Tag: Survival

  • Cancer Survival and Medicinal Mushrooms

    Cancer Survival and Medicinal Mushrooms

    Did the five randomized controlled trials of reishi mushrooms in cancer patients show benefits in terms of tumor response rate, survival time, or quality of life?

    Can mushrooms be medicinal? Mushroom-based products make up a sizable chunk of the $50 billion supplement market. “This profitable trade provides a powerful incentive for companies to test the credulity of their customers and unsupported assertions have come to define the medical mushroom business.” For example, companies marketing herbal medicines “exploit references to studies on mice in their promotion of mushroom capsules and throat sprays for treating all kinds of ailments”—but we aren’t mice.

    It wouldn’t be surprising if mushrooms had some potent properties. After all, fungi are where we’ve gotten a number of drugs, not the least of which is penicillin, as well as the cholesterol-lowering drug lovastatin and the powerful immunosuppressant drug cyclosporin. Still don’t think a little mushroom can have pharmacological effects? Don’t forget they can produce some of our most powerful poisons, too, like the toxic Carolina false morel that looks rather toadstooly, while others, as you can see here and at 1:15 in my video Medicinal Mushrooms for Cancer Survival, have a more angelic look like the destroying angel—that is its actual name—and as little as a single teaspoon can cause a lingering, painful death.

    We should have respect for the pharmacological potential of mushrooms, but what can they do that’s good for us? Well, consuming shiitake mushrooms each day improves human immunity. Giving people just one or two dried shiitake mushrooms a day (about the weight-equivalent of five to ten fresh ones) for four weeks resulted in an increase in proliferation of gamma-delta T lymphocytes and doubled the proliferation of natural killer cells. Gamma-delta T cells act as a first line of immunological defense, and, even better, natural killer cells kill cancer. Shiitake mushrooms did all this while lowering markers of systemic inflammation.

    Oyster mushroom extracts don’t seem to work as well, but what we care about is whether mushrooms can actually affect cancer outcomes. Shiitakes have yet to show a cancer survival benefit, but what about reishi mushrooms, which have been used as a cancer treatment throughout Asia for centuries?

    What does the science say about reishi mushrooms for cancer treatment? A meta-analysis of five randomized controlled trials showed that patients who had been given reishi mushroom supplements along with chemotherapy and radiation were more likely to respond favorably,  compared to chemotherapy/radiotherapy on its own. Although adding a reishi mushroom extract improved tumor response rates, “the data failed to demonstrate a significant effect on tumour shrinkage when it was used alone,” without chemo and radiation. So, they aren’t recommended as a single treatment, but rather an adjunct treatment for patients with advanced cancer.

    “Response rate” just means the tumor shrinks. Do reishi mushrooms actually improve survival or quality of life? We don’t have convincing data suggesting reishi mushroom products improve survival, but those randomized to reishi were found to have “a relatively better quality of life after treatment than those in the control group.” That’s a win as far as I’m concerned.

    What about other mushrooms? Although whole shiitake mushrooms haven’t been put to the test for cancer yet, researchers have said that lentinan, a compound extracted from shiitakes, “completely inhibits” the growth of a certain kind of sarcoma in mice. But, in actuality, it only worked in one strain of mice and failed in nine others. So, are we more like the 90% of mouse strains in which it didn’t work? We need human trials—and we finally got them. There are data on nearly 10,000 cancer patients who have been treated with the shiitake mushroom extract injected right into their veins. What did the researchers find? We’ll find out next.

    Doctor’s Note

    Stay tuned for White Button Mushrooms for Prostate Cancer.

    Also check out Friday Favorites: Mushrooms for Prostate Cancer and Cancer Survival.

    For more on mushrooms, see Breast Cancer vs. Mushrooms and Is It Safe to Eat Raw Mushrooms?.



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  • New Hodgkin’s Lymphoma Treatment Boosts Fertility Preservation Without Sacrificing Survival

    New Hodgkin’s Lymphoma Treatment Boosts Fertility Preservation Without Sacrificing Survival

    Young adults diagnosed with advanced Hodgkin’s lymphoma may no longer have to choose between survival and future parenthood. A major international study, published in The Lancet Oncology, shows that a new chemotherapy regimen, BrECADD, significantly improves fertility outcomes compared to the long-used eBEACOPP protocol — without compromising recovery rates. Led by researchers from University Hospital Cologne and the German Hodgkin Study Group (GHSG), the findings are poised to shift standard treatment guidelines for younger patients hoping to have children after cancer.

