Category: Family Health

  • Hockey Safety Tips (for Teens)

    Hockey Safety Tips (for Teens)

    The nonstop action and high-speed team play makes ice hockey a popular sport. As fun as it is, though, injuries can happen — some of them very serious.

    To stay as safe as possible as a hockey player or hockey goalie, follow these tips.

    Staying Safe & Preventing Injuries

    What Hockey Safety Gear Do Players Need?

    Before playing ice hockey, it’s important to get all the right equipment and make sure you know how to put it on and use it correctly. All players need:

    Helmet

    When it comes to preventing serious injuries, a helmet is the most important piece of gear. Helmets should be certified by the Hockey Equipment Certification Council (HECC ), include a full-face mask with a protective chin cup and chin strap, and should fit you properly. Keep the chin strap fastened and tightened so the helmet stays in place.

    Skates

    Be sure to get skates that fit you well. They need to be laced up tight, so the wrong size can really hurt your feet. Skates should have plenty of ankle support and a steel or hard plastic toe cup. Keep skates sharp so they work better and are less likely to get caught in ruts in the ice.

    Shoulder Pads, Elbow Pads, Knee Pads, & Shin Pads

    These are all specific to hockey. For example, gear used in soccer or lacrosse won’t give you the protection you need for playing hockey. Lower leg (knee and shin) pads should have a hard plastic exterior and reach the top of your skates.

    Hockey Pants

    Also called breezers, these should come down to the knee and offer padding in the front, rear, and sides of the upper legs and midsection.

    Gloves

    Another sport-specific item, hockey gloves should let your hands move freely while protecting you well past the wrist.

    Athletic Supporter and Cup

    These items are available as part of hockey undershorts or may be sold separately.

    Neck Protector

    Also called a neck guard, this gear protects the neck from injury (for example, from a skate blade or hockey stick). Choose one that fits you well and covers as much of the neck as possible.

    Cut-Resistant Base Layers

    Even with all the padding worn in hockey, any exposed skin areas are still vulnerable to accidental cuts from skate blades or forceful hits. For that reason, it’s now recommended that all players wear cut-resistant socks, wrist sleeves, and undergarments (base layer shirts and pants).

    Mouth Guard

    This protects the teeth, lips, cheeks, and tongue, and can help prevent jaw injuries.

    What Safety Gear Do Goalies Need?

    Hockey goalies need a whole different set of equipment to stay safe. If you are going to play that position, you need a helmet, skates, a neck protector, and an athletic cup specifically made for goalies. You should also wear:

    Throat Protector

    Worn in addition to a neck protector, this gear is worn to block a fast-moving puck or stick from hitting the neck. It is “flapper-style,” which means it attaches to your helmet and dangles just below the face mask, so it can move freely when the helmet moves.

    Leg Pads

    These need to be the right length and thick enough to protect against hard slapshots. Wear pants and socks underneath leg pads to cover any exposed skin.

    Arm Pads & Chest Protector

    Arm pads should reach all the way to the wrist. Chest protectors should wrap slightly around the sides to keep your entire front well protected.

    Blocker Glove

    This glove should let your fingers grip the stick easily but be very thick and cover most of the forearm.

    Catcher Glove

    Similar to a first baseman’s glove in baseball, a catcher glove should have thick padding over the wrist and palm and should come well up the forearm.

    How Can I Stay Safe During Hockey Training & Games?

    Before starting the season, you should get a sports physical. Your doctor can check for any health problems and talk about sports safety. Most schools won’t let athletes play unless they’ve had a sports physical during the past year. And being in good shape can help players avoid injuries.

    It’s important to get comfortable on the ice before you learn hockey skills. It can help to take skating lessons and practice how to stop, turn, fall, and get up from a fall. It’s also helpful to know how to skate backward and stop and turn while skating backward.

    To stay safe, you should:

    • Always warm up and stretch before practice and matches.
    • Follow the rules and use proper techniques. Learn how to collide with the boards safely and not with your head. This helps to prevent spinal injuries.
    • Make sure your coach will be at all practices and games and will enforce all league safety rules.
    • In general, never hit another player on the head, never check from behind, and never use the stick as a weapon.
    • Stop playing if you feel pain or get hurt. Get checked by an athletic trainer, a coach, a doctor, or a nurse before going back on the rink.
    • Know the symptoms of a concussion, like a headache, dizziness, or confusion. If you hit your head or don’t feel well, tell your trainer or coach right away. Follow return-to-play guidelines.
    • Stay hydrated by drinking plenty of liquids before, during, and after games and practices.
    • Know the team plan for emergencies.

    What Else Should I Know?

    Follow your coach’s safe, fair play rules at practices and games. Be respectful of the referees and don’t argue with their calls. Stay calm if an opposing player does something you disagree with. Don’t take it personally or start a fight — let the referees handle it.

    It can help to play different sports throughout the year to prevent repetitive stress injuries (overuse injuries). These injuries happen when someone trains too much or makes the same motions over and over.

    Safety in Other Sports

    Safety matters whether you’re playing hockey or doing another athletic activity. To help prevent injuries in other sports, check out these articles:

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  • Autoinflammatory diseases: MedlinePlus Medical Encyclopedia

    Autoinflammatory diseases: MedlinePlus Medical Encyclopedia

    SAIDs occur due to a defect in the immune system. This may be due to a genetic mutation, or there may not be a clear cause. Environmental factors may trigger the response in some people.

    Your immune system protects you by detecting and fighting harmful substances in the body. These include bacteria, viruses, fungi, chemicals, toxins, and foreign particles (such as a splinter).

