Tag: Side

  • On the Other Side of Sadness: Teaching Our Kids (and Ourselves) That It’s Okay to Feel Anything

    On the Other Side of Sadness: Teaching Our Kids (and Ourselves) That It’s Okay to Feel Anything

    My six-year-old daughter, Opal, wants nothing more than to go to the Humane Society to visit the dogs that “need the most love.” So we leave right from a half-day of school to do just that, eating almond butter and jelly sandwiches on the way.

    The entryway of the Boulder Valley Humane Society smells like wood chips. There is a stack of hamster cages by the front door, placed like intended impulse purchases, like Chapstick and breath mints at Target.

    “May I help you?” The pleasant lady behind the counter says with a mouth that is more gums than teeth.  I tell her we’d like to visit a dog or two that are especially in need of love.

    “Hmmm,” she says, thinking, with a close-mouthed smile. “Yes, Leo could use a visit. He’s big, that ok?”

    We have an 85-pound lab at home. I assure her we are accustomed to Big.

    We find Leo asleep on a bed in a very large crate with a bone-shaped sign marked “Sweetie pie.”  He is a five-year-old pit bull with a face as wide as a loaf of bread and fur the shade of sand. We return to the front room where we wait for a staff person to bring him out.

    I notice as we walk through the halls, many—but not all—of the dogs have the same bone-shaped signs hanging from their cages, but with all different descriptions: “Playful!” “Timid.” It occurs to me that the ones without the signs must not be as forthcoming in their nameable characteristics. In my mind I imagine hosting a party in the New Year where I’ll have each guest wear a little sign around their neck that states one of their prominent qualities: People pleaser. Observer. Perfectionist.

    Leo busts through the swinging doors, pulling a staff member behind him on a pink leash. This should be an indication of what we’re in for, but I grab the leash anyway and out the front doors we go. Walking this dog is essentially like walking a linebacker who is heading in the opposite direction. I desperately try to keep my footing while he pulls me down a muddy decline and we leave Opal behind, yelling MOM!

    Giving this dog love is proving to be an arduous task. So we start to head back towards the building where we came from.

    As we walk, I notice the fur is missing from the tops of both of Leo’s ears and there are chalky mushroom-shaped lumps on his skin where the hair should be growing. Same on the backs of his legs. There are pin stripes in his short fur where the hair doesn’t grow, much more subtle than the scars that would have come from the mouth or claws of another animals.

    Opal says, “Why does he look like that?”

    I tell her it looks like he’s been in a fight with another dog. Harmless enough—animals fight. I don’t say that it looks like he has probably been in dogfights. That he was likely rescued from a rough situation with either an abusive owner or an owner who condoned violence. The kind of scenario that gives pit bulls a bad name. He is horrid on a leash—left both of my hands red and burned from the yanking—but he doesn’t seem to have any fear of or aggression towards people. This, to me, is a marvel.

    Upon our return, we catch sight of a man playing with a pit bull puppy, smiling and laughing as the pup climbs into his lap then flops over the side. I can see that Opal wants that experience, so we give Leo a final head-scratch and then ask to trade him in for a puppy.

    The Discomfort, the Squirming Away, the Return to Presence

    We take one of seven pit bull puppies to a fenced-in area outside. The fresh air and the puppy-energy feel like a relief. He’s as small as a football and slick-black except for his belly and the tips of his paws, which are pure white. Watching him teeter and fumble from point A to point B is pure comedy. Opal is beside herself with delight.

    Then she asks the inevitable question: “Can we take him home?”

    I tell her no.  A puppy is way too much work. They poop and chew on everything. But we can come visit him next week.

    “What if he’s gone by then?”

    Opal doesn’t say much on the way home. “Blackbird” by the Beatles is playing on the radio—Take these broken wings and learn to fly. I can see her in the rear-view mirror gazing out the window with a million-mile stare.

    I tell her that if he’s gone, that would mean a good family adopted him. These puppies would probably get adopted really fast.

    Opal doesn’t say much on the way home. “Blackbird” by the Beatles is playing on the radio—Take these broken wings and learn to fly. I can see her in the rear-view mirror gazing out the window with a million-mile stare.

    At home, Opal drapes her body over my lap as we sit on the couch. Our huge lab is snoring at my feet. Opal is sniffling and periodically wipes her nose on her sleeve. I caress her hair.

    She says, “What if nobody wants to adopt Leo?” Plump little tears pool in the corners of her eyes.

    I tell Opal that maybe we shouldn’t return to the Humane Society if it’s just going to break her heart. But that only upsets her more and I quickly realize those words are counter to everything we’ve been teaching her.

    We—the Grimes family—have spent the better part of a year as a foster family. And we frequently talk about how we never need to shy away from big emotions, especially when they come as a repercussion of helping others. But it’s such a habit to either tense-up or cower in the face of unhappiness, and to want to shield others from the pain of being human.

    “Honey, the Humane Society will find a good home for Leo. And for the little puppy and all his brothers and sisters.”

    “But what if the man who adopts them is mean?”

    I know there are no shortcuts to getting to the other side of sadness aside from going through it.

    “Oh honey,” I say. I am constantly at odds with how much truth to share with her about this crazy, uncertain, often-terrifying-but-also-beautiful-and-miraculous world. I swing back and forth between feeling like I say too much, and not knowing what else to say.

    So I return to simply paying attention—to my own thoughts, my own discomfort, my own shallow breath, my own want to talk about happier things—because I know there are no shortcuts to getting to the other side of sadness aside from going through it.

    I ask, “Can you take a deep breath with me?”

    “Uh-huh.” She is looking up at me now as we inhale and exhale. Choppy, partial breaths at first, then calm and deep.

    “Hey, it’s okay to feel sadness, sweetie. Fact is, there is a lot of sadness in the world. We just keep doing what we can. And you did good today, giving love like you did.”

    It in that moment, she stands up, gathers herself, and flashes me a tiny but genuine smile as she moves on with her day.

    Realizing: It’s Okay to Feel My Own Sadness, Too

    Two days later, we take a trip to visit our beloved foster baby of nearly a year who returned to live with her parents three weeks earlier. This baby, we’ll call her Little Blue Eyes.

    I’m so pleased to find her looking happy and healthy, very connected to her mother. She has an adorable room with quilts on the walls, loads of toys and books. Their pit bull strangely resembles the one from the humane society, though he is exponentially more calm and civilized.

    I didn’t realize it, but many of my feelings of loss had been shuffled in with the hubbub of the holidays and travel. The grief is immediately present when I rest my gaze on her face and hear her say OpalOpalOpal.

    All good news. And yet, in spite of the fact that we will likely see her again, it feels as if this visit is a good-bye. Little Blue Eyes went home days before Christmas and I didn’t realize it, but many of my feelings of loss had been shuffled in with the hubbub of the holidays and travel. The grief is immediately present when I rest my gaze on her face and hear her say OpalOpalOpal.

    The sorrow feels like fatigue at first, then grumpy over-sensitivity during dinner. Then, later, after Opal is asleep, a torrent of tears comes like a valve has burst behind my eyes. I can’t stop it, though my first inclination is to do just that. My mindful self is telling me that crying is a natural and healthy reaction, and that I can relax with my sadness. But my body—bones and muscles—wants to make the discomfort go away. I am aware of all of this.

    I make my way into our bedroom where Jesse is watching TV. He sees my face and says, “Little Blue Eyes?”