    The results were published in The Lancet Oncology under the title “Fertility in patients with advanced-stage classic Hodgkin lymphoma treated with BrECADD versus eBEACOPP: a secondary analysis of the multicentre, randomised, parallel, open-label, phase 3 HD21 Trial.”

    A Fertility-Friendly Option for Young Cancer Patients

    Hodgkin’s lymphoma, a cancer of the lymphatic system, is one of the most common cancers affecting adolescents and young adults. While current therapies are effective in achieving remission, they often come at a high cost: permanent infertility, particularly for male patients.

    The HD21 trial compared two treatments: the standard eBEACOPP regimen and the newer, experimental BrECADD protocol. Among more than 1,500 participants across nine countries, those treated with BrECADD showed significantly better hormonal recovery three years after treatment.

    Specifically, 95% of women and 86% of men in the BrECADD group had regained normal hormone levels—compared to just 73% of women and 40% of men in the eBEACOPP group. The study also recorded higher numbers of pregnancies and births among those who received BrECADD.

    “For young adults with Hodgkin’s lymphoma, BrECADD offers a better chance at building a family after beating cancer—without compromising survival,” said Dr. Justin Ferdinandus, Study Physician with the GHSG and first author of the study. “It’s a win-win.”

    A New Standard of Care

    BrECADD is already being adopted as the new standard first-line treatment at University Hospital Cologne and has been integrated into the current Onkopedia guideline for treating Hodgkin’s lymphoma in patients who desire fertility preservation.

    “The HD21 study is fundamentally changing clinical practice,” said Dr. Karolin Behringer, Study Physician and senior author of the paper. “Our data clearly support BrECADD as the preferred option for younger patients—especially those who want children in the future.”

    The study tracked hormone recovery through blood serum levels of follicle-stimulating hormone (FSH), a key marker of fertility in both men and women. Researchers also collected data on actual pregnancies and live births, providing real-world evidence of BrECADD’s long-term benefits beyond the lab.

    Backed by Global Collaboration

    The HD21 trial was a randomized, phase III clinical study involving 233 medical centers in nine countries, encompassing patients up to age 60. The study was supported by Takeda Oncology and represents one of the most comprehensive efforts to evaluate fertility outcomes after cancer treatment.

    “This marks a pivotal moment in oncology and survivorship care,” said Dr. Ferdinandus. “We’re not just saving lives—we’re helping patients live the kind of life they dreamed about before cancer.”

    What This Means for Patients

    The findings are particularly meaningful for adolescent and young adult (AYA) cancer patients, who often face difficult decisions about fertility preservation at the time of diagnosis. With BrECADD, fewer may need to resort to invasive or costly fertility preservation procedures before starting treatment.

    For men especially, the study indicates a substantial increase in the likelihood of fathering biological children post-treatment—an area where eBEACOPP was notably limited.

    The researchers hope these findings will encourage oncologists worldwide to consider BrECADD as a frontline option for Hodgkin’s lymphoma in fertility-conscious patients.

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  • Compassion Is Key to Our Survival

    Compassion Is Key to Our Survival

    A fun fact about hummingbirds is that they are wary of loud noises. Barking dogs and loud music can scare the tiny creatures away because they don’t feel safe in noisy environments. People respond to unsafe environments like hummingbirds. We avoid situations that don’t feel safe, and when we find ourselves in one, we don’t stay long. But here’s where people differ from hummingbirds: safety issues can confuse us. Sometimes, we don’t recognize that the reason we’re uncomfortable is because we don’t feel safe, and other times we think we feel uncomfortable because we’re not safe, even though that’s not the reason.

    What do you need to be safe and take care of yourself ? The answer may not be as straightforward as it seems. Safety depends, at least in part, on whom you’re with, where you are, and how you feel. When I was in my twenties and thirties, living in New York City on my own, I regularly assessed whether riding the subway at a particular hour or in a certain neighborhood was safe. Later, living in Los Angeles with young children, I made a judgment call on whether their climbing on the high bars of a rickety jungle gym was safe. When they got older, I balanced their wish to be with friends against whether their driving a long distance at night was safe. As an empty nester, my focus shifted back to my husband Seth and me, and whether choices like getting a walk-up apartment rather than one in an elevator building made sense since our ability to climb stairs carrying luggage or groceries would change as we grew older. The answers to these questions hinged on physical safety and the odds of someone getting hurt.