    Your immune system involves:

    • Innate immunity — this is the protection you were born with. Innate immunity involves barriers that keep harmful materials from entering your body. Examples include your skin, stomach acid, and mucus. This is the first line of defense against invaders.
    • Adaptive immunity — this is the protection you gain as your body learns over time which substances are harmful. Your immune system builds a defense against that specific substance. Vaccines work by training your adaptive immunity to recognize harmful invaders, for example flu viruses, and attacking them.

    SAIDs occur due to an abnormal reaction of innate immunity. Autoimmune diseases occur due to an abnormal reaction of
    adaptive immunity.

    When innate immunity is activated, it triggers your immune response. Certain chemicals in the body are released at the infection or injury site causing signs of inflammation, including redness, heat, pain, and swelling. Inflammation is part of the body’s self-healing process. As you recover from your illness or injury, inflammation goes away.

    SAIDs occur when innate immunity is activated without a clear cause. This may cause inflammation to occur in excess or to last for long periods of time. Excess inflammation can damage healthy tissues in the skin, bones, eyes, liver, heart, or kidneys.

    The defective MEFV gene responsible for the most common autoinflammatory disease, familial Mediterranean fever (FMF), was first identified in 1997. Since then, many SAIDs have been identified. Not all have a clear genetic cause.

    There are more than 50 SAIDs, including:

    • Familial Mediterranean fever (FMF)
    • Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
    • Cryopyrin-associated periodic syndromes (CAPS)
    • Hyperimmunoglobulinemia D with periodic fever syndrome (HIDS)
    • Aicardi-Goutières syndrome
    • Blau syndrome
    • Adult Still disease
    • Hereditary angioedema
    • Behçet disease

    Each SAID affects people differently. Some occur for a few years and never return. Some last a life-time and need ongoing
    management.

    SAIDs can be passed down in families. So if your parent or siblings have an SAID, you are more at risk for also developing it.

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  • Treatment of Cardiac Arrest | American Heart Association

    Treatment of Cardiac Arrest | American Heart Association

    Cardiac arrest can strike without warning. Do you suspect someone is experiencing cardiac arrest? The signs are:

    • Sudden loss of responsiveness – The person doesn’t respond, even if you tap them hard on the shoulders or ask loudly if they’re OK. The person doesn’t move, speak, blink or otherwise react.
    • No normal breathing – The person isn’t breathing or is only gasping for air.

    What to do

    If you think the person may be suffering cardiac arrest and you’re a trained lay rescuer:

    • Ensure scene safety.
    • Check for responsiveness.
    • Shout for help. Tell someone nearby to call 911 or your emergency response number. Ask that person or another lay responder to bring you an AED (automated external defibrillator) if there’s one on hand. Tell them to hurry. Time is critical. If you’re alone with an adult who has signs of cardiac arrest, call 911 and get an AED (if one is available).
    • Check for no breathing or only gasping. If the person isn’t breathing or is only gasping, begin CPR with compressions.
    • Administer CPR. Push down at least two inches in the center of the chest at a rate of 100 to 120 pushes a minute. Allow the chest to return to its normal position after each push.
    • Use an AED. As soon as it arrives, turn it on and follow the prompts.
    • Continue CPR. Administer it until the person starts to breathe or move, or until someone with more advanced training, such as an EMS team member, takes over.

    What treatment will I receive in the hospital?

    Tests will be done to assess your condition. The test results can help the health care team decide on a treatment plan to reduce your risk of long-term health problems and death.

    Your health care team will closely monitor your heart. They will also focus on preventing organ damage, especially to your brain.

    You may receive one or more of the following treatments:

    • Targeted temperature management (TTM) is a treatment to lower the body temperature to help protect the brain. Cooling blankets, cooling helmets, ice packs or other cooling methods may be used.
    • Oxygen therapy helps you get enough oxygen so your organs continue to work as you are recovering.
    • Extracorporeal membrane oxygenation (ECMO) treatment pumps your blood through an artificial lung. It adds oxygen and removes carbon dioxide from your blood before returning it to your body. The ECMO takes the stress off your lungs and heart to promote healing.

    What other tests and treatments may I receive?

    Your health care team will try to find out what caused your cardiac arrest. Some tests you may have include:

    If you are diagnosed with coronary heart disease, treatment may include:

    These treatments help restore blood flow through narrowed or blocked coronary arteries.

    Genetic testing may be recommended for you and your blood relatives. This testing is done because some conditions that can increase the risk of cardiac arrest run in families.

    It’s important to find out what caused your cardiac arrest. It’s also important for your family members to find out if they may be at risk of cardiac arrest due to an inherited condition or a gene that puts them at greater risk for one.

    Am I at risk of another cardiac arrest?

    If you’ve had one cardiac arrest, you may be at risk of another.

    Your health care team may advise that you get an implantable cardioverter defibrillator (ICD). This may happen during your hospital stay or shortly after. Or you may be asked to wear an external cardiac defibrillator. Either can save your life by providing a low-energy shock to your heart to restore a normal heart rhythm if ventricular fibrillation or tachycardia occurs.

    People with an ICD have some restrictions, though many can resume their normal activities.

    How do I live with an ICD?

    ICD batteries usually last four to seven years. Your health care professional should check them every three to six months.

    Talk to your health care team about your activities. Ask them what you can and can’t do. Also ask which types of machines or equipment you should avoid. Those with magnets and strong electrical fields may interfere with your ICD’s operation.

    You should also:

    • Tell airport security guards that you have an ICD. Ask them not to use handheld metal detectors on you.
    • Tell your other health care professionals, including your dentist, that you have an ICD.
    • Tell the doctors and nurses that you have one anytime you go to the hospital.
    • Always carry a card with the details about your ICD and emergency contact information so others know that you have one in case of a medical emergency.

    What if I’m anxious about living with my ICD?