    I think of how intense these emotions feel to me, a “big strong grown-up,” and I can only imagine how the same vast emotions must feel to my daughter, on the planet only six years and with much less experience in seeing her feelings through to the other side. It’s up to us to show her that emotions are fluid, always in flux.

    I nod and lie down next to him. I put my head on his chest the way Opal did with me a few days earlier. His heart is in my ear like a distant drum against my shifting breath. I think of how intense these emotions feel to me, a “big strong grown-up,” and I can only imagine how the same vast emotions must feel to my daughter, on the planet only six years and with much less experience in seeing her feelings through to the other side. It’s up to us to show her that emotions are fluid, always in flux.

    “It’s okay to feel sad,” Jesse says to me. “I feel sad, too.”

    These are the same words I spoke to Opal when we were on the couch, the same compassionate tone. I sit up and stretch my arms high and to the sides, the sound of inner-movement like a soft rumble deep in the canals of my ears. Some life re-enters my bones.

    Those words, “It’s okay to feel sad,” open a window in the tiny, claustrophobic room of emotion I am crouched in. And it isn’t so stifling anymore. This is what happens when I am mindful of not trying to manipulate, hide, or wrestle with my sadness. I can let it roam more freely until, naturally and eventually, it simply dissolves on the back of an unsuspecting outbreath.



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  • Does Berberine Help With Weight Loss? Benefits, Side Effects, and What You Need to Know

    Does Berberine Help With Weight Loss? Benefits, Side Effects, and What You Need to Know

    Berberine has become one of the most discussed natural compounds in the world of weight loss supplements. Many people use it for support with blood sugar balance, cholesterol levels, and body weight, especially when metabolic health is a concern.

    Interest in berberine weight loss continues to rise because it may work through several pathways tied to insulin sensitivity and energy regulation. While results are usually moderate, berberine may offer useful support when paired with nutrition, movement, and consistent habits.

    Berberine Benefits: Metabolic Effects Beyond Weight Reduction

    Many people first hear about berberine benefits because of weight management, but its potential effects go beyond the number on the scale. Berberine is often linked to activation of AMPK, an enzyme involved in cellular energy use, glucose metabolism, and fat oxidation.

    This may help improve blood sugar control, particularly for individuals dealing with insulin resistance or early metabolic dysfunction. Better glucose handling can also support appetite balance and lower energy crashes that make healthy eating harder. According to the Mayo Clinic, berberine has shown promise for lowering blood sugar and cholesterol levels, though more long-term research is still needed.

    Berberine may also support lipid health by helping reduce LDL cholesterol and triglycerides. Because of this, it is often discussed in relation to metabolic syndrome, where blood sugar, cholesterol, blood pressure, and abdominal weight gain occur together. Some early research also points toward anti-inflammatory effects. Since chronic inflammation can worsen obesity and insulin resistance, this may be another reason berberine remains popular in wellness circles.

    Berberine Weight Loss: Mechanisms, Dosage, and Clinical Results

    When discussing berberine weight loss, realistic expectations are important. It is not typically associated with rapid transformations, but some people may experience modest reductions in body weight over time. One reason is that berberine may improve insulin sensitivity, making it easier for the body to regulate stored energy and hunger signals. It may also influence gut bacteria involved in digestion and metabolism.

    Researchers have also explored whether berberine affects pathways related to satiety hormones and mechanisms similar to GLP-1 agonists. While it is not equivalent to prescription GLP-1 medications, overlapping appetite and glucose benefits are often discussed.

    Based on information from WebMD, berberine is commonly used in divided doses ranging from 900 mg to 1,500 mg daily, often taken with meals to improve tolerance. Most users need several weeks before noticeable changes occur. Results are generally stronger when combined with calorie awareness, exercise, sleep improvement, and consistent routines.

    Berberine Side Effects: Safety, Interactions, and Contraindications

    Understanding berberine side effects is essential before using it regularly. While many people tolerate it well, digestive complaints are the most common issue.These may include nausea, bloating, gas, diarrhea, constipation, or stomach discomfort. Starting with smaller doses and taking berberine with food may reduce these gastrointestinal issues.

    According to the National Center for Complementary and Integrative Health (NCCIH), supplements can interact with medications and should be used carefully, especially by people with chronic conditions or those taking prescriptions.Because berberine may lower blood sugar, people using diabetes medications should be cautious. Combining treatments without guidance could increase the risk of hypoglycemia.

    It may also affect how the body processes certain drugs, including blood thinners, some cholesterol medications, and immune-related prescriptions. Berberine is generally avoided during pregnancy and breastfeeding unless approved by a healthcare professional. Quality matters too. Choosing third-party tested brands may reduce risks related to contamination or inaccurate labeling.

    Berberine Daily Habits: How to Support Better Weight and Metabolic Results

    Many people focus only on the supplement itself, but daily habits strongly influence results. If you are using berberine, combining it with smart routines may improve both weight and metabolic outcomes.

    • Take Berberine With Meals: Taking berberine with food may help reduce gastrointestinal issues such as nausea, bloating, or stomach discomfort. It may also support a steadier blood sugar response after meals.
    • Prioritize Protein and Fiber: Meals rich in protein, vegetables, legumes, and whole grains can improve fullness and support berberine weight loss goals. This combination may also reduce cravings and overeating.
    • Stay Consistent With Movement: Walking, strength training, and regular exercise can improve insulin sensitivity. Pairing movement with berberine may enhance metabolic support.
    • Monitor Blood Sugar Changes: People using berberine for blood sugar control should watch for signs of low blood sugar, especially if taking diabetes medication. Tracking levels may help identify changes early.
    • Improve Sleep Quality: Poor sleep can increase hunger hormones and worsen insulin resistance. Better sleep habits may strengthen the overall effect of weight management supplements.
    • Stay Hydrated Daily: Good hydration supports digestion, energy levels, and workout performance. It may also help reduce constipation sometimes linked to supplements.
    • Review Progress Every Few Weeks: Check body weight, waist size, energy, and eating habits instead of expecting overnight changes. Sustainable progress is usually gradual and more realistic.
    • Use Medical Guidance if Needed: If you have diabetes, heart disease, or metabolic syndrome, speak with a healthcare professional before long-term use. Personalized guidance can improve both safety and results.

    Weight Management Supplements: Where Berberine Fits Best

    Among modern weight management supplements, berberine stands out because it focuses on metabolic pathways rather than stimulant effects. That may appeal to people who want support without the jittery feeling linked to some fat burners.

    Still, no supplement replaces the fundamentals. Nutrition quality, calorie balance, stress control, movement, and sleep remain the strongest drivers of sustainable progress.

    For people with obesity, diabetes, or advanced metabolic syndrome, medical treatment may be more effective than supplements alone. In those cases, professional care can help identify better options. Berberine is best viewed as one supportive tool, not the entire strategy.

    Smarter Berberine Results Through Lifestyle and Safety

    The strongest outcomes from berberine benefits usually happen when supplement use is paired with consistent daily habits. Better food choices, regular exercise, and healthy sleep patterns create the foundation for lasting metabolic improvement.

    For anyone considering berberine weight loss, patience and safety matter more than hype. With realistic expectations and proper guidance, berberine may play a useful role in a balanced long-term plan.

    Frequently Asked Questions

    1. How much weight can berberine help you lose?

    Results vary depending on diet, activity, and health status. Many people experience modest weight loss rather than dramatic changes. Some may lose a few pounds over several weeks. Consistency matters most.

    2. How long does berberine take to work?

    Some people notice appetite or digestion changes within a few weeks. Metabolic effects often take longer. Many studies examine results over two to three months. Individual responses can differ.

