 fluid ounces) of pure ethanol, which equates to:

    • 12 ounces of regular beer (5% alcohol by volume)
    • 5 ounces of table wine (12% alcohol by volume)
    • 1.5 ounces of 80-proof distilled spirits (40% alcohol by volume)

    ▶ Are people limiting their alcohol enough?

    In the US, people tend to drink more than the recommended guidelines.

    In 2021, the National Institute on Alcohol Abuse and Alcoholism reported that the average American aged 21 or older consumed 2.51 gallons of pure alcohol over the course of a year—equivalent to about 10 standard drinks/week.99 However, research suggests surveys typically underestimate consumption by 40 to 50 percent.100 Further, other research shows that the heavier a person drinks, the more significantly they’re likely to underestimate and/or underreport their drinking.101

    All that to say, the average American is likely having more (or even far more) than 10 drinks per week.

    Add to that:

    • In 2016, 36.4 percent of Americans (age 15+) said they had at least one episode of binge drinking (6+ drinks in one session) in the last month102
    • About 7 percent of the world’s population aged 15+ years have an alcohol use disorder96
    • Alcohol-related deaths have been rising: in the last five years, alcohol-induced deaths have increased by 26 percent103

    ▶ Is more abstinence from alcohol better?

    In 2023, the WHO released a statement saying no amount of alcohol is “safe.”104 This interpretation is still debated, and data continues to emerge.

    Here’s our take: An abstinence-only policy is likely a failed policy for many. Rather, we want people to be informed so they can make intentional decisions.

    To be clear, alcohol is not beneficial for physical health; it’s a known human carcinogen. However, while alcohol does increase health risks, risk does not rise in a linear fashion with intake. Meaning, small doses are unlikely to have a significant impact on your health. But when you drink more heavily, the risks rise exponentially.105

    Drinking heavily can mean either:

    • Having more than 7 drinks in a week for a woman, or more than 14 drinks in a week for a man, or
    • Having 4 or more drinks in one sitting for a woman, or 5 or more drinks in one sitting for a man (binge drinking).

    (Reminder: A single drink refers to those definitions mentioned previously. Pints of beer, and heavily poured wine glasses and cocktails are more than single servings… Just because it fits in a single glass doesn’t mean it counts as “one” drink.)

    Ultimately, it’s about finding the level of risk you’re willing to tolerate relative to whatever benefits you feel alcohol provides you.

    Our general recommendations:

    • If you’re otherwise healthy and have no other alcohol-related risk factors, limit drinking to moderate levels or less
    • If you’re otherwise healthy but have one or two alcohol-related risk factors (such as breast cancer history), limit drinking to light levels (1 to 3 or 4 drinks per week) with occasional moderate intakes on special occasions, or less
    • If you have several alcohol-related risk factors (such as breast cancer history, family history of alcoholism, or contraindicated medications) abstain from alcohol entirely

    Foundational Health Behavior #7: Do Basic Preventive Health Measures

    In all the chatter about longevity optimization, it can be easy to forget about all the boring—but no less important—things that help you stay safe and healthy throughout your life.

    These include things like:

    • Getting regular check-ups, or seeing your doctor or healthcare provider if questions or concerns arise
    • Getting recommended bloodwork, screenings, and vaccines
    • Getting and keeping blood cholesterol, sugar, and pressure in recommended ranges as early as possible
    • Regularly seeing your dentist, and regularly brushing and flossing
    • Practicing safer sex
    • Seeing medical specialists as recommended or appropriate (OBGYN, optometrist, ENT, dermatologist, etc.)
    • Wearing seatbelts (Buckling up in the front seat reduces risk of fatal injury by 45 percent!106)
    • Wearing a helmet when cycling, skateboarding, or motorbiking
    • Regularly wearing sunscreen (Used appropriately, sunscreen decreases risk of skin cancers by 40 to 50 percent107 108)
    • Protecting your hearing (Untreated hearing loss increases risks for depression, social isolation,109 110 cognitive decline,111 dementia,112 113 and falls114 115)

    … And generally using common sense. (As in, avoid the “hold my beer” type stuff.)

    Basic health maintenance and risk avoidance practices matter—a lot.

    Notably, we can’t control every element of our environment. Some factors influencing our health are more structural and systemic, woven into the fabric of our societies.