    It’s common for people to feel anxious or depressed, especially in the first months or year after they get their ICD. You need to know that you are not alone or without support. If you have these feelings, talk with your health care team and get help.

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  • Health Information Privacy: HIPAA for Individuals

    Health Information Privacy: HIPAA for Individuals

    Source: Department of Health and Human Services, Office for Civil Rights
    Related MedlinePlus Pages: Personal Health Records

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  • Research | HHS.gov

    Research | HHS.gov

    45 CFR 164.501, 164.508, 164.512(i) (See also 45 CFR 164.514(e), 164.528, 164.532)  (Download a copy in PDF)

    Background

    The HIPAA Privacy Rule establishes the conditions under which protected health information may be used or disclosed by covered entities for research purposes. Research is defined in the Privacy Rule as, “a systematic investigation, including research development, testing, and evaluation, designed to develop or contribute to generalizable knowledge.” See 45 CFR 164.501.  A covered entity may always use or disclose for research purposes health information which has been de-identified (in accordance with 45 CFR 164.502(d), and 164.514(a)-(c) of the Rule) without regard to the provisions below.

    The Privacy Rule also defines the means by which individuals will be informed of uses and disclosures of their medical information for research purposes, and their rights to access information about them held by covered entities. Where research is concerned, the Privacy Rule protects the privacy of individually identifiable health information, while at the same time ensuring that researchers continue to have access to medical information necessary to conduct vital research. Currently, most research involving human subjects operates under the Common Rule (45 CFR Part 46, Subpart A) and/or the Food and Drug Administration’s (FDA) human subject protection regulations (21 CFR Parts 50 and 56), which have some provisions that are similar to, but separate from, the Privacy Rule’s provisions for research. These human subject protection regulations, which apply to most Federally-funded and to some privately funded research, include protections to help ensure the privacy of subjects and the confidentiality of information. The Privacy Rule builds upon these existing Federal protections. More importantly, the Privacy Rule creates equal standards of privacy protection for research governed by the existing Federal human subject regulations and research that is not. 

    How the Rule Works 

    In the course of conducting research, researchers may obtain, create, use, and/or disclose individually identifiable health information. Under the Privacy Rule, covered entities are permitted to use and disclose protected health information for research with individual authorization, or without individual authorization under limited circumstances set forth in the Privacy Rule. Research Use/Disclosure Without Authorization. To use or disclose protected health information without authorization by the research participant, a covered entity must obtain one of the following: 

    • Documented Institutional Review Board (IRB) or Privacy Board Approval. Documentation that an alteration or waiver of research participants’ authorization for use/disclosure of information about them for research purposes has been approved by an IRB or a Privacy Board. See 45 CFR 164.512(i)(1)(i). This provision of the Privacy Rule might be used, for example, to conduct records research, when researchers are unable to use de-identified information, and the research could not practicably be conducted if research participants’ authorization were required. A covered entity may use or disclose protected health information for research purposes pursuant to a waiver of authorization by an IRB or Privacy Board, provided it has obtained documentation of all of the following:
      • Identification of the IRB or Privacy Board and the date on which the alteration or waiver of authorization was approved; 
      • A statement that the IRB or Privacy Board has determined that the alteration or waiver of authorization, in whole or in part, satisfies the three criteria in the Rule; 
      • A brief description of the protected health information for which use or access has been determined to be necessary by the IRB or Privacy Board;
      • A statement that the alteration or waiver of authorization has been reviewed and approved under either normal or expedited review procedures; and 
      • The signature of the chair or other member, as designated by the chair, of the IRB or the Privacy Board, as applicable. 

    The following three criteria must be satisfied for an IRB or Privacy Board to approve a waiver of authorization under the Privacy Rule: 