    3. Is berberine safer than prescription weight loss drugs?

    Not necessarily. Natural supplements can still cause side effects and drug interactions. Prescription medications are tested differently and may be more effective for certain people. Medical guidance helps compare options safely.

    4. Can I take berberine every day?

    Many users take it daily in divided doses. Long-term use should still be monitored, especially if medications are involved. Digestive tolerance may change over time. Ask a healthcare provider before regular use.



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  • Comparing GLP‑1 Injectable Weight‑Loss Meds, Semaglutide vs Tirzepatide, and Real Side Effects

    Comparing GLP‑1 Injectable Weight‑Loss Meds, Semaglutide vs Tirzepatide, and Real Side Effects

    The debate of Ozempic vs Mounjaro has become one of the most discussed topics in modern weight management. These injectable weight-loss meds, often referred to as GLP‑1 weight-loss drugs, have gained massive attention for their effectiveness in helping people lose significant weight while also improving blood sugar control.

    Both medications were initially developed to treat type 2 diabetes, but clinical results showing dramatic weight reductions sparked their evolution into tools for obesity management.

    While Ozempic and Mounjaro share some similarities, they differ in composition, mechanisms, and potential side effects. Understanding how each drug works and what distinguishes semaglutide vs tirzepatide can help individuals and clinicians make informed choices about treatment options.

    What Are GLP-1 Weight-Loss Drugs?

    GLP-1 receptor agonists are medications that mimic the natural hormone glucagon-like peptide-1 (GLP-1). This hormone helps regulate blood sugar and satiety by slowing down digestion, promoting insulin release, and reducing appetite. When administered as once-weekly injections, these drugs assist patients in feeling full longer and eating less.

    Ozempic (which contains semaglutide) and Mounjaro (which contains tirzepatide) are among the most well-known of this group. Other related drugs include Wegovy and Zepbound, versions approved specifically for weight management rather than diabetes.

    Ozempic vs Mounjaro: Key Differences

    When comparing Ozempic vs Mounjaro, the key difference lies in the drugs’ active ingredients and how they act on the body.

    • Ozempic (semaglutide) targets only the GLP‑1 receptor.
    • Mounjaro (tirzepatide), on the other hand, acts on both the GLP‑1 and GIP (glucose-dependent insulinotropic polypeptide) receptors.

    This dual mechanism allows Mounjaro to potentially offer stronger effects on both insulin control and appetite regulation. Some studies suggest that tirzepatide may lead to greater average weight loss than semaglutide, though long-term outcomes are still being studied.

    Both medications are injectable and typically used once a week. Ozempic has been FDA-approved for type 2 diabetes, while Wegovy (its higher-dose version) is approved for chronic weight management. Similarly, Mounjaro is FDA-approved for diabetes, while its twin drug Zepbound is approved for obesity.

    How Do Ozempic and Mounjaro Help You Lose Weight?

    The success of GLP‑1 weight-loss drugs such as Ozempic and Mounjaro comes down to appetite control and metabolic balance. These medications not only lower blood sugar but also trigger signals that make the body feel full sooner.

    GLP‑1 and GIP hormones play a critical role in sending satiety messages to the brain. By mimicking these hormones, semaglutide and tirzepatide slow gastric emptying (the speed at which food leaves the stomach). As a result, people consume fewer calories without feeling deprived.

    In clinical trials, individuals using semaglutide reported an average weight loss of around 15% of their body weight over 68 weeks, while tirzepatide users experienced reductions as high as 20% in some studies. These results position injectable weight-loss meds like these as some of the most effective non-surgical treatments available today.

    Side Effects of Ozempic and Mounjaro

    As with any medication, both Ozempic and Mounjaro come with potential side effects. For most people, these are temporary and mild, but understanding them helps in managing expectations and safety, according to the World Health Organization.

    Common side effects include:

    • Nausea and vomiting
    • Constipation or diarrhea
    • Bloating or indigestion
    • Mild fatigue or dizziness

    More serious side effects, though less common, can occur. These include pancreatitis, gallbladder inflammation, kidney complications, and in rare cases, thyroid-related tumors. Patients are often monitored for early signs of these conditions, especially if they have a family history of thyroid disease.

    When comparing Ozempic side effects vs Mounjaro side effects, reports suggest that Mounjaro users might experience slightly stronger gastrointestinal symptoms initially, possibly because of its dual-agonist action.

    However, gradual dose adjustments and dietary changes, like eating smaller meals and avoiding greasy foods, can minimize these effects.

    Doctors typically start patients on the lowest dosage to allow the body to adjust. Staying hydrated and taking injections on the same day each week also help reduce discomfort.

    Who Should and Shouldn’t Use Injectable Weight-Loss Meds

    These medications are designed for adults with type 2 diabetes or those classified as overweight or obese (BMI of 30 or higher, or 27 with weight-related conditions). They are not intended for short-term or cosmetic weight loss.

    People with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, pancreatitis, or severe gastrointestinal conditions should avoid GLP‑1 weight-loss drugs unless specifically advised by their physician.

    It’s crucial for potential users to consult their healthcare providers before starting these treatments. A comprehensive health assessment ensures safety and identifies whether related lifestyle changes may be sufficient before turning to medication.

    Cost, Accessibility, and Insurance Coverage

    Access and affordability remain major challenges. Ozempic and Mounjaro can cost anywhere from $900 to $1,300 per month without insurance, and coverage often depends on medical necessity. While insurers frequently cover these drugs for diabetes, weight-loss-only prescriptions may face denials.

    To help offset the price, both drug manufacturers offer savings programs and patient assistance plans. Prices also vary by region and dosage strength, making it worthwhile to consult pharmacies or clinics to find cost-effective options.

    For those comparing Ozempic vs Mounjaro, it’s worth noting that tirzepatide-based drugs (Mounjaro or Zepbound) might have limited availability in some areas due to high demand, as per the Centers for Disease Control and Prevention.

    Ozempic vs Mounjaro: Which One Is Better for You?

    The choice between Ozempic vs Mounjaro depends on a person’s health goals, metabolic profile, and tolerance. Clinical trials show both drugs yield significant weight loss and improved glucose control, but the response varies individually.

    • Those seeking steadier blood sugar control with proven long-term data may prefer Ozempic (semaglutide).
    • Those targeting faster or more substantial fat loss may respond better to Mounjaro (tirzepatide).

    Doctors often base their recommendation on the patient’s overall health, co-existing conditions, and potential side effect management.

    In practice, both options can be effective, success largely depends on consistency, proper dosing, and accompanying lifestyle adjustments such as balanced meals and physical activity.

    Frequently Asked Questions

    1. Can you stop taking Ozempic or Mounjaro once you reach your goal weight?

    Stopping these medications often leads to regained weight because appetite and metabolism return to baseline. Ongoing medical guidance is recommended before tapering off.

    2. Do Ozempic and Mounjaro affect muscle mass as well as fat loss?

    Some users may lose small amounts of lean muscle alongside fat, but maintaining protein intake and resistance exercise helps preserve muscle mass.

    3. Can you drink alcohol while using GLP‑1 weight-loss drugs?

    Light to moderate drinking is generally safe, but alcohol can worsen nausea or affect blood sugar control. It’s best to consult your healthcare provider for limits.

    4. Are there any natural alternatives to GLP‑1 weight-loss drugs?

    Certain lifestyle changes, like high-protein diets, fiber-rich foods, and regular exercise, can naturally boost satiety hormones, though not as powerfully as medical GLP‑1 therapy.