    These are called social determinants of health, and include poverty, racism, homophobia, lack of accommodation for disabilities, and displacement (as in the case of refugees). For some folks, doing the above protective behaviors—like visiting the family doctor, getting glasses, going to the dentist, or even walking safely down the street—will be harder, sometimes near impossible.

    This isn’t meant to be a throwaway line that diminishes the difficult reality for so many people, but rather a gritty, realistic mantra: Do the best you can with what you’ve got.

    ▶ How much preventative health care do you need to do?

    Generally speaking, aim to be consistent with the habits you know you “should” do.

    You know the drill: Brush and floss daily; wear your helmet every time you ride a bike; wear your seatbelt every time you drive; put on sunscreen when you go out into the midday sun; don’t regularly blast your music at full volume; and so on.

    And if you have lingering things on your “I should really do that” list (like getting that weird mole checked out, or that bloodwork done), go do it.

    ▶ Are people practicing enough basic preventative health measures?

    We’ve offered a long-ish list of basic health practices that can protect health, so we won’t go into each in-depth.

    That said, when looking at the above list, it’s probably fair to say most people will notice a few behaviors they might practice more consistently.

    For example, while most of us are really consistent with our seat belts (usage is close to 92 percent!116), many of us could break out the floss more often (only 32 percent of Americans floss daily117).

    And, research shows that only about half of cyclists and motorcyclists wear helmets when riding118 119 120 (and use is even lower among skateboarders and rollerbladers121).

    Hearing loss is the number one modifiable risk factor for dementia,122 so make sure you also follow the “60/60 rule” if you like to pump up the tunes on your headphones: Listen at 60 percent of your device’s maximum volume for 60 minutes, then take a break. (And wear earplugs when you mow the lawn!)

    ▶ Are more preventative measures better?

    Once again, there’s likely a law of diminishing returns when it comes to preventative health measures, just like everything else.

    The point isn’t to become obsessed with eliminating all possible risks at every turn.

    Rather, it’s that reasonable efforts towards protecting your health do count, and they‘re immeasurably more important for overall health than the latest optimization fads.

    Bonus Foundational Health Behavior: Foster a sense of purpose and meaning

    Research consistently shows that having a strong sense of purpose and meaning for our life improves our health, overall well-being, and longevity too.123

    A sense of purpose seems to help people live longer, even when controlling for other markers of psychological well-being.

    There’s something uniquely beneficial about having a strong purpose that’s different from, say, being happy.

    Having a strong sense of purpose can mean many things, but it generally indicates that you have goals, and an aim in life.

    This purpose can be many things:

    • Helping others
    • Being connected to family and/or close friends
    • Being a key part of a community
    • Enjoying a hobby
    • Learning new skills

    Having purpose may help with longevity for a few reasons:

    It makes you more likely to engage in health-promoting behaviors, such as getting enough sleep and eating more fruits and vegetables.123

    It also tends to improve mental health. For example, one study showed that people with the strongest sense of purpose had a 43 percent reduced risk of depression.123

    Finally, it may simply help people live longer because it makes you want to live longer. When people have a sense of purpose, they often want to live longer, healthier lives, so they can fulfill that purpose to its fullest. And while wanting to live won’t make it so, it certainly doesn’t hurt.

    Still thinking about optimizing? Consider these additional tradeoffs

    We hope it’s clear by now: You can take yourself really far with some solid basics (that will themselves take some decent time and effort!).

    But, if you want to go even further, your effort might have to increase exponentially, just as those gains become less certain, and more marginal.

    Here’s what to keep in mind.

    First, it takes a lot of time (and money) to optimize.

    Let’s compare the time and financial investment of two imaginary people.

    The first person is what you might call a “healthy” or “medium effort” person. They’re someone who is pretty consistently meeting all of the above recommendations.

    The second person is what you might call an “optimizer.” They do all the above recommendations, but to the max, and many of the fringe recommendations often discussed on health-related podcasts and books.

    How much time and money might each of these people invest in their health efforts on a weekly basis? Here’s what that might look like.

    Table compares various activities and costs of a regular healthy person and an “optimizer”. Generally, it takes 3 to 4 times the time and cost to “optimize” exercise, nutrition, and self-care activities.