    1. The use or disclosure of protected health information involves no more than a minimal risk to the privacy of individuals, based on, at least, the presence of the following elements:
      • an adequate plan to protect the identifiers from improper use and disclosure; 
      • an adequate plan to destroy the identifiers at the earliest opportunity consistent with conduct of the research, unless there is a health or research justification for retaining the identifiers or such retention is otherwise required by law; and 
      • adequate written assurances that the protected health information will not be reused or disclosed to any other person or entity, except as required by law, for authorized oversight of the research project, or for other research for which the use or disclosure of protected health information would be permitted by this subpart; 
    2. The research could not practicably be conducted without the waiver or alteration; and 
    3. The research could not practicably be conducted without access to and use of the protected health information. 
    • Preparatory to Research. Representations from the researcher, either in writing or orally, that the use or disclosure of the protected health information is solely to prepare a research protocol or for similar purposes preparatory to research, that the researcher will not remove any protected health information from the covered entity, and representation that protected health information for which access is sought is necessary for the research purpose. See 45 CFR 164.512(i)(1)(ii). This provision might be used, for example, to design a research study or to assess the feasibility of conducting a study.  The Privacy Rule does not prohibit a covered entity’s granting remote access to PHI to a researcher for activities that qualify as reviews preparatory to research, provided reasonable and appropriate safeguards are in place, as described in OCR’s guidance, Remote Access to PHI for Activities Preparatory to Research.
    • Research on Protected Health Information of Decedents. Representations from the researcher, either in writing or orally, that the use or disclosure being sought is solely for research on the protected health information of decedents, that the protected health information being sought is necessary for the research, and, at the request of the covered entity, documentation of the death of the individuals about whom information is being sought. See 45 CFR 164.512(i)(1)(iii). 
    • Limited Data Sets with a Data Use Agreement. A data use agreement entered into by both the covered entity and the researcher, pursuant to which the covered entity may disclose a limited data set to the researcher for research, public health, or health care operations. See 45 CFR 164.514(e). A limited data set excludes specified direct identifiers of the individual or of relatives, employers, or household members of the individual. The data use agreement must:
      • Establish the permitted uses and disclosures of the limited data set by the recipient, consistent with the purposes of the research, and which may not include any use or disclosure that would violate the Rule if done by the covered entity; 
      • Limit who can use or receive the data; and 
      • Require the recipient to agree to the following:
        • Not to use or disclose the information other than as permitted by the data use agreement or as otherwise required by law; 
        • Use appropriate safeguards to prevent the use or disclosure of the information other than as provided for in the data use agreement; 
        • Report to the covered entity any use or disclosure of the information not provided for by the data use agreement of which the recipient becomes aware; 
        • Ensure that any agents, including a subcontractor, to whom the recipient provides the limited data set agrees to the same restrictions and conditions that apply to the recipient with respect to the limited data set; and
        • Not to identify the information or contact the individual. 
    • Research Use/Disclosure With Individual Authorization. The Privacy Rule also permits covered entities to use or disclose protected health information for research purposes when a research participant authorizes the use or disclosure of information about him or herself. Today, for example, a research participant’s authorization will typically be sought for most clinical trials and some records research. In this case, documentation of IRB or Privacy Board approval of a waiver of authorization is not required for the use or disclosure of protected health information. To use or disclose protected health information with authorization by the research participant, the covered entity must obtain an authorization that satisfies the requirements of 45 CFR 164.508. The Privacy Rule has a general set of authorization requirements that apply to all uses and disclosures, including those for research purposes. However, several special provisions apply to research authorizations:
      • Unlike other authorizations, an authorization for a research purpose may state that the authorization does not expire, that there is no expiration date or event, or that the authorization continues until the “end of the research study”.
      • An authorization for the use or disclosure of protected health information for a research study may be combined with a consent to participate in the research, or with any other legal permission related to the research study.
      • An authorization for the use or disclosure of protected health information for a research study may be combined with an authorization for a different research activity, provided that, if research-related treatment is conditioned on the provision of one of the authorizations, such as in the context of a clinical trial, then the compound authorization must clearly differentiate between the conditioned and unconditioned components and provide the individual with an opportunity to opt in to the unconditioned research activity.
      • An authorization may be obtained from an individual for uses and disclosures of protected health information for future research purposes, so long as the authorization adequately describes the future research such that it would be reasonable for the individual to expect that his or her protected health information could be used or disclosed for the future research purposes.
      • New Guidance on HIPAA and individual authorization of uses and disclosures of protected health information for research.  This guidance explains certain requirements for an authorization to use or disclose PHI for future research.  The guidance also clarifies aspects of the individual’s right to revoke an authorization for research uses and disclosures of PHI.
    • Accounting for Research Disclosures. In general, the Privacy Rule gives individuals the right to receive an accounting of certain disclosures of protected health information made by a covered entity. See 45 CFR 164.528. This accounting must include disclosures of protected health information that occurred during the six years prior to the individual’s request for an accounting, or since the applicable compliance date (whichever is sooner), and must include specified information regarding each disclosure. A more general accounting is permitted for subsequent multiple disclosures to the same person or entity for a single purpose. See 45 CFR 164.528(b)(3). Among the types of disclosures that are exempt from this accounting requirement are:
      • Research disclosures made pursuant to an individual’s authorization; 
      • Disclosures of the limited data set to researchers with a data use agreement under 45 CFR 164.514(e). 

    In addition, for disclosures of protected health information for research purposes without the individual’s authorization pursuant to 45 CFR164.512(i), and that involve at least 50 records, the Privacy Rule allows for a simplified accounting of such disclosures by covered entities. Under this simplified accounting provision, covered entities may provide individuals with a list of all protocols for which the patient’s protected health information may have been disclosed under 45 CFR 164.512(i), as well as the researcher’s name and contact information. Other requirements related to this simplified accounting provision are found in 45 CFR 164.528(b)(4). 

    Transition Provisions. Under the Privacy Rule, a covered entity may use and disclose protected health information that was created or received for research, either before or after the applicable compliance date, if the covered entity obtained any one of the following prior to the compliance date

    • An authorization or other express legal permission from an individual to use or disclose protected health information for the research; 
    • The informed consent of the individual to participate in the research; 
    • A waiver of authorization approved by either an IRB or a privacy board (in accordance with 45 CFR  164.512(i)(1)(i)); or
    • A waiver of informed consent by an IRB in accordance with the Common Rule or an exception under FDA’s human subject protection regulations at 21 CFR 50.24. However, if a waiver of informed consent was obtained prior to the compliance date, but informed consent is subsequently sought after the compliance date, the covered entity must obtain the individual’s authorization as required at 45 CFR 164.508. For example, if there was a temporary waiver of informed consent for emergency research under the FDA’s human subject protection regulations, and informed consent was later sought after the compliance date, individual authorization would be required before the covered entity could use or disclose protected health information for the research after the waiver of informed consent was no longer valid. The Privacy Rule allows covered entities to rely on such express legal permission, informed consent, or waiver of authorization of informed consent, which they create or receive before the applicable compliance date, to use and disclose protected health information for specific research studies, as well as for future unspecified research that may be included in such permission.

    OCR HIPAA Privacy
    December 3, 2002 Revised December 18, 2017

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    Other HIPAA and Research Resources

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  • Childhood MEN1 Syndrome – NCI

    Childhood MEN1 Syndrome – NCI

    Causes of childhood MEN1 syndrome 

    MEN1 syndrome is an inherited disorder, meaning it is caused by an inherited, harmful genetic change (also called pathogenic variant or mutation) in the MEN1 gene. In most families, this mutation is inherited from a parent. In some cases, the mutation in the MEN1 gene appears for the first time in the child. Most cases of MEN1 syndrome are caused by a mutation in the MEN1 gene. Learn more about how cancer develops at What Is Cancer? 