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  • Benefits, Side Effects, and the Truth About Long-Term Use

    Benefits, Side Effects, and the Truth About Long-Term Use

    Melatonin for sleep has become one of the most widely used sleep supplements, especially for people struggling with falling asleep or adjusting to irregular schedules. As interest in melatonin benefits grows, many users now take it nightly, assuming it is a safer long-term option than prescription sleep medications. Yet while short-term improvements are well documented, questions remain about whether regular use stays effective—or safe—over time.

    Understanding how melatonin side effects, dosage, and duration interact is essential before committing to nightly use. This article examines what research reveals about melatonin benefits, short-term risks, and long-term safety concerns, helping you decide whether melatonin fits into a sustainable sleep strategy.

    Melatonin Benefits for Sleep Quality and Circadian Timing

    Melatonin benefits are most consistent in helping users fall asleep faster rather than dramatically extending total sleep time. According to the National Center for Complementary and Integrative Health (NCCIH), melatonin supplements modestly reduce sleep-onset latency in people with insomnia, delayed sleep-wake phase disorder, and jet lag by supporting circadian rhythm alignment rather than inducing sedation.

    Clinical trials show that melatonin benefits average a 7-minute reduction in time to fall asleep and an 8-minute increase in total sleep duration, with stronger effects seen in older adults whose natural melatonin production declines with age. These gains may appear small, but they are statistically consistent across multiple placebo-controlled studies. For circadian-based sleep disorders, such as shift work sleep disorder, benefits can be more pronounced due to phase-shifting effects.

    Melatonin for sleep also shows value when paired with behavioral strategies like light exposure management. Evening dosing combined with morning bright-light therapy can advance circadian timing more effectively than supplements alone. While melatonin benefits do not match the potency of prescription hypnotics, its low dependency risk makes it appealing for short-term or situational use.

    Melatonin Side Effects During Short-Term Use

    Melatonin side effects are generally mild during short-term use, particularly at doses below 5 mg. Based on a clinical evidence review by the American Academy of Sleep Medicine (AASM), common reactions include headache, dizziness, nausea, and daytime sleepiness, typically affecting 10–15% of users during the first week.

    Daytime grogginess is the most frequently reported issue, especially with extended-release formulas that prolong melatonin’s half-life. Vivid dreams or nightmares may also occur, particularly at higher doses or when taken too close to bedtime. These effects often resolve with dose reduction or earlier administration in the evening.

    Interactions remain an under-discussed concern among sleep supplements. Melatonin may amplify sedation when combined with alcohol or other sleep aids, and theoretical interactions exist with antidepressants and blood-thinning medications. While serious adverse events are rare in short-term studies lasting up to six months, clinicians recommend caution when melatonin is used nightly rather than intermittently.

    Melatonin Long-Term Safety and Ongoing Health Risks

    Melatonin side effects over long-term use remain less clearly understood, largely due to limited extended clinical trials. Based on a population-based cohort study published in BMJ Open, prolonged melatonin use was associated with higher rates of cardiovascular events and all-cause mortality compared to non-users, though causality was not definitively established.

    The study followed adults using melatonin for over one year and observed increased rates of hospitalizations related to heart failure. While confounding factors such as preexisting illness may influence outcomes, the findings highlight the lack of long-term safety data for continuous use. This uncertainty explains why melatonin remains unapproved as a chronic insomnia treatment by regulatory agencies.

    Hormonal effects also raise questions, particularly at higher doses. Animal studies suggest prolonged melatonin exposure may suppress reproductive hormones, and limited pediatric data link extended use to delayed pubertal markers. Although tolerance does not appear to develop, experts recommend reassessment after two to three months rather than indefinite nightly supplementation.

    What This Means for Long-Term Sleep Health

    Melatonin for sleep can be useful, but its role is best defined as a short-term or situational aid rather than a permanent solution. The most consistent melatonin benefits involve helping users fall asleep faster and adjust circadian timing, not delivering deep or prolonged sleep. While melatonin side effects are typically mild at first, unanswered questions remain about cardiovascular and hormonal outcomes with extended use.

    For those considering nightly supplementation, dose moderation and periodic breaks may reduce potential risks. Combining melatonin with sleep hygiene improvements—such as consistent schedules, reduced evening light exposure, and stress management—often delivers better long-term results than supplements alone. Melatonin works best when used thoughtfully, not automatically.

    Frequently Asked Questions

    1. Is melatonin safe to take every night?

    Melatonin appears safe for short-term use, but evidence supporting nightly long-term use is limited. Some observational studies suggest possible health risks with prolonged supplementation. Medical guidance is recommended if use exceeds two to three months. Periodic reassessment helps reduce uncertainty.

    2. What is the best melatonin dose for sleep?

    Most people respond to doses between 0.5 mg and 3 mg. Higher doses do not necessarily improve sleep and may increase side effects. Starting low allows you to assess effectiveness without unnecessary exposure. More is not always better with melatonin.

    3. Does melatonin lose effectiveness over time?

    Current evidence suggests tolerance does not develop in the same way as prescription sleep medications. However, benefits may plateau, making nightly use less noticeable over time. Behavioral sleep strategies often sustain improvements more reliably. Melatonin works best as a support tool, not a replacement.

    4. Can melatonin cause heart problems?

    Some long-term observational studies show an association between melatonin use and increased cardiovascular events, but causation has not been proven. Underlying health conditions may contribute to these findings. This uncertainty is why clinicians urge caution with extended use. Monitoring becomes more important with ongoing supplementation.



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  • The Real Benefits of Statins and Their Side Effects 

    The Real Benefits of Statins and Their Side Effects 

    A Mayo Clinic visualization tool can help you decide if cholesterol-lowering statin drugs are right for you.

    “Physicians have a duty to inform their patients about the risks and benefits of the interventions available to them. However, physicians rarely communicate with methods that convey absolute information, such as numbers needed to treat, numbers needed to harm, or prolongation of life, despite patients wanting this information.” That is, for example, how many people are actually helped by a particular drug, how many are actually hurt by it, or how much longer the drug will enable you to live, respectively.

    If doctors inform patients only about the relative risk reduction—for example, telling them a pill will cut their risk of heart attacks by 34 percent—nine out of ten agree to take it. However, give them the same information framed as absolute risk reduction—“1.4% fewer patients had heart attacks”—then those agreeing to take the drug drops to only four out of ten. And, if they use the number needed to treat, only three in ten patients would agree to take the pill. So, if you’re a doctor and you really want your patient to take the drug, which statistic are you going to use?

    The use of relative risk stats to inflate the benefits and absolute risk stats to downplay any side effects has been referred to as “statistical deception.” To see how one might spin a study to accomplish this, let’s look at an example. As you can see below and at 1:49 in my video, The True Benefits vs. Side Effects of Statins, there is a significantly lower risk of the incidence of heart attack over five years in study participants randomized to a placebo compared to those getting the drug. If you wanted statins to sound good, you’d use the relative risk reduction (24 percent lower risk). If you wanted statins to sound bad, you’d use the absolute risk reduction (3 percent fewer heart attacks).