    On top of that, there are “optimizing” behaviors and assessments that might be performed less often—say, monthly, seasonally, annually, or even every few years. Of course, these practices will still require time and money, so even though they’re less frequent, they still have to be accounted for.

    Here are some examples of those kinds of products, therapies, and tests:

    • Dietary supplements (vitamin, mineral, and/or herbal supplements; “superfoods”; fish oil; probiotics, resveratrol, NAD+, NAC, curcumin, & more)
    • Bloodwork testing (for advanced lipid testing, inflammatory markers, hormone levels, and nutrient status)
    • IV therapy (for hydration, vitamins, glutathione, or NAD+)
    • Infrared sauna sessions
    • Plasma transfusions
    • Gene therapy
    • Stem cell therapy
    • Medical tourism and therapeutics retreats
    • Full-body MRIs
    • Genetic testing
    • Concierge medical services
    • And more…

    Though it’s hard to estimate the cost of these items, opting to do just a handful could easily cost an extra $10,000+ per year.

    Overall, we’d estimate it takes at least three to four times the time, effort, and money to follow an “optimizer” type lifestyle, compared to a plain old “healthy” lifestyle.

    As we’ve seen above, this 3-4x effort will likely translate to some extra benefits, but the medium-effort “healthy” lifestyle will likely get most people at least 80 percent of the results they’re after (such as improved lifespan, healthspan, and quality of life).

    Besides, optimizing too much can negatively impact your well-being and quality of life.

    The harder and more extreme someone’s fitness or health regime, the harder they typically fall off the wagon. So, taking on too much can actually put you more at risk of quitting the foundational health behaviors we mentioned earlier.

    Even if you stick with it, over-focusing on health and longevity will almost certainly interfere with your ability to enjoy a full, well-rounded, meaningful life.

    For example, if you get too focused on physical health, you may find other aspects of your deep health and overall wellbeing suffer, such as your relational, existential, mental, and emotional health.

    Image shows that there are six domains of deep health: social, physical, existential, emotional, mental, and environmental.

    Take this a step further, and “optimizing” can tip over into obsession. Sometimes, under the surface of “I just really care about my health” is disordered eating, orthorexia, or another mental health condition.

    Graph shows that with small amounts of health effort, life satisfaction and overall well-being can improve a lot, but as those efforts increase, well-being benefits plateau

    This, to us, is the heart of things: It’s important to not only stay relatively healthy, but also to enjoy your life while you’re living it.

    In fact, enjoying your life isn’t separate from good health. It’s part of it.

    What to do next

    1. Clarify your goals.

    Take a step back and consider what you really want most for yourself.

    What kind of life do you want to have?

    How important is it to maximize your healthspan and lifespan, and how does that line up with your other priorities?

    2. Consider the tradeoffs.

    Given what you want most for yourself, and the resources you have available, what’s realistic for you?

    How much time, money, and effort are you willing to put in to achieve health and lifespan goals?

    What are you prepared to give up? What aren’t you prepared to give up?

    3. When looking to make improvements, start with the basics first.

    Review the foundational health behaviors in this article. How many of them are you already doing? Consistently?

    If you’re covering most of the basics, you might not need to do more. (Give yourself a pat on the back. You’re already elite!)

    Or, maybe there’s some room for improvement and you’d like to step it up a bit. Great! For the vast majority of people, improving any of these behaviors will deliver real, tangible results. Start with these, before chasing faddish, fringe, “super-optimal” stuff.

    4. Tune out the noise.

    Those people you hear on podcasts or social media aren’t the experts on you and your life.

    You get to decide what you want, and how to go about getting it.

    Be honest with yourself, and make choices aligned with what matters most to you.

    There’s plenty of advice out there, but remember: It’s your life. You get to make decisions that work for you.

    References

    Click here to view the information sources referenced in this article.

    If you’re a coach, or you want to be…


    You can help people build sustainable nutrition and lifestyle habits that will significantly improve their physical and mental health—while you make a great living doing what you love. We’ll show you how.


    If you’d like to learn more, consider the PN Level 1 Nutrition Coaching Certification. (You can enroll now at a big discount.)