    I don’t think about safety in such literal terms anymore. I now see safety as more nuanced and recognize the ways that my reactions spring from an evolutionary survival mechanism designed to keep me alive to pass my genes on to future generations, rather than critical thinking. We’re hardwired for survival. None of the ideas or takeaways I describe are scary. Still, some might carry you outside your comfort zone and trigger the survival mechanisms that run automatically when you’re in physical danger.

    When we feel safe, we’re in our comfort zones, where we perform well, set appropriate boundaries, rest, recharge, and reflect. It feels good when we’re in our comfort zones, but it’s not where we take risks or where much growth takes place. Development takes place when we’re on the far edge of our comfort zones, stretching existing skills and abilities. When a stretch is in reach, but we feel unsafe anyway, one of our innate survival mechanisms can switch into gear and shut us down. Then, a mechanism designed to protect us short-circuits our growth and gets in the way of reaching our goals. This tendency can be mitigated in several ways, but for now, I’ll mention one: kindness.

    As far back as Charles Darwin, scientists, philosophers, artists, and poets have drawn a straight line between our warmhearted urge to respond to suffering with kindness and the likelihood that we’ll survive, even thrive.

    As far back as Charles Darwin, scientists, philosophers, artists, and poets have drawn a straight line between our warmhearted urge to respond to suffering with kindness and the likelihood that we’ll survive, even thrive. To borrow from the preface of Dacher Keltner’s excellent book, Born to Be Good:[S]urvival of the kindest may be just as fitting a description of our origins as survival of the fittest.”

    Navigating Sorrow With Kindness

    I was introduced to the poem “Kindness” from Naomi Shihab Nye’s first poetry collection when I heard it recited by Jon Kabat-Zinn, the founder of Mindfulness-Based Stress Reduction (MBSR). Kabat-Zinn and his teaching partner Saki Santorelli (at the time, executive director of the Center for Mindfulness at the University of Massachusetts medical school) were international rock stars in the secular mindfulness world, and I was primed to listen. It was early morning, midway through a weeklong MBSR retreat/training in the late 1990s at the Mount Madonna retreat center in Northern California. Light streamed through the floor-to-ceiling windows in the meditation hall to backlight Kabat-Zinn, who was sitting cross-legged on a meditation cushion, up on a dais. The golden early morning light gave him and the entire session an otherworldly quality. He recited the poem from memory to a room full of meditators sitting around him in a semicircle, most of whom were also sitting cross-legged on cushions. One of the images in the poem stood out then and has remained with me since:

    You must wake up with sorrow.
    You must speak to it till your voice
    catches the thread of all sorrows
    and you see the size of the cloth.

    I’m struck by how often I’ve remembered this image of the enormity of sorrow in the world since I first heard it. The phrase has come back to me when someone I love has fallen ill or has died and when the loved ones of people close to me have struggled with illness or death. The size of the cloth hit me at an even greater level of magnitude as I watched news coverage of the Twin Towers coming down on 9/11 in New York City. The size of the cloth was almost unimaginable when I saw footage of the refrigerated trailers parked in front of hospitals in New York City functioning as temporary morgues during the early days of the pandemic. Maybe the theme of Shihab Nye’s poem that “it’s only kindness that makes sense anymore” resonated with me because it echoed rabbinic sage Hillel the Elder’s call to action: “If not now, when? If not me, who?”

    Discomfort is one way our bodies ask us to listen.

    Scientists have long suspected that kindness in response to other people’s pain is a survival mechanism that’s wired into our nervous systems. What’s often harder for people to remember is that kindness in response to our own sorrow is also a survival mechanism. For many of us, being kind to ourselves is more of a leap than being kind to others. It was for me. I thought kindness was the Golden Rule we teach young children—do unto others as you would have them do unto you. It didn’t occur to me to apply the Golden Rule to myself. I wanted to be a good mother, a good partner with Seth in providing for our family, and to make a difference in the world. I was one of the lucky ones and wanted to pay it forward. There was no room for me to take it easy. The harder I tried to do good and be good, the more of a toll it took on me. Still, it didn’t register that the pace at which I was working was unkind to my family and me. I had to burn myself out emotionally and physically a few times before I could internalize the commonsense truth that discomfort is one way our bodies ask us to listen. Just as it took me a while to develop a more nuanced stance toward safety, it took me time to adopt a more expansive idea of kindness that included being kind to myself.

    Exploring What Safety and Kindness Feel Like

    The following practices and activity-based takeaways are designed for you to integrate into daily life easily. Doing them shouldn’t be a heavy lift and tax you, but sometimes, mindfulness and meditation bring up big feelings that are painful to confront. Please be kind to yourself. Take a break if you feel overwhelmed or if discomfort becomes too much to manage easily. Time is your friend when it comes to inner discovery, and you have plenty of room to allow the process to unfold at its own pace.