    Genetic counseling for children who may have MEN1 syndrome

    It may not be clear from the family medical history whether your child has MEN1 syndrome. Genetic counseling before genetic testing can help assess your child’s risk of having a gene change that caused your child’s tumor and whether genetic testing is needed. Genetic counselors and other specially trained health professionals can discuss your child’s diagnosis and your family’s medical history to understand: 

    • the options for testing for the MEN1 gene or for other genes that may increase the risk of endocrine tumors
    • the risk of endocrine tumors for your child and their siblings
    • the risks and benefits of learning genetic information 

    Genetic counselors can also help you cope with your child’s genetic test results, including how to discuss the results with family members. They can advise you about whether other members of your family should receive genetic testing. 

    Learn more about genetic testing at Genetic Testing for Inherited Cancer Risk

    Symptoms of tumors caused by childhood MEN1 syndrome

    Tumors in the parathyroid gland, pituitary gland, or islet cells in the pancreas may make extra hormones. The signs and symptoms of disease depend on the type of hormone made by the tumor. It’s important to check with your child’s doctor if your child has any of the symptoms below. 

    The most common condition associated with MEN1 syndrome is hyperparathyroidism (a condition in which the parathyroid gland makes too much parathyroid hormone). Symptoms of hyperparathyroidism include: 

    • bone pain
    • kidney stone
    • weakness or tiredness
    • weight loss
    • nausea and vomiting
    • increased thirst
    • increased urination
    • constipation 

    There are other conditions associated with MEN1 syndrome. The conditions and symptoms include: 

    Sometimes children with MEN1 syndrome do not have any symptoms. If your child has symptoms, they may be caused by problems other than MEN1 syndrome. The only way to know is to see your child’s doctor. 

    Tests to diagnose tumors caused by MEN1 syndrome

    If your child has symptoms that suggest MEN1 syndrome, their doctor will need to find out if these are due to this syndrome or to another problem. The doctor will ask when the symptoms started and how often your child has been having them. They will also ask about your child’s personal and family medical history and do a physical exam. Depending on these results, they may recommend other tests. If your child is diagnosed with MEN1 syndrome, the results of these tests will help you and your child’s doctor plan treatment. 

    A diagnosis is made when a MEN1 mutation is found or when tumors are found in two of the following glands or organs: parathyroid gland, pituitary gland, or islet cells in the pancreas. 

    The tests used to diagnose a mutation in the MEN1 gene or tumors caused by MEN1 syndrome may include: 

    Lab tests

    • Blood chemistry study measures the amounts of certain substances released into the blood by organs and tissues in the body. An unusual amount of a substance can be a sign of disease.
    • Blood hormone study measures the amounts of certain hormones released into the blood by organs and tissues in the body. An unusual amount of a substance can be a sign of disease in the organ or tissue that makes it. The blood may also be checked for high levels of the hormone calcitonin or parathyroid hormone (PTH).
    • 24-hour urine test is used to diagnose neuroendocrine tumors, such as pheochromocytoma. Urine is collected for 24 hours to measure the amounts of a group of hormones called catecholamines in the urine. Substances caused by the breakdown of catecholamines are also measured. An unusual amount of a substance can be a sign of disease in the organ or tissue that makes it. Higher-than-normal amounts may be a sign of pheochromocytoma.
    • Venous sampling for an overactive parathyroid gland is a procedure in which a sample of blood is taken from veins near the parathyroid glands. The sample is checked to measure the amount of parathyroid hormone released into the blood by each gland. Venous sampling may be done if blood tests show there is an overactive parathyroid gland but imaging tests don’t show which one it is.
    • Genetic testing analyzes cells or tissue to look for changes in genes or chromosomes. These changes may be a sign that a person has or is at risk of having a specific disease or condition. To diagnose MEN1 syndrome, a sample of blood or saliva is checked for the MEN1 gene. 

    Imaging tests

    • Ultrasound exam uses high-energy sound waves (ultrasound) that bounce off internal tissues or organs and make echoes. The echoes form a picture of body tissues called a sonogram.
    • MRI uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the body. This procedure is also called nuclear magnetic resonance imaging (NMRI).
    • CT scan (CAT scan) uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-D views of tissues and organs. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography. Learn more about Computed Tomography (CT) Scans and Cancer.
    • Sestamibi scan is a type of radionuclide scan used to find an overactive parathyroid gland. A very small amount of a radioactive substance called technetium 99 is injected into a vein and travels through the bloodstream to the parathyroid gland. The radioactive substance will collect in the overactive gland and show up brightly on the special camera that detects radioactivity.
    • PET scan (positron emission tomography scan) uses a small amount of radioactive sugar that is injected into a vein. Then the PET scanner rotates around the body to make detailed, computerized pictures of areas inside the body where the glucose is taken up. Because cancer cells often take up more glucose than normal cells, the pictures can be used to find cancer cells in the body.
    • Somatostatin receptor scintigraphy is a type of radionuclide scan that may be used to find tumors. A very small amount of radioactive octreotide (a hormone that attaches to tumors) is injected into a vein and travels through the blood. The radioactive octreotide attaches to the tumor and a special camera that detects radioactivity is used to show whether there are islet cell tumors in the pancreas. This procedure is also called octreotide scan and SRS.
    • MIBG scan is used to find neuroendocrine tumors, such as pheochromocytoma. A very small amount of a substance called radioactive MIBG is injected into a vein and travels through the bloodstream. Neuroendocrine tumor cells take up the radioactive MIBG and are detected by a scanner. Scans may be taken over 1–3 days. An iodine solution may be given before or during the test to keep the thyroid gland from absorbing too much of the MIBG. 