    Then you could flip it for side effects. For example, the researchers found that 0.3 percent (1 out of 290 women in the placebo group) got breast cancer over five years, compared to 4.1 percent (12 out of 286) in the statin group. So, a pro-statin spin might be a 24 percent drop in heart attack risk and only 3.8 percent more breast cancers, whereas an anti-statin spin might be only 3 percent fewer heart attacks compared to a 1,267 percent higher risk of breast cancer. Both portrayals are technically true, but you can see how easily you could manipulate people if you picked and chose how you were presenting the risks and benefits. So, ideally, you’d use both the relative risk reduction stat and the absolute risk reduction stat.

    In terms of benefits, when you compile many statin trials, it looks like the relative risk reduction is 25 percent. So, if your ten-year risk of a heart attack or stroke is 5 percent, then taking a statin could lower that from 5 percent to 3.75 percent, for an absolute risk reduction of 1.25 percent, or a number needed to treat of 80, meaning there’s about a 1 in 80 chance that you’d avoid a heart attack or stroke by taking the drug for the next ten years. As you can see, as your baseline risk gets higher and higher, even though you have that same 25 percent risk reduction, your absolute risk reduction gets bigger and bigger. And, with a 20 percent baseline risk, that means you have a 1 in 20 chance of avoiding a heart attack or stroke over the subsequent decade if you take the drug, as seen below and at 3:31 in my video.

    So, those are the benefits. In terms of risk, that breast cancer finding appears to be a fluke. Put together all the studies, and “there was no association between use of statins and the risk of cancer.” In terms of muscle problems, estimates of risk range from approximately 1 in 1,000 to closer to 1 in 50.

    If all those numbers just blur together, the Mayo Clinic developed a great visualization tool, seen below and at 4:39 in my video.

    For those at average risk, 10 people out of 100 who do not take a statin may have a heart attack over the next ten years. If, however, all 100 people took a statin every day for those ten years, 8 would still have a heart attack, but 2 would be spared, so there’s about a 1 in 50 chance that taking the drug would help avert a heart attack over the next decade. What are the downsides? The cost and inconvenience of taking a pill every day, which can cause some gastrointestinal side effects, muscle aching, and stiffness in about 5 percent, reversible liver inflammation in 2 percent, and more serious damage in perhaps 1 in 20,000 patients.

    Note that the two happy faces in the bottom left row of the YES STATIN chart represent heart attacks averted, not lives saved. The chance that a few years of statins will actually save your life if you have no known heart disease is about 1 in 250.

    If you want a more personalized approach, the Mayo Clinic has an interactive tool that lets you calculate your ten-year risk. You can get there directly by going to bit.ly/statindecision.



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  • Statins and Muscle Pain Side Effects 

    Statins and Muscle Pain Side Effects 

    Why is the incidence of side effects from statins so low in clinical trials while appearing to be so high in the real world?

    “There is now overwhelming evidence to support reducing LDL-C (low-density lipoprotein cholesterol)”—so-called bad cholesterol—to reduce atherosclerotic cardiovascular disease (CVD),” the number one killer of men and women. So, why is adherence to cholesterol-lowering statin drug therapy such “a major challenge worldwide”? Researchers found “that the majority of studies reported that at least 40%, and as much as 80%, of patients did not comply fully with statin treatment recommendations.” Three-quarters of patients may flat out stop taking them, and almost 90 percent may discontinue treatment altogether.

    When asked why they stopped taking the pills, most “former statin users or discontinuers…cited muscle pain, a side effect, as the primary reason…” “SAMSs”—statin-associated muscle symptoms—“are by far the most prevalent and important adverse event, with up to 72% of all statin adverse events being muscle-related.” Taking coenzyme Q10 supplements as a treatment for statin-associated muscle symptoms was a good idea in theory, but they don’t appear to help. Normally, side-effect symptoms go away when you stop the drug but can sometimes linger for a year or more. There is “growing evidence that statin intolerance is predominantly psychosocial, not pharmacological.” Really? It may be mostly just in people’s heads?

    “Statins have developed a bad reputation with the public, a phenomenon driven largely by proliferation on the Internet of bizarre and unscientific but seemingly persuasive criticism of these drugs.” “Does Googling lead to statin intolerance?” But people have stopped taking statins for decades before there even was an Internet. What kinds of data have doctors suggested that patients are falsely “misattribut[ing] normal aches and pains to be statin side effects”?

    Well, if you take people who claim to have statin-related muscle pain and randomize them back and forth between statins and an identical-looking placebo in three-week blocks, they can’t tell whether they’re getting the real drug or the sugar pill. The problem with that study, though, is that it may take months not only to develop statin-induced muscle pain, but months before it goes away, so no wonder three weeks on and three weeks off may not be long enough for the participants to discern which is which.

    However, these data are more convincing: Ten thousand people were randomized to a statin or a sugar pill for a few years, but so many more people were dying in the sugar pill group that the study had to be stopped prematurely. So then everyone was offered the statin, and the researchers noted that there was “no excess of reports of muscle-related AEs” (adverse effects) among patients assigned to the statin over those assigned to the placebo. But when the placebo phase was over and the people knew they were on a statin, they went on to report more muscle side effects than those who knew they weren’t taking the statin. “These analyses illustrate the so-called nocebo effect,” which is akin to the opposite of the placebo effect.

    Placebo effects are positive consequences falsely attributed to a treatment, whereas nocebo effects are negative consequences falsely attributed to a treatment, as was evidently seen here. There was an excess rate of muscle-related adverse effects reported only when patients and their doctors were aware that statin therapy was being used, and not when its use was concealed. The researchers hope “these results will help assure both physicians and patients that most AEs associated with statins are not causally related to use of the drug and should help counter…exaggerated claims about statin-related side effects.”

    These are the kinds of results from “placebo-controlled randomised trials [that] have shown definitively that almost all of the symptomatic adverse events that are attributed to statin therapy in routine practice are not actually caused by it (ie, they represent misattribution.)” Now, “only a few patients will believe that their SAMS are of psychogenic origin” and just in their head, but their denial may have “deadly consequences.” Indeed, “discontinuing statin treatment may be a life-threatening mistake.”

    Below and at 4:46 in my video How Common Are Muscle Side Effects from Statins?, you can see the mortality of those who stopped their statins after having a possible adverse reaction compared to those who stuck with them. This translates into about “1 excess death for every 83 patients who discontinued treatment” within a four-year period. So, when there are media reports about statin side effects and people stop taking them, this could “result in thousands of fatal and disabling heart attacks and strokes, which would otherwise have been avoided. Seldom in the history of modern therapeutics have the substantial proven benefits of a treatment been compromised to such an extent by serious misrepresentations of the evidence for its safety.” But is it a misrepresentation to suggest “that statin therapy causes side-effects in up to one fifth of patients”? That is what is seen in clinical practice; between 10 to 25 percent of patients placed on statins complain of muscle problems. However, because we don’t see anywhere near those kinds of numbers in controlled trials, patients are accused of being confused. Why is the incidence of side effects from statins so low in clinical trials while appearing to be so high in the real world? 

    Take this meta-analysis of clinical trials, for example: It found muscle problems not in 1 in 5 patients, but only 1 in 2,000. Should everyone over a certain age be on statins? Not surprisingly, every one of those trials was funded by statin manufacturers themselves. So, for example, “how could the statin RCTs [randomized controlled trials] miss detecting mild statin-related muscle adverse side effects such as myalgia [muscle pain]? By not asking. A review of 44 statin RCTs reveals that only 1 directly asked about muscle-related adverse effects.” So, are the vast majority of side effects just being missed in all these trials, or are the vast majority of side effects seen in clinical practice just a figment of patients’ imagination? The bottom line is we don’t know, but there is certainly an urgent need to figure it out.