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  • Best Resveratrol Supplements to Unlock the Secret to Longevity and Vitality

    Best Resveratrol Supplements to Unlock the Secret to Longevity and Vitality

    Resveratrol, a natural compound found in red wine, grapes, and certain berries, has gained significant attention in recent years for its potential health benefits. Often referred to as the “longevity molecule,” Resveratrol is celebrated for its powerful antioxidant properties that combat oxidative stress and promote cellular health. This potent compound is now available in supplement form, offering a convenient way to harness its benefits without the need to consume large quantities of wine or berries.

    The Science Behind Resveratrol
    Research suggests that Resveratrol may play a key role in promoting heart health by supporting healthy blood vessels and reducing inflammation. Additionally, it has been linked to improved cognitive function, potentially delaying the onset of age-related cognitive decline. Some studies even hint at its ability to activate certain genes associated with longevity, making Resveratrol a popular choice for those seeking to enhance their overall well-being and slow down the aging process.

    Who Can Take Resveratrol Supplements?
    Resveratrol supplements are generally considered safe for most adults who are looking to support heart health, cognitive function, or general well-being. They are particularly popular among individuals over 30 who are interested in anti-aging strategies or those with a family history of heart disease. However, pregnant or breastfeeding women, individuals with hormone-sensitive conditions, and those on blood-thinning medications should consult their healthcare provider before adding Resveratrol to their regimen.

    Precautions and Considerations
    While Resveratrol is a natural compound, it’s essential to approach supplementation with care. High doses of Resveratrol may interact with certain medications, including blood thinners, NSAIDs, and certain cancer treatments. Additionally, individuals with liver disorders should use caution, as Resveratrol can affect liver enzyme levels. As with any supplement, it’s important to start with a lower dose and gradually increase it as needed, while monitoring your body’s response.

    Choosing the Right Supplement
    When selecting a Resveratrol supplement, it’s crucial to consider the purity and potency of the product. High-quality supplements often contain trans-resveratrol, the most active form of the compound. Additionally, some supplements are combined with other beneficial ingredients, such as quercetin, to enhance absorption and efficacy. Opting for a reputable brand that prioritizes transparency and quality control ensures that you’re getting the most out of your Resveratrol supplement.

    Incorporating Resveratrol into Your Routine
    Adding Resveratrol supplements to your daily regimen is a simple and effective way to support your health. Whether you’re looking to boost your antioxidant intake, support heart health, or promote longevity, Resveratrol can be a valuable addition to your wellness toolkit. For best results, pair your supplement with a balanced diet rich in fruits, vegetables, and whole grains, and maintain an active lifestyle.

    1. Carlyle Resveratrol Supplement 

    Carlyle’s Resveratrol supplement delivers a potent 1,800 mg Ultra Resveratrol Complex per serving, harnessing the powerful antioxidant benefits of grapes and berries. This premium formula is designed to support your wellness journey with trusted ingredients and superior quality. Laboratory-tested and 100% guaranteed, Carlyle ensures you receive a product free from gluten, wheat, yeast, lactose, and artificial additives. Experience natural, non-GMO herbal support that aligns with your commitment to healthy living.

    2. NOW Supplements, Extra Strength Resveratrol 350mg 

    NOW’s Extra Strength Resveratrol supplement delivers 350 mg of trans-resveratrol per capsule, derived from 700 mg of Japanese knotweed extract. Known for its potent free radical scavenging and cardiovascular support, this product offers enhanced cellular anti-aging benefits. Each capsule is crafted under strict GMP quality standards, ensuring stability, potency, and superior formulation. Packaged in the USA by a trusted family-owned company since 1968, NOW’s Resveratrol supports your wellness with proven quality.

    3. Toniiq Ultra High Purity Resveratrol Capsules 

    Toniiq Resveratrol capsules provide 600mg of highly purified resveratrol, with each serving containing 98% standardized purity, far surpassing the typical 50% or less found in other products. This exceptional purity is achieved through an advanced extraction process, ensuring the most potent polyphenol nutrients. Each batch undergoes rigorous quality testing both in-house and by independent laboratories to confirm purity and the absence of contaminants. Manufactured in a GMP-certified and NSF-approved facility in the USA, Toniiq ensures the highest level of quality for every capsule.

    4. Resveratrol 1600mg 

    This Resveratrol supplement offers a potent 800 mg of organic Trans-Resveratrol per serving, combined with powerful ingredients like Green Tea, Grapeseed, Acai, Quercetin, and Red Wine. Designed for maximum anti-aging benefits, it helps protect against cell damage caused by free radicals. The formula enhances antioxidant content, supporting cardiovascular health and overall well-being.