    Biopsy

    A biopsy is a procedure in which a sample of tissue is removed from the tumor so that a pathologist can view it under a microscope to check for signs of cancer. The following biopsies are used: 

    • Fine-needle aspiration biopsy is a procedure in which tissue is removed using a thin needle.
    • Surgical biopsy is the removal of tissue during surgery. 

    Getting a second opinion

    You may want to get a second opinion to confirm your child’s MEN1 diagnosis and treatment plan. If you seek a second opinion, you will need to get medical test results and reports from the first doctor to share with the second doctor. The second doctor will review the genetic test report, pathology report, slides, and scans. They may agree with the first doctor, suggest changes to the treatment plan, or provide more information about your child’s condition. 

    To learn more about choosing a doctor and getting a second opinion, visit Finding Cancer Care. You can contact NCI’s Cancer Information Service via chat, email, or phone (both in English and Spanish) for help finding a doctor or hospital that can provide a second opinion. For questions you might want to ask at your child’s appointments, visit Questions to Ask Your Doctor About Cancer

    Cancer surveillance for children with MEN1 syndrome

    Surveillance is closely following a child’s condition without giving any treatment unless there are changes in test results. Children diagnosed with MEN1 syndrome will be checked for signs of cancer starting at age 5 years and will continue to be checked throughout life. Talk with your child’s doctor about the tests and procedures needed to check for signs of cancer and how often they should be done.

    Who treats children with tumors caused by MEN1 syndrome?

    A pediatric oncologist, a doctor who specializes in treating children with cancer, oversees treatment for children with tumors caused by MEN1 syndrome. The pediatric oncologist works with other health care providers who are experts in treating children with cancer and who specialize in certain areas of medicine. Other specialists may include: 

    Treatment of children with tumors caused by MEN1 syndrome

    There are different types of treatment for children and adolescents with tumors caused by MEN1 syndrome. You and your child’s cancer care team will work together to decide treatment. Many factors will be considered, such as your child’s overall health and whether the cancer is newly diagnosed or has come back. 

    Your child’s treatment plan will include information about the tumor, the goals of treatment, treatment options, and the possible side effects. It will be helpful to talk with your child’s cancer care team before treatment begins about what to expect. For help every step of the way, see our booklet, Children with Cancer: A Guide for Parents

    Surgery may be used to treat hyperparathyroidism, which is the most common sign of MEN1 syndrome. Children with MEN1 syndrome and primary hyperthyroidism may have surgery to remove at least three parathyroid glands and the thymus. Treatment is also given for pancreatic islet cell and pituitary tumors, and other conditions linked to MEN1 syndrome as needed. 

    If the cancer comes back after treatment, your child’s doctor will talk with you about what to expect and possible next steps. There might be treatment options that may shrink the cancer or control its growth. If there are no treatments, your child can receive care to control symptoms from cancer so they can be as comfortable as possible. 

    Clinical trials

    For some children, joining a clinical trial may be an option. There are different types of clinical trials for childhood cancer. For example, a treatment trial tests new treatments or new ways of using current treatments. Supportive care and palliative care trials look at ways to improve quality of life, especially for those who have side effects from cancer and its treatment. 

    You can use the clinical trial search to find NCI-supported cancer clinical trials accepting participants. The search allows you to filter trials based on the type of cancer, your child’s age, and where the trials are being done. Clinical trials supported by other organizations can be found on the ClinicalTrials.gov website. 

    Learn more about clinical trials, including how to find and join one, at Cancer Clinical Trial Information for Patients and Caregivers

    Prognosis for children with tumors caused by MEN1 syndrome 

    If your child has been diagnosed with tumors caused by MEN1 syndrome, you likely have questions about how serious the cancer is and your child’s chances of survival. The likely outcome or course of a disease is called prognosis. The prognosis for MEN1 syndrome is usually good. However, your child’s cancer care team is in the best position to talk with you about your child’s prognosis. 

    Follow-up care

    As your child goes through treatment, they will have follow-up tests or check-ups. Some of the tests that were done to diagnose the cancer may be repeated to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests. 

    Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your child’s condition has changed or if the cancer has recurred (come back). 

    Coping with your child’s cancer

    When your child has a tumor, every member of the family needs support. Taking care of yourself during this difficult time is important. Reach out to your child’s treatment team and to people in your family and community for support. Learn more at Support for Families: Childhood Cancer

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  • Childhood MEN2 Syndrome – NCI

    Childhood MEN2 Syndrome – NCI

    There are different types of treatment for children and adolescents with tumors related to MEN2 syndrome. You and your child’s cancer team will work together to decide treatment. Many factors will be considered, such as your child’s overall health and whether the cancer is newly diagnosed or has come back. 

    Your child’s treatment plan will include information about the cancer, the goals of treatment, treatment options, and the possible side effects. It will be helpful to talk with your child’s cancer care team before treatment begins about what to expect. For help every step of the way, see our booklet, Children with Cancer: A Guide for Parents

    Types of treatment your child might have include: 

    Surgery

    Surgery may be done to remove the thyroid gland when a child has medullary thyroid cancer caused by MEN2 syndromes. The thyroid may also be removed to prevent medullary thyroid cancer from developing.

    Targeted therapy 

    Targeted therapy uses drugs or other substances to block the action of specific enzymes, proteins, or other molecules involved in the growth of tumor cells. 

    Selpercatinib and vandetanib are used to treat medullary thyroid cancer caused by MEN2 syndrome.

    Learn more about Targeted Therapy to Treat Cancer.