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  • Uses and Side Effects of Ozempic and Other GLP-1 Weight Loss Drugs

    Uses and Side Effects of Ozempic and Other GLP-1 Weight Loss Drugs

    Ozempic and others in a new class of weight-loss drugs have been called “the medical sensation of the decade.” Are they worthy of all the hype?

    For a deep dive, please see my primer on this topic. OZEMPIC: Risks, Benefits, and Natural Alternatives to GLP-1 Weight-Loss Drugs is available as an ebook, audiobook, and paperback. You can also view my video series for free on the Ozempic topic page or our YouTube channel. Here are some of the key takeaways.

     

    What Is GLP-1?

    A naturally occurring hormone in our body, glucagon-like peptide-1 (GLP-1) plays a role in regulating our blood sugar, appetite, and digestion. Our gastrointestinal tract releases more than 20 different peptide hormones, including GLP-1. The primary stimuli for secreting GLP-1 are meals rich in fats and carbohydrates, and GLP-1’s main action is to signal satiety to the brain. It also slows our digestion. Delaying the rate at which food leaves our stomach not only helps us feel fuller for longer, but also helps with our blood sugar control. When GLP-1 or an agonist (mimic) is dripped into people’s veins, appetite is reduced, leading to markedly reduced food consumption—a decrease in caloric intake by as much as 25 to 50 percent.

     

    About GLP-1 Drugs

    Our GLP-1 hormone acts as an appetite suppressant by targeting parts of the brain responsible for hunger and cravings. GLP-1-secreting cells don’t only line our intestines; they’re also in our brains. These new anti-obesity drugs are GLP-1 agonists, mimicking the hormone’s action by binding to GLP-1 receptors.

    Our body breaks down GLP-1 so quickly that it hardly makes it even one time around our circulatory system, which is why we can’t just take the hormone directly. A compound was discovered—in the venomous saliva of a lizard called the Gila monster—that mimics GLP-1 but is resistant to breakdown. Using that compound as a template, the first GLP-1 agonist was created and approved for the treatment of diabetes about 20 years ago. Instead of most of it being cleared from the body within two and a half minutes, like native, natural GLP-1, much of the drug remains in the body for two and a half hours. That still means twice-daily injections, though, so then came liraglutide, which lasts all day. 

     

    What Is Ozempic?

    Eventually, semaglutide was developed and branded as Ozempic, which could be injected just once a week. Ozempic was approved in 2017 to treat diabetes. Within a few years, a daily oral version had been developed, again for diabetes, but researchers running those clinical trials noticed a surprising side effect: People’s appetites diminished.

     

    How Does Ozempic Work?

    In a way, GLP-1 agonist drugs work like birth control pills. The Pill mimics placental hormones, thereby tricking our body into thinking we’re pregnant all the time. Ozempic-type drugs mimic GLP-1, thereby tricking our body into thinking we’re eating all the time. That’s how it dials down our hunger drive.

     

    Ozempic for Weight Loss

    In the longest trial to date, more than 17,000 individuals were randomized to injections of either high-dose semaglutide or placebo for four years. Overall, those on the drug lost 9 percent more body weight than those in the placebo group, but all the weight was lost in the first 65 weeks. Even though they continued to get injected every week for three more years, they didn’t lose any more weight over the subsequent 143 weeks.

    Weight loss tends to plateau because the same amount of effort to cut calories—whether through willpower, drugs, or surgery—is met with growing resistance as ongoing weight loss increasingly activates our feedback control circuit, stimulating our appetite. In the case of the GLP-1 drugs, the weight loss caused by the initial drop in appetite is undercut by an apparent exponential increase in caloric intake as our body ratchets up our hunger again. Within 12 months, this resistance, combined with the decreased caloric needs from being lighter, matches the persistent effort to cut calories, and weight loss plateaus. And, as soon as we stop taking the drugs, our full appetite resumes and we start regaining the weight we initially lost.

     

    The Cost of Ozempic

    Wegovy, the high-dose Ozempic used for weight loss, costs up to $1,350 a month, which, again, may have to be paid in perpetuity since any lost weight can pile back on if you stop taking it. So, that could cost more than $16,000 a year if paid out-of-pocket for those whose insurance doesn’t cover it.

     

    Ozempic Side Effects

    The most common side effects include nausea, vomiting, diarrhea, and constipation. Gallbladder issues are another side effect; excess cholesterol shed from fat cells can crystalize in our bile like rock candy, forming gallstones.

    Rare but serious adverse effects are also emerging. The package inserts for both semaglutide and tirzepatide list a series of “warnings and precautions” that include thyroid tumors, acute inflammation of the pancreas (pancreatitis), acute gallbladder disease, acute kidney injury (that may stem from dehydration due to excess vomiting or diarrhea), allergic reactions, a heightened risk of bottoming out blood sugars while on blood sugar–lowering medications, worsening eye disease for those with type 2 diabetes, an increase in heart rate requiring monitoring, and suicidal thoughts and behaviors.

     

    What Is “Ozempic Face”?

    “Ozempic face” is a term used to describe a distorted facial appearance among users of the drug. (Similar accounts have been made of “Ozempic butt.”) Media reports have linked the drug with facial aging, but the sagging appearance has been ascribed simply to the accelerated loss of fat in the face. While this interpretation seems logical, a review of the phenomenon concluded that “this explanation cannot fully account for the markedly accelerated facial aging….” Other factors suspected as being responsible for the appearance of premature facial aging include the loss of facial muscle mass, diminished structural integrity of the skin, and changes in stem cell function and hormonal secretion.

     

    Is Ozempic Safe?

    In the first quantitative benefit-versus-harm balance analysis, the researchers concluded that those achieving a 10 percent weight loss had a more than 90 percent chance that the benefits of taking the drugs outweigh the harms, but the opposite was found for individuals achieving only a 5 percent weight loss.

    At this time, we don’t know about the long-term harms or benefits because some of these drugs and dosing schedules are so new. To complicate matters, the American Academy of Pediatrics has suggested offering these drugs for teens and even tweens as young as age 12. These drugs work by acting on the brain, so who knows what effect they might have on childhood development and beyond if young people end up taking them for the rest of their lives. Although we now have evidence of near-term benefit over a few years, we cannot assume long-term safety until it has been demonstrated.

     

    Ozempic Alternatives

    We don’t need to take GLP-1-mimicking drugs. Not only can the ingestion of a plant-based meal more than double GLP-1 secretion, compared to a meat meal, but plant-based diets can also cause weight loss by boosting our resting metabolic rate and incorporating “calorie-trapping” high-fiber foods that flush calories away. The largest study of people eating strictly plant-based found they are about 35 pounds lighter on average.

    When we eat a donut, its fat, sugar, and starch get absorbed quickly, high up, before reaching the part of our digestive tract where we produce most of the hormone that suppresses our appetite, GLP-1. Since the cells that produce GLP-1 in response to calorie exposure are concentrated at the end of our digestive tract, while the majority of the calories we consume are absorbed early on, most calories never make it down far enough. That’s why our appetites aren’t suppressed very much these days. From a GLP-1 standpoint, when we have that donut, it’s like we never ate much of anything. No wonder we reach for donut number two.

    Our prehistoric ancestors are believed to have consumed as much as 100 daily grams of fiber, which is more than six times what most of us are getting these days. We evolved eating massive amounts of whole plant foods—the only places fiber is found in abundance. That enabled out natural satiety mechanisms to keep us from overeating. By eating the way nature intended, we can release GLP-1 the way nature intended. That helps explains why in the medical literature, compared to any other way of eating that didn’t involve portion control, a whole food, plant-based diet has been shown to lead to greater average weight loss than any other diet.