    Practice: Reflect on What You Need to Feel Safe

    Identifying your safety needs and factoring them into your choices are a meaningful and effective way to be kind to yourself. Ask yourself, “What do I need to feel safe?” “Are my safety needs being met?” “How?” If they aren’t being met, “Why not?” Remember that whether you feel safe depends on various factors, including if you’re tired, hungry, or stressed. When safety and inclusion needs are unacknowledged and unmet, our nervous systems are ripe to become hijacked by one of our innate survival mechanisms.

    Reflecting on safety needs can seem like a waste of time. When you’re in your comfort zone, it’s easy to miss the point of looking at what it takes to feel safe. Here’s why you should do it anyway: If you identify your safety needs up front, while you’re in your comfort zone, you can better take care of yourself later when you are outside of it.

    1. Find a comfortable place where you won’t be interrupted. Close your eyes or softly gaze ahead or downward. 
    2. A few breaths later, listen for the loudest sound. When you are ready, listen for the quietest sound. Don’t chase a sound that’s hard to hear; relax and let it come to you. Let your mind be open and rest in the whole soundscape. 
    3. Ask yourself, “What does it take to feel safe and welcome in a new situation?” Hold the question in mind and listen to the answers that emerge. 
    4. When you’re ready, open your eyes if they are closed and jot down your insights. 
    5. Then, draw three concentric circles on a blank piece of paper. Prioritize your insights by writing the most important ones in the inner circle. Write those that are the least important in the outer circle. Write what’s left on your list in the circle in between. All your insights matter, but doublecheck to ensure the essential items are in the inner circle. 
    6. Review the diagram and consider ways to increase the odds that, in a new situation, you will feel safe and included.

    Takeaway: How might connecting with playfulness, attention, balance, and compassion help you feel safer and more welcome?

    Practice: Let Yourself Be Immersed in Self-Compassion

    Throughout our evolutionary history, humans have relied on kindness to survive. Strong social bonds, effective communication, and meaningful collaboration create a supportive external environment that allows us to thrive in diverse situations and overcome challenges. Similarly, we create a supportive internal environment when we are kind to ourselves, one where we become more emotionally resilient. Kindness is a self-reinforcing behavior. By being kind to ourselves, we can better support and care for those around us. By being kind to others, we build trust, strengthen relationships, and create a sense of social support and belonging that helps us cope with stress and navigate adversity.

    I first learned about the following self-compassion practice reading Zen priest Edward Espe Brown’s book No Recipe: Cooking as a Spiritual Practice where he writes: “[I]n the early ’80s, when Thich Nhat Hanh was giving a talk prior to departing from the San Francisco Zen Center where I was living, he said he had a goodbye present for us. We could, he said, open and use it anytime, and if we did not find it useful, we could simply set it aside. Then he proceeded to explain that, ‘As you inhale, let your heart fill with compassion, and as you exhale, pour the compassion over your head.’”

    1. Imagine you are in a sweltering but beautiful jungle, holding a coconut shell in one hand. Can you feel the rough shell against the palm of your hand? Picture a wooden barrel filled with cool rainwater on the ground next to you. Can you see your reflection in the sparkling water? 
    2. Imagine the rainwater is a nectar of compassion that soothes busy minds and big feelings. As you breathe in, imagine filling the coconut shell with compassionate rainwater. As you breathe out, imagine pouring the nectar of compassion over the crown of your head. 
    3. Let go of the images of the bucket and coconut shell to focus on sensation. Imagine what it would feel like for a nectar of compassion to wash over you and soothe your body from head to toe. 
    4. Starting at the crown of your head, feel the compassion rinse slowly over your face and head, then over your neck, shoulders, chest, upper arms, lower arms, and hands. 
    5. Move your attention to your torso and imagine feeling a nectar of compassion wash slowly over your torso, pelvis, upper legs, knees, lower legs, and feet. 
    6. When you’re ready, lightly rest your attention on your outbreath. If thoughts and emotions arise, don’t fight them. With no goal or purpose, allow your mind to be open and rest.

    Takeaway: Find at least one way to be kind to yourself today, then see if there’s a ripple effect.

    From Real-World Enlightenment: Discovering Ordinary Magic in Everyday Life by Susan Kaiser Greenland © 2024 by S. Greenland, Inc. Reprinted in arrangement with Shambhala Publications, Inc. Boulder, CO. www.shambhala.com



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