    5. Garden Of Life Heart Resveratrol Supplement 

    This Raw Resveratrol supplement provides 350 mg of active trans-Resveratrol per capsule, equivalent to the amount found in 200 bottles of red wine. It supports healthy aging with a powerful blend of raw organic Sauvignon grape, fermented Japanese Knotweed, probiotics, and enzymes for enhanced digestion. Designed to promote cardiovascular health, this supplement offers potent antioxidant support in a convenient vegan capsule form. Certified Non-GMO, Vegan, Kosher, and Carbon Neutral, the capsules can be opened and mixed into juice or water for easy consumption.

     

    6. Designs for Health Resveratrol Supreme 

    Resveratrol Supreme combines two potent antioxidants, delivering 200 mg of Trans-Resveratrol and 200 mg of Quercetin per serving to combat free radical damage and support overall health. The resveratrol is standardized to the active trans form, ensuring maximum biological benefit. Designed for higher potency, this Non-GMO, Gluten-Free, and Vegetarian-friendly supplement offers a concentrated dose of resveratrol that surpasses what a typical diet provides.

     

    7. Nutricost Resveratrol 700mg 

    This Premium Resveratrol supplement delivers a powerful 700 mg per serving, offering a convenient way to support overall well-being. The vegan, Non-GMO, and gluten-free formula caters to various dietary needs, ensuring suitability for many users. Each batch is rigorously third-party tested for potency and purity, guaranteeing a high-quality product free from harmful additives. Manufactured in an NSF certified GMP compliant and FDA registered facility, this supplement upholds the highest standards of quality and safety.

     

    8. Clean Nutra’s Renouth Advanced Resveratrol Supplemen

    Clean Nutra’s Renouth Advanced Resveratrol Supplement combines the power of Resveratrol, Berberine, Quercetin, and Grapeseed Extract into one potent formula, delivering an equivalent of 6000 mg of Quercetin Powder per serving. This all-in-one supplement also includes Red Wine Extract, NAC, and Black Pepper Extract for enhanced absorption, providing comprehensive support beyond typical individual supplements. With a unique blend of full-dose ingredients like Acai, Noni, Blueberry, and Pomegranate, Renouth offers a more potent alternative to standard Resveratrol and Berberine products. Manufactured in a registered and certified facility, Renouth ensures trusted quality and effectiveness in every capsule.

     

    ProHealth’s Trans-Resveratrol

    ProHealth’s Trans-Resveratrol supplement provides 1,000 mg of pure, biologically active trans-resveratrol per serving, with no inactive cis-resveratrol. The formula features an advanced absorption matrix, including quercetin, red wine extract, and BioPerine, which increases absorption by up to 1,544%. Each batch is triple lab tested for potency, purity, and safety, ensuring the highest quality. Manufactured in GMP-compliant facilities in the USA, ProHealth continues its 35-year legacy of trusted excellence with an A+ rating from the Better Business Bureau.

     

    10. Life Extension Optimized Resveratrol Elite 

    Optimized Resveratrol Elite features trans-resveratrol in a hydrogel coating, delivering up to 10 times greater bioavailability for enhanced healthy aging support. This powerful formula promotes cardiovascular and cognitive health while protecting cells from oxidative stress, thanks to the addition of quercetin, a potent plant-derived antioxidant. Crafted with the finest raw ingredients, this supplement is non-GMO, gluten-free, and manufactured in the USA, ensuring top quality and purity. Committed to scientific research, this product is designed to help you live your healthiest life by using ingredients and dosages backed by studies.

     

    11. Vitamax Resveratrol 

    Vitamax Age Smart Fusion Supplement offers a powerful blend of NAD+, Collagen Peptides, Berberine, Resveratrol, and additional nutrients like Blueberry Extract and Quercetin in one comprehensive formula. This all-in-one supplement supports healthy aging, enhancing hair, nails, skin, and joint health with a potent mix of Biotin, Hyaluronic Acid, and Omegas. With advanced ingredients like NAC and Black Pepper Extract for improved absorption, Vitamax surpasses traditional supplements in effectiveness. Made in the USA with premium quality standards, Vitamax ensures purity, potency, and a cruelty-free approach to your wellness.

