Health Journal Online

Tag: PREGNANCY

  • Exposure To Air Pollution During Pregnancy And Childhood Have Lasting Effects On Brain: Study

    Exposure To Air Pollution During Pregnancy And Childhood Have Lasting Effects On Brain: Study

    Long-term exposure to air pollutants is known to affect physical well-being, increasing the risk of respiratory illnesses, cardiovascular diseases, and cancers. A recent study revealed that early-life exposure to air pollution has lasting effects on the brain.

    According to the research led by the Barcelona Institute for Global Health (ISGlobal), exposure to fine particles (PM2.5) and nitrogen oxides (NOx) during pregnancy and childhood can lead to significant changes in the microstructure of the brain’s white matter. Alarmingly, these alterations can persist into adolescence, raising concerns about the long-term impact of air pollution on brain development.

    Earlier studies have explored the impact of air pollutants on the brain’s white matter, but most were limited to a single time point and did not track participants throughout childhood.

    The latest study published in Environmental Research involved 4,000 participants in Rotterdam, the Netherlands who were part of the Generation R Study and were followed up since birth. Based on the participants’ location, the team estimated the amount of exposure to 14 different air pollutants during pregnancy and childhood.

    To examine changes in white matter microstructure, researchers conducted brain scans on 1,314 children, once around the age of 10 and again around 14.

    “Following participants throughout childhood and including two neuroimaging assessments for each child would shed new light on whether the effects of air pollution on white matter persist, attenuate, or worsen,” said ISGlobal researcher Mònica Guxens in a news release.

    The results revealed that higher exposure to PM2.5 during pregnancy, as well as elevated levels of PM2.5, PM10, PM2.5-10, and NOx during childhood, led to a reduction in fractional anisotropy, a measure of how water molecules diffuse within the brain. In more mature brains, water tends to flow more in one direction, resulting in higher values for this marker. This association persisted into adolescence, indicating a long-term impact of air pollution on brain development.

    “Every increase in exposure level to air pollution corresponded to more than a 5-month delay in the development of fractional anisotropy,” the researchers wrote.

    “We think that the lower fractional anisotropy is likely the result of changes in myelin, the protective sheath that forms around the nerves, rather than in the structure or packaging of the nerve fibers,” said first author of the study, Michelle Kusters.

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  • Eating Fish During Pregnancy May Cut Offspring’s Autism Risk, Not Omega-3: Study Says

    Eating Fish During Pregnancy May Cut Offspring’s Autism Risk, Not Omega-3: Study Says

    Prenatal consumption of fish may reduce autism risk in children, but omega-3 supplements may not have the same effect, a recent study revealed.

    Including fish in the diet during pregnancy is linked to a 20% reduction in the risk of autism spectrum disorder and a decreased risk of autism-related traits in children, with particularly notable benefits for female offspring, according to the study published in the American Journal Of Clinical Nutrition.

    “Our study contributes to a growing body of evidence that demonstrates the role that prenatal diet can play in autism-related outcomes in offspring,” said the researcher Dr. Emily Oken in a news release.

    To understand how intake of fish and omega-3 supplements during pregnancy affects neurodevelopmental outcomes, researchers evaluated the dietary information of around 4,000 participants. Based on the frequency of fish consumption, the participants were grouped into four: less than once a month, more than once a month but less than weekly, weekly, and two or more servings per week.

    Around 25% of them never ate fish or consumed it less than once a month, and most of the participants never took omega-3 fish oil supplements during their pregnancy.

    The researchers then examined the incidence of autism diagnoses in children and parent-reported autism-related traits, which were measured using the Social Responsiveness Scale (SRS), a widely used survey completed by parents or caregivers.

    “Consuming fish during pregnancy was associated with a lower likelihood of offspring being diagnosed with autism and a slight decrease in total SRS scores compared to not eating fish. These results were consistent across all levels of fish consumption, from “any” amount or “less than once per week” to “more than twice per week,” the news release stated.

    However, the researchers could not find any significant association between omega-3 conception and autism diagnosis, or traits.

    “This study provides yet more evidence for the safety and benefit of regular fish consumption during pregnancy. Other proven benefits include lower risk for preterm birth and improved cognitive development,” said Dr. Oken.

    “Given the low fish intake in the United States general population and the rising autism prevalence, these findings suggest the need for better public health messaging regarding guidelines on fish intake for pregnant individuals,” the researchers concluded.

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  • Study Says Even Light Smoking During Pregnancy Affects Newborn’s Health

    Study Says Even Light Smoking During Pregnancy Affects Newborn’s Health

    Smoking during pregnancy is known to raise the risk of preterm delivery, low birth weight, and restricted growth of the fetus. But can light smoking during pregnancy, just one or two cigarettes, still harm the newborn?

    A study published in Journal of Epidemiology and Community Health suggests “that there is no safe period and no safe level of cigarette smoking shortly before or during pregnancy.” The new study provides further evidence of the harmful effects of smoking during pregnancy, emphasizing the need to completely quit the habit for the baby’s health.

    The research team utilized data from the US National Vital Statistics System (NVSS) that has recorded a total of 15,379,982 live births between 2016 and 2019. After filtering out factors such as multiple births, high blood pressure or diabetes before pregnancy, and lack of information on the smoking status 3 months before and during their pregnancy, the researchers narrowed it down to 12,150,535 mother-infant pairs.

    The study noted that over 9% of them reported smoking cigarettes before pregnancy, 7% during the first trimester, 6% in the second trimester, and around 6% in the third trimester. The intensity of smoking was measured based on the number of cigarettes smoked per day: 0, 1–2, 3–5, 6–9, 10–19, and 20 or more.

    “The women who smoked had more risk factors for neonatal health issues: they tended to be younger, non-Hispanic White, unmarried, and obese, and to have low educational attainment, more previous births, and fewer attendances for prenatal care,” the news release stated.

    The estimated prevalence of neonatal health issues was around 9.5%. Neonatal health issues included cases where newborns required immediate assisted ventilation, ventilation for more than 6 hours, NICU admission for continuous mechanical ventilation, surfactant replacement therapy, as well as cases of suspected sepsis, seizures, or serious neurological problems.

    “Smoking either before pregnancy or in each of the 3 trimesters of pregnancy was associated with an increased risk of major neonatal health issues, either separately or combined, after adjusting for potentially influential factors, including age, ethnicity, and weight (BMI) before pregnancy,” the news release stated.

    In cases where expectant mothers smoked before pregnancy, there was more 27% higher risk of having more than one major neonatal health issue. The risk was 31-32% higher if she smoked at any time during her pregnancy.

    When compared to expectant mothers who did not smoke at all, both smoking before pregnancy and during any point of pregnancy puts newborns at higher risk of having more than one health issue.

    “Even light smoking—1–2 cigarettes a day—was associated with a heightened risk of major neonatal health issues. For example, among mothers who smoked 1–2 cigarettes a day before pregnancy, the risk was 16% higher, rising to 31% higher if they smoked 20 or more a day,” the news release stated.

    When an expectant mother smokes just one or two cigarettes a day, the newborn’s risk of admission to intensive care is 13% higher. This risk increases to 29% for those who smoke 20 or more cigarettes daily.

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