    Clinical trials

    For some children, joining a clinical trial may be an option. There are different types of clinical trials for childhood cancer. For example, a treatment trial tests new treatments or new ways of using current treatments. Supportive care and palliative care trials look at ways to improve quality of life, especially for those who have side effects from cancer and its treatment.

    You can use the clinical trial search to find NCI-supported cancer clinical trials accepting participants. The search allows you to filter trials based on the type of cancer, your child’s age, and where the trials are being done. Clinical trials supported by other organizations can be found on the ClinicalTrials.gov website.

    Learn more about clinical trials, including how to find and join one, at Cancer Clinical Trial Information for Patients and Caregivers.

    Treatment of tumors caused by childhood MEN2A syndrome

    There is an increased risk of medullary thyroid cancer, an aggressive form of thyroid cancer, in people with MEN2A syndrome. Children with MEN2A syndrome and certain changes in the RET gene usually have surgery to remove the thyroid before age 5 years to lessen the chance cancer will form or spread. Treatment is also given for pheochromocytoma and hyperparathyroidism as needed. 

    Treatment of medullary thyroid cancer in children who have MEN2A syndrome may include: 

    Treatment of tumors caused by childhood MEN2B syndrome

    There is an increased risk of medullary thyroid cancer, an aggressive form of thyroid cancer, in people with MEN2B syndrome. Infants with MEN2B syndrome and certain changes in the RET gene usually have surgery to remove the thyroid to lessen the chance cancer will form. Treatment is also given for pheochromocytoma and other conditions as needed. 

    Children with MEN2B syndrome who have medullary thyroid cancer may be treated with: 

    Treatment of recurrent tumors caused by childhood MEN2 syndrome

    If the cancer linked to MEN2 syndrome comes back after treatment, your child’s doctor will talk with you about what to expect and possible next steps. There might be treatment options that may shrink the cancer or control its growth. If there are no treatments, your child can receive care to control symptoms from cancer so they can be as comfortable as possible.

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  • Secondhand Tobacco Smoke (Environmental Tobacco Smoke) – Cancer-Causing Substances

    Secondhand Tobacco Smoke (Environmental Tobacco Smoke) – Cancer-Causing Substances

    What is secondhand tobacco smoke?

    Secondhand tobacco smoke is the combination of the smoke given off by a burning tobacco product and the smoke exhaled by a smoker. It is also called environmental tobacco smoke, involuntary smoke, and passive smoke.

    More than 7,000 chemicals have been identified in secondhand tobacco smoke. At least 69 of these chemicals are known to cause cancer, including arsenic, benzene, beryllium, chromium, and formaldehyde.

    How are people exposed to secondhand smoke?

    People can be exposed to secondhand smoke in homes, cars, the workplace, and public places. In the United States, the source of most secondhand smoke is from cigarettes, followed by pipes, cigars, and other tobacco products.

    Which cancers are associated with secondhand smoke?

    Inhaling secondhand smoke causes lung cancer in nonsmokers. Some research also suggests that secondhand smoke may increase the risk of breast cancer, nasal sinus cavity cancer, and nasopharyngeal cancer in adults and leukemia, lymphoma, and brain tumors in children, although more research is needed on this subject.

    How can exposures to nonsmokers be reduced?

    There is no safe level of exposure to secondhand smoke; even low levels of secondhand smoke can be harmful. In the United States, legislation has helped to reduce nonsmokers’ exposure to secondhand smoke. Federal law bans smoking on all domestic airline flights, nearly all flights between the United States and foreign destinations, interstate buses, and most trains. Smoking is also banned in most federally owned buildings. Many state and local governments have also passed laws prohibiting smoking in public facilities, such as schools, hospitals, and airports, as well as private workplaces, including restaurants and bars.

    Internationally, a growing number of nations require all workplaces, including bars and restaurants, to be smoke free.

    Selected References:

    • National Toxicology Program. Tobacco-Related Exposures, Report on Carcinogens, Fifteenth Edition. Triangle Park, NC: National Institute of Environmental Health and Safety, 2021. Also available online. Last accessed December 8, 2022.
    • Office on Smoking and Health. About Secondhand Smoke. Atlanta, GA: U.S. Centers for Disease Control and Prevention, 2024. Available online. Last accessed June 13, 2024.
    • U.S. Department of Health and Human Services. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2006.
    • U.S. Department of Health and Human Services. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014.

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  • Vaccine Basics | Vaccines & Immunizations

    Vaccine Basics | Vaccines & Immunizations

    Every vaccine ingredient serves a purpose

    To provide immunity

    We become immune to (or protected from) a disease when our bodies create specific antibodies to fight that disease. Vaccines contain ingredients that help your body build this immunity.

    To keep the vaccine safe and long-lasting

    Vaccines need to be safe and effective. Certain ingredients help keep vaccines safe from contamination and toxins. Others, like stabilizers, help vaccines stay effective for a long time.

    To make the vaccine more effective

    All vaccine ingredients help to make a vaccine as effective as possible, while being safe. Ingredients like aluminum salt help boost the body’s response to the vaccine.