     

     12. DoubleWood’s Resveratrol Supplement

    DoubleWood’s Resveratrol supplement supports overall health and healthy aging with 500 mg per capsule, providing a substantial 120-capsule, two-month supply. Formulated with vegan-friendly, plant-based ingredients, these capsules are designed to be 100% vegan. Manufactured in the USA from globally sourced ingredients, the supplement is both gluten-free and non-GMO. Enjoy the benefits of high-quality Resveratrol with a commitment to purity and ethical standards.

     

    13. ResVitále Resveratrol 500 mg 

    ResVitále’s Resveratrol supplement supports longevity and cellular health with its blend of trans-resveratrol and quercetin, boosting immune function and aiding healthy aging. Featuring wildcrafted Japanese knotwood, this supplement helps combat oxidative stress effectively. Designed for convenience, each vegetarian capsule offers a 4-hour sustained release for consistent antioxidant support. Embrace revitalized vitality with ResVitále’s commitment to enhancing your well-being through premium, effective supplements.

     

    14. Reserveage Beauty 

    Reserveage’s Resveratrol Supplement promotes healthy aging by supporting heart and cellular health with its pure, potent formula. It features organic muscadine red wine grapes and wildcrafted Japanese knotweed to enhance brain health and cognitive function. The supplement offers sustained antioxidant support through three blends of trans-resveratrol, with effects lasting up to 4 hours. Free from gluten, soy, sugar, and preservatives, it aligns with Reserveage’s commitment to empowering beauty and wellness at every age.

     

    15. NatureBell Resveratrol Supplement 1000mg

    This NatureBell Resveratrol Supplement offers 1,000 mg per serving of 99% pure trans-resveratrol in easily absorbed, bioavailable veggie capsules. Each bottle contains 180 capsules, providing a total of 60 servings, with each dose derived from Polygonum Cuspidatum root extract. The supplement supports overall cellular recovery and may enhance healthy aging, brain function, heart health, and immune support. Formulated with non-GMO ingredients and free from soy, dairy, gluten, and preservatives, it is third-party lab tested for purity and potency.

     

    16. Purify Life Sugar-Free Resveratrol Gummies 

    Purify Life’s premium Resveratrol Gummies deliver 1,500 mg of potent Polygonum Cuspidatum per serving, promoting youthful vigor, energy, and overall wellness. These vegan gummies, flavored with natural watermelon and raspberry, provide a delicious alternative to traditional capsules, powders, and pills. Rich in antioxidant properties, Resveratrol supports a youthful appearance and enhances overall wellness. Made in the USA from globally sourced ingredients, these gummies are tested in ISO-certified labs and packaged in a GMP-certified, FDA-registered facility, ensuring the highest quality standards.

     

    17. Simple Organics Resveratrol 1600mg 

    This Resveratrol supplement provides 800 mg per serving of potent trans-resveratrol, combined with organic Green Tea, Grapeseed, Acai Fruit, Quercetin, and Red Wine for enhanced efficacy. The powerful antioxidant formula is designed to combat age-related diseases and prevent cell damage caused by free radicals, potentially lowering risks of obesity and other health issues. Organic Green Tea and Quercetin further boost antioxidant content, supporting cardiovascular health and overall well-being. With all ingredients clearly listed for transparency, this supplement ensures maximum potency and effectiveness in promoting healthy aging.

     

    18. Totaria Health Resveratrol Supplement

    Totaria Resveratrol Complex Plus combines Berberine Powder, Resveratrol, Quercetin, and a range of additional extracts, including Vitamin C and Acai Fruit, to support immune function and cardiovascular health. With highly bioavailable ingredients, this supplement delivers the equivalent of 8,000 mg of Resveratrol and 4,000 mg of Quercetin, enhancing anti-aging and overall well-being. The concentrated trans-resveratrol formula promotes heart health and combats oxidative stress for a longer, healthier life. Formulated with high-quality, all-natural ingredients, the vegan-friendly capsules are free from artificial colors, flavors, gluten, soy, and dairy, ensuring optimal nutrient retention and effectiveness.