     

    For more in-depth information on Ozempic and GLP-1, check out these resources:



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  • Uses, Benefits And Side Effects

    Uses, Benefits And Side Effects

    Chlorella is a type of green algae that is harvested in fresh water to be used as a dietary supplement. It is rich in numerous nutrients and vitamins, including D and B12. Microalgae like chlorella are used in the pharmaceutical and cosmetic industries as well. These algae are reported to promote human health.

    Chlorella supplementation in humans is known to work as antidiabetic, antihypertensive, and antihyperlipidemic. Some studies have even suggested that it improves total cholesterol levels, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels.

    The History:

    It was first discovered by a famous microbiologist and botanist, Dr. Martinus Willem Beijerinck, in 1890. However, more research on its properties began after the Second World War due to a global food crisis.

    Researchers in the United States found that chlorella can be used as an additive for conventional foods. Currently, Chorella pecies have been divided into three varieties: C. vulgaris, C. lobophora, and C. sorokiniana. The most commonly used form in supplements is C. vulgaris.

    Humans cannot digest chlorella in its natural form; this is why its cell walls are mechanically broken down and added into supplements.

    Why Must You Include Chlorella Supplements In Your Diet?

    Several studies over the years have confirmed that it contains a variety of nutrients and bioactive compounds that help prevent certain diseases.

    Contains Essential Nutrients: It has all essential amino acids, including arginine, which is necessary for making proteins. It contains all the vitamins required by humans, such as vitamin B1, B2, B6, B12, niacin, folate, biotin, pantothenic acid, C, D2, E, and K.

    Some studies conducted on rats and mice have confirmed that C. vulgaris or C. pyrenoidosa are capable of preventing the development of various diseases.

    Supports Immune Function: A small study published on the National Center for Biotechnology Information (NCBI) found that men who were given chlorella supplements were able to produce more antibodies and improve mucosal immune function.

    Reduces Anemia Risk: Chlorella contains folate, vitamin B-12, and iron in large amounts, making it an ideal supplement for pregnancy-associated anemia, proteinuria, edema, and hypertensive disorder, according to a study published in 2009.

    Vitamin Deficiency: Chlorella is a potent source of vitamin B-12. Researchers have found that its supplements are immensely helpful for people with B-12 deficiency. They found that the human body can absorb B-12 from chlorella effectively.

    Reduces Blood Pressure: Chlorella has been found effective in reducing blood pressure in both humans and animals due to the presence of arginine and antioxidants. It also has been found useful in increasing young individuals’ capacity to exercise at moderate intensity for extended periods.

    Is It Safe For Everyone?

    Chlorella is usually considered safe to use by everyone; however, like all supplements, it may have some side effects such as nausea, diarrhea, and stomach cramps. It is also extremely important to consult a healthcare provider before including it in your diet. You also must not take a chlorella supplement if you are pregnant, allergic to molds, or have iodine sensitivity.

    Chlorella is essentially an algae that is vulnerable to viral infection. These viruses could also affect humans. Therefore, you must buy your chlorella supplement only from trusted brands.

    Chlorella and spirulina are the most popular algae supplements. Several supplements combine both algae to ensure maximum effectiveness and efficiency.

    Chlorella may have some benefits as a dietary supplement, However, you must consult your healthcare provider before including it in your diet. Here are some of the Chlorella supplements that you can try.

    1. Good Natured Premium Spirulina and Chlorella Capsules

    This is a sustainable and organic product that contains a combination of two of the most nutrient-dense superfoods. It assists your body in digestion and energizes you from within. It is a nutrient-rich product with 13 vitamins, 10 minerals, 18 amino acids, and 3 phytonutrients. These non-GMO, non-irradiated capsules are the perfect nutritional supplement for a healthy and active lifestyle.

    2. Organic Chlorella Tablets by Micro Ingredients

    One of the bestsellers on Amazon, these chlorella tablets are packed with the goodness of essential vitamins and minerals. It is a highly concentrated formula that uses pure vegan-friendly ingredients. The choreography in the product is raw, organic, and treated under low temperature. It is an organic and non-GMO product made without fillers, preservatives, artificial colors or flavors, soy, or gluten. Best for those who do not really love eating the greens but wish to include essential nutrients in their food.

    3. Chlorella Spirulina Powder Capsules

    An ultra-pure organic spirulina chlorella powder, this supplement is harvested in clean, pollution-free water. The supplement promises to assist you in your health journey. It energizes you from within, enhances digestion, and reduces fatigue. It comes in capsule form and leaves no aftertaste. The brand offers a full refund if you are not happy with the quality of the product. However, you must keep in mind supplements are not quick fixes; these are only meant to aid your overall fitness routine.

    4. NOW Supplements’ Organic Chlorella

    This high-quality chlorella supplement has been manufactured in a GMP-certified facility. The supplement contains aturally occurring chlorophyll, plus beta-carotene, mixed carotenoids, vitamin C, iron, and protein. Most of its ingredients are organic, making it suitable for those looking for climate-friendly alternatives. Make your diet more wholesome by including this multipurpose supplement.

    5.  Sunlit Best USDA Organic Premium Chlorella Tablets

    A USDA-certified organic supplement, this product supports your overall well-being due to its purity and potency. It works as an adaptogen for your body, which essentially implies that it assists your body in responding to stress, fatigue, and anxiety. Sunlit offers one of the few products that support natural body odor control. Each chlorella tablet is made of 100% pure chlorella pyrenoidosa. All ingredients included in the product are pure, clean, and safe. The chlorella has also been processed under low temperatures to ensure superior quality. A powerhouse of nutrients and plant-based protein, this supplement will help you lead an energetic and healthy life.

    6. Sun Chlorella Green Algae Superfood Supplement

    Give your body the chance to repair and rejuvenate with this Chlorella pyrenoidosa freshwater algae formula. This product does not use heat or chemicals to break the cell walls of chlorella to preserve all nutrients. It has been tested for purity to ensure you get all the essential vitamins and amino acids that chlorella offers. It comes without gluten, GMOs, binders, fillers, preservatives, yeast, artificial colors, or flavors. The unique process followed to make this supplement allows your body to absorb and digest its amazing nutrition.

    7. EARTH CIRCLE ORGANICS Chlorella Tablets

    A high-quality herbal supplement, Earth Circle’s chlorella tablets have been made with organic compounds. It is a sustainable product packed with protein, vitamins, fiber, enzymes, and Chlorella Gorwth Factor (CGF). It is vegan and gluten-free to ensure that people with dietary restrictions can also have a nutrient-rich diet. It is a cruelty-free product that has been independently tested for maximum potency and purity. Experience the power of chlorella through these tablets.

    8. Nutricost Chlorella Capsules

    A non-GMO, preservative, additive, and filler-free dietary supplement, Nutricost’s chlorella capsules have the benefits of all green foods rolled in one! This pack contains over 240 capsules, each packed with different vitamins, minerals, amino acids, and phytonutrients. Manufactured in a GMP-compliant and FDA-registered facility, it is vegan and gluten-free. The cell walls in these capsules have been mechanically broken down to aid digestibility. A must-try supplement for those looking for a plant-based supplement.