    Ingredients found in some vaccines

    Stabilizers

    • Purpose: To keep the vaccine effective after manufacturing
    • Most commonly found in: Jell-O®, naturally in the body
    • Examples: Sugars, gelatin

    Adjuvants

    • Purpose: To help boost the body’s response to the vaccine
    • Most commonly found in: Drinking water, infant formula, and some health products such as antacids, buffered aspirin, and antiperspirants
    • Examples: Aluminum salts

    Residual inactivating ingredients

    • Purpose: To kill viruses or inactivate toxins during the manufacturing process
    • Most commonly found in: Naturally in the human body, fruit, household furnishings (carpets, upholstering)
    • Example: Formaldehyde

    Residual cell culture materials

    • Purpose: To grow enough of the virus or bacteria to make the vaccine
    • Most commonly found in: Eggs, and foods that contain eggs
    • Examples: Egg protein

    Residual antibiotics

    • Purpose: To prevent contamination by bacteria during the vaccine manufacturing process
    • Most commonly found in: Common antibiotics. Antibiotics that people are most likely to be allergic to—like penicillin—aren’t used in vaccines.
    • Examples: Neomycin, Kanamycin, Streptomycin

    Preservatives

    • Purpose: To prevent contamination
    • Most commonly found in: Some kinds of fish
    • Example: Thimerosal (only in multi-dose vials of flu vaccine)

    Most vaccines don’t contain any mercury

    Most vaccines do not have any mercury in them. However, multi-dose flu vaccines and one type of tetanus-diphtheria (Td) vaccine contain a small amount of thimerosal. Thimerosal contains a form of mercury (ethylmercury) that does not cause mercury poisoning and is safe for use in vaccines. Flu and Td vaccines are also available in thimerosal-free versions.

    Different types of vaccines work in different ways

    Vaccines can help protect against certain diseases by imitating an infection. This helps teach the immune system how to build immunity to fight off a future infection. Different vaccines provide immunity in different ways.

    Ingredients in specific vaccines

    The Food and Drug Administration (FDA), which is responsible for making sure vaccines are safe and effective, has information about all approved vaccines. Check out the below links to discover the different vaccine options and the various ingredients.

    Learn about the vaccines that are currently approved in the U.S. by the FDA to prevent different diseases.

    See approved vaccines

    Want to know more? Read about common vaccine ingredients from the FDA.

    Learn from the FDA

    Vaccine information for you and your family

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  • 5 Reasons It Is Important for Adults to Get Vaccinated | Adult Vaccines

    5 Reasons It Is Important for Adults to Get Vaccinated | Adult Vaccines

    1. Vaccines Have Saved Lives for Over 100 Years—But Serious Disease Is Still a Threat

    Vaccines have greatly reduced diseases that once routinely harmed or killed babies, children, and adults. People all over the world—including in the United States—still become seriously ill or even die from diseases that vaccines can help prevent. It is important that you stay up to date on recommended vaccines.

    A young man listens to a healthcare provider at a clinic.

    A healthcare professional discussing vaccines with a patient.

    The protection some vaccines provide can fade over time, and you might need additional vaccine doses (boosters) to maintain protection. For example, adults should receive a tetanus booster every 10 years to protect against infection from dirty wounds. Talk to your health care provider about vaccination to see whether you might have missed any vaccines or need a booster.

    2. Vaccines Are the Best Way to Protect Yourself and Your Loved Ones from Preventable Disease

    Did you know that vaccines are the best way to protect yourself from certain preventable diseases? Vaccines help your body create protective antibodies—proteins that help it fight off infections.

    Two adults sitting on a couch with a small child.

    Adult family members together with their child.

    By getting vaccinated, you can protect yourself and also avoid spreading preventable diseases to other people in your community. Some people cannot get certain vaccines because they are too young or too old or they have a weakened immune system or other serious health condition. Those people are less likely to catch a preventable disease when you and others around them are vaccinated against it. Help protect yourself and the people you love by staying up to date on recommended vaccinations.

    3. Vaccines Can Prevent Serious Illness

    Some vaccine-preventable diseases can have serious complications or even lead to later illnesses. For them, vaccination provides protection not only against the disease itself but also against the dangerous complications or consequences that it can bring. Some examples:

    An adult man smiling and pointing to his arm after getting his shot.

    An adult man showing his band-aid after getting a vaccine.

    • Seasonal influenza (flu) is a respiratory virus that sickens tens of millions of people every year in the United States. The annual flu vaccine helps you avoid infection and reduces your chances of being hospitalized or dying if you do become infected. Flu vaccine also protects you from flu-related pneumonia and flu-related heart attacks or stroke—complications that can affect anyone but are especially dangerous for persons with diabetes or chronic heart or lung conditions.
    • Hepatitis B is a serious, potentially deadly infection of the liver caused by the hepatitis B virus (HBV). There is no cure, but vaccination prevents HBV infection as well as the chronic liver damage and cancer that hepatitis B can cause.
    • Human papillomavirus (HPV) is a leading cause of cervical cancer and can cause other cancers in both women and men. HPV vaccine keeps you from being infected with the virus or passing it to others, protecting you and them from the immediate effects of the virus as well as from the various cancers it can trigger.

    4. The Vaccines You Receive Are Safe

    Vaccine safety is a high priority. CDC and other experts carefully review safety data before recommending any vaccine, then continually monitor vaccine safety after approval.

    Three adults standing together pointing at their post-vaccine arm band aids.

    Three young adults after getting their vaccines.

    Vaccines can have side effects, but most people experience only mild side effects—if any—after vaccination. The most common side effects are fever, tiredness, body aches, or redness, swelling, and tenderness where the shot was given. Mild reactions usually go away on their own within a few days. Serious or long-lasting side effects are extremely rare, and vaccine safety is continually monitored.

    5. Vaccines May Be Required

    Certain vaccines are required for school, work, travel, and more. Students, military personnel, and residents of rehabilitation or care centers must be vaccinated against diseases that circulate in close quarters. Health care workers and others whose job puts them at risk of catching and spreading preventable diseases need to be vaccinated against them.

    Six healthcare workers together in a room talking.

    A group of healthcare workers gather to share information.

    And, of course, vaccination is required before travel to many places around the world. Because vaccination protects you and those around you, vaccines can be required for everyday activities as well as for extraordinary situations. It is important that you stay up to date on recommended vaccinations.

    Resources

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