     

    19. Nutrivein Resveratrol 1450mg

    Nutrivein Resveratrol offers a potent 1,450 mg per serving of 100% pure resveratrol, combined with immune-boosting vitamin C and fruit powders to support vitality and overall wellness. This high-strength formula helps combat aging and promotes youthful vigor, joint health, and overall well-being. The supplement features vegan-friendly, easy-to-swallow capsules, providing a convenient alternative to larger pills. Manufactured in the USA in a GMP-compliant facility, Nutrivein Resveratrol is GMO-free and third-party tested, with a satisfaction guarantee ensuring quality and customer satisfaction.

     

    20. BulkSupplements.com Resveratrol Powder

    Our Resveratrol 1000 mg powder is rich in natural antioxidants, sourced from Polygonum cuspidatum root, offering essential nutrients for overall health and well-being. Designed for intuitive daily use, this powder simplifies your wellness routine with a straightforward approach to achieving nutritional goals. It ensures transparency and trustworthiness through rigorous third-party testing and a commitment to clarity in formulation. Produced in a cGMP-compliant facility, our supplement upholds high standards of quality and consistency, delivering excellence in every batch.

     

    21. Designs for Health Resveratrol Supreme

    Resveratrol Supreme combines 200 mg of trans-resveratrol with 200 mg of quercetin, delivering a potent blend of antioxidants to combat free radicals and support cellular health. Standardized to contain only active trans-resveratrol, this formula offers higher concentration and effectiveness compared to typical dietary sources. Designs for Health ensures quality by using non-GMO, gluten-free, and vegetarian-friendly ingredients. Clinically trusted and recommended by functional medicine professionals, this supplement adheres to rigorous quality standards for optimal results.

    22. Organic Resveratrol Supplement 1200mg 

    Organic Resveratrol capsules offer 1200mg of 99% standardized trans-resveratrol from Organic Japanese Knotweed, providing a potent source of polyphenol nutrients for enhanced health benefits. This supplement is designed to combat the signs of aging, protect against free radical damage, and support DNA repair for a youthful appearance. It also promotes cardiovascular and cognitive health by improving blood flow, memory, and focus. With peak immune support and increased energy, this 100% organic, vegan-friendly formula is made in the USA and is third-party tested for purity and effectiveness.

     

    23. Vazatisi High Purity Resveratrol Gummies

    Vazatisi High Purity Resveratrol Gummies provide 1500 mg of resveratrol per serving, combined with Vitamin C and grape, for quick absorption and long-lasting effects. The 10-in-1 advanced formula includes green tea, grape seed, acai fruit, blueberry, and other beneficial extracts to enhance antioxidant support and improve bioavailability. These gummies offer powerful antioxidant and anti-aging benefits, supporting cellular health, brain function, and immune support. Delicious grape-flavored and easy to take, each bottle contains 30 servings of two gummies, made in a quality-assured facility with attentive customer support available.

    24. Solgar Resveratrol 500 mg 

    Solgar’s Resveratrol capsules are a potent source of the natural polyphenol resveratrol, found in Polygonum cuspidatum and other plants, providing more resveratrol per capsule than a typical bottle of red wine. These capsules offer powerful antioxidant properties to combat cell-damaging free radicals and help mitigate oxidative stress, potentially reducing premature cell aging. The product is Kosher and gluten-free, free from gluten, dairy, soy, yeast, sugar, and artificial additives. With over 70 years of dedication to quality, Solgar ensures each batch is crafted with the finest ingredients and rigorous research.

     

    25. Jarrow Formulas Resveratrol 100 mg

    Jarrow Formulas Resveratrol offers a 120-day supply with one bottle containing 120 capsules, providing a daily dose of trans-resveratrol and resveratrol glucosides. This antioxidant formula is designed to support cardiovascular health and overall antioxidant defense for adults. The capsules are IGEN non-GMO tested and gluten-free, ensuring they fit a variety of dietary needs. For optimal use, take one capsule daily with food or as directed by a healthcare professional.

     

    (Disclaimer: This article is meant for informational and educational use only and is not a replacement for professional medical advice. For any health-related concerns or questions, please consult a licensed healthcare provider. Additionally, Medical Daily suggests opting for products that have been verified by independent third-party testing to ensure their quality and effectiveness.
    Editorial Policies & Methodology: These products are selected independently and objectively, based on online reviews, various data sources, and proprietary research.)

    Published by Medicaldaily.com

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