    9. Organic Spirulina And Chlorella Tablets

    This supplement contains the benefits of both spirulina and chlorella, the most nutrient-rich compounds. Both contain over 100 micronutrients needed for optimal health. It has organic certification from the USDA, EU, and Naturland. Made under stringent conditions, this product offers you maximum purity. In fact, Triquetra uses 100% organic and plant-based fertilizers in the farming process as well. It is free of pesticides, herbicides, chemical fertilizers, and animal by-products and is non-GMO. You can trust this brand if you’re looking for an environment-friendly clean supplement.

    10. Piping Rock Chlorella

    This supplement is a must-have if you are looking for a pure, potent, and safe chlorella source! It is a vegan and vegetarian-friendly way of getting the benefits of algae-based nutrients and vitamins. It has several health benefits, including improved heart health, joint mobility, skin smoothness, muscle recovery, and improved brain function. It is a gluten-free, non-GMO supplement that has been made with trusted ingredients. And the best part about it is its sustainability features recognized by trusted certifications.

    11. ENERGYBITS – Organic Chlorella Tablets

    This supplement makes sure amino acids, proteins’ building blocks, enter your body easily, providing much-needed strength to your bones, muscles, skin, and tendons. It is worth your time and money if you follow a keto or vegan diet. It acts as a natural detoxifier and immune booster, offering various health benefits. These algae-based tablets serve as a comprehensive resource of vitamins and minerals. Easy to include in your diet, these tablets can be blended into a smoothie or swallowed with water.

    12. On Target Living Organic Spirulina Chlorella

    This supplement has been made using chlorella and spirulina cultivated in fresh water in Taiwan. Each batch of this product has been third-party tested for fillers, additives, and fillers. A vegan immunity-boosting supplement, this product is USDA-certified for its organic ingredients. It will give you an adequate amount of protein and other necessary nutrients if you do not eat meat and seafood. It is grown in ozonated water then filtered for purity making sure you only get the purest form of chlorella supplement.

    13. FRESH HEALTHCARE Chlorella Supplement

    Premium vegan chlorella powder capsules are healthy and enjoyable both as they provide an easily digestible way for you to absorb the benefits of chlorella, including anti-aging antioxidants, lowered blood sugar, improved anti-inflammatory role in heart health, and a boost in your immune system. Fresh Healthcare is one of the few brands that believes in giving back to society and donates at least 5% of our profits to charities. By helping this brand, you not only benefit your health but also help make this world a little better place to live.

    14. PURE ORIGINAL INGREDIENTS Chlorella Powder

    The supplement is packed with a high-potency formula that delivers a wide range of health benefits, including improved heart health and brain function. The package comes in powder form to ensure you can include it in your diet easily. This product is one of the top-rated supplements on Amazon.

    15. Premier Research Labs Medi Chlorella-FX Supplement

    Every serving of this capsule-form supplement contains 636 mg of premium chlorella powder. The chlorella used to make this supplement was grown in fresh water, ensuring that you get a clean, pollution-free product. Manufactured in the United States, this product is free of synthetic fillers.

    16. BulkSupplements’ Chlorella Powder

    This supplement gives your body all the essential nutrients required to lead a healthy life. It is suitable for daily use and can fit into your routine effortlessly. Produced in a facility compliant with strict GMP standards, the product has been tested for quality and purity. It can be added to coffee, tea, or shakes. Experience the confidence that comes with choosing a supplement that supports your wellness journey.

    17. Sunfood Superfoods Chlorella Tablets

    An ultra-pure, third-party-tested supplement, this product offers you an excellent source of immunity-supporting vitamin D. It is free of fillers, binders, additives, or preservatives. The chlorella used to make the supplement was grown indoors in a controlled environment to avoid any possible atmospheric contamination. You can even eat it out of the bag! These tablets can be taken with food or on an empty stomach. It comes in an earthy and nutty flavor, making it easy to consume.

    18. Nature’s Way Chlorella Micro-algae

    Farmed in environmentally controlled ponds, this supplement is vegetarian-friendly. The bottles used to pack these chlorella bottles are made from recycled plastic. This vegan supplement uses a unique formula to avoid using harmful chemicals and ensure a pure, all-natural product.

    19. Biotics Research Chlorella Capsules

    This supplement combines the best of science and nature to give you the most potent chlorella supplement. Manufactured in a GMP-certified facility, this product is gluten-free and third-party tested. It contains the purest ingredients, so you can be assured of the highest quality products. It is a great supplement for overall support.

    20. Simple Life Nutrition Supplements

    As the name suggests, this supplement contains a simple yet powerful blend of ingredients to ensure you get all the benefits of including chlorella in your diet. It is a non-GMO, vegan, and easy-to-swallow product. The supplement has been made using certified organic, non-irradiated, ultra-pure chlorella powder. Produced in a certified facility, these chlorella capsules are free of preservatives, fillers, or binders. You must include it in your diet if you are looking for a supplement that supports your health in a holistic manner.

    21. Biogenesis Organic Chlorella

    Produced in a USA FDA-accredited BioSecure site, this supplement is offered by Australia’s only licensed chlorella grower. The supplement is full of phytonutrients, amino acids, and other essential minerals. It is vegan, non-GMO, gluten-, dairy-, and soy-free. It assists in normal muscle function, reducing fatigue, and maintaining bone and teeth. The chlorella used to make this powder-form supplement was grown in the pristine waters of the Great Barrier Reef region, making it one of the most unique chlorella supplements available in the market.

    22. Dr. Mercola Fermented Chlorella with Chlorophyll

    This fermented chlorella supplement plays a key role in the body’s normal detoxification processes. It contains a unique blend of fermented chlorella, chlorophyll, and red algae rich in amino acids, vitamins, minerals, polysaccharides, and beta-glucans. Its fermented formula makes it highly digestible and bioavailable. It is third-party NSF content certified for health and safety. It also helps maintain healthy liver function as well as blood sugar levels. A gluten, soy, and GMO-free complex, this supplement delivers 13 mg of chlorophyll per serving.

    23. Source Naturals Yaeyama Chlorella

    Suitable for vegans and vegetarians, this supplement does not contain yeast, dairy, egg, gluten, corn, soy, or wheat. It is also free of sugar, starch, salt, preservatives, or artificial color, flavor, or fragrance. The product has been manufactured in the USA under the Good Manufacturing Practices (cGMPs) established by the US Food and Drug Administration. This supplement includes well-researched ingredients in their most bioavailable forms. Its USP is its non-GMO freshwater chlorella, grown on the coral reef island of Ishigaki, Japan.

    24. Earthborn Elements Chlorella Capsules

    One of the top chlorella supplements on Amazon, this product has been manufactured in the USA. It comes in easy-to-swallow capsule form with no additives or fillers. One pack gives you almost 2 months supply. Pregnant and lactating women consult their physicians before taking this supplement.

    25. Pure Mountain Botanicals Broken Cell Wall Chlorella Capsules

    These chlorella capsules contain organic chlorella and are much easier to swallow than chlorella tablets. It is vegan, kosher, and gluten-free. It has been manufactured in an FDA-registered facility to ensure the highest quality. Made with no harsh preservatives, fillers, or Flowing Agents, this product ensures you get a pure and authentic chlorella supplement.

    (Disclaimer: This article is meant for informational and educational use only and is not a replacement for professional medical advice. For any health-related concerns or questions, please consult a licensed healthcare provider. Additionally, Medical Daily suggests opting for products that have been verified by independent third-party testing to ensure their quality and effectiveness.
    Editorial Policies & Methodology: These products are selected independently and objectively, based on online reviews, various data sources, and proprietary research.)

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